The blood oxygen level dependent effect that provides the contrast in functional magnetic resonance imaging has been demonstrated to affect the linewidth of spectral peaks as measured with magnetic resonance spectroscopy and through this, may be used as an indirect measure of cerebral blood flow related to neural activity. By acquiring MR-spectra interleaved with frames without water suppression, it may be possible to image the BOLD effect and associated metabolic changes simultaneously through changes in the linewidth of the unsuppressed water (...) peak. The purpose of this study was to implement this approach with the MEGA-PRESS sequence, widely considered to be the standard sequence for quantitative measurement of GABA at field strengths of 3 T and lower, to observe how changes in both glutamate and GABA levels may relate to changes due to the BOLD effect. MR-spectra and fMRI were acquired from the occipital cortex of 20 healthy participants whilst undergoing intrascanner visual stimulation in the form of a red and black radial checkerboard, alternating at 8 Hz, in 90 s blocks comprising 30 s of visual stimulation followed by 60 s of rest. Results show very strong agreement between the changes in the linewidth of the unsuppressed water signal and the canonical haemodynamic response function as well as a strong, negative, but not statistically significant, correlation with the Glx signal as measured from the OFF spectra in MEGA-PRESS pairs. Findings from this experiment suggest that the unsuppressed water signal provides a reliable measure of the BOLD effect and that correlations with associated changes in GABA and Glx levels may also be measured. However, discrepancies between metabolite levels as measured from the difference and OFF spectra raise questions regarding the reliability of the respective methods. (shrink)

The Principle of Sufficient Reason says that all contingent facts must have explanation. In this 2006 volume, which was the first on the topic in the English language in nearly half a century, Alexander Pruss examines the substantive philosophical issues raised by the Principle Reason. Discussing various forms of the PSR and selected historical episodes, from Parmenides, Leibnez, and Hume, Pruss defends the claim that every true contingent proposition must have an explanation against major objections, including Hume's imaginability argument (...) and Peter van Inwagen's argument that the PSR entails modal fatalism. Pruss also provides a number of positive arguments for the PSR, based on considerations as different as the metaphysics of existence, counterfactuals and modality, negative explanations, and the everyday applicability of the PSR. Moreover, Pruss shows how the PSR would advance the discussion in a number of disparate fields, including meta-ethics and the philosophy of mathematics. (shrink)

Necessary Existence breaks ground on one of the deepest questions anyone ever asks: why is there anything? Pruss and Rasmussen present an original defence of the hypothesis that there is a necessarily existing being capable of providing an ultimate foundation for the existence of all things.

Alexander R. Pruss examines a large family of paradoxes to do with infinity - ranging from deterministic supertasks to infinite lotteries and decision theory. Having identified their common structure, Pruss considers at length how these paradoxes can be resolved by embracing causal finitism.

Introduction : the computer as a mode of mediation -- The unworkable interface -- Software and ideology -- Are some things unrepresentable? -- Disingenuous informatics -- Postscript : we are the gold farmers.

Assuming S5, the main controversial premise in modal ontological arguments is the possibility premise, such as that possibly a maximally great being exists. I shall offer a new way of arguing that the possibility premise is probably true.

This chapter contains sections titled: Introduction The PSR Nonlocal CPs Toward a First Cause The Gap Problem Conclusions and Further Research References.

Regularity is the thesis that all contingent propositions should be assigned probabilities strictly between zero and one. I will prove on cardinality grounds that if the domain is large enough, a regular probability assignment is impossible, even if we expand the range of values that probabilities can take, including, for instance, hyperreal values, and significantly weaken the axioms of probability.

