BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

The feminization of agriculture narrative has been reproduced in development literature as an oversimplified metric of empowerment through changes in women’s labor and managerial roles with little attention to individuals’ heterogeneous livelihoods. Grounded in feminist political ecology, we sought to critically understand how labor and managerial feminization interact with changing agricultural practices. Working with a local NGO as part of an international, donor-funded research-for-development project, we conducted semi-structured interviews, focus group discussions, and participant observation with over 100 farmers in Mid-Western (...) Nepal in 2017. Household structure and headship are dynamic in the context of male out-migration, pushing women to take on new agricultural duties and increasing household labor responsibilities. In this context, decision-making processes related to agricultural management and new cultivation practices illustrate ongoing renegotiations of gender and cultivation practices within and beyond the household. We contend that the heterogeneity of household power dynamics muddies the empowering impacts of migration and emphasize the importance of community spaces as a locus of subjectivity formation and social value. We conclude that FPE can illuminate complexities of power, space, and individual responses to socio-ecological conditions that challenge the current feminization of agriculture framework. (shrink)

This series provides a complete introduction to essential coding skills. Key coding concepts are explained through fun robot adventure stories. Written by a qualified coding educator and neuroscience expert.

Analysing sexual harassment law in British Columbia, this paper argues that in highly sexualised work environments, in which practices including sexual ‘jokes’ or innuendo may be common, law embodies and (re)creates the gendered subtext of the workplace. When a complaint of sexual harassment from a sexualised workplace is raised in a legal forum, a complainant has an obligation to clearly object to the sexual remarks, ‘jokes,’ banter, etc.—which may be the ‘norm’—to show the conduct in question was unwelcome. At the (...) same time, however, a workplace may be structured, in part by law, in a way that restricts employee resistance to uncomfortable sexual experiences. This is the case, I argue, for women working in full-service restaurants when it comes to sexual interactions with customers. This paper explores how restaurant work, in the Canadian context with a focus on the province of British Columbia, is organised in a manner that makes women vulnerable to enduring sexually harassing practices as a routine part of their jobs. (shrink)

Natural language involves both speaking and listening. Recent models claim that production and comprehension share aspects of processing and are linked within individuals (Dell & Chang, 2014; MacDonald, 2013; Pickering & Garrod, 2004; 2013a). Evidence for this claim has come from studies of cross-modality structural priming, mainly examining processing in the direction of comprehension to production. The current study replicated these comprehension to production findings and developed a novel cross-modal structural priming paradigm from production to comprehension using a temporally-sensitive online (...) measure of comprehension, Event-Related Potentials. For Comprehension-to-Production priming, participants first listened to active or passive sentences and then described target pictures using either structure. In Production-to-Comprehension priming, participants first described a picture using either structure and then listened to target passive sentences while EEG was recorded. Comprehension-to-Production priming showed the expected passive sentence priming for syntactic choice, but not response time or average syllable duration. In Production-to-Comprehension priming, primed, versus unprimed, passive sentences elicited a reduced N400. These effects support the notion that production and comprehension share aspects of processing and are linked within the individual. Moreover, this paradigm can be used for the exploration priming at different linguistic levels as well as the influence of extra-linguistic factors on natural language use. (shrink)

PurposeEven low intensity exercise bouts of at least 15 min can improve feelings of energy and reduce systolic blood pressure. However, little is known about the psychological outcomes of briefer exercise bouts, particularly for modes of exercise that are more intense than level walking, and readily available to many working adults. This study assessed the effects of a 4-min bout of stair walking on FOE and feelings of fatigue.MethodsThirty-six young adult participants were randomized to either stair walking or seated control (...) groups. All participants walked on level-ground from a laboratory to a nearby stairwell and were seated for 4 min before beginning their experimental condition. Stair-walking participants walked up and down one flight of 16 stairs at their own pace for 4 min, while control participants remained seated during that time. Participants walked back to the laboratory for post-condition assessments. Measures of blood pressure, heart rate, rated perceived exertion, and the intensity of feelings of mental energy, mental fatigue, physical energy, and physical fatigue were assessed pre-and post-condition. Separate one-way ANOVAs were conducted on change scores for all variables.ResultsThe stair climbing group experienced significant increases in heart rate [F = 13.167, p < 0.001] and RPE [F = 93.844, p < 0.001] that were not observed in the seated control group. Four minutes of self-paced stair climbing resulted in small changes and non-significant differences within and between groups in blood pressure as well as FOE and FOF.ConclusionAlthough a 4-min self-paced exercise bout can convey short-term physiological health benefits, a 4-min bout of self-paced indoor stair walking in a stairwell was insufficient to lower blood pressure or change subjective FOE and fatigue in a sample that exhibited better than typical FOE and FOF at the pre-test. (shrink)

