15 found
Order:
See also
Mackenzie Graham
Oxford University
  1.  32
    Assessing Decision-Making Capacity in the Behaviorally Nonresponsive Patient With Residual Covert Awareness.Andrew Peterson, Lorina Naci, Charles Weijer, Damian Cruse, Davinia Fernández-Espejo, Mackenzie Graham & Adrian M. Owen - 2013 - American Journal of Bioethics Neuroscience 4 (4):3-14.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   20 citations  
  2.  27
    An Ethics of Welfare for Patients Diagnosed as Vegetative With Covert Awareness.Mackenzie Graham, Charles Weijer, Damian Cruse, Davinia Fernandez-Espejo, Teneille Gofton, Laura E. Gonzalez-Lara, Andrea Lazosky, Lorina Naci, Loretta Norton, Andrew Peterson, Kathy N. Speechley, Bryan Young & Adrian M. Owen - 2015 - American Journal of Bioethics Neuroscience 6 (2):31-41.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  3.  26
    Can They Feel? The Capacity for Pain and Pleasure in Patients with Cognitive Motor Dissociation.Mackenzie Graham - 2019 - Neuroethics 12 (2):153-169.
    Unresponsive wakefulness syndrome is a disorder of consciousness wherein a patient is awake, but completely non-responsive at the bedside. However, research has shown that a minority of these patients remain aware, and can demonstrate their awareness via functional neuroimaging; these patients are referred to as having ‘cognitive motor dissociation’. Unfortunately, we have little insight into the subjective experiences of these patients, making it difficult to determine how best to promote their well-being. In this paper, I argue that the capacity to (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  4.  27
    A Fate Worse Than Death? The Well-Being of Patients Diagnosed as Vegetative With Covert Awareness.Mackenzie Graham - 2017 - Ethical Theory and Moral Practice 20 (5):1005-1020.
    Patients in the vegetative state are wholly unaware of themselves, or their surroundings. However, a minority of patients diagnosed as vegetative are actually aware. What is the well-being of these patients? How are their lives going, for them? It has been argued that on a reasonable conception of well-being, these patients are faring so poorly that it may be in their best interests not to continue existing. I argue against this claim. Standard conceptions of well-being do not clearly support the (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  5.  4
    Precedent Autonomy and Surrogate Decisionmaking After Severe Brain Injury.Mackenzie Graham - 2020 - Cambridge Quarterly of Healthcare Ethics 29 (4):511-526.
    Patients with disorders of consciousness after severe brain injury need surrogate decision makers to guide treatment decisions on their behalf. Formal guidelines for surrogate decisionmaking generally instruct decision makers to first appeal to a patient’s written advance directive, followed by making a substituted judgment of what the patient would have chosen, and lastly, to make decisions according to what seems to be in the patient’s best medical interests. Substituted judgment is preferable because it is taken to preserve patient autonomy, by (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  6.  45
    Ethics of Neuroimaging After Serious Brain Injury.Charles Weijer, Andrew Peterson, Fiona Webster, Mackenzie Graham, Damian Cruse, Davinia Fernández-Espejo, Teneille Gofton, Laura E. Gonzalez-Lara, Andrea Lazosky, Lorina Naci, Loretta Norton, Kathy Speechley, Bryan Young & Adrian M. Owen - 2014 - BMC Medical Ethics 15 (1):41.
    Patient outcome after serious brain injury is highly variable. Following a period of coma, some patients recover while others progress into a vegetative state (unresponsive wakefulness syndrome) or minimally conscious state. In both cases, assessment is difficult and misdiagnosis may be as high as 43%. Recent advances in neuroimaging suggest a solution. Both functional magnetic resonance imaging and electroencephalography have been used to detect residual cognitive function in vegetative and minimally conscious patients. Neuroimaging may improve diagnosis and prognostication. These techniques (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  7.  13
    Working for the Weekend Is Not Meaningful Work.Charles Weijer & Mackenzie Graham - 2019 - American Journal of Bioethics 19 (9):48-50.
