Kv10.1 is a voltage‐gated potassium channel relevant for tumor biology, but the underlying mechanism is still unclear. We propose that Kv10.1 plays a role coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base. Most non‐dividing cells display a primary cilium, an antenna‐like structure important for cell physiology. The cilium is disassembled when the cell divides, which requires an increase of Ca2+ concentration and a redistribution of phospholipids in its basal region, both (...) of which would be facilitated by local hyperpolarization. Cells lacking Kv10.1 show impaired ciliary disassembly and delayed entrance into mitosis. Kv10.1 is predominantly expressed during G2/M, a critical period for ciliary resorption, and localizes to the ciliary base and vesicles associated with the centrosome. This could explain the influence of Kv10.1 in cell proliferation, as well as phenotypic features of patients carrying gain of function mutations in the gene. (shrink)

In the city of Elche, every year, on the 14th and 15th of August, a sacred musical play about the death, the Assumption and the Coronation of the Virgin Mary is held. This event, known as the “Misterio de Elche”, is unique in the world. Since the middle of the 15th century it has been performed in the Basilica of Santa Maria and in the streets of the ancient city of Elche, located in the Valencian Community. In this work, classified (...) as a UNESCO World Heritage Site, the interior of the temple is transformed into 2 main stages, the scaffold, located in the lower part, and the aerial stage, located in the dome at a height of 27 m. The structure and the traction mechanisms located on the aerial stage allow the aerial devices that take part in the play, “El Araceli”, “La Mangrana” and “La Santísima Trinidad”, to be raised and lowered. It should be noted that between 2 and 5 singing actors are embarked on these devices. This article describes the main characteristics of the aerial stage structure, the 3 apparatus and the mechanical systems used. In addition, the age and modifications of “El Araceli” are analysed, as well as the results of a non-destructive test carried out on this device. (shrink)

The widespread critical evidence surrounding executive compensation of listed corporations has boosted shareholder activism in recent decades. The say-on-pay (SOP) mechanism—a vote in which shareholders express their (dis)agreement with executive pay designs—is one of the corporate governance mechanisms that has led to this activism among listed firms. Merging agency and socioemotional wealth (SEW) arguments, this paper analyzes how effective SOP voting results are among listed family firms in terms of CEO compensation efficiency and equity. Using a sample of UK listed (...) firms from 2011 to 2018, our results show that SOP effectiveness is positively influenced by family ownership and is strongly moderated by family involvement in management and in governance as well as by family generation. Our findings stress the strong family effect and the ethical perceptions of family shareholders on SOP voting, showing how family participation in the firm encourages fairer and more aligned CEO compensation packages. SOP institutional and practical implications oriented to preserve shareholder value and family wealth are finally outlined. (shrink)

The Coalition of Immokalee Workers (CIW) has successfully combated modern-day slavery by transforming the ways that over a dozen major brands, including Taco Bell, Subway, and Wal-Mart, manage their supply chains. The CIW’s efforts over more than 20 years have effectively stopped enslavement practices, including abuses such as wage theft and peonage indebtedness. We conducted a field ethnography, interviews, and archival analyses to understand this success. We find that the CIW employs a decentered, egalitarian, and ensemble approach to their multiplicities (...) of alliances by collectively “animating” themselves and their partners through ensemble leadership. This combination of alliances, along with worker-driven monitoring, brings life to the CIW motto “We are all leaders.” Translating this motto into daily practice is how the CIW virtually eradicates enslavement practices in corporate supply chains. (shrink)

Desde principios del siglo xxi la modernización del sector público, impulsada por las Tecnologías de la Información y la Comunicación, ha desencadenado una serie de aspectos positivos y negativos para los ciudadanos entre las reformas más innovadoras que ha sufrido el ambiente gubernamental ante el fomento de los procesos electrónicos a través del gobierno electrónico. El uso de las tic busca reformar algunos procesos de la gestión pública y vincular activamente a los ciudadanos con la Administración, para que se convierta (...) en una herramienta que disminuya la carga burocrática en los trámites, promueva la participación ciudadana, fortalezca la confianza en el Estado y viabilice e incremente la transparencia y la rendición de cuentas. Su implementación ha traído la modificación de modelos y políticas de gobierno por los Estados. Las actividades que los ciudadanos realizan con la Administración Pública se efectúan de forma electrónica desde finales del siglo xx, suceso que ha avanzado con la smart city. (shrink)

