Glioblastoma is a brain tumor condition marked by rapid neurological and clinical demise, resulting in disproportionate disability for those affected. Caring for this group of patients is complex, intense, multidisciplinary in nature, and fraught with the need for expensive treatments, surveillance imaging, physician follow-up, and rehabilitative, psychological, and social support interventions. Few of these patients return to the workforce for any meaningful time frame, and because of the enormity of the financial burden that patients, their caregivers, and society face, utilization (...) reviews become the focus of ethical scrutiny. (shrink)

While primary malignant brain tumors account for only two percent of all adult cancers, these neoplasms cause a disproportionate amount of cancer-related disabilities and death. The five-year survival rates for brain tumors are the third lowest among all types of cancer. Malignant gliomas comprise the most common types of primary central nervous system tumors and have a combined incidence of five to eight cases per 100,000 people. The median survival rate of conservatively treated patients with malignant gliomas is 14 weeks; (...) with surgical resection alone, 20 weeks; with surgery and radiation, 36 weeks; and with the addition of newer biochemotherapies such as temozolomide and bevacizumab, upward of 14-18 months.The profound cost of caring for terminally ill patients with primary malignant brain tumors raises ethical considerations for the American public; the stewardship of health care dollars for the population at large maintains a juxtaposed tension against a dynamic, necessary balance of hope, care, rehabilitation and research efforts for affected patients and their advocates. (shrink)

In 1992, the Walloon Region modified its investment incentive legislation. The new legislation applies the notion of SME to any business employing up to 250 people and which turnover does not exceed 20 million ECU, and replaces the former interest subsidies and capital premiums by a grant calculated as a percentage of investment. According to the size of the business, the activity sector and the area, the maximum aid may vary from 13 to 21 %. The grant total percentage is (...) calculated by summing up the percentage of aid obtained for five criteria under which job creation is by far the most important. The new legislation gives a partial answer to traditional criticisms against investment incentives. First of all it aims at reducing the risk of accelerated substitution of capital for Labour. Besides, it simplifies adminsitrative procedures and reduces the "sprinkling". It should also reduce the risk of inefficient allocation of resources thatarises when grants go to loss-making entreprises. But the question of whether investment incentives actually increase the level of investment remains largely unanswered. Evidence suggests that investment incentives might have contributed to attract foreign investments hut have little impact on thelevel of domestic investment. Nevertheless, as far as SMEs are concerned, public grants might contribute to increased investment not by reducing the cost or increasing the profitability of the project but rather by increasing the means available in the business. (shrink)

The dominant feature of eighteenth-century aesthetic is the inquiry and discussion concerning the theory of “taste.” There is material or bibliographical evidence of this in the rapid sequence of treatises, essays, inquiries, observations, and controversies on this subject, extending from the close of the seventeenth to the last years of the eighteenth century, and bearing the names, in France, of Dacier, Bellegarde, Bouhours, Rollin, Seran de la Tour, Trublet, Formey, Bitaubé, Marmontel, and, still more eminent, of Montesquieu, Voltaire, d’Alembert; in (...) England, of Addison, Hume, Gerard, Home, Burke, Priestley, Blair, Beattie, Percival, Reid, Alison; in Italy, of Muratori, Calepio, Pagano, Corniani; in Germany, of Thomasius, J. U. König, Bodmer, A. von Schlegel, Wegelin, Heyne, Herz, Eberhard, J. C. König, and, by German influence in Hungary, Szardahely; and, greatest of all, Immanuel Kant, whoseCritique of Judgmentconsists in the main of a critique of the aesthetic judgment of taste. (shrink)

Since 1974 Belgian traditional sectors have been facing important financial difficulties, which compelled them to seek both increased productivity through more capital intensive techniques, and goods with higher valued added.This twofold evolution implied investments and job-reductions that could hardly have been possible without adequate public policies. As far as steel and textile are concerned those policies used mainly a common scheme based on public financial intervention and social measures. Public financial support required to cover annual losses and investments consisted of (...) either grants or state equities. It amounted to over 200 billions BEF.Besides, policies were designed in favour of people losing their jobs : early retirement was made possible and was even accompanied with tax cuts. However the budgetary cost of those policies is very high, they may be considered successful as Belgian producers now seem able to stand unternational competition. (shrink)

