This paper is a theoretical and empirical investigation into whether persons in subordinate social contexts possess agency and if they do, how do we recognise and recover their agency given the oppressive conditions of their lives. It aims to achieve this through forging closer links between the philosophical arguments and the ethnographic evidence of women's agency. Through such an exercise, this paper hopes to bridge the existing gap between feminist theoretical interventions and feminist politics as well as to increase ‘sociological (...) awareness’ within feminist philosophical arguments. In order to think about women's agency in oppressive social contexts, the paper evaluates the suitability of existing theoretical frameworks for examining, describing and capturing the autonomy of persons and concludes that a new and a more complex thinking is required to facilitate thinking about human agency within oppressive transcultural contexts. The social context of subordination, the exhibition of agency within and oppressive context and the application of the new theoretical framework is illustrated in an extensive empirical study of the contact with modernity and its accompanying ideas of autonomy and individual rights of rural women belonging to two districts in Rajasthan, North western India. (shrink)

Realist and liberal understandings of ethics as the dominant approaches to ethics in international relations are unable to respond efficiently to the call of the other in the age of war against terrorism as they revolve around the needs and the interests of the self. Such self-centred understandings of ethics cannot respond to the other ethically and respect the other in its otherness. Therefore, in this work I attempt to develop responsive ethics by drawing on Levinasian ethics which can create (...) the possibilities of concrete non-violent responses to the other in the age of war against terrorism. (shrink)

Realist and liberal understandings of ethics as the dominant approaches to ethics in international relations are unable to respond efficiently to the call of the other in the age of war against terrorism as they revolve around the needs and the interests of the self. Such self-centred understandings of ethics cannot respond to the other ethically and respect the other in its otherness. Therefore, in this work I attempt to develop responsive ethics by drawing on Levinasian ethics which can create (...) the possibilities of concrete non-violent responses to the other in the age of war against terrorism. (shrink)

The very name of Bihar, a district in the eastern part of India, evokes images of anarchy, banditry, and disarray. Already traversed by distinct cultural zones - Bhojpuri, Mithila, Magadha, and the tribal zone of Jharkhand - Bihari society is characterized by bloody clan conflict over territorial rights. The doggedness with which the region's protagonists form militias is a perpetual source of front-page news. Pitted against the Brahmans and Bhumihar Rajputs, the large landowners, are the herding and soldier castes such (...) as the livestock-herding Yadavas, the farming Kurmis, and the former saltpeter miners, the Noniyas, whose economic, social, and political growth has given them real power. And although Magadha's rich Buddhist past attracts pilgrims and tourists, and Mithila's beautiful painted murals and villages draw art connoisseurs, Bihar ranks as one of the least safe regions of India. The rate of banditry and other crime reaches surprising levels. (shrink)

A central question in the study of presuppositions is how a presupposition trigger contributes to the meaning of a complex expression containing it. Two competing answers are found in the literature on quantificational expressions. According to the first, a quantificational expression presupposes that every member of its domain satisfies the presuppositions triggered in its scope, and according to the second, a quantificational expression presupposes that at least one member of its domain satisfies the presuppositions triggered in its scope. The former (...) view implies that an interrogative clause, a kind of quantificational expression, presupposes all of its possible answers’ presuppositions, whereas the latter view implies that an interrogative clause presupposes that the presuppositions of at least one of is possible answers are satisfied. This paper contributes to the debate by showing that ‘alternative’ interrogatives, formed with or, project presuppositions in the same, distinctive manner that other disjunctive constructions do: generally, universally. A theory that treats disjunctive words as restricted variables, bindable by various quantificational operators, is extended to account for the presuppositions of ‘alternative’ interrogatives, disjoined declaratives, and disjoined conditional antecedents in a uniform manner. The paper then explores some ways to reconcile the proposal with two special cases where interrogatives have been claimed to have weaker presuppositions: constituent interrogatives in presupposition-weakening contexts, and polar interrogatives containing bias-inducing scalar particles like even. (shrink)

