Biofilms can be viewed as tissue‐like structures in which microorganisms are organized in a spatial and functional sophisticated manner. Biofilm formation requires the orchestration of a highly integrated network of regulatory proteins to establish cell differentiation and production of a complex extracellular matrix. Here, we discuss the role of the essential Bacillus subtilis biofilm activator RemA. Despite intense research on biofilms, RemA is a largely underappreciated regulatory protein. RemA forms donut‐shaped octamers with the potential to assemble into dimeric superstructures. The (...) presumed DNA‐binding mode suggests that RemA organizes its target DNA into nucleosome‐like structures, which are the basis for its role as transcriptional activator. We discuss how RemA affects gene expression in the context of biofilm formation, and its regulatory interplay with established components of the biofilm regulatory network, such as SinR, SinI, SlrR, and SlrA. We emphasize the additional role of RemA played in nitrogen metabolism and osmotic‐stress adjustment. (shrink)

Ever since Parmenides, one of philosophy's riddles has been how we are able to direct our thoughts to non-being. Erhard uses the problem of non-existence as the starting point for an analysis of Husserl's phenomenology. He examines Husserl's interpretation of judgments about non-being as judgments made "under assumption" and his analysis of "free fantasy." Erhard thus demonstrates that Husserl is compatible with today's non-relational theories.

Erhard Wiersing ; Literaturverz. S. [1013] - 1071 ; Inhaltsverzeichnis ; Volltext // Exemplar mit der Signatur: München, Bayerische Staatsbibliothek -- PVA 2007.1762.

Dans un discours prononcé à Zurich vers la fin des années 1940, Hermann Weyl a examiné l'épistémologie dialectique de Ferdinand Gonseth et l'a considérée comme trop strictement limitée aux aspects de changement historique. Son expérience de la philosophie diaclectique post-kantienne, en particulier la dérivation du concept de l'espace et de la matière chez Johann Gottlieb Fichte, avait constitué une base dialectique solide pour ses propres études de 1918 en une géométrie purement infinitésimale et la théorie antérieure d'un champ de matière (...) géométriquement unifié (en prolongement du programme Mie-Hilbert). Bien que Weyl se fût alors éloigné des aspects spéculatifs de la philosophie de sa jeunesse et eût montré, en particulier, moins d'enthousiasme qu'auparavant pour Fichte, il nourrissait encore de nombreux doutes sur la base culturelle de la science mathématique moderne et sur son rôle dans la culture matérielle du modernisme de pointe. Pour Weyl, la « réflexion » philosophique était une nécessité culturelle ; il se tourna alors vers lexistentialisme de Karl Jaspers et de Martin Heidegger pour trouver des raisons plus profondes, dans un mouvement comparable à son orientation vers la philosophie de Fichte après la Première Guerre mondiale. Le débat de la fin des années 1940 peut être compris comme une sorte de supplément postérieur à la Seconde Guerre mondiale par rapport à ses commentaires plus connus sur les mathématiques et les sciences naturelles publiés au milieu des années 1920. (shrink)

Bd. 1. Darstellung.-- Bd. 2. Kataloge und Anmerkungen.

In this paper I argue that the almost forgotten early dissertation of the phenomenologist Hans Reiner Freiheit, Wollen und Aktivität. Phänomenologische Untersuchungen in Richtung auf das Problem der Willensfreiheit engages with what I call the unity problem of activity. This problem concerns the question whether there is a structure in virtue of which all instances of human activity—and not only “full-blown” intentional actions—can be unified. After a brief systematic elucidation of this problem, which is closely related to the contemporary “problem (...) of action,” I elaborate and critically discuss two relevant threads running through Reiner’s work. The first view concerns the alleged motivational asymmetry between activity and passivity according to which it is essential only for active experiences to be motivated by an underlying passivity. The second view focuses on Reiner’s phenomenology of the will, especially on his notions of “ego-centrality” and “inner will” the latter being introduced in analogy to Brentano’s notion of “inner consciousness.” These two notions are supposed to unify all manifestations of the human will, including “full-blown” intentional actions and non-intentional doings such as laughter. Reiner’s extension of will-based actions to non-intentional activity is one of the most remarkable aspects of his early work. Finally, I show that Reiner ultimately answers the unity problem in the negative because he ends up with the view that besides will-based agency he also acknowledges so-called “motor activity” which is not intrinsically related to the will. I close with a couple of tentative proposals how volitional and motor actions might be unified nonetheless. (shrink)

Este artículo trata sobre la discusión en torno al conflicto entre la seguridad y la libertad, y, más concretamente, entre la prevención policial y los derechos de los ciudadanos. El autor va más allá de la mera afirmación de que entre esos dos polos existe una relación de tensión, e intenta fijar los elementos que en el Estado de Derecho son absolutamente irrenunciables si es que no se quiere abandonar este tipo de Estado. Analiza para ello, críticamente, la jurisprudencia del (...) Tribunal Constitucional Federal Alemán, con referencias al acervo normativo de la Unión Europea. Su conclusión es que la intervención del Estado en la esfera privada del ciudadano debe estar sujeta a límites infranqueables, también en lo que concierne al control preventivo de riesgos relacionados con el terrorismo. (shrink)