Studying the typical development of reading is key to understanding the precise deficits that underlie reading disabilities. An important correlate of efficient reading is the speed of naming arrays of simple stimuli such as letters and pictures. In this cross-sectional study, we examined developmental changes in visual processing that occurs during letter and object naming from childhood to early adulthood in terms of behavioral task efficiency, associated articulation and eye movement parameters, and the coordination between them, as measured by eye-voice (...) span in both the spatial and temporal domains. We used naming speed tasks, in which participants were required to name sets of letters or simple objects as quickly and as accurately as possible. Single stimulus manipulations were made to these tasks to make the stimuli either more visually and/or phonologically similar to one another in order to examine how these manipulations affected task performance and the coordination between speech and eye movements. Across development there was an increased efficiency in speech and eye movement performance and their coordination in both the spatial and temporal domains. Furthermore, manipulations to the phonological and visual similarity of specific letter and object stimuli revealed that orthographic processing played a greater role than phonological processing in performance, with the contribution of phonological processing diminishing across development. This comprehensive typical developmental trajectory provides a benchmark for clinical populations to elucidate the nature of the cognitive dysfunction underlying reading difficulties. (shrink)

In his early essay, “Reality and Its Shadow,” Levinas appears to take a strong position against art, and while the strength of his admonitions against aesthetics has been questioned, the fact remains that Levinas refers to art as an act that is like “feasting during a plague.” Art becomes offensive. However, is it possible that we could imagine the artwork as a site where the encounter with the Other becomes possible? That is, when we encounter certain artworks, do we not (...) also encounter the radical alterity of one whose experiences and very existence cannot possibly be assimilated to the Same, or to our own experiences? In this paper, I argue that art marks a site where the encounter with the Other is made possible by examining the post-genocide and post-war photographs of Simon Norfolk. I maintain that art thus contains ethical possibilities that actually align with Levinasian ethics, rather than run counter to it, as Levinas seemed to believe. This art cannot be understood through the lens of enjoyment—as “feasting during a plague”—but rather must be understood as an experience which throws us outside of ourselves and our interiority and, in so doing, forces us to confront an alterity and a horror that awakens responsibility and awareness of the Other. (shrink)

This research assessed how the performance and team skills of three-person teams working with an Intelligent Team Tutoring System on a virtual military surveillance task were affected by feedback privacy, participant role, task experience, prior team experience, and teammate familiarity. Previous work in Intelligent Tutoring Systems has focused on outcomes for task skill training for individual learners. As research extends into intelligent tutoring for teams, both task skills and team skills are necessary for good team performance. This work includes a (...) brief review of previous research on ITTSs, feedback, teams, and teamwork, including the recounting of two categories of a framework of teamwork performance, Communication and Cognition, which are relevant to the present study. This research examines the effects of an intelligent agent, as well as features of the team, its members, and the task being undertaken, on team communication and team situation awareness. Thirty-seven teams of three participants, each at their own computer running a multiplayer surveillance simulation, were given just-in-time private or public performance feedback during four 5-min trials. In the fourth trial, two of the three participants switched roles. Feedback type, teamwork experience, and teammate familiarity had no statistically significant effect on communication or team situation awareness. However, higher levels of role experience and task experience showed significant and medium-sized effects on communication performance. Results, based on performance data and structured interview responses, also revealed areas of improvement in future feedback design and a potential benchmark for feedback frequency in an action-oriented serious game-based ITTS. Among the conclusions are six design objectives for future ITTSs, establishing a foundation for future research on designing effective ITTSs that train interpersonal skills to nascent teams. (shrink)

Nietzsche is perhaps best known for his diagnosis of the problem of nihilism. Though his elaborations on this diagnosis often include descriptions of certain beliefs characteristic of the nihilist (such as beliefs in the meaninglessness or worthlessness of existence), he just as frequently specifies a variety of affective symptoms experienced by the nihilist that weaken their will and diminish their agency. This affective dimension to nihilism, however, remains drastically underexplored. In this book, Kaitlyn Creasy offers a comprehensive account of (...) affective nihilism that draws on Nietzsche’s drive psychology, especially his reflections on affects and their transformative potential. After exploring Nietzsche’s account of affectivity (illuminating especially the transpersonal nature of affect in Nietzsche’s thought) and the phenomenon of affective nihilism, Creasy argues that affective nihilism might be overcome by employing a variety of Nietzschean strategies: experimentation, self-narration, and self-genealogy. (shrink)

