I‐J has been regarded as a polymorphic genetic marker controlled by a locus in the major histocompatibility complex (MHC) which is expressed only on functional T cells. However, this antigenic determinant has been found not to be directly encoded by the MHC gene per se but is somatically generated according to the MHC of the cellular environment during ontogeny. This explains the apparent linkage of I‐J to MHC, despite the failure to find the structural gene for I‐J within the MHC. (...) The I‐J paradox provides an instance of a polymorphism that does not follow the standard genetics of Mendelian structural genes. (shrink)

We define and investigate a uniformly locally o-minimal structure of the second kind in this paper. All uniformly locally o-minimal structures of the second kind have local monotonicity, which is a local version of monotonicity theorem of o-minimal structures. We also demonstrate a local definable cell decomposition theorem for definably complete uniformly locally o-minimal structures of the second kind. We define dimension of a definable set and investigate its basic properties when the given structure is a locally o-minimal structure which (...) admits local definable cell decomposition. (shrink)

Consider a definably complete uniformly locally o-minimal expansion of the second kind of a densely linearly ordered abelian group. Let $f:X \rightarrow R^n$ be a definable map, where X is a definable set and R is the universe of the structure. We demonstrate the inequality $\dim ) \leq \dim $ in this paper. As a corollary, we get that the set of the points at which f is discontinuous is of dimension smaller than $\dim $. We also show that the (...) structure is definably Baire in the course of the proof of the inequality. (shrink)

Although dual-process or divided-mind models of self-control dominate the literature, they suffer from empirical and conceptual challenges. We propose an alternative approach, suggesting that self-control can be characterized by a fragmented part versus integrated whole dynamic. Whereas responses to events derived from fragmented parts of the mind undermine self-control, responses to events derived from integrated wholes enhance self-control. We review empirical evidence from psychology and related disciplines that support this model. We, moreover, discuss the implications of this work for psychology, (...) neuroscience, economics, and philosophy. In particular, we highlight how this model addresses many of the conceptual and empirical short-comings of divided-mind models. We suggest that understanding self-control as the interplay between fragmented parts versus integrated wholes, moreover, provides novel insights and testable new hypotheses. (shrink)

We consider locally o-minimal structures possessing tame topological properties shared by models of DCTC and uniformly locally o-minimal expansions of the second kind of densely linearly ordered abelian groups. We derive basic properties of dimension of a set definable in the structures including the addition property, which is the dimension equality for definable maps whose fibers are equi-dimensional. A decomposition theorem into quasi-special submanifolds is also demonstrated.

We first show that the projection image of a discrete definable set is again discrete for an arbitrary definably complete locally o‐minimal structure. This fact together with the results in a previous paper implies a tame dimension theory and a decomposition theorem into good‐shaped definable subsets called quasi‐special submanifolds. Using this fact, we investigate definably complete locally o‐minimal expansions of ordered groups when the restriction of multiplication to an arbitrary bounded open box is definable. Similarly to o‐minimal expansions of ordered (...) fields, Łojasiewicz's inequality, Tietze's extension theorem and affiness of pseudo‐definable spaces hold true for such structures under the extra assumption that the domains of definition and the pseudo‐definable spaces are definably compact. Here, a pseudo‐definable space is a topological space having finite definable atlases. We also demonstrate Michael's selection theorem for definable set‐valued functions with definably compact domains of definition. (shrink)

If no property of a system of many particles discriminates among the particles, they are said to be indistinguishable. This indistinguishability is equivalent to the requirement that the many-particle distribution function and all of the dynamic functions for the system be symmetric. The indistinguishability defined in terms of the discrete symmetry of many-particle functions cannot change in the continuous classical statistical limit in which the number density n and the reciprocal temperature β become small. Thus, microscopic particles like electrons must (...) remain indistinguishable in the classical statistical limit although their behavior can be calculated as if they move following the classical laws of motion. In the classical mechanical limit in which quantum cells of volume (2πħ)3 are reduced to points in the phase space, the partition functionTr{exp(−βĤ) for N identical bosons (fermions) approaches (2πħ)−3N(N!) ∫ ... ∫ d3r1 d3p1 ... d3rN d3pN exp(−βH). The two factors, (2πħ)−3N and (N!)−1, which are often added in anad hoc manner in many books on statistical mechanics, are thus derived from the first principles. The criterion of the classical statistical approximation is that the thermal de Broglie wavelength be much shorter than the interparticle distance irrespective of any translation-invariant interparticle interaction. A new derivation of the Maxwell velocity distribution from Boltzmann's principle is given with the assumption of indistinguishable classical particles. (shrink)