A cost analysis of the utilization of new expensive vascular grafts is performed, applying the methodology of decision analysis to the theoretical case of a sixty year old male patient undergoing femoropopliteal grafting for limb threatening ischemia. The problem is presented graphically as a decision tree, uncertainties are quantified in terms of probabilities and end outcomes are evaluated in monetary terms. This informations is then utilized to calculate cost values associated with alternative actions.Based on initial cumulative patency figures of the (...) new more expensive grafts and the known performance of the older grafts, the initial high expense for the new grafts is justified economically, if the saphenous vein is not available. This analysis, apart from giving an answer to a specific clinical problem, can be viewed as a general model for cost analysis of surgical procedures. (shrink)

Pourquoi refuser une médiation? Quels sont les mécanismes, humains, sociologiques, professionnels qui peuvent pousser certains acteurs, parties à un différend, à préférer le coût, la durée et l’aléa d’un contentieux à la tentative de trouver rapidement un accord satisfaisant? Pour comprendre ces ressorts, il faut s’intéresser aux enjeux de pouvoir.

A l'heure où l'on souligne l'émergence indienne du post -colonialisme, Bollywood et ses films à grand budget se penchent sur le passé colonial. Héritière d'une littérature romanesque et tributaire des exposi­tions universelles, la guerre des images livrée entre la Grande-Bretagne et l'Inde à travers le support du cinéma, traduit un décalage. Tandis que la machinerie hollywoodienne s'est emparée d'un regard sur l'Inde à travers de grandes fresques d'aven­ture et de guerre, la riposte indienne s'est focalisée sur les répercussions psychiques intimes (...) de la domina­tion. Mais des fondements communs cimentent ces deux traditions. La guerre des images renvoie-t-elle au règlement de compte d'une déconstruction post-moderne, ou apporte-t-elle, comme l'induit Ashish Nandy, l'indice supplémentaire d'une culture partagée, celle de la colonisation?With India's emergence from the post-colonial age coming under the spotlight, Bollywood's big-budget films are turning to the country's colonial past. In the war of images being waged through the cinema between Great Britain and India, the two sides are out of phase. While the Hollywood machine views India through epic stories of war and adventure, India' s riposte focuses on the intimate psychological repercussions of domination. And yet, the two traditions are bonded together by their common foundations. Does the war of images echo scores being settled over a post-modern deconstructing trend? Or, as Ashish Nandy deduces, is it a new indication of a shared colonial culture? (shrink)

We explore a network architecture introduced by Elman (1988) for predicting successive elements of a sequence. The network uses the pattern of activation over a set of hidden units from time-step 25-1, together with element t, to predict element t + 1. When the network is trained with strings from a particular finite-state grammar, it can learn to be a perfect finite-state recognizer for the grammar. When the network has a minimal number of hidden units, patterns on the hidden units (...) come to correspond to the nodes of the grammar, although this correspondence is not necessary for the network to act as a perfect finite-state recognizer. We explore the conditions under which the network can carry information about distant sequential contingencies across intervening elements. Such information is maintained with relative ease if it is.. (shrink)

When Ian Hacking won the Holberg International Memorial Prize 2009 his candidature was said to strengthen the legitimacy of the prize after years of controversy. Ole Jacob Madsen, Johannes Servan and Simen Andersen Øyen have talked to Ian Hacking about current questions in the philosophy and history of science.

En este artículo analizamos la figura de Alexandra Elbakyan y su proyecto Sci-Hub, en cuya web se encuentran alojados más de 85 millones de documentos científicos a los que se puede acceder gratuitamente.Reflexionaremos sobre los cercamientos al conocimiento científico, el colonialismo en la producción académica y las propuestas que trabajan por un acceso abierto a la información científica. Tomaremos como referencia la desobediencia protagonizada por Elbakyan que, como mujer joven, no occidental e ideológicamente comprometida con posiciones anti neoliberales, representa una (...) identidad no hegemónica. (shrink)

(1996). Servan and the birth of human rights. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 515-519.

Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA function including amino acid substitution to give proteins not encoded in the genome. What determines which adenosines in an mRNA are subject to this modification reaction? The answer lies in an understanding of the mechanism and substrate recognition properties of adenosine deaminases that act on RNA (ADARs). Our recent publication of X‐ray crystal structures of the human ADAR2 deaminase domain bound to RNA editing substrates shed considerable (...) light on how the catalytic domains of these enzymes bind RNA and promote adenosine deamination. Here we review in detail the deaminase domain‐RNA contact surfaces and present models of how full length ADARs, bearing double stranded RNA‐binding domains (dsRBDs) and deaminase domains, could process naturally occurring substrate RNAs. (shrink)

L’ouvrage codirigé par Antoine Garapon et Pierre Servan-Schreiber vise à illustrer un changement de « paradigme » opéré au cours des dernières années dans la régulation des affaires internationales.En effet, traditionnellement, l’activité des entreprises multinationales est organisée selon le droit de l’Etat de leur siège social, et éventuellement selon le(s) droit(s) des Etats au sein desquels elles poursuivent leur activité. Par exemple, dans l’affaire Siemens, chaque acte illicite pouvait ainsi être soumis à trois droits nationaux (p. 10). Par conséquent, (...) l’organisation d’institutions complexes comme les entreprises multinationales dont le siège, les actionnaires et l’activité marchande sont généralement situés dans des Etats distincts a ouvert à ces dernières des possibilités inégalées de contournement des lois étatiques. En particulier, ces institutions ont structuré certaines de leurs opérations commerciales et financières de manière à ce que l’office du juge devienne ineffectif .. (shrink)

Comprehensive study of the Vākyapadīya of Bhartr̥hari, work on semantics and philosophy of Sanskrit grammar.

Tools for coping with a deceptive world.

RNA editing is a major post-transcriptional mechanism that changes specific nucleotides at the RNA level. The most common RNA editing type in humans is adenosine to inosine editing, which is mediated by ADAR enzymes. RNA editing events can not only change amino acids in proteins, but also affect the functions of non-coding RNAs such as miRNAs. Recent studies have characterized thousands of miRNA RNA editing events across different cancer types. Importantly, individual cases of miRNA editing have been reported to (...) play a role in cancer development. In this review, we summarize the current knowledge of miRNA editing in cancer, and discuss the mechanisms on how miRNA-related editing events modulate the initiation and progression of human cancer. Finally, we discuss the challenges and future directions of studying miRNA editing in cancer. RNA editing is introduced by ADAR or APOBEC enzymes, leading to specific nucleotide changes, respectively. The interplays between RNA editing and miRNAs may play important roles in cancer. This graphical abstract shows four major mechanisms through which miRNAs interact with RNA editing to confer a functional impact on tumor development. (shrink)

Previous studies of Zika virus (ZIKV) pathogenesis have focused primarily on virus‐driven pathology and neurotoxicity, as well as host‐related changes in cell proliferation, autophagy, immunity, and uterine function. It is now hypothesized that ZIKV pathogenesis arises instead as an (unintended) consequence of host innate immunity, specifically, as the side effect of an otherwise well‐functioning machine. The hypothesis presented here suggests a new way of thinking about the role of host immune mechanisms in disease pathogenesis, focusing on dysregulation of post‐transcriptional RNA (...) editing as a candidate driver of a broad range of observed neurodevelopmental defects and neurodegenerative clinical symptoms in both infants and adults linked with ZIKV infections. The authors collect and synthesize existing evidence of ZIKV‐mediated changes in the expression of adenosine deaminases acting on RNA (ADARs), known links between abnormal RNA editing and pathogenesis, as well as ideas for future research directions, including potential treatment strategies. (shrink)

