Several commentators since Aristotle have sought to convince us that Plato's discussion of political constitutions or politeiai in Republic 8 is full of problems. In effect, such commentators argue that Plato's account is not all that helpful in our efforts to understand political life. This paper argues that, despite several objections to Plato's discussion of political constitutions in Republic 8, there is much that is helpful for thinking about political life. The following issues are taken up in an effort to (...) clarify Plato's account of regimes: the role of such an account in the main ethical argument of the dialogue ; whether Plato's discussion has both an a priori perspective and one based on experience; the analogy of the city and the soul and whether this holds together in Republic 8; Plato's depiction of regime change in temporal/historical terms; and the fact that the account of political regimes seems incomplete because each regime is presented in the manner of a sketch. (shrink)

Several commentators since Aristotle have sought to convince us that Plato’s discussion of political constitutions or politeiai in Republic 8 is full of problems. In effect, such commentators argue that Plato’s account is not all that helpful in our efforts to understand political life. This paper argues that, despite several objections to Plato’s discussion of political constitutions in Republic 8, there is much that is helpful for thinking about political life. The following issues are taken up in an effort to (...) clarify Plato’s account of regimes: the role of such an account in the main ethical argument of the dialogue ; whether Plato’s discussion has both an a priori perspective and one based on experience; the analogy of the city and the soul and whether this holds together in Republic 8; Plato’s depiction of regime change in temporal/historical terms; and the fact that the account of political regimes seems incomplete because each regime is presented in the manner of a sketch. (shrink)

Man, being per natura «in the image of God», finds himself constitutionally incardinated in the «God archetype». The ousia of man is therefore at the same time hyperousios, anthropology and metaphysics coincide. Entrusting his own existence under the aegis of Love, man can transcend the iconic condition of his created being and immerge himself, body and soul, in the sphere of the uncreated energies of God, becoming similar to God; in this way he fulfills his ontological constitution of zôon theoùmenon.

Many decades ago Patrick Suppes argued rather convincingly that theoretical hypotheses are not confronted with the direct, raw results of an experiment, rather, they are typically compared with models of data. What exactly is a data model however? And how do the interactions of particles at the subatomic scale give rise to the huge volumes of data that are then moulded into a polished data model? The aim of this paper is to answer these questions by presenting a detailed case (...) study of the construction of data models at the LHCb for testing Lepton Flavour Universality in rare decays of B-mesons. The close examination of the scientific practice at the LHCb leads to the following four main conclusions: raw data in their pure form are practically useless for the comparison of experimental results with theory, and processed data are in some cases epistemically more reliable, real and simulated data are involved in the co-production of the final data model and cannot be easily distinguished, theory-ladenness emerges at three different levels depending on the scope and the purpose for which background theory guides the overall experimental process and the overall process of acquiring and analysing data in high energy physics is too complicated to be fully captured by a generic methodological description of the experimental practice. (shrink)

What are scientific models? Philosophers of science have been trying to answer this question during the last three decades by putting forward a number of different proposals. Some say that models are best understood as abstract Platonic objects or fictional entities akin to Sherlock Holmes, while others focus on their mathematical nature and see them as set theoretical structures. Although each account has its own strengths in offering various insights on the nature of models, several objections have been raised against (...) these views which still remain unanswered, making the debate on the ontology of models seem unresolvable. The primary aim of this paper is to show that a large part of these difficulties stems from an inappropriate reading of the main question on the ontology of models as a purely metaphysical question. Building on Carnap, it is argued that the question of the ontology of scientific models is either an internal theoretical question within an already accepted linguistic framework or an external practical question regarding the choice of the most appropriate form of language in order to describe and explain the practice of scientific modelling. The main implication of this view is that the question of the ontology of models becomes a means of probing other related questions regarding the overall practice of scientific modelling, such as questions on the capacity of models to provide knowledge and the relation of models with background theories. (shrink)