In this paper, I explore the sociality of emotional experience in the work of Friedrich Nietzsche. Specifically, I describe four key mechanisms through which an individual's sociocultural context shapes her emotional experience on Nietzsche's view—emotional contagion as habitual affective mimicry, the production of emotions' felt character through the assimilation of dominant social beliefs and norms, affective interpretation à la Christopher Fowles, and the imposition of dominant notions of emotional appropriateness—fleshing out a dimension of Nietzsche's thought which is largely taken for (...) granted but remains undertreated. After detailing these mechanisms, I argue that attending to the sociality of emotional experience in Nietzsche's thought is crucial not only for understanding key elements of his moral psychology (including certain of his reflections on freedom and self‐transformation), but also for understanding his interpretation of nihilism as a psychological‐affective phenomenon produced by the society to which one belongs. On Nietzsche's view, attending to the sociality of emotion helps individuals recognize the way in which the sociocultural contexts they inhabit might undermine their flourishing—and also helps them envision the conditions (especially sociocultural conditions) requisite for healthier, more empowering emotional lives. (shrink)

In this paper, I examine a set of theoretical tools Nietzsche offers for making sense of the emotional dynamics and psychophysiological impacts of sexist oppression. Specifically, I indicate how Nietzsche’s account of the social and cultural production of emotional experience (i.e. his account of the transpersonal nature of emotional experience) can serve as a conceptual resource for understanding the detrimental emotional impacts of social norms, beliefs, and practices that systematically devalue certain of one’s ends and interests.

In The Affirmation of Life, Bernard Reginster argues that Nietzschean nihilism is best characterized as a "philosophical claim."1 This account has inspired a number of critical responses from contemporary scholars.2 Ken Gemes and John Richardson, for example, both point out that while Reginster's characterization presents nihilism as a purely cognitive phenomenon involving particular beliefs about meaning and value, it is just as frequently presented by Nietzsche as a feeling-based phenomenon, a weariness that comports one negatively toward the world of which (...) one is a part.3 How, then, should Nietzsche's reader understand the problem of nihilism in his thought?In... (shrink)

Reflections on Theoretical Issues in Argumentation Theory Frans H. van Eemeren and Bart Garssen Cham: Springer International Publishing, 2015. Pp. xiv, 1-293. ISBN 978-3-319-21102-2. eBook US$139.00, €118,99; Hardcover US$179.00, €147,69.

In this chapter, I contend that Nietzsche’s robust critiques of human exceptionalism and the “humanization of nature [Vermenschlichung der Natur]”, as well as his positive, proto-ecocentric vision of the “naturalization of humanity [Vernatürlichung des Menschen]”, afford contemporary environmental philosophy a novel perspective from which to critique anthropocentric conservation ideologies (according to which nature conservation ought to be motivated by the interests and aims of humanity, especially economic development and prosperity). Importantly, I also argue that Thus Spoke Zarathustra is the work (...) in which Nietzsche’s positive vision appears most conspicuously, as suggested by Zarathustra’s relationship to the natural world and exhortations to “remain faithful to the earth.” -/- As Nietzsche’s critique of anthropocentrism reinforces his positive project, I will begin by detailing Nietzsche’s rejection of human exceptionalism (section 1). In addition, I will analyze Nietzsche’s critique of the “humanization of nature” (KSA 10:10[43]; 10:13[20]; 12:1[29]), emphasizing specific pernicious projections of human values onto the other-than-human world. Although these themes appear throughout Nietzsche’s body of work, they are central to Zarathustra. -/- After describing Nietzsche’s critical project, I present his positive, proto-ecocentric vision for humanity’s re-naturalization, one he most emphatically endorses and fleshes out in Zarathustra (section 2). This positive vision can be found in his calls for the human being to become more natural and to cultivate a noble reverence and gratitude for the natural world so that we may learn from it about ourselves—rather than falsifying it for our ends and then insisting that we are part of this other, falsified nature. Only when we can see ourselves as natural beings—specifically, as living beings willing power, embedded in a world with other living beings who do the same—can we identify tasks and pursue aims that empower and strengthen us. In Nietzsche’s view, this recognition results only from an attunement to the other-than-human world. Finally, after adding a few important caveats to proto-ecocentric strains in Nietzsche’s thought, I briefly explain the contributions his thought might make to contemporary environmental philosophy and policy (section 3). (shrink)