Digital and analog: What do these terms mean today? The use and meaning of such terms change through time. The analog, in particular, seems to go through various phases of popularity and disuse, its appeal pegged most frequently to nostalgic longings for nontechnical or romantic modes of art and culture. The definition of the digital vacillates as well, its precise definition often eclipsed by a kind of fever-pitched industrial bonanza around the latest technologies and the latest commercial ventures. One common (...) response to the question of the digital is to make reference to things like Twitter, Playstation, or computers in general. Here one might be correct, but only coincidentally, for the basic order of digitality (the digitality of digitality) has not yet been demonstrated through mere denotation. And the second question—the question of the analog—is harder still, with responses often also consisting of mere denotations of things: sound waves, the phonograph needle, magnetic tape, a sundial. At least denotation itself is analogical. This article will aim to define the analog explicitly and argue, perhaps counterintuitively, that the golden age of analog thinking was not a few decades past, prior to the wide-spread adoption of the computer. In fact, the fields of structuralism and poststructuralism that emerged in the middle to late twentieth century, concurrent with the deployment of the digital computer, were characteristically digital, what with their focus on the symbolic order and logical economies. If anything, the golden age of analog is happening today, all around us, as evidenced by the proliferation of characteristically analog concerns: sensation, materiality, experience, affect, ethics, and aesthetics. (shrink)

This important philosophical reflection on love and sexuality from a broadly Christian perspective is aimed at philosophers, theologians, and educated Christian readers. Alexander R. Pruss focuses on foundational questions on the nature of romantic love and on controversial questions in sexual ethics on the basis of the fundamental idea that romantic love pursues union of two persons as one body. _One Body_ begins with an account, inspired by St. Thomas Aquinas, of the general nature of love as constituted by (...) components of goodwill, appreciation, and unitiveness. Different forms of love, such as parental, collegial, filial, friendly, fraternal, or romantic, Pruss argues, differ primarily not in terms of goodwill or appreciation but in terms of the kind of union that is sought. Pruss examines romantic love as distinguished from other kinds of love by a focus on a particular kind of union, a deep union as one body achieved through the joint biological striving of the sort involved in reproduction. Taking the account of the union that romantic love seeks as a foundation, the book considers the nature of marriage and applies its account to controversial ethical questions, such as the connection between love, sex, and commitment and the moral issues involving contraception, same-sex activity, and reproductive technology. With philosophical rigor and sophistication, Pruss provides carefully argued answers to controversial questions in Christian sexual ethics. "This is a terrific—really quite extraordinary—work of scholarship. It is quite simply the best work on Christian sexual ethics that I have seen. It will become the text that anyone who ventures into the field will have to grapple with—a kind of touchstone. Moreover, it is filled with arguments with which even secular writers on sexual morality will have to engage and come to terms." —_Robert P. George, Princeton University __ "_One Body_ is an excellent piece of philosophical-theological reflection on the nature of sexuality and marriage. This book has the potential to become a standard go-to text for professors and students working on sex ethics issues, whether in philosophy or theology, both for the richness of its arguments, and the scope of its coverage of cases. " — Christopher Tollefsen, University of South Carolina_ "Alexander Pruss here develops sound and humane answers to the whole range of main questions about human sexual and reproductive choices. His principal argument for the key answers is very different from the one I have articulated over the past fifteen years. But his argumentation is at every point attractively direct, careful, energetic in framing and responding to objections, and admirably attentive to realities and the human goods at stake." —_John Finnis, University of Oxford _. (shrink)

We show that infinitesimal probabilities are much too small for modeling the individual outcome of a countably infinite fair lottery.

(2013). Incompatibilism proved. Canadian Journal of Philosophy. ???aop.label???

