BackgroundTranscranial direct current stimulation targeting the primary motor hand area may induce lasting shifts in corticospinal excitability, but after-effects show substantial inter-individual variability. Functional magnetic resonance imaging can probe after-effects of TDCS on regional neural activity on a whole-brain level.ObjectiveUsing a double-blinded cross-over design, we investigated whether the individual change in corticospinal excitability after TDCS of M1-HAND is associated with changes in task-related regional activity in cortical motor areas.MethodsSeventeen healthy volunteers received 20 min of real or sham TDCS on separate (...) days in randomized order. Real and sham TDCS used the classic bipolar set-up with the anode placed over right M1-HAND. Before and after each TDCS session, we recorded motor evoked potentials from the relaxed left first dorsal interosseus muscle after single-pulse transcranial magnetic stimulation of left M1-HAND and performed whole-brain fMRI at 3 Tesla while participants completed a visuomotor tracking task with their left hand. We also assessed the difference in MEP latency when applying anterior-posterior and latero-medial TMS pulses to the precentral hand knob.ResultsReal TDCS had no consistent aftereffects on mean MEP amplitude, task-related activity or motor performance. Individual changes in MEP amplitude, measured directly after real TDCS showed a positive linear relationship with individual changes in task-related activity in the supplementary motor area and AP-LM MEP latency.ConclusionFunctional aftereffects of classical bipolar anodal TDCS of M1-HAND on the motor system vary substantially across individuals. Physiological features upstream from the primary motor cortex may determine how anodal TDCS changes corticospinal excitability. (shrink)

Fairness, the notion that people deserve or have rights to certain resources or kinds of treatment, is a fundamental dimension of moral cognition. Drawing on recent evidence from economics, psychology, and neuroscience, we ask whether self-interest is always intuitive, requiring self-control to override with reasoning-based fairness concerns, or whether fairness itself can be intuitive. While we find strong support for rejecting the notion that self-interest is always intuitive, the literature has reached conflicting conclusions about the neurocognitive systems underpinning fairness. We (...) propose that this disagreement can largely be resolved in light of an extended Social Heuristics Hypothesis. Divergent findings may be attributed to the interpretation of behavioral effects of ego depletion or neurostimulation, reverse inference from brain activity to the underlying psychological process, and insensitivity to social context and inter-individual differences. To better dissect the neurobiological basis of fairness, we outline how future research should embrace cross-disciplinary methods that combine psychological manipulations with neuroimaging, and that can probe inter-individual, and cultural heterogeneities. (shrink)

Machine ethics and robot rights are quickly becoming hot topics in artificial intelligence and robotics communities. We will argue that attempts to attribute moral agency and assign rights to all intelligent machines are misguided, whether applied to infrahuman or superhuman AIs, as are proposals to limit the negative effects of AIs by constraining their behavior. As an alternative, we propose a new science of safety engineering for intelligent artificial agents based on maximizing for what humans value. In particular, we challenge (...) the scientific community to develop intelligent systems that have human-friendly values that they provably retain, even under recursive self-improvement. (shrink)

Interdisciplinary courses on science, engineering and society have been successfully established in two cases, at Bilkent University, Ankara, Turkey, and at the University of Hamburg, Germany. In both cases there were institutional and perceptual barriers that had to be overcome in the primarily disciplinary departments. The ingredients of success included a clear vision of interdisciplinary themes and didactics, and the exploitation of institutional opportunities. Haldun M. Ozaktas in Ankara used the dynamics of an accreditation process to establish courses on engineering (...) and society. At the University of Hamburg the introduction of optional courses into all curricula allowed for the establishment of a seminar series on physics and society, as well as on peace education and peace building. Both of these approaches have a weakness in common: the courses can disappear once their initiators have left, unless the interdisciplinary themes are integrated into compulsory core curricula. (shrink)

Since its inception in the 1970's, critical realism has grown to address a broad range of subjects, including economics, philosophy, science, and religion. It has also gone through a number of key evolutions that have changed its direction, and seen it develop into a complex and mature branch of philosophy. Critical Realism: A Brief Introduction, is the first book to look back over the entire field of critical realism in one concise and accessible volume. As the originator and chief exponent (...) of CR, Roy Bhaskar draws from his experience of countless introductory lectures, seminars, workshops and courses to give a definitive and compelling account of this increasingly influential, international and multi-disciplinary approach. Its eight chapters examine the following topics: Transcendental Realism and the Philosophy of Science Critical Naturalism and the Philosophy of Social Science Explanatory Critique and Ethics Language and Critical Discourse Analysis The Development of Critical Realism Interdisciplinarity and Applied Critical Realism Modernity, Theories of Science and Metacritique The Advantages of Critical Realism Everything from the definition of CR and its applicability to the social sciences, to explanations of dialectical critical realism and the philosophy of meta-reality are addressed in detail, making this the essential introduction for students of CR at all levels. (shrink)

