TGFβ signaling plays a central role in regulating a broad range of cellular responses in a variety of organisms. TGFβ signaling from the cell membrane to the nucleus is mediated by the Smad family of proteins. During the past five years of intense investigation, key events in TGFβ signaling have been documented at the molecular and cellular level. Recent structural studies have improved our understanding of how specificity is generated in the TGFβ signaling pathways. Despite this progress, significant questions remain (...) regarding the precise mechanisms of signaling and point to the urgent need for well-controlled biochemical studies. Rather than giving a comprehensive review on Smad-mediated TGFβ signaling, this review focuses on functional insights provided by recent structural studies and discusses several existing controversies. BioEssays 23:223–232, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Critical Discourse Analysis has excelled with its functional and ideological analysis of socio-political texts. Its capacities and achievements notwithstanding, this tradition is constituted of Western concepts, values, ways of thinking, analytic tools and topics of interest; such becomes problematic when universalised and globalised in international academic discourse. It is against this backdrop of cultural and intellectual tension that a culturally conscious and critical paradigm of discourse and communication research is emerging: Cultural Discourse Studies. It is manifested in the forms of (...) participation by searchers from the Developing World in significant proportions, development of locally grounded, globally minded research frameworks; and a growing multicultural awareness in the discipline. Inspired by Third World experiences, aspirations and scholarships on the one side and drawing on culturally critical insights in the human and social sciences on the other side, this multicultural scholarship endeavours to deconstruct ethnocentrism, construct culturally diversified modes of research and propel intercultural dialogue and debate in the discipline, all with a view to enhancing human cultural coexistence, harmony and prosperity. One exemplar of this new trend is Chinese Discourse Studies, characterised by a holistic philosophy, equilibrium and discrepancy theory, all-encompassing methodology and development-minded research agenda. (shrink)

胡適（1891-1962），安徽績溪人。原名嗣穈，後改名胡適，字適之，曾用筆名希彊、臧暉等。新文化運動的奠基人與領袖之一，倡導約翰・杜威的實用主義。1917年回國任教北大，參與編輯《新青年》《努力周報 》《獨立評論》等雜誌，先後擔任中華民國駐美大使、國立北京大學校長、台北「中央研究院」院長等職，著有《中國哲學史大綱》《嘗試集》《胡適文存》等書，並獲諾貝爾文學獎提名。.

內容簡介 二十世紀的「現象學運動」影響了存在哲學（存在主義）、哲學詮釋學、解構主義、現代美學、藝術哲學等等，以及所謂「後現代的文化思潮」之發展。 二十一世紀的今日，我們對「中華古典哲學」的反思，似乎可以從歐洲的現象學運動之思潮中，找到一些足以對話和互為理解的可能。 本書就試著嘗試這種互為理解與東西文化交涉的努力，希望提供給對這個話題有興趣的讀者們，開顯出一扇觀照內外在的哲學之門，而通過這扇門能夠走向人生的智慧之旅。.

本卷收入胡适哲学与文化方面的论文、函牍、讲演、札记80余篇。其中包括实验主义、我们对于西洋近代文明的态度等重要文章。所收文章全面反映了胡适哲学思想、学术主张和对于中西文化的态度,对于了解和研究胡适本人 以及现代中国学术史、现代中国启蒙运动等内容。.

人人都有一雙藝術家的眼睛。 「不論你曾崇仰何人何物，並以誰為師，最後你必須回到你自己本身。 藝術從未遠人，只是人遠離了他真正的自己。 在都市中，我們先失去了我們的眼睛，然後我們失去了一切。」－史作檉 本書為史作檉談論藝術美學文章集結，強調人人都有藝術家的眼睛，只在於人們失去了觀看的方式與純粹的初衷。 共分四大篇九章節，從藝術本質談起，援引賈克梅第、康丁斯基、蒙德里安、李德等藝術家創作，從繪畫、雕塑、音樂，旁述及顏氏篆書中的圖形特性，進臻至哲學美學、形上美學，淺明清晰，在一本書的閱讀時間裡就可在繁多 的藝術理論中找到自己的「眼睛」與觀看角度。.

本书分为神话与诉讼,历史与诉讼,故事与诉讼,制度法理,学术争鸣,法学教育,治学人生等八辑,收录了剧与诉的随想,正义之舞,游戏与诉讼,圣殿骑士的死亡密码,走向刑事宪法,法官权力之源与品格之治,法国法学教 育三题,关问于山水之间等文章.

Research Ethics, Volume 18, Issue 1, Page 39-50, January 2022. Internet users’ comments in online spaces have attracted researchers’ attention in recent years. Although this data is typically publicly available, its use requires careful consideration so as to not cause harm to the users, while complying with the terms and conditions of the online spaces. However, the Ts & Cs and researchers’ ethical considerations may sometimes be in conflict. I faced such a conflict when I conducted discourse analysis of online (...) discussions that were sourced from a public online learning platform owned by a private company. In this article, I reflect on how I navigated the Ts & Cs and copyright law, taking users’ likely expectations into consideration when deciding whether to seek informed consent and anonymize content. I employed an ‘attribution with anonymization’ method to acknowledge users for their comments while safeguarding their confidentiality. Given the variety of online spaces and research methods, ethical decision-making must be a contextualized process that requires researchers to consider the nature of the online platform and the potential experience of the users, rather than simply following guidelines or Ts & Cs. (shrink)

本书内容包括20世纪90年代以后的生态社会主义概述, 20世纪90年代以后的生态社会主义的新变化与动因, 20世纪90年代以后的生态社会主义的主要新观点——反思与批判, 生态社会主义的实践和启示等.

The Vessantara J?taka is not only the most popular of all the Buddhist J?taka tales, but is important in the tradition as a whole, generally considered by the Therav?din tradition to display the epitome of the Bodhisatta’s perfection of giving. While most studies have focused on philological approaches, numerous questions as to the text’s structure and how to interpret individual parts within that structure have remained unresolved. My study shall employ the theory of ‘chiasmus’ to shed new light on both (...) the key message of the story and also the sub-themes within it. In terms of textual criticism, I shall first elucidate the chiastic structure of the text and discuss how this structure can provide insights on text-critical readings. In terms of interpretation, I shall then see how the structure clearly demarcates the text’s scope through its prologue and conclusion with surrounding framework, its paired parallel sub-themes, and its central climax point, all in the light of its chiastic structure. Finally, considering broader implications, on comparison with other recently discovered Buddhist textual chiasmi I shall present a tentative hypothesis as to the origins of such structures in the ‘bodhisatta’ literary genre. (shrink)

al-Masāʼil al-qudsīyah -- Mutashābihāt al-Qurʼān -- Ajwibat al-masāʼil.

Facsimile of miscellaneous Persian and Arabic texts in Mullā Ṣadrā's handwriting.