In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

In studies of scientific methodology, surprisingly little attention has been given to tests of hypotheses. Such testing constitutes a methodology common to various scientific disciplines and is an essential factor in the development of science since it determines which theories are retained. The classical theory of tests is a major accomplishment but requires modification in order to produce a theory that accounts for the success of science. The revised theory is an analysis of the nondeductive aspect of scientific reasoning. It (...) results in a new definition of probability and a nonclassical point of view with regard to the foundations of probability. (shrink)

Ignoring the temporal dimension, an object such as a railway tunnel or a human body is a three-dimensional whole composed of three-dimensional parts. The four-dimensionalist holds that a physical object exhibiting identity across time—Descartes, for example—is a four-dimensional whole composed of 'briefer' four-dimensional objects, its temporal parts. Peter van Inwagen (1990) has argued that four-dimensionalism cannot be sustained, or at best can be sustained only by a counterpart theorist. We argue that different schemes of individuation of temporal parts are available, (...) which undermines van Inwagen's argument. (shrink)

The host actin nucleation machinery is subverted by many bacterial pathogens to facilitate their entry, motility, replication, and survival. The majority of research conducted in the past primarily focused on exploitation of a host actin nucleator, the Arp2/3 complex, by bacterial pathogens. Recently, new studies have begun to explore the role of formins, another family of host actin nucleators, in bacterial pathogenesis. This review provides an overview of recent advances in the study of the exploitation of the Arp2/3 complex and (...) formins by bacterial pathogens. Secreted bacterial effector proteins seem to manipulate the regulation of these actin nucleators or functionally mimic them to drive bacterial entry, motility and survival within host cells. An enhanced understanding of how formins are exploited will provide us with greater insight into how a fundamental eurkaryotic cellular process is utilized by bacteria and will also advance our knowledge of host‐pathogen interactions. (shrink)

Probably to most students of Moral Philosophy there comes a time when they feel a vague sense of dissatisfaction with the whole subject. And the sense of dissatisfaction tends to grow rather than to diminish. It is not so much that the positions, and still more the arguments, of particular thinkers seem unconvincing, though this is true. It is rather that the aim of the subject becomes increasingly obscure. "What," it is asked, "are we really going to learn by Moral (...) Philosophy?" "What are books on Moral Philosophy really trying to show, and when their aim is clear, why are they so unconvincing and artificial?" And again: "Why is it so difficult to substitute anything better?" Personally, I have been led by growing dissatisfaction of this kind to wonder whether the reason may not be that the subject, at any rate as usually understood, consists in the attempt to answer an improper question. And in this article, I shall venture to contend that the existence of the whole subject, as usually understood, rests on a mistake, and on a mistake parallel to that on which rests, as I think, the subject usually called the Theory of Knowledge. (shrink)

A promise to do some action seems to create a binding obligation to do that action. And yet, paradoxically, an obligation seems not to be a fact that we can create or bring into existence; we can create an obligation only by creating or bringing into existence something else. The only way to avoid the paradox is to show that the act of promising creates something other than an obligation, which nonetheless binds us to perform the action in question. After (...) considering and rejecting various options such as the promisee's expectation and the promisor's resolve, Prichard locates the bindingness of a promise in a prior general promise, which allows the noises we make when promising to generate an obligation to perform the promised action. (shrink)

This note is in answer to some criticisms by professor mundle of dobb's work on the above topic. he first presents a general argument, relevant to those criticisms, regarding the physical significance of the fifth dimension. (staff).

What role does the wild duck play in Ibsen's famous drama? I argue that, besides mirroring the fate of the human cast members, the duck is acting as animal subject in a quasi-experiment, conducted in a private setting. Analysed from this perspective, the play allows us to discern the epistemological and ethical dimensions of the new scientific animal practice (systematic observation of animal behaviour under artificial conditions) emerging precesely at that time. Ibsen's play stages the clash between a scientific and (...) a romantic understanding of animals that still constitutes the backdrop of most contemporary debates over animals in research. Whereas the scientific understanding reduces the animal's behaviour, as well as its environment, to discrete and modifiable elements, the romantic view regards animals as being at one with (or violently disconnected from) their natural surroundings. (shrink)