_Laruelle_ is one of the first books in English to undertake in an extended critical survey of the work of the idiosyncratic French thinker François Laruelle, the promulgator of non-standard philosophy. Laruelle, who was born in 1937, has recently gained widespread recognition, and Alexander R. Galloway suggests that readers may benefit from colliding Laruelle’s concept of the One with its binary counterpart, the Zero, to explore more fully the relationship between philosophy and the digital. In _Laruelle_, Galloway argues that (...) the digital is a philosophical concept and not simply a technical one, employing a detailed analysis of Laruelle to build this case while referencing other thinkers in the French and Continental traditions, including Alain Badiou, Gilles Deleuze, Martin Heidegger, and Immanuel Kant. In order to explain clearly Laruelle’s concepts such as the philosophical decision and the principle of sufficient philosophy, Galloway lays a broad foundation with his discussions of “the One” as it has developed in continental philosophy, the standard model of philosophy, and how philosophers view “the digital.” Digital machines dominate today’s world, while so-called digital thinking—that is, binary thinking such as presence and absence or self and world—is often synonymous with what it means to think at all. In examining Laruelle and digitality together, Galloway shows how Laruelle remains a profoundly non-digital thinker—perhaps the only non-digital thinker today—and engages in an extensive discussion on the interconnections between media, philosophy, and technology. (shrink)

One of the problems that Bayesian regularity, the thesis that all contingent propositions should be given probabilities strictly between zero and one, faces is the possibility of random processes that randomly and uniformly choose a number between zero and one. According to classical probability theory, the probability that such a process picks a particular number in the range is zero, but of course any number in the range can indeed be picked. There is a solution to this particular problem on (...) the books: a measure that assigns the same infinitesimal probability to each number between zero and one. I will show that such a measure, while mathematically interesting, is pathological for use in confirmation theory, for the same reason that a measure that assigns an infinitesimal probability to each possible outcome in a countably infinite lottery is pathological. The pathology is that one can force someone to assign a probability within an infinitesimal of one to an unlikely event. (shrink)

Few studies have examined how trait emotion dysregulation relates to momentary affective experiences and the emotion regulation strategies people use in daily life. In the current study, 112 c...

Cantor proved that no set has a bijection between itself and its power set. This is widely taken to have shown that there infinitely many sizes of infinite sets. The argument depends on the princip...

Classical real-valued probabilities come at a philosophical cost: in many infinite situations, they assign the same probability value—namely, zero—to cases that are impossible as well as to cases that are possible. There are three non-classical approaches to probability that can avoid this drawback: full conditional probabilities, qualitative probabilities and hyperreal probabilities. These approaches have been criticized for failing to preserve intuitive symmetries that can be preserved by the classical probability framework, but there has not been a systematic study of the (...) conditions under which these symmetries can and cannot be preserved. This paper fills that gap by giving complete characterizations under which symmetries understood in a certain “strong” way can be preserved by these non-classical probabilities, as well as by offering some results to make it plausible that the strong notion of symmetry here is the right one. Philosophical implications are briefly discussed, but the main purpose of the paper is to offer technical results to help make further philosophical discussion more sophisticated. (shrink)

According to the Russo-Williamson Thesis, causal claims in the health sciences need to be supported by both difference-making and mechanistic evidence. In this article, we attempt to determine whether Evidence-based Medicine can be improved through the consideration of mechanistic evidence. We discuss the practical composition and function of each RWT evidence type and propose that exposure-outcome evidence provides associations that can be explained through a hypothesis of causation, while mechanistic evidence provides finer-grained associations and knowledge of entities that ultimately explains (...) a causal hypothesis. We suggest that mechanistic evidence holds untapped potential to add value to the assessment of evidence quality in EBM and propose initial recommendations for the integration of mechanistic and exposure-outcome evidence to improve EBM by robustly leveraging available evidence in support of good medical decisions. (shrink)

The free-will defence holds that the value of significant free will is so great that God is justified in creating significantly free creatures even if there is a risk or certainty that these creatures will sin. A difficulty for the FWD, developed carefully by Quentin Smith, is that God is unable to do evil, and yet surely lacks no genuinely valuable kind of freedom. Smith argues that the kind of freedom that God has can be had by creatures, without a (...) risk of creatures doing evil. I shall show that Smith's argument fails – the case of God is disanalogous to the case of creatures precisely because creatures are creatures. (shrink)