El libro “El presente de la filosofía del derecho” de Milagros Otero Parga, catedrática de la Universidad de Santiago de Compostela, es una de las principales novedades bibliográficas del año en el ámbito jurídico. El título da cuenta del carácter comprehensivo de su contenido, pues el ensayo realiza un recorrido por el pasado y el presente de la filosofía del derecho en toda su amplitud. En ese camino, Otero se adentra en las grandes discusiones doctrinales de la disciplina y dialoga (...) con las más autorizadas voces del pasado y el presente, formulando en todo momento una tesis propia que vertebra todo el trabajo. (shrink)

A través de un repaso a las teorías científicas más ortodoxas (a fines del siglo XIX) acerca de la diversidad biológica en nuestra especie —tal y como aparecen en la obra de autores como Darwin, Broca, Huxley, Haeckel, Vogt, etc.— el presente artículo propone la existencia de una conexión ideológica entre las teorías evolutivas sobre las así llamadas "razas humanas" (especialmente los modelos darwinistas sobre evolución humana), y las jerarquías raciales que, a su vez, establecía la lógica económica del imperialismo (...) occidental. (shrink)

John Locke's philosophy was deeply affected by medicine of his times. It was specially influenced by the medical thought and practice of Thomas Sydenham. Locke was a personal friend of Sydenham, expressed an avid interest in his work and shared his views and methods. The influence of Sydenham's medicine can be seen in the following areas of Locke's philosophy: his “plain historical method”; the emphasis on observation and sensory experience instead of seeking the essence of things; the rejection of hypotheses (...) and principles; the refusal of research into final causes and inner mechanisms; the ideal of irrefutable evidence and skepticism on the possibilities of certainty in science. The science which for Locke held the highest paradigmatic value in his theory of knowledge was precisely medicine. To a great extent, Locke's Essay on Human Understanding can be understood as an attempt to justify, substantiate, and promote Sydenham's medical method. This method, generalized, was then proposed as an instrument for the elaboration of all natural sciences. (shrink)

Derrida’s thought is a dynamic dimension, a movement beyond any attempt of conclusive definition. However, is there any possibility to grasp this task of endless destabilization? This paper brings up the proposal of reading Derrida’s work from the close but at the same time aporetical relation between place and space. In this sense, we question the common understanding of space as uniform and empty continuum where place would be just a ‘limit’, a perimeter. In order to do so, we will (...) pay attention to the particular Topology that ‘translation’ illustrates in Derrida’s work, just as the reality of the spectre and mourning, stating these two dimensions as examples of Derrida’s strategy. In this sense, through translation and mourning, we manage to make out that Derrida’s work, even though cannot be summarized in a single object or idea, it might be understood as the endless question about the place of and for deconstruction, that is, about place as deconstruction of space. Thus, Derrida’s Topology may constitute a new and radical way to read not only his own work, but to question ourselves. (shrink)

This book introduces readers to central concepts and ideas in Mexican philosophy. Couched in stories and anecdotes from the author's life, the book offers these concepts and ideas as orientations, recommendations, or exhortation for navigating today's world. The structure and the style of the book aims at making these accessible to both specialists and non-specialist or anyone who may have had some experience with contemporary forms of marginalization, alienation, objectification, or any of the various forms of dread and accidentality familiar (...) to modern life. This, the author thinks, is most of us. Narrowing down the scope of the tradition, the author draws from the history of Mexican philosophy in the 20th century, as it is at this time that Mexican philosophy comes into its own. The book begins with two short introductions, one is an introduction philosophy in Mexico, the other to Mexican philosophy. Here, readers are introduced to Alfonso de la Veracruz, who offered the first philosophy course in the Americas in 1540 in the monastery of a small town in Michoacán, Mexico. From there, it presents four main themes from Mexican philosophy that recur in the philosophical literature. The remainder of the book serves as a "guide" for living a better, more fulfilling life. The main characters in what the author considers an uncontroversial retelling of Mexican philosophy are Antonio Caso, Samuel Ramos, Emilio Uranga, Leopoldo Zea, Jorge Portilla, Rosario Castellanos, Elsa Cecilia Frost, and, of course, persons in the author's own life. (shrink)