In the domain of evolutionary cognitive archaeology, the early body ornaments from the Middle Stone Age/Palaeolithic are generally treated as mere by-products of an evolved brain-bound cognitive architecture selected to cope with looming social problems. Such adaptive artefacts are therefore taken to have been but passive means of broadcasting a priori envisaged meanings, essentially playing a neutral role for the human mind. In contrast to this epiphenomenalist view of material culture, postphenomenology and the Material Engagement Theory have been making a (...) case for the active role of artefacts on the count that they can actually shape and restructure the human mind. By bringing these dissenting voices together, the paper at hand employs an enactive way of thinking in order to challenge the epiphenomenalist take on early body ornaments. In fact, two variants of enactivism are presented, each advancing a unique explanation of how the engagement of early humans with body ornaments transformed their minds along the two postphenomenological categories of embodied and hermeneutic cognition. Our theoretical frameworks specifically seek to explore how early beadworks could have scaffolded the creation of semiotic categories and the development of cognitive processes. Despite relying on inherently different premises, both theories suggest that beads fostered the emergence of an epistemic apparatus which thoroughly transformed the way humans engaged with the world. Having concurred on the ornaments’ transformative effects, we ultimately conclude that the epiphenomenalist paradigm best be replaced with an enactive approach grounded on the dictates of postphenomenology and the MET. (shrink)

Current cosmological observations place little constraints on the nature of dark matter, allowing the development of a large number of models and various methods for probing their properties, which seem to provide ideal grounds for the employment of robustness arguments. In this article, the extent to which such arguments can be used to overcome various methodological and theoretical challenges is examined. The conclusion is that while robustness arguments have a limited scope in the context of dark matter research, they can (...) still be used for increasing the scientists’ confidence about the properties of specific models. (shrink)

In October 2018, Slavoj Žižek published a two-part contribution titled ‘Should the Left’s answer to rightist populism be really a ‘‘me too’’?’. In this text, Žižek reproduced his diachronic skepticism on populism as a fruitful strategy for the Left. In a critical vein, we believe that Žižek’s latest interventions join - unconsciously or not - an avalanche of anti-populist discourses that usually emanate from elitist politicians and journalists, and reproduce a moralist, alarmist stance against populism. As a consequence, anti-populist elitism (...) blurs the concept of populism even more thereby hampering our possibilities to capture the changing politico-historic reality in the age of collapsing neoliberalism. (shrink)

Negotiation research primarily focuses on negotiators? interests in order to understand negotiation and offer advice about the prospective outcome. Win-win outcomes, i.e., outcomes that serve the interests of all negotiating parties, have been established and promoted as the ultimate goal for any negotiation situation. We offer a perspective that draws on Aristotle's philosophical program and discuss how the outcome is not defined by the parties? interests, but by the intersubjective validity of claims, which can essentially be treated as representative of (...) the ?truth.? (shrink)

The antecedents of immigration attitudes have been extensively examined in academic research, in particular, with respect to media use and personal contact with immigrants. Research on the role of interpersonal discussions about the issue of immigration has been scarce, however. Results from a two-wave panel survey show that individuals holding unfavorable attitudes towards immigration engaged more often in interpersonal communication about immigration, which colored the overall effect of engaging in such discussions. The implications of these results are discussed in the (...) concluding section. (shrink)

Negotiation is mainly treated as a process through which counterparts try to satisfy their conflicting interests. This traditional, subjective approach focuses on the interests-based relation between subjects and the resources which are on the bargaining table; negotiation is viewed as a series of joint decisions regarding the relation of each subject to the negotiated resources. In this paper, we will attempt to outline an intersubjective perspective that focuses on the communication-based relation among subjects, a relation that is founded upon communicative (...) rationality mechanisms which are inherent in social activity. Much in contrast to the concept of interests which describe the relationship of each subject alone to the resources, we will use the concept of ?claim-rights? which are properly formed and validated only vis-à-vis negotiating partners and on the basis of the communication that develops among them. We will offer a step-by-step account of the creation of claim-rights and argue that their validation does not necessarily lie in the parties? interests, but in the communication mechanisms that induce consensus and result in mutually acceptable outcomes. (shrink)