Genetic variability is considered a key to the evolvability of species. The conversion of an adenosine (A) to inosine (I) in primary RNA transcripts can result in an amino acid change in the encoded protein, a change in secondary structure of the RNA, creation or destruction of a splice consensus site, or otherwise alter RNA fate. Substantial transcriptome and proteome variability is generated by A‐to‐I RNA editing through site‐selective post‐transcriptional recoding of single nucleotides. We posit that this epigenetic source of (...) phenotypic variation is an unrecognized mechanism of adaptive evolution. The genetic variation introduced through editing occurs at low evolutionary cost since predominant production of the wild‐type protein is retained. This property even allows exploration of sequence space that is inaccessible through mutation, leading to increased phenotypic plasticity and provides an evolutionary advantage for acclimatization as well as long‐term adaptation. Furthermore, continuous probing for novel RNA editing sites throughout the transcriptome is an intrinsic property of the editing machinery and represents the molecular basis for increased adaptability. We propose that higher organisms have therefore evolved to systems with increasing RNA editing activity and, as a result, to more complex systems. (shrink)

ḥeleḳ 1. - Elul, Tishre - Adar -- ḥeleḳ 2. Nisan-Av.

ḥeleḳ 1. - Elul, Tishre - Adar -- ḥeleḳ 2. Nisan-Av.

The most recent work toward compiling a comprehensive database of adenosine‐to‐inosine RNA editing events suggests that the potential for RNA editing is much more pervasive than previously thought; indeed, it is manifest in more than 100 million potential editing events located primarily within Alu repeat elements of the human transcriptome. Pairs of inverted Alu repeats are found in a substantial number of human genes, and when transcribed, they form long double‐stranded RNA structures that serve as optimal substrates for RNA editing (...) enzymes. A small subset of edited Alu elements has been shown to exhibit diverse functional roles in the regulation of alternative splicing, miRNA repression, and cis‐regulation of distant RNA editing sites. The low level of editing for the remaining majority may be non‐functional, yet their persistence in the primate genome provides enhanced genomic flexibility that may be required for adaptive evolution. (shrink)

In the paper it is argued that bridging the digital divide may cause a new ethical and social dilemma. Using Hardin's Tragedy of the Commons, we show that an improper opening and enlargement of the digital environment (Infosphere) is likely to produce a Tragedy of the Digital Commons (TDC). In the course of the analysis, we explain why Adar and Huberman's previous use of Hardin's Tragedy to interpret certain recent phenomena in the Infosphere (especially peer-to-peer communication) may not be (...) entirely satisfactory. We then seek to provide an improved version of the TDC that avoids the possible shortcomings of their model. Next, we analyse some problems encountered by the application of classical ethics in the resolution of the TDC. In the conclusion, we outline the kind of work that will be required to develop an ethical approach that may bridge the digital divide but avoid the TDC. (shrink)

How people learn chunks or associations between adjacent items in sequences was modelled. Two previously successful models of how people learn artificial grammars were contrasted: the CCN, a network version of the competitive chunker of Servan‐Schreiber and Anderson [J. Exp. Psychol.: Learn. Mem. Cogn. 16 (1990) 592], which produces local and compositionally‐structured chunk representations acquired incrementally; and the simple recurrent network (SRN) of Elman [Cogn. Sci. 14 (1990) 179], which acquires distributed representations through error correction. The models' susceptibility to (...) two types of interference was determined: prediction conflicts, in which a given letter can predict two other letters that appear next with an unequal frequency; and retroactive interference, in which the prediction made by a letter changes in the second half of training. The predictions of the models were determined by exploring parameter space and seeing howdensely different regions of the space of possible experimental outcomes were populated by model outcomes. For both types of interference, human data fell squarely in regions characteristic of CCN performance but not characteristic of SRN performance. (shrink)

One of the distinctive features of the primate genome is the Alu element, a repetitive short interspersed element, over a million highly similar copies of which account for >10% of the genome. A direct consequence of this feature is that primates' transcriptome is highly enriched in long stable dsRNA structures, the preferred target of adenosine deaminases acting on RNAs (ADARs), which are the enzymes catalyzing A‐to‐I RNA editing. Indeed, A‐to‐I editing by ADARs is extremely abundant in primates: over a hundred (...) million editing sites exist in their genomes. However, there are few essential editing sites conserved across mammals that have maintained their editing level despite the radical change in ADAR target landscape. Here, we review and discuss the cost of having an unusual amount of dsRNA and editing in the transcriptome, as well as the opportunities it presents, which might have contributed to the accelerated evolution of the primates. (shrink)