This article interprets David E. Storey’s foundation of an environmental ethic on Nietzsche’s philosophy of life as a version of new conservationism. Critically examining Storey’s various claims, the article demonstrates potentially problematic aspects of the new conservationist project. In order to both question Storey’s interpretation of a Nietzschean philosophy of life and problematize the new conservationist understanding of nature, this article returns to the work of Friedrich Nietzsche. In particular, it argues from a Nietzschean perspective that the new conservationist projection (...) of human teleology and values onto wild nature and non-human life results in a nihilistic conception of wild nature. (shrink)

In recent work, Bernard Reginster argues for an interpretation of the relationship between morality and the affects in Nietzsche which he calls ‘sentimental pragmatism’. According to this view, the values, value judgments, and moral practices agents develop and adopt function to serve specific affective needs. Reginster deploys this interpretation to argue for a functional interpretation of Nietzsche’s On the Genealogy of Morality, according to which all three essays of the Genealogy comprise psychological studies designed to uncover Christian morality’s function to (...) serve the affect of ressentiment. In this paper, I first develop Reginster’s sentimental pragmatism by specifying a need to feel powerful as the one affective need which all moral developments aim to serve on Nietzsche’s view. Then, I argue that while Reginster’s functional interpretation of the Genealogy makes sense of key moral phenomena discussed in the first and third essays, it works less well to explain key developments in the second essay. I then suggest that my power-based sentimental pragmatism does better in this regard, allowing us to identify one basic function of morality that Nietzsche intends to uncover in all three essays of the Genealogy, one basic affective need it aims to serve: the need to feel powerful. (shrink)

Vaccination is a highly effective public health strategy that provides protection to both individuals and communities from a range of infectious diseases. Governments monitor vaccination rates carefully, as widespread use of a vaccine within a population is required to extend protection to the general population through “herd immunity,” which is important for protecting infants who are not yet fully vaccinated and others who are unable to undergo vaccination for medical or other reasons. Australia is unique in employing financial incentives to (...) increase vaccination uptake, mainly in the form of various childcare payments and tax benefits linked to timely, age-appropriate vaccination. Despite relatively high compliance with the childhood vaccination schedule, however, the Australian government has determined that rates should be higher and has recently introduced policy that includes removing certain tax and childcare benefits for non-vaccinators and formally disallowing conscientious objection to vaccination. In addition, it has raised the possibility of banning unvaccinated children from childcare centres. This article examines the impact of coercive approaches to childhood vaccination and raises the question of the ethical justification of health policy initiatives based on coercion. We consider the current evidence regarding childhood vaccination in Australia, the small but real risks associated with vaccination, the ethical requirement for consent for medical procedures, and the potential social harms of targeting non-vaccinators. We conclude that the evidence does not support a move to an increasingly mandatory approach that could only be delivered through paternalistic, coercive clinical practices. (shrink)

In an 1881 letter, Nietzsche remarks incredulously that he is "utterly amazed" to have found in Spinoza "a precursor" with whom he shares an "overtendency [...] to make knowledge the most powerful affect."1 It is this tendency to assign knowledge and ways of knowing the functional role of an affect that I intend to investigate as a means of overcoming affective nihilism.2 In particular, it is by participating in certain practices of self-knowledge and introducing oneself, experimentally, to new sites and (...) bodies of knowledge that one might reengage oneself with one's world and affirm life.In his work, Nietzsche describes affects as "reactions of the will", as "inclinations" and "aversions... (shrink)