I offer examples showing that, pace G. E. Moore, it is possible to assert ?Q and I don't believe that Q? sincerely, truly, and without any absurdity. The examples also refute the following principles: (a) justification to assert p entails justification to assert that one believes p (Gareth Evans); (b) the sincerity condition on assertion is that one believes what one says (John Searle); and (c) to assert (to someone) something that one believes to be false is to lie (Don (...) Fallis). (shrink)

Always connect—that is the imperative of today’s media. But what about those moments when media cease to function properly, when messages go beyond the sender and receiver to become excluded from the world of communication itself—those messages that state: “There will be no more messages”? In this book, Alexander R. Galloway, Eugene Thacker, and McKenzie Wark turn our usual understanding of media and mediation on its head by arguing that these moments reveal the ways the impossibility of communication is (...) integral to communication itself—instances they call excommunication. In three linked essays, _Excommunication_ pursues this elusive topic by looking at mediation in the face of banishment, exclusion, and heresy, and by contemplating the possibilities of communication with the great beyond. First, Galloway proposes an original theory of mediation based on classical literature and philosophy, using Hermes, Iris, and the Furies to map out three of the most prevalent modes of mediation today—mediation as exchange, as illumination, and as network. Then, Thacker goes boldly beyond Galloway’s classification scheme by examining the concept of excommunication through the secret link between the modern horror genre and medieval mysticism. Charting a trajectory of examples from H. P. Lovecraft to Meister Eckhart, Thacker explores those instances when one communicates or connects with the inaccessible, dubbing such modes of mediation “haunted” or “weird” to underscore their inaccessibility. Finally, Wark evokes the poetics of the infuriated swarm as a queer politics of heresy that deviates from both media theory and the traditional left. He posits a critical theory that celebrates heresy and that is distinct from those that now venerate Saint Paul. Reexamining commonplace definitions of media, mediation, and communication, _Excommunication_ offers a glimpse into the realm of the nonhuman to find a theory of mediation adequate to our present condition. (shrink)

Some, notably Peter van Inwagen, in order to avoid problems with free will and omniscience, replace the condition that an omniscient being knows all true propositions with a version of the apparently weaker condition that an omniscient being knows all knowable true propositions. I shall show that the apparently weaker condition, when conjoined with uncontroversial claims and the logical closure of an omniscient being's knowledge, still yields the claim that an omniscient being knows all true propositions.

This chapter contains sections titled: Introduction Two Interrelated Problems Lewis's Solution Inductive Paradox Identity versus Counterpart Theory Platonism: The Main Realist Alternative to Lewis An Aristotelian Alternative Leibniz's Account A Combined Account.

Plantinga’s Free Will Defense is an argument that, possibly, God cannot actualize a world containing significant creaturely free will and no wrongdoings. I will argue that if standard Molinism is true, there is a pair of worlds w1 and w2 each of which contains a significantly free creature who never chooses wrongly, and that are such that, necessarily, at least one of these worlds is a world that God can actualize.

It is often loosely said that Ramsey The foundations of mathematics and other logical essays, Routledge and Kegan Paul, Abingdon, pp 156–198, 1931) and de Finetti Studies in subjective probability, Kreiger Publishing, Huntington, 1937) proved that if your credences are inconsistent, then you will be willing to accept a Dutch Book, a wager portfolio that is sure to result in a loss. Of course, their theorems are true, but the claim about acceptance of Dutch Books assumes a particular method of (...) calculating expected utilities given the inconsistent credences. I will argue that there are better ways of calculating expected utilities given a potentially inconsistent credence assignment, and that for a large class of credences—a class that includes many inconsistent examples—these ways are immune to Dutch Books and single-shot domination failures. The crucial move is to replace Finite Additivity with Monotonicity, then \\le P\)) and then calculate expected utilities for positive U via the formula \\, dy\). This shows that Dutch Book arguments for probabilism, the thesis that one’s credences should be consistent, do not establish their conclusion. Finally, I will consider a modified argument based on multi-step domination failure that does better, but nonetheless is not as compelling as the Dutch Book arguments appeared to be. (shrink)