In this article, we will concentrate on the two true norm definitions that have existed throughout the history of the Deontic Logic: that offered by Professor Kalinowski and that proposed by the semantics of possible worlds. The former is based on Tarski’s definition of the true proposition, but it has the drawback of depending on a concrete, philosophical theory concerning the nature of norms. The latter, widely accepted nowadays, presents difficulties which we will analyse, using as a reference, K. Solt’s (...) critique. Despite its limitations, it offers the indisputable advantage of being independant of any concrete, philosophical option, and indicates, in our opinion, the correct way of proceeding. (shrink)

The sequencing of the human genome has opened the way for using bioinformatics to identify sets of genes controlled by specific regulatory signals. Here, we review the unexpected diversity of DNA response elements mediating transcriptional regulation by estrogen receptors (ERs), which control the broad physiological effects of estrogens. Consensus palindromic estrogen response elements are found in only a few known estrogen target genes, whereas most responsive genes contain only low‐affinity half palindromes, which may also control regulation by other nuclear receptors. (...) ERs can also regulate gene expression in the absence of direct interaction with DNA, via protein–protein interactions with other transcription factors or by modulating the activity of upstream signaling components, thereby significantly expanding the repertoire of estrogen‐responsive genes. These diverse mechanisms of action must be taken into account in screening for potential estrogen‐responsive sequences in the genome or in regulatory regions of target genes identified by expression profiling. BioEssays 24:244–254, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10066. (shrink)

Apresentação do n.1 da Revista Filosfia e Educação, dedicado à temática Educação e epistemologias. A organização deste número temático contou com a colaboração do Prof. Dr. Marcelo Donizete da Silva da |Universidade Federal de Ouro Preto. A seleção de trabalhos inclui nove artigos diretamente relacionados com a temática proposta e que compõem a seção do dossiê e seis artigos da seção de fluxo contínuo da revista Filosofia e Educação.

O presente artigo pretende deslindar o cenário teórico da primeira investigação de Logische Untersuchungen, refazendo o percurso de Husserl na fundamentação da teoria da significação. Obstina-se, ainda, apontar os elementos fulcrais que possibilitarão a fundamentação da fenomenologia, bem como os embates de Husserl com alguns eminentes pensadores da tradição lógica.

In a journal entry from 1906, Husserl complains of lacking "internal stability" and of his desire to "achieve" it. My claim in this paper is that the "phenomenological method," which he made public in his 1907 lectures "Die Idee der Phänomenologie" was, and is, a means to achieve the inner harmony that Husserl longed for. I do not provide an analysis of why Husserl might have felt the way he did; my aim is to show what internal stability might be (...) and how one might achieve it. I conclude that the phenomenological method is the means, the "how," to internal stability, which I characterize as "clarity" and "harmony" regarding our beliefs and, and ultimately, our authentic comportment. (shrink)

The lysine demethylase KDM5A collaborates with PARP1 and the histone variant macroH2A1.2 to modulate chromatin to promote DNA repair. Indeed, KDM5A engages poly(ADP‐ribose) (PAR) chains at damage sites through a previously uncharacterized coiled‐coil domain, a novel binding mode for PAR interactions. While KDM5A is a well‐known transcriptional regulator, its function in DNA repair is only now emerging. Here we review the molecular mechanisms that regulate this PARP1‐macroH2A1.2‐KDM5A axis in DNA damage and consider the potential involvement of this pathway in transcription (...) regulation and cancer. Using KDM5A as an example, we discuss how multifunctional chromatin proteins transition between several DNA‐based processes, which must be coordinated to protect the integrity of the genome and epigenome. The dysregulation of chromatin and loss of genome integrity that is prevalent in human diseases including cancer may be related and could provide opportunities to target multitasking proteins with these pathways as therapeutic strategies. (shrink)