Published data show that new HIV prevention strategies including treatment‐as‐prevention and pre‐exposure prophylaxis (PrEP) using oral antiretroviral drugs (ARVs) are highly, but not completely, effective if regimens are taken as directed. Consequently, their implementation may challenge norms around HIV prevention. Specific concerns include the potential for ARV‐based prevention to reframe responsibility, erode beneficial sexual norms and waste resources. This paper explores what rights claims uninfected people can make for access to ARVs for prevention, and whether moral claims justify the provision (...) of ARV therapy to those who do not yet clinically require treatment as a way of reducing HIV transmission risk. An ethical analysis was conducted of the two strategies, PrEP and treatment‐as‐prevention, using a public health stewardship model developed by the Nuffield Bioethics Council to consider and compare the application of PrEP and treatment‐as‐prevention strategies. We found that treating the person with HIV rather than the uninfected person offers advantages in settings where there are limited opportunities to access care. A treatment‐as‐prevention strategy that places all the emphasis upon the positive person's adherence however carries a disproportionate burden of responsibility. PrEP remains an important option for receptive partners who face increased biological vulnerability. We conclude that the use of ARV for prevention is ethically justified, despite imperfect global to drugs for those in clinical need. The determination of which ARV‐based HIV prevention strategy is ethically preferable is complex and must take into account both public health and interpersonal considerations. (shrink)

In 2010, randomized controlled trials (RCTs) of two different biomedical strategies to prevent HIV infection had positive findings. However, despite ongoing very high levels of HIV infection in some countries and population groups, it has been made clear by regulatory authorities that the evidence remains insufficient to support either product being made available outside of research contexts in the developing world for at least two years. In addition, prevention trials in endemic areas will continue to test new interventions against placebo. (...) But the judgments of evidentiary standards are never value-neutral. Using the recent trials and their contexts as case studies, we examine the basis for these decisions, which will potentially delay access to scientific innovation to the people who are most urgently in need of it. (shrink)

The principle of providing post-trial access for research participants to successful products of that research is widely accepted and has been enshrined in various declarations and guidelines. While recent ethical guidelines recognise that the responsibility to provide post-trial access extends to sponsors, regulators and government bodies as well as to researchers, it is the researchers who have the direct duty of care to participants. Researchers may thus need to act as advocates for trial participants, especially where government bodies, sponsors, and (...) regulatory bodies have complex interests vested in decisions about whether or not new interventions are made available, how, and to whom. This paper provides an empirical account of post-trial access in the context of HIV prevention research. It describes both access to the successful products of research and the provision antiretroviral drugs for trial participants who acquire HIV. First, we provide evidence that, in the current system, there is considerable variation in the duration and timeliness of access. We then argue that by analysing the difficulties faced by researchers to this point, and their efforts to meet this obligation, much can be learned about how to secure post-trial access in HIV biomedical preventions trials. While researchers alone have a limited obligation, their advocacy on behalf of trial participants may be necessary to call the other parties to account. (shrink)

The experience of pain is subjective, yet many people have their pain invalidated or not believed. Pain invalidation is associated with poor mental health, including depression and lower well-being. Qualitative investigations of invalidating experiences identify themes of depression, but also social withdrawal, self-criticism, and lower self-worth, all of which are core components of shame. Despite this, no studies have quantitatively assessed the interrelationship between pain invalidation, shame, and depression. To explore this relationship, participants recounted the frequency of experienced pain invalidation (...) from family, friends, and medical professionals, as well as their feelings of internalized shame and depressive symptoms. As shame has been shown to be a precursor for depression, we further explored the role of shame as a mediator between pain invalidation and depressive symptoms. All sources of pain invalidation were positively associated with shame and depressive symptoms, and shame fully mediated the relationship between each source of pain invalidation and depression. Relative to other sources, pain invalidation from family was most closely tied to shame and depression. Overall, findings indicate that one mechanism by which pain invalidation may facilitate depression is via the experience of shame. Future research may explore shame as a potential upstream precursor to depression in the context of pain. Findings provide more insight into the harmful influence of pain invalidation on mental health and highlight the impact of interpersonal treatment on the experiences of people in pain. (shrink)

The successful demonstration that antiretroviral (ARV) drugs can be used in diverse ways to reduce HIV acquisition or transmission risks – either taken as pre-exposure prophylaxis (PrEP) by those who are uninfected or as early treatment for prevention (T4P) by those living with HIV – expands the armamentarium of existing HIV prevention tools. These findings have implications for the design of future HIV prevention research trials. With the advent of multiple effective HIV prevention tools, discussions about the ethics and the (...) feasibility of future HIV prevention trial designs have intensified. This article outlines arguments concerning the inclusion of newly established ARV-based HIV prevention interventions as standard of prevention in HIV prevention trials from multiple perspectives. Ultimately, there is a clear need to incorporate stakeholders in a robust discussion to determine the appropriate trial design for each study population. (shrink)