    Volume 19, Issue 9, September 2019, Page 48-50.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  8.  16
    Informed Consent for Functional MRI Research on Comatose Patients Following Severe Brain Injury: Balancing the Social Benefits of Research Against Patient Autonomy.Tommaso Bruni, Mackenzie Graham, Loretta Norton, Teneille Gofton, Adrian M. Owen & Charles Weijer - 2019 - Journal of Medical Ethics 45 (5):299-303.
    Functional MRI shows promise as a candidate prognostication method in acutely comatose patients following severe brain injury. However, further research is needed before this technique becomes appropriate for clinical practice. Drawing on a clinical case, we investigate the process of obtaining informed consent for this kind of research and identify four ethical issues. After describing each issue, we propose potential solutions which would make a patient’s participation in research compatible with her rights and interests. First, we defend the need for (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  9.  30
    Acknowledging Awareness: Informing Families of Individual Research Results for Patients in the Vegetative State.Mackenzie Graham, Charles Weijer, Andrew Peterson, Lorina Naci, Damian Cruse, Davinia Fernández-Espejo, Laura Gonzalez-Lara & Adrian M. Owen - 2015 - Journal of Medical Ethics 41 (7):534-538.
  10.  5
    From Awareness to Prognosis: Ethical Implications of Uncovering Hidden Awareness in Behaviorally Nonresponsive Patients.Mackenzie Graham, Eugene Wallace, Colin Doherty, Alison Mccann & Lorina Naci - 2019 - Cambridge Quarterly of Healthcare Ethics 28 (4):616-631.
    :Long-term patient outcomes after severe brain injury are highly variable, and reliable prognostic indicators are urgently needed to guide treatment decisions. Functional neuroimaging is a highly sensitive method of uncovering covert cognition and awareness in patients with prolonged disorders of consciousness, and there has been increased interest in using it as a research tool in acutely brain injured patients. When covert awareness is detected in a research context, this may impact surrogate decisionmaking—including decisions about life-sustaining treatment—even though the prognostic value (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  11.  4
    Burying Our Mistakes: Dealing with Prognostic Uncertainty After Severe Brain Injury.Mackenzie Graham - 2020 - Bioethics 34 (6):612-619.
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  12.  4
    Domains of Well-Being in Minimally Conscious Patients: Illuminating a Persistent Problem.Mackenzie Graham - 2018 - American Journal of Bioethics Neuroscience 9 (2):128-130.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  13.  12
    More Harm Than Good: Neurotechnological Thought Apprehension in Forensic Psychiatry.Mackenzie Graham & Phoebe Friesen - 2019 - American Journal of Bioethics Neuroscience 10 (1):17-19.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  14.  2
    Taking It to the Bank: The Ethical Management of Individual Findings Arising in Secondary Research.Mackenzie Graham, Nina Hallowell, Berge Solberg, Ari Haukkala, Joanne Holliday, Angeliki Kerasidou, Thomas Littlejohns, Elizabeth Ormondroyd, John-Arne Skolbekken & Marleena Vornanen - forthcoming - Journal of Medical Ethics:medethics-2020-106941.
    A rapidly growing proportion of health research uses ‘secondary data’: data used for purposes other than those for which it was originally collected. Do researchers using secondary data have an obligation to disclose individual research findings to participants? While the importance of this question has been duly recognised in the context of primary research, it remains largely unexamined in the context of research using secondary data. In this paper, we critically examine the arguments for a moral obligation to disclose individual (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  15.  4
    Memory During the Presumed Vegetative State: Implications for Patient Quality of Life.Nicola Taylor, Mackenzie Graham, Mark Delargy & Lorina Naci - 2020 - Cambridge Quarterly of Healthcare Ethics 29 (4):501-510.
    A growing number of studies show that a significant proportion of patients, who meet the clinical criteria for the diagnosis of the vegetative state, demonstrate evidence of covert awareness through successful performance of neuroimaging tasks. Despite these important advances, the day-to-day life experiences of any such patient remain unknown. This presents a major challenge for optimizing the patient’s standard of care and quality of life. We describe a patient who, following emergence from a state of complete behavioral unresponsiveness and a (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark