In the work of both Ludwik Fleck and Thomas Kuhn the scientific literature plays important roles for stability and change of scientific phenomenal worlds. In this article we shall introduce the analyses of scientific literature provided by Fleck and Kuhn, respectively. From this background we shall discuss the problem of how divergent thinking can emerge in a dogmatic atmosphere. We shall argue that in their accounts of the factors inducing changes of scientific phenomenal worlds Fleck and Kuhn offer substantially different (...) approaches, and we shall discuss in which respects their approaches may be compatible. (shrink)

`Proto-idea' was a central concept in the thinking of the Polish microbiologist and philosopher of science Ludwik Fleck (1896–1961). Based on studies of the origin of the modern concept of syphilis, Fleck claimed that many established scientific facts are best understood as interpretations of pre scientific, somewhat hazy `proto-ideas' in the framework of a certain `thought-style'. As an example,Fleck saw the modern knowledge of infection as an interpretation of the ancient proto-idea of diseases as caused by minute `animalcules'. However, the (...) epistemological aspects of the concept of proto-ideas have only been sparsely developed and discussed by Fleck and his critics. This paper attempts to bridge the gap. Firstly, I reconstruct the concept of proto-ideasin the context of Fleck's constructivist theory of knowledge. Secondly, I illustrate the relation between Fleck's concept of proto-ideas and his nominalist view on medical taxonomy. Finally, I discuss four philosophical problems implied by Fleck's concept of proto-ideas: (a) the problem of combining two conflicting perspectives on the history of science (b) the problem of accounting for the notion of` continuity' within a non realist theory of knowledge (c) the problem of ascribing no truth-content to proto-ideas, and (d) the problem concerning the non-neutrality of the analyst's viewpoint. (shrink)

The purpose of this paper is to show that the methods of determining monetary values of biodiversity depend on one's ethical point of departure. After a short summary of the ethical principles of anthropocentrism and biocentrism, the paper discusses the problem wether we shouldextend the market system and let the price mechanism encompass biological diversity, i.e. put prices on biodiversity. Basically, the anthropocentric approach leads to an ethics of freedom, where the individual has the right to decide what is good (...) and to implement it. Then the individual's willingness to pay for biodiversity is a relevant criterion for its price. But the biocentric approach rather implies that an ethic of law is more important, valuing the real needs of Nature higher than the preferences of the individual consumers. Then the costs for protection or replacement are relevant, because they reflect what Nature needs.One further question concerns who is to decide the proces of biodiversity. If the willingness to pay is the criterion, then obviously the market should decide, using well-developed methods. If on the other hand the costs of protection or replacement are relevant, technical and economic experts have to calculat them—given the politically decided level of biodiversity to be restored.The basic question, whether the market and the price mechanism should be considered acceptable instruments to protect biodiversity, is not discussed in the paper. However, some environmentalists find the wish to maximize one's utility incompatible with environmental ethics. Also, the price mechanism may take various roles. Thus, prices may convey different information about the value of biodiversity, depending on which role we assign to them. (shrink)

This article examines the Kierkegaard reception of the Danish theologians K. Olesen Larsen and Johannes Sløk, who both understood Kierkegaard as attempting to radically subvert the freedom of the human being. Initially, I show how current Kierkegaard research on the question of subjectivity, freedom and indirect communication differs from the readings of Olesen Larsen and Sløk. Subsequently, and in contrast to this, Olesen Larsen’s somewhat ambivalent attempt to read Kierkegaard as undermining human freedom is presented. Third, I show how Sløk (...) arrives at a somewhat similar result, though in a more coherent way. In conclusion, the article offers a brief discussion on the plausibility of this interpretation. (shrink)

Lewis, D. Semantic analyses for dyadic deontic logic.--Salomaa, A. Some remarks concerning many-valued propositional logics.--Chellas, B. F. Conditional obligation.--Jeffrey, R.C. Remarks on interpersonal utility theory.--Hintikka, J. On the proper treatment of quantifiers in Montague semantics.--Mayoh, B.H. Extracting information from logical proofs.--Åqvist, L. A new approach to the logical theory of actions and causality.--Pörn, I. Some basic concepts of action.--Bouvère, K. de. Some remarks concerning logical and ontological theories.--Hacking, I. Combined evidence.--Äberg, C. Solution to a problem raised by Stig Kanger (...) and a set theoretical statement equivalent to the axiom of choice.--Lindström, P. On characterizing elementary logic.-- Scott, D. Rules and derived rules.--Hansson, B. A program for pragmatics.--Hermerén, G. Models.--Fenstad, J.E. Remarks on logic and probability.--Stenlund, S. Analytic and synthetic arithmetical statements. (shrink)

This Festschrift bears impressive testimony to the fascination which Icelandic and Norwegian sagas and Faroese ballads still exercise on researchers. Fifteen original papers examine central literary and historical aspects of Nordic sagas and ballads. The papers are published in German, English or Danish.