Published data show that new HIV prevention strategies including treatment-as-prevention and pre-exposure prophylaxis (PrEP) using oral antiretroviral drugs (ARVs) are highly, but not completely, effective if regimens are taken as directed. Consequently, their implementation may challenge norms around HIV prevention. Specific concerns include the potential for ARV-based prevention to reframe responsibility, erode beneficial sexual norms and waste resources. This paper explores what rights claims uninfected people can make for access to ARVs for prevention, and whether moral claims justify the provision (...) of ARV therapy to those who do not yet clinically require treatment as a way of reducing HIV transmission risk. An ethical analysis was conducted of the two strategies, PrEP and treatment-as-prevention, using a public health stewardship model developed by the Nuffield Bioethics Council to consider and compare the application of PrEP and treatment-as-prevention strategies. We found that treating the person with HIV rather than the uninfected person offers advantages in settings where there are limited opportunities to access care. A treatment-as-prevention strategy that places all the emphasis upon the positive person's adherence however carries a disproportionate burden of responsibility. PrEP remains an important option for receptive partners who face increased biological vulnerability. We conclude that the use of ARV for prevention is ethically justified, despite imperfect global to drugs for those in clinical need. The determination of which ARV-based HIV prevention strategy is ethically preferable is complex and must take into account both public health and interpersonal considerations. (shrink)

The American Journal of Bioethics, Volume 11, Issue 12, Page 48-50, December 2011.

In many countries around the world, people who inject drugs remain at high risk of HIV acquisition not because effective forms of prevention are unknown, nor because they find effective prevention undesirable, but because those in charge, mainly politicians but also bureaucrats, find evidence-based practice politically unacceptable. The evidence for preventive efficacy of harm reduction strategies, most prominently needle and syringe programmes but also treatment programmes such as opiate substitution, is irrefutable.1 However, political responses to drug use issues are varied (...) and complex, so the will to implement appropriate harm reduction programmes in the interests of public health remains lacking in too many jurisdictions. As a consequence, the discussion of how best, in the context of research, to reduce HIV incidence in populations of people who inject drugs but are not offered comprehensive access to known prevention strategies is—tragically—an important one. Dawson et al 2 focus on access to sterile injecting equipment and recognise that this should remain the ‘default’ standard of prevention for HIV prevention trials involving people for whom injecting drug use is the primary risk factor for HIV acquisition. ‘Standard of prevention’ means the background or minimal HIV risk reduction interventions offered to all participants in a trial, regardless of what other investigational interventions they are assigned to receive. The standard of prevention concept is grounded in the ethical principle of beneficence—that researchers and sponsors are obliged to maximise benefits and minimise risks to participants in research studies.3 …. (shrink)

In clinical research there is a tension between the role of a doctor, who must serve the best interests of the patient, and the role of the researcher, who must produce knowledge that may not have any immediate benefits for the research participant. This tension is exacerbated in HIV research in low and middle income countries, which frequently uncovers comorbidities other than the condition under study. Some bioethicists argue that as the goals of medicine and those of research are distinct, (...) it is a mistake for researchers to assume therapeutic responsibilities while engaging in research. Others propose that there is a duty of care, but disagree as to how this is limited and specified. In this qualitative study, principal investigators from HIV prevention trials discuss their experience of providing medical benefits to participants within the context of conducting research into HIV biomedical prevention technologies. They describe the limitations imposed at times by funders and at times by infrastructure constraints, and canvass the importance of ancillary care provision and capacity building in trial communities. The views of the principal investigators are compatible with the perspective that there is a duty of care, limited by the nature of the research, the depth of the relationship between research and participant, and the capacity of the research site. The therapeutic orientation in HIV prevention trial appears to be indivisible from competent research practise by making concrete and appropriate benefits available to trial participants and their communities that support rather than compete with local infrastructure. (shrink)

In this study, we replicated what is known about the relative importance of dealbreakers and dealmakers in romantic and sexual relationships and extended it to an examination of self-reports of mate value, self-esteem, and loneliness. In two experiments we manipulated the information people were told about potential partners and asked them about their intentions to have sex again with or go on a second date with opposite sex targets. People were less interested in partners after learning dealbreakers, effects which operated (...) more strongly in the long-term than short-term context, but similarly in men and women. People who reported less self-esteem or more loneliness were more receptive to people with dealbreakers. People who thought they had more mate value, more self-esteem, or less loneliness were more receptive to dealmakers. Results are discussed using sociometer, prospect, and sexual strategies theories. (shrink)

Volume 20, Issue 10, October 2020, Page 47-49.