Graphical AbstractHow exactly specific biological pathways and eventually life arise from the crowded molecular environment of the cell is a problem that has long vexed humanity and will require a paradigm shift toward mechanistic experimental and computational approaches that probe intracellular diversity and complexity more directly. More details can be found in article number 1800244 by Nils G. Walter. DOI: 10.1002/bies.201800244.

The human genome project's lasting legacies are the emerging insights into human physiology and disease, and the ascendance of biology as the dominant science of the 21st century. Sequencing revealed that >90% of the human genome is not coding for proteins, as originally thought, but rather is overwhelmingly transcribed into non‐protein coding, or non‐coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic DNA is “junk”, a term still championed by some geneticists and evolutionary biologists. In contrast, (...) molecular biologists and biochemists studying the vast number of transcripts produced from most of this genome “junk” often surmise that these ncRNAs have biological significance. What gives? This essay contrasts the two opposing, extant viewpoints, aiming to explain their bases, which arise from distinct reference frames of the underlying scientific disciplines. Finally, it aims to reconcile these divergent mindsets in hopes of stimulating synergy between scientific fields. (shrink)

Biology arises from the crowded molecular environment of the cell, rendering it a challenge to understand biological pathways based on the reductionist, low‐concentration in vitro conditions generally employed for mechanistic studies. Recent evidence suggests that low‐affinity interactions between cellular biopolymers abound, with still poorly defined effects on the complex interaction networks that lead to the emergent properties and plasticity of life. Mass‐action considerations are used here to underscore that the sheer number of weak interactions expected from the complex mixture of (...) cellular components significantly shapes biological pathway specificity. In particular, on‐pathway—i.e., “functional”—become those interactions thermodynamically and kinetically stable enough to survive the incessant onslaught of the many off‐pathway (“nonfunctional”) interactions. Consequently, to better understand the molecular biology of the cell a further paradigm shift is needed toward mechanistic experimental and computational approaches that probe intracellular diversity and complexity more directly. Also see the video abstract here https://youtu.be/T19X_zYaBzg. (shrink)

Ich will meine Gedanken folgendermaßen zusammenfassen: Ein spontanes und früh erlerntes Glaubenserlebnis ringt immer mit einer wissenschaftlichen Analyse. Zwar wird die Religionspsychologie negativ aufgefaßt, aber sie hilft uns auch einzusehen, wie solch eine Einstellung entstehen kann. Die intensive Glaubenserfahrung enthält immer eine Totalitätsorientierung, die den eigentlichen Grund in transzendentalen Größen sucht. Eine aufgezwängte Umorientierung bringt immer einen gewissen Schmerz mit sich. Eine religionspsychologische Analyse der Glaubensmotive führt jedoch auch zu einem Verständnis für das wichtige Zusammenspiel, das die Symbol-motive der Tradition (...) haben, und müßte auch mit den persönlich erlebten Situationen seit der Kindheit rechnen. Dadurch, daß man Zusammenspielsmöglichkeiten zwischen den historisch gegebenen Modellen und den individuellen Situationen findet, geschieht ein Wechsel, der wichtige Modelle des menschlichen Lebens vertieft und ins Bewußtsein bringt. Dies ist doch kein selbstverständlicher oder automatischer Prozeß, sondern falsche Verbindungen und negative Bindungen sind auch möglich. Hier muß eine religionsspychologische Ethik entwickelt werden. Große Aufträge erwarten uns in der Zukunft. Das oben Erwähnte kann man auch so ausdrücken: Der Glaube an Gottes Wirken ist nicht streitig mit dem Handhaben wissenschaftlicher Modelle. Ebensowenig wie das Brot und der Wein des Abendmahls was anderes als Brot und Wein zu sein brauche, ebensowenig brauchen das Gesundbeten, das Zungenreden, die Prophezeiung, die Stigmatisierung, ja des Lebens heilige Momente etwas anderes zu sein als die Ergebnisse menschlich gegebener Prozesse, um Gottes Gegenwart zu erleben. Durch die innere symbolische Interaktion wird menschliche Dürftigkeit in eine Heiligkeit mit Ewigkeitswert verwandelt - und umgekehrt: Die jahrhundertelange Mythologie findet ihre menschliche Inkarnation. (shrink)

This Is A New Release Of The Original 1910 Edition.

The last several years have seen vibrant debates among policymakers and scholars on whether to craft new human rights (or novel interpretations of existing ones) around neurotechnologies. These con...

We present a meta-analytic review on the processing of negations in conditional reasoning about affirmation problems (Modus Ponens: "MP", Affirmation of the Consequent "AC") and denial problems (Denial of the Antecedent "DA", and Modus Tollens "MT"). Findings correct previous generalisations about the phenomena. First, the effects of negation in the part of the conditional about which an inference is made, are not constrained to denial problems. These inferential-negation effects are also observed on AC. Second, there generally are reliable effects of (...) a negation in the clause referred to by the categorical premise, and these referred-negation effects are constrained to the logically fallacious AC and DA inferences. All findings are presented and discussed in relation to contemporary mental model (MM) and mental logic (ML) theories. It is argued that a double-negation elimination hypothesis provides a sufficient explanation of inferential-negation effects within both MM theory and ML theory, if the latter is extended by a validating search for counter examples. Both MM and ML theories adhere to a processing scheme that allows them to incorporate an account of referred-negation effects based on the thesis that counter-example frequency is modulated by the scope of a contrast class delineated by a false affirmative. We conclude that MM and ML theories provide adequate processing schemes to accommodate for the explanatory hypotheses, at least in principle. In practice, both approaches remain equivocal as regards the connectivity and interactivity with long-term memory knowledge invoked in generating, manipulating, and testing the mental representations of negative state of affairs. (shrink)

In defending his interest-relative account of knowledge in Knowledge and Practical Interests (2005), Jason Stanley relies heavily on intuitions about several bank cases. We experimentally test the empirical claims that Stanley seems to make concerning our common-sense intuitions about these bank cases. Additionally, we test the empirical claims that Jonathan Schaffer seems to make in his critique of Stanley. We argue that our data impugn what both Stanley and Schaffer claim our intuitions about such cases are. To account for these (...) results, one must develop a better conception of the connection between a subject's interests and her body of knowledge than those offered by Stanley and Schaffer. (shrink)

With almost incredible rapidity Marxist socialism has spread throughout the world and other forms of socialism have penetrated societies on all continents. Communist governments have not only come to dominate the U.S.S.R. and China but also eastern Europe and Cuba; Africa has not only non-Marxist forms of socialism but is the contending ground for world powers; and Latin America has seen duly elected socialist governments overthrown by rightist forces with the collusion of multinational corporations based in the U.S.A. Socialism has (...) proved itself to be not a monolithic world movement. It is its history of theory and practice. With respect to the future it depends on what organized men and women will make of it. (shrink)

With almost incredible rapidity Marxist socialism has spread throughout the world and other forms of socialism have penetrated societies on all continents. Communist governments have not only come to dominate the U.S.S.R. and China but also eastern Europe and Cuba; Africa has not only non-Marxist forms of socialism but is the contending ground for world powers; and Latin America has seen duly elected socialist governments overthrown by rightist forces with the collusion of multinational corporations based in the U.S.A. Socialism has (...) proved itself to be not a monolithic world movement. It is its history of theory and practice. With respect to the future it depends on what organized men and women will make of it. (shrink)