Hume's Reception in Early America: Expanded Edition brings together the original American responses to one of Britain's greatest men of letters, David Hume. Now available as a single volume paperback, this new edition includes updated further readings suggestions and dozens of additional primary sources gathered together in a completely new concluding section. From complete pamphlets and booklets, to poems, reviews, and letters, to extracts from newspapers, religious magazines and literary and political journals, this book's contents come from a wide variety (...) of sources published in colonial America and the early United States between 1758 and 1850. As well as classics by Thomas Jefferson, John Adams and Alexander Hamilton, it contains scores of unknown and hard-to-locate items, many of which have not been reprinted since their original publication. These responses are divided into four parts covering Hume's Essays; his Philosophical Writings; his History of England; and his Character and Death. Each of those parts has a separate introductory essay, and every selection is introduced by a short headnote that sets the piece in its historical context and provides bibliographical references. Packed with new insights into Hume and American thought and culture, Hume's Reception in Early America reveals the relevance and impact of Hume on American political, philosophical, historical, religious, and aesthetic debates. (shrink)

Just as contemporary metaphysics, in general, is marked by an interest in ground, contemporary social metaphysics, in particular, is marked by an interest in social construction. It’s no surprise, then, that some contemporary metaphysicians have come to understand social construction in terms of ground. In this paper, I argue that this is a mistake. In particular, I argue that any otherwise plausible account of construction as ground is objectionably revisionary. First, I discuss an argument for the view that construction is (...) ground that is endorsed by its proponents, and identify its weaknesses. I then consider, and dispense with, different versions of the view that construction is ground, and argue that these either overgeneralize, undergeneralize, or both. After responding to the objection that my arguments presuppose monism with respect to construction, I conclude that though ground is relevant to construction, extant ground-theoretic accounts of its relevance fail to capture it. (shrink)

Brian Epstein has argued (in The Ant Trap and ‘Anchoring versus grounding’) that social kinds ‘export’ across worlds. Although the conditions for war criminality are not ‘fixed’ in the Empire, for instance, Darth Vader is a war criminal there. And, according to Epstein, an account of social construction should imply that he is. Ultimately, he argues that ‘grounding-only’ accounts of social construction – like those proposed by Jonathan Schaffer and Aaron Griffith – imply that social kinds do not export across (...) worlds. As a result, he argues that we need more than grounding; in particular, we need both grounding and what he calls ‘anchoring’ to account for it. In this paper, I argue that, once we draw a distinction between what I call ‘thick’ and ‘thin’ social kinds, Epstein’s argument is either invalid or irrelevant. (shrink)

This paper aims at testing the hypothesis of growing ideological uniformity of political speeches. If political speeches lack ideological differences, it should be difficult to re-classify them only by analyzing the presence or absence of lexical items. We first worked out a method to classify political speeches and then carried a test on two speeches by leading Belgian French-speaking politicians. The method is based on discriminant analysis. It utilizes the words most encountered in one speech and not in the other (...) as discriminant factors. Statistical softwares then assess a discriminant function used to re-classify short parts of each speech called blocks. The most discriminating 10 factors re-classify correctly 89% of the blocks. The percentage increases to 93% with 20 factors and to 98% with 30 factors.However the results should be taken with caution because of the limited sample, the test tends to question the growing uniformity of political speeches. The sampled ones had enough specific features for allowing a rather simpte method to re-classify most parts of them correctly, even if some typically ideological items are not to be found. (shrink)

The way in which securities are traded is very different from the idealized picture of a frictionless and self-equilibrating market offered by the typical finance textbook. Market Liquidity offers a more accurate and authoritative take on liquidity and price discovery. The authors start from the assumption that not everyone is present at all times simultaneously on the market, and that even the limited number of participants who are have quite diverse information about the security's fundamentals. As a result, the order (...) flow is a complex mix of information and noise, and a consensus price only emerges gradually over time as the trading process evolves and the participants interpret the actions of other traders. Thus a security's actual transaction price may deviate from its fundamental value, as it would be assessed by a fully informed set of investors. This book takes these deviations seriously, and explains why and how they emerge in the trading process and are eventually eliminated. The authors draw on a vast body of theoretical insights and empirical findings on security price formation that have accumulated in the last thirty years, and have come to form a well-defined field within financial economics known as 'market microstructure.' Focusing on liquidity and price discovery, they analyze the tension between the two, pointing out that when price-relevant information reaches the market through trading pressure rather than through a public announcement, liquidity suffers. The book also confronts many puzzling phenomena in securities markets and uses the analytical tools and empirical methods of market microstructure to understand them. These include issues such as why liquidity changes over time, why large trades move prices up or down, and why these price changes are subsequently reversed, why we see concentration of securities trading, why some traders willingly disclose their intended trades while others hide them, and why we observe temporary deviations from arbitrage prices. (shrink)