DNA glycosylases remove aberrant DNA nucleobases as the first enzymatic step of the base excision repair (BER) pathway. The alkyl‐DNA glycosylases AlkC and AlkD adopt a unique structure based on α‐helical HEAT repeats. Both enzymes identify and excise their substrates without a base‐flipping mechanism used by other glycosylases and nucleic acid processing proteins to access nucleobases that are otherwise stacked inside the double‐helix. Consequently, these glycosylases act on a variety of cationic nucleobase modifications, including bulky adducts, not previously associated with (...) BER. The related non‐enzymatic HEAT‐like repeat (HLR) proteins, AlkD2, and AlkF, have unique nucleic acid binding properties that expand the functions of this relatively new protein superfamily beyond DNA repair. Here, we review the phylogeny, biochemistry, and structures of the HLR proteins, which have helped broaden our understanding of the mechanisms by which DNA glycosylases locate and excise chemically modified DNA nucleobases. (shrink)

Novel regulatory elements that enabled expression of pre‐existing immune genes in reproductive tissues and novel immune genes with pregnancy‐specific roles in eutherians have shaped the evolution of mammalian pregnancy by facilitating the emergence of novel mechanisms for immune regulation over its course. Trade‐offs arising from conflicting fitness effects on reproduction and host defenses have further influenced the patterns of genetic variation of these genes. These three mechanisms (novel regulatory elements, novel immune genes, and trade‐offs) played a pivotal role in refining (...) the regulation of maternal immune systems during pregnancy in eutherians, likely facilitating the establishment of prolonged direct maternal–fetal contact in eutherians without causing immunological rejection of the genetically distinct fetus. (shrink)

_Framing the Dialogues: How to Read Openings and Closures in Plato_ focuses on the intricate and multifarious ways in which Plato frames his dialogues, with a view to exploring the complex association between framework and philosophical content.

This article examines the role of attention in encounters with the unknown. By examining this process of the unknown becoming known through a reading of some seminal works, notably by Merleau-Ponty, Wittgenstein, and Waldenfels, the article focuses on the existentially significant characteristics of the function of attention that are disclosed by the encounter with an alien environment. Thereby, attention is considered as being neither fully under the control of the subject, nor completely the result of the external conditioning of our (...) sense perception. Rather, attention will be seen to reside within a reciprocal field of tension between the familiar and the alien. This is related to Merleau-Ponty’s concept of ‘intentional arch’, describing the process of transition from the indeterminate to the determinate. Endorsing this account of attention will allow us to understand the limits of approaches to enacted and embodied cognition that still understand the process of getting to know something new, and even something alien, as a form of ‘domestication’. (shrink)

In order to understand what we are talking about when we talk about joint attention, I will scrutinize how the mainstream view that builds on representational and intentionalist theories of mind is constituted. My aim is to show that much of the theory of joint attention is quite narrowly constructed and comes with tacit disciplinary biases that exclude much of what is existentially important in our practices of sharing our perceptions and guiding others to attend to the world in novel (...) ways. By using the frameworks of classical phenomenology and enactivist theories of mind, I aim to show how we, in our interactions, share our perceptions even with beings that are distinctly different from us. And, that this _difference_ in our personal worldview, our cognitive capacities, and our sensory modalities should be seen as a constitutive aspect of our practices of shared attention. I will articulate attention as a revelatory practice that aids us in discovering a shared world through the plurality, rather than similarity, of our perceptual actions. Attention is, in this sense, not solely driven by subjective intentions; it is also formed and co-constituted by my being addressed by the other. (shrink)