A number of philosophers have attempted to solve the problem of null-probability possible events in Bayesian epistemology by proposing that there are infinitesimal probabilities. Hájek and Easwaran have argued that because there is no way to specify a particular hyperreal extension of the real numbers, solutions to the regularity problem involving infinitesimals, or at least hyperreal infinitesimals, involve an unsatisfactory ineffability or arbitrariness. The arguments depend on the alleged impossibility of picking out a particular hyperreal extension of the real numbers (...) and/or of a particular value within such an extension due to the use of the Axiom of Choice. However, it is false that the Axiom of Choice precludes a specification of a hyperreal extension—such an extension can indeed be specified. Moreover, for all we know, it is possible to explicitly specify particular infinitesimals within such an extension. Nonetheless, I prove that because any regular probability measure that has infinitesimal values can be replaced by one that has all the same intuitive features but other infinitesimal values, the heart of the arbitrariness objection remains. (shrink)

Assuming S₅, the main controversial premise in modal ontological arguments is the possibility premise, such as that possibly a maximally great being exists. I shall offer a new way of arguing that the possibility premise is probably true.

We shall use Gödel’s Second Incompleteness Theorem to show that consistency is not possibility, and then argue that the argument does serious damage to some theories of modality where consistency plays a major but not exclusive role.

This article focuses on the question of whether the doctrine of the real presence of Christ's body and blood, and likewise the doctrine of the real absence of bread and wine, can be defended philosophically. It argues for an affirmative answer, and does so by considering a variety of metaphysical models, including that of Aquinas. It will appear, thus, that transubstantiation is a philosophical possibility. If it is possible for two substances to be in the same place at the same (...) time, consubstantiation will be a philosophical possibility as well. Of course, the question of actuality is a theological one. (shrink)

Scoring rules measure the deviation between a credence assignment and reality. Probabilism holds that only those credence assignments that satisfy the axioms of probability are rationally admissible. Accuracy-based arguments for probabilism observe that given certain conditions on a scoring rule, the score of any non-probability is dominated by the score of a probability. The conditions in the arguments we will consider include propriety: the claim that the expected accuracy of _p_ is not beaten by the expected accuracy of any other (...) credence _c_ by the lights of _p_ if _p_ is a probability. I argue that if we think through how a non-probabilist can respond to pragmatic arguments for probabilism, we will expect the non-probabilist to accept a condition _stronger_ than propriety for the same reasons that the probabilist gives for propriety, but this stronger condition is incompatible with the other conditions that the probabilist needs to run the accuracy argument. This makes it unlikely for the probabilist’s argument to be compelling. (shrink)

Clinical trials aim to minimise participant risk and generate new clinical knowledge for the wider population. Many military agencies are now investing efforts in pushing towards developing new treatments involving Brain-Computer Interfaces, Gene Therapy and Stem Cells interventions. These trials are targeting smaller disease groups, as such they give rise to novel participant risks of harms that are largely not accommodated by existing practice. This is of most concern with irreversible harms at early trial stages, where participants may forfeit any (...) future therapy, and in personalised medicine, where the individual participant assumes all of the trial risk. Given these new experimental interventions involve high risk of irreversible harms, how much risk should patients be exposed to when participating in experimental testing of innovative technologies? Designing clinical trials which better balance risk/benefit ratios for participants is crucial. The aim of this book chapter is to suggest a new stratified risk framework aimed at minimising the risk-benefit ratio to participants in clinical trials associated with high risk of irrevocable harms. We will argue it demands a higher-level of clinical data capture at earlier trial stages than predicated by current trial doctrine; it also requires publication of all trial data to minimise risk to participants of any future trial. (shrink)