A Karger 'Publishing Highlights 1890-2015' title These three volumes are the revised and enlarged edition of a classic work hailed as bringing a new perspective to knowledge of the mind-brain relationship. In the tradition of highest scholarship, the author uses both neurological and epistemological approaches to provide a unique interpretation of the relationship of brain and consciousness.

Protestant documents conceming the status of the human embryo are empirically founded on biological observations and their interpretation. In Germany the beginning of individual human life is the end of the pre-core-state, the British embryo begins at the end of phase of possible sp1itting into twins. Both argue that the once manifest human embryo carries the full human dignity. As definitions thus no Ionger can plead innocent, additional factors of the argument have to be revealed.

Sie führt zurück zu etwas, das es im Unterschiede zu dem Nichts tatsächlich gibt, zu dem genuinen Individuum namens "Zeit".

Dictionary of Critical Realism fills a vital gap in the literature. The dictionary seeks to redress the problem of accessibility by explaining all the main concepts and key developments. It has more than 500 entires on these themes, with contributions from many leading critical realists, and is thoroughly cross-referenced. However, this text does not stop at the elucidation of concepts. It incorporates surveys of critical realist work and prospects in more than fifty areas of study across the humanities and social (...) sciences, thereby demonstrating the appropriate use and possibilities of the concepts in action."--BOOK JACKET. (shrink)

Name der Zeitschrift: Zeitschrift für kritische Sozialtheorie und Philosophie Jahrgang: 1 Heft: 2 Seiten: 298-324.

A wider than just a biological approach to the human embryo provides a relational perception of it, which may open a dialogue between those who plead for the protection of the embryo and those who seek to help their patients with therapies developed through embryo research. According to all german speaking protestant churches and theologians riskful research on human embryos shall be prohibited, some theologians however concede, that for high ranking therapeutical goals the law should provide an exception. The author (...) shows that it is impossible to define any therapeutical goals unless one allows non-therapeutical research in advance. This dilemma so far is unsolved. (shrink)

The volume is dedicated to the work of Chajim H. Steinthal (1823-1899), who in the second half of the nineteenth century was a prominent philosophical linguist and also an eminent teacher of the "Science of Judaism." Together with Moritz Lazarus he founded the discipline of "Voelkerpsychologie" ("psychology of nations").

"Hermann Cohen war ein herausragender deutscher Philosoph und jüdischer Denker. In nahezu allen Bereichen seiner verzweigten Tätigkeit beeinflusste er das akademische, politische und religiöse Leben seiner Zeit. Aus Anlass des hundertsten Todestages Cohens am 4. April 2018 widmet sich der vorliegende Band Kontexten und Netzwerken, in die Cohen zeit seines Lebens eingebunden war"--.

Russland und das Russische werden für Nietzsche in den 188034 Jahren, besonders nach seiner "Entdecklung" Dostojewkijs, zu signifikanten Metaphern in sienen Überlegungen zur Zukunft Europas und der europäischen Kultur. In geopolitischer, geschichts- und moralphilosophischer Hinsicht bestimmte Nietzsche Russland als ein "Zwischenreich" zwischen Europa und Asien, das durch seinen Machtwillen in der Lage sein Könnte, das Überleben der europäischen Kultur in den von Nietzsche vorhergesehenen globalen Auseinandersetzungen des kommenden Jahrhunderts zu fördern. In psychologischer under metaphysischer under metaphysischer Hinsicht sah Nietzsche in (...) dem "beherzten Falalismus ohne Revolte" der Russen eine große Nähe zum amor fati und seiner eigenen Experimentalphilosophie.Russia and the Russian culture became significant metaphors in Nietzsche's reflections on the future of Europe and European culture in the 80s, especially after his "discovery" of Dostjevskij. On one hand, concerning geopolitics, history, and morality, Nietzsche identified Russie as an "empire-between" Europe and Asia that could guarantee the survival of European culture in the global contests of the coming century. On the other hand, concerning metaphysics and psychology, he connected the "fatalism without revolt" of the Russian people with the amor fati and his own experimental philosophy. (shrink)