italiano: Secondo l’interpretazione di Hegel gli edifici religiosi egiziani, e tra essi in particolare i templi, rappresentano l’inizio della storia dell’architettura, e con ciò di tutta la storia dell’arte.L’architettura religiosa egiziana ha un carattere simbolico, perché la sua forma cerca di rappresentare il contenuto spirituale senza esservi pienamente adeguata. Così il tempio egizio allude al divino con la sua intera struttura, ma non ha propriamente un interno, dedicato al culto dell’immagine del dio.L’egittologia contemporanea ha corretto Hegel su questo punto, perché (...) in generale il tempio egizio aveva un interno che custodiva l’immagine della divinità. Tuttavia la tesi di Hegel rimane paradossalmente valida per un caso particolare dell’esperienza egiziana, che egli non poteva conoscere: nella religione monoteista di Amarna il tempio del dio solare Aton non ha immagini e non ha un centro, perché il divino è presente dappertutto, come la luce del sole, che illumina egualmente ogni parte del tempio..Parole chiave: Egitto; architettura; tempio; simbolo; immagine. (shrink)

We are living a historical phase in which phenomena of enormous significance intersect: the digital turn, the “ecological transition”, the pandemic contingency, against the backdrop of a unique event in the history of human civilization and of Earth itself: for the first time behaviours and choices of a living species are among the main causes of a biotic transition.The way of thinking, planning, building cities and houses faces with new scenarios. Human and social sciences are called to a deep and (...) fundamental reflection, in the sign of complexity and of the overcoming of scientisms. This contribution, starting from a radical re-thinking of dwelling, intends to provide a critical review of some concrete perspectives of “urban and housing transition” towards new spatial and relational models. (shrink)

Fanconi anaemia (FA) is a cancer‐prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P‐450 reductase and with glutathione S‐transferase, and of FANCG (...) with cytochrome P‐450 2E1, as well as redox‐dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co‐ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6–12). BioEssays 25:589–595, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In recent years a paradigm has emerged for which urban liveability coincides with the existence of conditions of order, rationality, predictability and safety. If we combine this with the enormous technological progress applied to the management of urban ecosystems and the strongly transitional nature of our age (digital transition, climate change, ecological transition...), we understand why in the last twenty years the concept of “Smart City” has been one of the most successful. But exactly what are we talking about when (...) we talk about Smart City? In reality, the process of smartification does not only concern the urban dimension but, in some way, seems to apply to so many aspects of life. What kind of rationality is hidden in the dynamics of smartification? Are there dark sides of the Smart Cities? Are there alternatives to the Order based on standardization, digital surveillance, massive use of increasingly invasive technologies? These are categories whose application is generally argued with the need to generate “sustainable” ways of life but to what extent are these categories sustainable themselves? Martin Heidegger warned that the fact that “everything works” is exactly the problem and not the solution. Is humanity generating an increasingly _irrational rationality_? The provocation launched by some Authors (above all Richard Sennett) is that there is the possibility of an antagonism to this process, designing cities as something open, never concluded, _dis-organized_. But what exactly does this disorder consist of? Is it a mere utopia or is it really possible to develop concrete categories and urban planning practices consistent with it? (shrink)

According to the interpretation of Hegel, Egyptian religious buildings, and among them especially the temples, represent the beginning of the history of architecture, and so the beginning of the entire history of art.The Egyptian religious architecture has a symbolic character, because its configuration tries to represent the spiritual content without being fully adequate to it. So the Egyptian temple alludes to the divine through its entire structure, but does not have a proper internal space, dedicated to the worship of the (...) image of God.On this point, contemporary Egyptology corrected Hegel’s view, because broadly speaking the Egyptian temple had an interior where the image of the deity was safeguarded. However, Hegel’s thesis paradoxically remains suitable for a particular case of the Egyptian experience that he could not know at that time: in the monotheistic religion of Amarna, the temple of the sun-god Aton has no images and does not have a center, because the Divine is present everywhere, like the sunlight that illuminates equally all over the temple. (shrink)

An increasing interest for the theme of recognition and of intersubjective relationships has been registered in the last decades. In this frame a new interest for Hegel’s theory of recognition has also been developed. This new interest focuses mostly only on the figure of struggle for recognition in the Phenomenology of Spirit. Nevertheless, Hegel’s theory of recognition has a much wider structure: it is not limited to this conflictual moment, but also connects to the themes of forgiveness and of love. (...) That’s why it also offers the premise for a discussion of the theme of hospitality. The connection between recognition and hospitality has been emphasized by Paul Ricoeur in his last writings, dedicated to the theme of translation and to the different courses of recognition. (shrink)