Like Kant at his time, Jürgen Habermas wants to encourage the reader to use his „reasonable liberty“. There is no doubt, that the philosophical positions of Kant on the one hand and of Hegel on the other hand hold, until today, a key role in the development of the „discourse of modern age“. In order to oppose a short-circuited synthesis of both systems, which are obliged to the idea of liberty quite differently, this essay demonstrates the substantial differences regarding to (...) elementary concepts like peculiarity of the individual will, law and legislation, people and sovereignty of the people. That both philosophers differ in their interest of questioning becomes quite clear regarding to the citizen/state relation. While Hegel tries to describe the reality of the state as a „moral universe“ and therefore as „reality of reason“, Kant is interested in knowing about the potential state togetherness of individuals which have experienced in them the „radical evil“. The differences concerning the estimation of the „subjective“ individual will in its relationship to the „objective“ will of „generality“, concerning also the (Rousseauian) concept of contract and the citizens as „co-legislators“ are culminating in the relationship between „law“ and „morality“. Whereas Kant (wrongly) ignores ethos and history, Hegel is lacking the concept of „intersubjective communication“ (so Habermas states). From both insufficiencies conclusions are resulting which are important for coping with the actual difficulties with „inclusion“ and „integration“. (shrink)

Dieses voluminöse Werk ist Abhandlung, Lehrbuch und Nachschlagewerk in einem! Vertretern unterschiedlicher Forschungsgebiete, vor allem aber denen der Pädagogik, liegt hier der im heutigen Wissenschaftsraum erstmals unternommene Versuch vor, das Phänomen »Menschenbildung« nicht allein erziehungswissenschaftlich, sondern umfassend humanwissenschaftlich zu begründen. Unter Berücksichtigung der naturgeschichtlichen, historisch-kulturellen wie historisch-gesellschaftlichen Bedingungen wird auf eine grundsätzliche Vergewisserung des Verständnisses von Menschenbildung hingearbeitet, um letztendlich auch eine neue Sichtweise auf das Phänomen Bildung zu ermöglichen. Praxis wird nur insoweit thematisiert, als sie Gegenstand der Theorie ist (...) und damit ihrer Aufklärung dient. Unter Bildung wird dabei jener alles umfassende Wirkungs- und Handlungszusammenhang verstanden, in dem das menschliche Individuum vom Anbeginn seines Lebens bis zu seinem Tode geformt wird und sich selbst formt. (shrink)

During his whole scientific life Hermann Weyl was fascinated by the interrelation of physical and mathematical theories. From the mid 1920s onward he reflected also on the typical difference between the two epistemic fields and tried to identify it by comparing their respective automorphism structures. In a talk given at the end of the 1940s he gave the most detailed and coherent discussion of his thoughts on this topic. This paper presents his arguments in the talk and puts it in (...) the context of the later development of gauge theories. (shrink)

ERHARD SCHEIBE Kant's Apriorism and Some Modern Positions The terms a priori and its counterpart a posteriori are of medieval origin.1 In the fourteenth ...

Inwiefern ist Metaphysik heutzutage noch relevant? Gibt es einen Sinn, in dem Metaphysik fur die Philosophie unverzichtbar ist? Was ist gute Metaphysik, und worin unterscheidet sie sich von schlechter Metaphysik? Was sind Chancen und Probleme genuin metaphysischen Denkens? Die Beitrage des Sammelbandes widmen sich diesen Fragen aus historischer und systematischer Perspektive.

1. Universi corporis pansophici caput summum --2. Arithmetische Beschreibung der Moral-Weisheit von Personen und Sachen.

It seems a generally acknowledged view that physics is confined to the investigation of events that can be reproduced. “The natural scientist — says Pauli1 — is concerned with a particular kind of phenomena … he has to confine himself to that which is reproducible… I do not claim that the reproducible by itself is more important than the unique. But I do claim that the unique exceeds the treatment by scientific method. Indeed it is the aim of this method (...) to find and to test natural laws…” Here for Pauli as for everybody else a natural law is a statement expressing a regularity more or less directly related to repeatable events. And one may add that it is not only the possibility of testing that is responsible for our demand of reproducibility. Rather it is the very fact of regularity expressed in it that gives a natural law its dignity and makes it a subject worth studying on its own account. (shrink)

Hermann Weyl was one of the early contributors to the mathematics of general relativity. This article argues that in 1929, for the formulation of a general relativistic framework of the Dirac equation, he both abolished and preserved in modified form the conceptual perspective that he had developed earlier in his “analysis of the problem of space.” The ideas of infinitesimal congruence from the early 1920s were aufgehoben in the general relativistic framework for the Dirac equation. He preserved the central idea (...) of gauge as a “purely infinitesimal” aspect of symmetries in a group extension schema. With respect to methodology, however, Weyl gave up his earlier preferences for relatively a-priori arguments and tried to incorporate as much empiricism as he could. This signified a clearly expressed empirical turn for him. Moreover, in this step he emphasized that the mathematical objects used for the representation of matter structures stood at the center of the construction, rather than interaction fields which, in the early 1920s, he had considered as more or less derivable from geometrico-philosophical considerations. (shrink)

We study a Weyl geometric scalar tensor theory of gravity with scalar field \ and scale invariant “aquadratic” kinematical Lagrange density. The Weylian scale connection in Einstein gauge induces an additional acceleration. In the weak field, static, low velocity limit it acquires the deep MOND form of Milgrom/Bekenstein’s gravity. The energy momentum of \ leads to another add on to Newton acceleration. Both additional accelerations together imply a MOND-ian phenomenology of the model. It has unusual transition functions \, \nu _w\). (...) They imply higher phantom energy density than in the case of the more common MOND models with transition functions \, \, \mu _2\). A considerable part of it is due to the scalar field’s energy density which, in our model, gives a scale and generally covariant expression for the self-energy of the gravitational field. (shrink)