Material Engagement Theory is currently driving a conceptual change in the archaeology of mind. Drawing upon the dictates of enactivism and active externalism, it specifically calls for a radical reconceptualization of mind and material culture. Unpersuaded by the common assumption that cognition is brain-bound, Malafouris argues in favour of a process ontology that situates thinking in action. In granting ontological primacy to material engagement, MET seeks to illuminate the emergence of human ways of thinking through the practical effects of the (...) material world. Considering that this is a characteristic example of a pragmatic take on cognition, this contemporary theoretical platform appears to share a lot with pragmatism. As of late, scholars working at the intersection of philosophy, semiotics, and cognitive science have made important steps towards the rapprochement between pragmatism and externalism. Looking to contribute to this growing corpus of work, the present paper focuses on MET’s relation to the pragmatism of Peirce, Dewey, and Mead. Having elsewhere recognized the overlap and complementarity between Malafouris’ and Peirce’s theories in particular, I developed a pragmatic and enactive theory of cognitive semiotics that is suitably geared to trace the nature, emergence, and evolution of material signs. Therefore, besides noting some obvious historical connections, I hereby aim to establish the theoretical backdrop upon which this composite theory is supposed to function, while also exploring new potential avenues. Given that this cognitive semiotic framework can be seen as a pragmatic extension of Malafouris’ enactivist approach to archaeology, the current paper delves into MET’s theoretical underpinnings, seeking to complement its working hypotheses and concepts with philosophical notions and ideas advanced long ago. This synthesis ultimately concludes with a call for the reconceptualization of ‘representation’ as a heuristic concept. (shrink)

Gender dysphoria is a persistent distress about one’s assigned gender. Referrals regarding gender dysphoria have recently greatly increased, often of a form that is rapid in onset. The sex ratio ha...

The current legal status and medical ethics of routine or religious penile circumcision of minors is a matter of ongoing controversy in many countries. We focus on the United Kingdom as an illustrative example, giving a detailed analysis of the most recent British Medical Association guidance from 2019. We argue that the guidance paints a confused and conflicting portrait of the law and ethics of the procedure in the UK context, reflecting deeper, unresolved moral and legal tensions surrounding child genital (...) cutting practices more generally. Of particular note is a lack of clarity around how to apply the “best interests” standard—ordinarily associated with time-sensitive proxy decision making regarding therapeutic options for a medically unwell patient—to a parental request for a medically unnecessary surgery to be carried out on the genitalia of a healthy child. Challenges arise in measuring and assigning weights to intended sociocultural or religious/spiritual benefits, and even to health-related prophylactic benefits, and in balancing these against potential physical, functional, and psychosexual risks or harms. Also of concern are apparently inconsistent safeguarding standards being applied to children based on their birth sex categorization or gender of rearing. We identify and discuss recent trends in British and international medical ethics and law, finding gradual movement toward a more unified standard for evaluating the permissibility of surgically modifying healthy children's genitals before they can meaningfully participate in the decision. (shrink)

Recently, many philosophers have been interested in using locative relations to clarify and pursue debates in the metaphysics of material objects. Most begin with the relation of exact location. But what if we begin instead with the relation known as weak location – the relation an object x bears to any region not completely bereft of x? I explore some of the consequences of pursuing this route for issues including coincidence, extended simples, and endurance, with an eye to evaluating the (...) prospects for taking weak location as our fundamental locative relation. (shrink)

Many researchers believe the tremendous industrial development over the past two centuries is unsustainable because it has led to unintended ecological deterioration. Despite the ever-growing attention sustainable supply-chain management has received, most SSCM research and models look at the consequences, rather than the antecedents or motives of such responsible practices. The few studies that explore corporate motives have remained largely qualitative, and large-scale empirical analyses are scarce. Drawing on multiple theories and combining supply-chain and business ethics literature, we purport that (...) instrumental, relational, and moral motives are behind a firm’s engagement in SSCM practices. Specifically, we examine the links between corporate motives, SSCM practices, and firm performance. Using a sample of 259 supply-chain firms in Germany, we empirically test five hypothesized relationships. Our results reveal that relational and moral motives are key drivers, and that firms exhibiting high levels of moral obligations tend to outperform those primarily driven by amoral considerations. Findings of this study contribute to multiple literatures espousing sustainability management and can help policy makers, stakeholder groups, and scholars develop more robust strategies for encouraging firms to practice SSCM. (shrink)