Abstract: This paper explores the relevance of themes from Wittgenstein's Tractatus Logico-Philosophicus to the ongoing discussion of metaphysical nihilism. I set out by showing how metaphysical nihilism is of paramount importance for cosmological arguments. Metaphysical nihilism is the position that there might have been nothing. Two conflicting intuitions emerge from a survey of discussions of metaphysical nihilism: Firstly, that metaphysical nihilism is true, and secondly, that formulations of the position are somehow unclear or nonsensical. By considering formalizations of philosophical language, (...) the second intuition is sharpened, while the first intuition is given expression through the Tractarian distinction between what is said and what is shown by our symbolism. I conclude by exploring and rejecting objections to making metaphysical nihilism a scientific, rather than a philosophical question. (shrink)

Stig Kanger made important contributions to logic and formal philosophy. Kanger's dissertation Provability in Logic, 1957, contained significant results in proof theory as well as the first fully worked out model-theoretic interpretation of quantified modal logic. It is generally accepted nowadays that Kanger was one of the originators of possible worlds semantics for modal logic. Kanger's most original achievements were in the areas of general proof theory, the semantics of modal and deontic logic, and the logical analysis of the (...) concept of rights. He also contributed to action theory, preference logic, and the theory of measurement. This is the first of two volumes dedicated to the work of Stig Kanger. The present volume is a complete collection of Kanger's philosophical papers. The second volume contains critical essays on Kanger's work, as well as biographical essays on Kanger written by colleagues and friends. (shrink)

Stig Kanger made important contributions to logic and formal philosophy. Kanger's most original achievements were in the areas of general proof theory, the semantics of modal and deontic logic, and the logical analysis of the concept of rights. But he contributed significantly to action theory, preference logic and the theory of measurement as well. This is the second of two volumes dedicated to the work of Stig Kanger. The first volume is a complete collection of Kanger's philosophical papers. (...) The present volume contains critical essays on the various aspects of Kanger's work as well as some biographical sketches. Lennart Åqvist, Jan Berg, Brian Chellas, Anatoli Degtyarev, Lars Gustafsson, Sören Halldén, Kaj Børge Hansen, Sven Ove Hansson, Risto Hilpinen, Jaakko Hintikka, Ghita Holmström-Hintikka, Lars Lindahl, Sten Lindström, Ingmar Pörn, Dag Prawitz, Wlodek Rabinowicz, Krister Segerberg, Amartya Sen, Sören Stenlund, Göran Sundholm, and Andrei Voronkov have contributed to this volume. (shrink)

BackgroundAntipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic medications. We investigated if CYP2D6 genetic variation influenced weight or BMI among people taking antipsychotic treatment.MethodsWe conducted a systematic review and a random effects meta-analysis of publications in Pubmed, Embase, PsychInfo, and CENTRAAL that had BMI and/or weight measurements of patients on long-term antipsychotics by their CYP2D6-defined metabolic groups.ResultsTwelve (...) studies were included in the systematic review. All cohort studies suggested that the presence of reduced-function or non-functional alleles for CYP2D6 was associated with greater antipsychotic-induced weight gain, whereas most cross-sectional studies did not find any significant associations. Seventeen studies were included in the meta-analysis with clinical data of 2,041 patients, including 93 poor metabolizers, 633 intermediate metabolizers, 1,272 normal metabolizers, and 30 UMs. Overall, we did not find associations in any of the comparisons made. The estimated pooled standardized differences for the following comparisons were PM versus NM; weight = –0.07, BMI = 0.40. IM versus NM; weight = 0.09 and BMI = 0.09. UM versus EM; weight = 0.01 and BMI = –0.08.ConclusionOur systematic review of cohort studies suggested that CYP2D6 poor metabolizers have higher BMI than normal metabolizers, but the data of cross-sectional studies and the meta-analysis did not show this association. Although our review and meta-analysis constitutes one of the largest studies with comprehensively genotyped samples, the literature is still limited by small numbers of participants with genetic variants resulting in poor or UMs status. We need further studies with larger numbers of extreme metabolizers to establish its clinical utility in antipsychotic treatment. CYP2D6 is a key gene for personalized prescribing in mental health. (shrink)

This book explores two questions that are integral to the question of the existence of God. The first question concerns the meaning of "existence" and the second concerns the meaning of "God". Regarding the first question, this book motivates, presents and defends the meta-ontology found in Gottlob Frege's writings and defended by Michael Dummett, Crispin Wright and Bob Hale. Frege's approach to questions of existence has mainly found use in connection with abstract objects such as numbers. This is one of (...) the first studies to systematically present Fregean meta-ontology and apply it to theology. Frege's meta-ontology is informed by his context principle. According to this, logico-syntactic notions such as "singular term" and "predicate" are pivotal to questions of what exists. These notions serve to throw light on the second question. Through thorough engagement with Old as well and New Testament texts, the book shows how Frege's logico-syntactic notions are of crucial importance when seeking to understand the meaning and use of "God". To complete the defence of Fregean meta-ontology, the book concludes by pointing to important differences between the otherwise closely associated concepts of an object found in Wittgenstein's Tractatus Logico-Philosophicus and Frege's writings. (shrink)

Summary According to the so-called Starnberger Group1, the amenability of a science to science policy measures, conceptualised by the Group in terms of finalization , depends crucially on conditions intrinsic to the science not invariably present at every stage of its development. Finalization is possible only at junctures where the science in question faces methodologically divergent alternative lines of development. The most significant kind of case depends on the presence of completed , or classical , theories.