Es de notar desde e] principio la actitud afirmativa, superadora, en la filosofía de Nietzsche y su mediación para sentir y crear bellamente, pues él se toma en serio el problema de la estética, como la actividad propiamente metafísica, en sentido schopenhaueriano. Aquí referimos nuestra meditación al aforismo 276 de El Cay saber «Quiero aprender cada vez más, a ver lo necesario como bello en las cosas y así seré uno de los que embellecen las cosas. Amorfati: que esto desde (...) ahora esté en mi amor. No quiero acusar, tampoco quiero acusar al acusador. ¡Mi única negación sea a~adar la mirada! Y de una vez y en grande, quiero en todo momento no ser más que un hombre siempre afirmativo.» También, en Así habló Zaratustra 1, muestra Nietzsche bella y estimulante la admiración ante la necesidad: «Oh voluntad, cambio de toda necesidad! ¡tú, mi necesidad. Resérvame para una gran victoria!» Lo que acontece necesariamente, lo que se nos impone por la fuerza de las cosas, que no puede ser cambiado en sí mismo, abre sin embargo una posibilidad de diferente actitud en el modo de vivirlo y quien vive conscientemente lo inexorable puede «ver lo necesario como bello en las cosas». Es el desarrollo de su primera actitud científico filológica, cuando este joven profesor quiere expresar lo más hondo de la cultura griega en El nacimiento de la tragedia, donde manifiesta su profundamente sentida admiración por la vida y la cultura del pueblo heleno, en los últimos párrafos, con las palabras del extranjero que exclama: «cuánto tuvo que sufrir este pueblo para haber llegado a ser tan bello». De este modo, belleza y sufrimiento se hacen constitutivos de la vida trágica como puede ser afrontar con elevación, imprimiendo un bello sentido a cuanto la necesidad nos impone. (shrink)

Graphical AbstractAdenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain-Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain-Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239.

1. Moʻadim u-zemane ha-shanah, Elul-Adar -- 2. Moʻadim u-zemane ha-shanah, Nisan-Av.

Experience has recently reemerged as an important analytical category for historians of the Old Regime and the French Revolution. Reacting against the perceived excesses of discourse analysis, which made political language independent of any social determinants, certain post-revisionists are now seeking to contextualize political language by relating it to the experience of those who use it. Political agency, in these analyses, is understood to be the effect of particular formative experiences. This article suggests that the search for an experiential antidote (...) to discourse is misconceived because it perpetuates an untenable dichotomy between thought and reality. Access to the phenomenon of historical agency should be pursued not through experience or discourse but through the category of consciousness, since the make-up of the subject's consciousness determines how he/she engages the world and decides to attempt changing it. After a brief discussion of an important study that exemplifies both the allure and the functionality of the notion of experience, Timothy Tackett's Becoming a Revolutionary, the article focuses on the evolving political consciousness of a man who became a revolutionary agitator in 1789, J.-M.-A. Servan. Analysis of his writings between 1769 and 1789 shows that the way in which his perspective was constructed, rather than the lessons of experience per se, determined the shape of his revolutionary intentions in 1789. (shrink)

[1] Elul, Rosh ha-Shanah -- [2] ʻAśeret yeme teshuvah, Yom Kipur, Sukot, Shemini ʻatseret -- [3] Ḥanukah, Ṭu bi-Shevaṭ, 7 be-Adar, Purim, 4 parashiyot -- [4] Pesah, Sefirat ha-ʻomer, Lag ba-ʻomer, Shavuʻot -- [5] Ben ha-metsarim, Galut u-geʼulah, Shabat ḳodesh.