In this article, incoherent results of the associations between subjective well-being and economic status at multiple social levels are shown. Although individual-level positive associations are shown within developed countries, national-level associations disappear among developed countries. Group/area-level associations, meanwhile, do exist within Japanese societies. From these inconsistent phenomena, a sociocultural unit is proposed, within which well-being of people is collectively shared based on mutual reciprocity. The simple addition of social scientific results themselves cannot reconstruct the whole range of phenomena. Humanities could (...) be considered as the glue, which adds sociocultural meanings to the generalized scientific results. (shrink)

Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway, mediated by nicotinamide phosphoribosyltransferase (NAMPT), a key NAD+ biosynthetic enzyme, plays a pivotal role in controlling many biological processes, such as metabolism, circadian rhythm, inflammation, and aging. Over the past decade, NAMPT‐mediated NAD+ biosynthesis, together with its key downstream mediator, namely the NAD+‐dependent protein deacetylase SIRT1, has been demonstrated to regulate glucose and lipid metabolism in a tissue‐dependent manner. These discoveries have provided novel mechanistic and therapeutic insights into obesity and its metabolic complications, such (...) as insulin resistance, an important risk factor for developing type 2 diabetes and cardiovascular disease. This review will focus on the importance of adipose tissue NAMPT‐mediated NAD+ biosynthesis and SIRT1 in the pathophysiology of obesity and insulin resistance. We will also critically explore translational and clinical aspects of adipose tissue NAD+ biology. (shrink)

仁斎にとっての「学問」とは、世界の見え方を刷新させるものである。そして、そのような「学問」の道を開いたのが孔子であった。.

「士農工商は天下を治めるたすけとなる」―江戸期、都市化・経済化の流動的な波の中で、人々の生のつながりの公共的意義を説いた梅岩。広範な影響を及ぼしたその心学は、人々に希望を与え、世界のすべての存在が共に 幸福になることをめざす創造的・運動的な営みであった。.

It is generally assumed that in early modern Britain, chivalry—allegedly typified by the Crusades—was considered a negative or even ridiculous ideology until its rehabilitation by the pre-Romantic movement. However, this paper argues that Hume and other Scottish Enlightenment thinkers had already shown a deep interest in its historical role and influence on modern civilization. That Hume shared a broad interest in chivalry with contemporary philosophers does not undermine the novelty of his thought on this topic. In fact, the pioneering and (...) unique aspects of his contributions can be clarified by setting them in context. (shrink)

Demonstrates the uniqueness of Hume as an Enlightenment thinker, illustrating how his 'spirit of scepticism' often leads him into seemingly paradoxical positions. This book will be of interest to Hume scholars, intellectual historians of 17th- to 19th-century Europe and those interested in the Enlightenment more widely.

The significance of Hume's positive attitude towards luxury might have been overemphasized by his commentators. In fact, arguments in favor of "moderate" luxury had already been entertained before the emergence of Hume's position. Therefore to argue that Hume's argument entailed the defense of moderate luxury is not to identify in it anything particularly unique. Thus, the first aim of this paper is to clarify the nature of Hume's contribution to the ongoing luxury debates. This does not consist merely of an (...) assertion of the compatibility of moral virtue with the enjoyment of luxury, but lies rather in Hume's emphasis on two aspects of the beneficial interaction between morality and luxury. First, the historical process of the introduction of luxury is regarded by Hume as fostering new morals peculiar to the commercial age; and secondly, the enjoyment of luxury is seen as a condition favorable to the maintenance of morals. The second aim of this paper is to shed some new light on an aspect of Hume's thought that, so far, has been relatively neglected, namely, his distinction between "innocent" and "vicious" forms of luxury, as well as his acknowledgement of the possibility of the emergence of the latter, as well as the former, in the modern commercial world. However, this does not necessarily lead us to a more pessimistic interpretation of Hume's view of luxury than those accepted thus far; only to the awareness of how difficult and delicate, in Hume's view, is the maintenance of the balance between the interlinked concepts of industry, knowledge, and humanity. (shrink)

The informational humidity model (IHM) classifies a message into two modes, and describes communication and community in a novel aspect. At first, a flame message, dry information vs. wet information, is introduced. Dry information is the message content itself, whereas wet information is the attributes of the message sender. Second, the characteristics of communities are defined by two factors: the message sender’s personal specifications, and personal identification. These factors affect the humidity of the community, which corresponds to two phases of (...) knowledge creation. In a rather wet community, members easily specify other members. This is effective for managing memberships and changing knowledge from tacit to formal. In a rather dry community, members barely identify with other members at all. This method is suitable for the formal-to-tacit phase of knowledge creation. Finally, it is discussed how social intelligence should be designed and what features are needed to support knowledge-creating communities. (shrink)

It is generally assumed that in early modern Britain, chivalry—allegedly typified by the Crusades—was considered a negative or even ridiculous ideology until its rehabilitation by the pre-Romantic movement. However, this paper argues that Hume and other Scottish Enlightenment thinkers had already shown a deep interest in its historical role and influence on modern civilization. That Hume shared a broad interest in chivalry with contemporary philosophers does not undermine the novelty of his thought on this topic. In fact, the pioneering and (...) unique aspects of his contributions can be clarified by setting them in context. (shrink)

In this study, we examine the determinants of corporate environmental responsibility, as well as the relationship between legal systems and CER as measured by a unique set of global environmental cost data. Results of our analyses show that firms’ legal origins affect CER, which requires a long-term management perspective. Specifically, our results indicate that civil law firms exhibit significantly higher levels of CER than common law firms. In addition, results of an auxiliary test suggest that manager shareholding has a significant, (...) nonlinear relationship with CER. The association between a firm’s legal origin and its CER performance remains robust after controlling for the effects of managerial ownership and issues related to endogeneity. Our findings imply that although the majority of corporate law studies in the past few decades provide support for the common law system emphasizing the maximization of shareholder value and investor protection, the civil law system stressing the maximization of stakeholder wealth and the importance of CER may become more influential in the coming decades as CER becomes central to firms’ operations. (shrink)

Car driving is supported by perceptual, cognitive, and motor skills trained through continuous daily practice. One of the skills that characterize experienced drivers is to detect changes in the driving environment and then flexibly switch their driving modes in response to the changes. Previous functional neuroimaging studies on motor control investigated the mechanisms underlying behaviors adaptive to changes in control properties or parameters of experimental devices such as a computer mouse or a joystick. The switching of multiple internal models mainly (...) engages adaptive behaviors and underlies the interplay between the cerebellum and frontoparietal network regions as the neural process. However, it remains unclear whether the neural mechanisms identified in previous motor control studies also underlie practical driving behaviors. In the current study, we measure functional magnetic resonance imaging activities while participants control a realistic driving simulator inside the MRI scanner. Here, the accelerator sensitivity of a virtual car is abruptly changed, requiring participants to respond to this change flexibly to maintain stable driving. We first compare brain activities before and after the sensitivity change. As a result, sensorimotor areas, including the left cerebellum, increase their activities after the sensitivity change. Moreover, after the change, activity significantly increases in the inferior parietal lobe and dorsolateral prefrontal cortex, parts of the FPN regions. By contrast, the posterior cingulate cortex, a part of the default mode network, deactivates after the sensitivity change. Our results suggest that the neural bases found in previous experimental studies can serve as the foundation of adaptive driving behaviors. At the same time, this study also highlights the unique contribution of non-motor regions to addressing the high cognitive demands of driving. (shrink)