We propose a mathematical model for a class of predator–prey systems more complex than the usual one, involving a commensalism effect consisting in an influence of the predator on the sustainability of the prey. This effect induces interesting new features, including bi-stability. The question of the possibility of reaching a certain attractor starting from initial conditions with a small population of predators, which presents an interest from the vewpoint of the onset of the predator in evolution, is addressed. We propose (...) two possibilities: the classical one involving adapted conditions in the far past and a new one using biodiversity, specifically the presence of another predator which operates as a starter, being displaced in the sequel. (shrink)

This paper addresses first the appticability of the main notions included in the general notion meant item, meant partial situation (MPST), meant activity (MACT), and implicitly meant background situation (IMBST) -that of meant agent will be only mentioned in an aside-, plus the notion meaning activity (MNGACT). It will be shown that, when coupled to other notions, such as ‘ontological status’ of IMBST relative to the focussed (part of) current situation (FCST), as well as to the matching ‘ontological’ properties of (...) the meant items above, they allow to set up unified and apparently successful methods to explore important and debated pragmatic issues. Then their usefulness for research in the domain traditionally accorded to speech-act theory is put to (a preliminary) test; and finally the general processual sketch of linguistic activity advanced in the last Sections of P.I is carefully gauged as to its prospects regarding actual implementation of more specific processual sketches of both emission and reception linguistic activities. (shrink)

The study described in this article examines whether wives' relative resources and material conditions affect husbands' domestic labor within varying economic development contexts. The study tests: whether wives' relative resources increase husbands' regularity of housework participation and whether the effects of wives' relative resources on husbands' regularity of housework participation vary in quantity and effect at different levels of economic development. The study indicates that wives' material conditions and relative resources have no consistent, significant effects on husbands' regularity of housework (...) participation. Levels of national economic development also have little effect. (shrink)

La Modernidad ha sido el escenario de su propia crisis ¿Acaso estaba ésta abocada a su quiebra? ¿Son la razón instrumental, el nazismo, el nihilismo o el capitalismo los hijos monstruosos de una Ilustración realizada? ¿Y el patriarcado?¿No ha sido también la razón una proclama masculina? Pretendemos defender que tanto la lucha feminista como el marxismo necesitan en el siglo XXI recuperar una Ilustración que no se ha realizado en la técnica, en los campos de concentración o en la nada (...) social que produce el capitalismo, sino en los resquicios rebeldes de una historia de vencedores y perdedores. La breve historia de la tradición republicana es la historia de una derrota política que la izquierda no debería olvidar. Se quiere, por tanto, defender a la Ilustración de ese olvido y, para ello, explicar qué sería una Ilustración republicana y en qué sentido es imprescindible —tanto para el feminismo como para el marxismo— en tiempos tan críticos. (shrink)

First in-depth analysis of this important Mexican philosopher’s work.

Smart grids are designed to revolutionize the energy sector by creating a smarter, more efficient and reliable power supply network. The rise of smart grids is a response to the need for a more comprehensive and sophisticated energy system that caters to the needs of homes and businesses. Key features of smart grids include the integration of renewable energy sources, decentralized generation and advanced distribution networks. At the heart of smart grids is a sophisticated metering system, consisting of intelligent electronic (...) devices that measure energy consumption and enable two-way communication between the utility company and the consumer. The information exchanged via these devices is critical, as it includes sensitive data such as energy consumption patterns and billing information. With the rise of the Internet of Things (IoT) and Industry 4.0, the security of this information is of utmost importance. This paper delves into the security challenges faced by advanced metering infrastructure (AMI) and highlights the crucial role played by cryptography in ensuring the secure exchange of sensitive information. Cryptographic protocols such as encryption, authentication and digital signatures are essential components of a secure smart grid infrastructure. These protocols work together to ensure the confidentiality, integrity and authenticity of the information exchanged between the utility company and the consumer. (shrink)