We provide a natural extension of the intuitionistic natural deduction system NJ with at most two consequences, which we call a binary conclusion natural deduction system. The classical natural deduction system NK is defined as NJ together with the law of the excluded middle or the double negation principle. However, in contrast to NK, the new BCN system has no such classical rule, but has two kinds of rules managing two consequences. One is to eliminate one consequence and the other (...) is to introduce another consequence. Except on this point, BCN proofs are derived in exactly the same way as those in NJ. It is shown that with respect to the propositional fragment of NK, the BCN system is sound and sufficiently complete to prove classical propositional theorems. Moreover, as a corollary we obtain a general form of Glivenko's theorem and disjunction property for one of the two consequences. We also show the normalization theorem for BCN. Finally, we study some extensions of BCN to classical predicate logic. (shrink)

This paper gives new confluence proofs for several lambda calculi with permutation-like reduction, including lambda calculi corresponding to intuitionistic and classical natural deduction with disjunction and permutative conversions, and a lambda calculus with explicit substitutions. For lambda calculi with permutative conversion, naïve parallel reduction technique does not work, and traditional notion of residuals is required as Ando pointed out. This paper shows that the difficulties can be avoided by extending the technique proposed by Dehornoy and van Oostrom, called the Z (...) theorem: existence of a mapping on terms with the Z property concludes the confluence. Since it is still hard to directly define a mapping with the Z property for the lambda calculi with permutative conversions, this paper extends the Z theorem to compositional functions, called compositional Z, and shows that we can adopt it to the calculi. (shrink)

In this article, we provide an ethical analysis of the first porcine cardiac xenotransplant, performed in Maryland, USA in early 2022. David Bennett was offered the experimental procedure after he was deemed ineligible for human heart transplantation and mechanical circulatory support, based on a history of non-compliance. It was reported that Mr Bennett’s previous instances of non-compliance were for medically non-life-threatening conditions years earlier, where the risks of non-compliance were not as high. We argue that, in Mr Bennett’s case, a (...) history of non-compliance in a different context, should not necessarily rule him ineligible for a potentially life-saving treatment now. Furthermore, using previous non-compliance to exclude individuals from donor organs may have the unintended effect of placing the burden of testing xenotransplantation on those who are already disadvantaged. We then argue that it is not enough to rely on patient consent to ethically justify xenotransplantation research. Taking a broad ethical perspective is crucial when mapping a clinical pathway for xenotransplantation. (shrink)

Dans 'les Deux sources de la morale et de la religion', Bergson évoque rarement le Japon. Et pourtant dans le quatrième chapitre du même texte, intitulé Remarques finales 'Mécanique et mystique', c'était lui qui a bien prévu Hiroshima avec ces mots testamentaires: ' Il faut que tous se battent contre tous, comme firent les hordes des premiers temps. Seulement on se bat avec les armes forgées par notre civilisation, et les massacres sont d'une horreur que les anciens n'auraient même pas (...) imaginée. Au train dont va la science, le jour approche où l'un des adversaires, possesseur d'un secret qu'il tenait en réserve, aura le moyen de supprimer l'autre'. Ainsi se pose la question de savoir comment envisager les Deux Sources, à travers les relations assez particulières de ce philosophe avec le Japon. À partir de cette interrogation, PBJ (Projet Bergson au Japon) a organisé, aux 5-8 novembre 2013, à Paris, un colloque qui s'intitule Remarques finales : autour des Deux sources de la morale et de la religion de Bergson. Le présent volume présente les actes de ce colloque ellipsoïdal dont les centres étaient Bergson et le Japon"--Back cover. (shrink)