Scoring rules measure the deviation between a forecast, which assigns degrees of confidence to various events, and reality. Strictly proper scoring rules have the property that for any forecast, the mathematical expectation of the score of a forecast p by the lights of p is strictly better than the mathematical expectation of any other forecast q by the lights of p. Forecasts need not satisfy the axioms of the probability calculus, but Predd et al. [9] have shown that given a (...) finite sample space and any strictly proper additive and continuous scoring rule, the score for any forecast that does not satisfy the axioms of probability is strictly dominated by the score for some probabilistically consistent forecast. Recently, this result has been extended to non-additive continuous scoring rules. In this paper, a condition weaker than continuity is given that suffices for the result, and the condition is proved to be optimal. (shrink)

According to David Lewis's extreme modal realism, every waythat a world could be is a way that some concretely existingphysical world really is. But if the worlds are physicalentities, then there should be a set of all worlds, whereasI show that in fact the collection of all possible worlds is nota set. The latter conclusion remains true even outside of theLewisian framework.

The classical principle of double effect offers permissibility conditions for actions foreseen to lead to evil outcomes. I shall argue that certain kinds of closeness cases, as well as general heuristic considerations about the order of explanation, lead us to replace the intensional concept of intention with the extensional concept of accomplishment in double effect.

Popper functions allow one to take conditional probabilities as primitive instead of deriving them from unconditional probabilities via the ratio formula P=P/P. A major advantage of this approach is it allows one to condition on events of zero probability. I will show that under plausible symmetry conditions, Popper functions often fail to do what they were supposed to do. For instance, suppose we want to define the Popper function for an isometrically invariant case in two dimensions and hence require the (...) Popper function to be rotationally invariant and defined on pairs of sets from some algebra that contains at least all countable subsets. Then it turns out that the Popper function trivializes for all finite sets: P=1 for all A ) if B is finite. Likewise, Popper functions invariant under all sequence reflections can’t be defined in a way that models a bidirectionally infinite sequence of independent coin tosses. (shrink)

Scoring rules measure the accuracy or epistemic utility of a credence assignment. A significant literature uses plausible conditions on scoring rules on finite sample spaces to argue for both probabilism—the doctrine that credences ought to satisfy the axioms of probabilism—and for the optimality of Bayesian update as a response to evidence. I prove a number of formal results regarding scoring rules on infinite sample spaces that impact the extension of these arguments to infinite sample spaces. A common condition in the (...) arguments for probabilism and Bayesian update is strict propriety: that according to each probabilistic credence, the expected accuracy of any other credence is worse. Much of the discussion needs to divide depending on whether we require finite or countable additivity of our probabilities. I show that in a number of natural infinite finitely additive cases, there simply do not exist strictly proper scoring rules, and the prospects for arguments for probabilism and Bayesian update are limited. In many natural infinite countably additive cases, on the other hand, there do exist strictly proper scoring rules that are continuous on the probabilities, and which support arguments for Bayesian update, but which do not support arguments for probabilism. There may be more hope for accuracy-based arguments if we drop the assumption that scores are extended-real-valued. I sketch a framework for scoring rules whose values are nets of extended reals, and show the existence of a strictly proper net-valued scoring rules in all infinite cases, both for f.a. and c.a. probabilities. These can be used in an argument for Bayesian update, but it is not at present known what is to be said about probabilism in this case. (shrink)

Gödel's ontological argument is a formal argument for a being defined in terms of the concept of a positive property. I shall defend several versions of Gödel's argument, using weaker premises than Anderson's (1990) version, and avoiding Oppy's (1996 and 2000) parody refutations.

I defend a simple argument for why considerations of epistemic probability should lead us away from Open Future views according to which claims about the future are never true.

Consider the regularity thesis that each possible event has non-zero probability. Hájek challenges this in two ways: there can be nonmeasurable events that have no probability at all and on a large enough sample space, some probabilities will have to be zero. But arguments for the existence of nonmeasurable events depend on the axiom of choice. We shall show that the existence of anything like regular probabilities is by itself enough to imply a weak version of AC sufficient to prove (...) the Banach–Tarski Paradox on the decomposition of a ball into two equally sized balls, and hence to show the existence of nonmeasurable events. This provides a powerful argument against unrestricted orthodox Bayesianism that works even without AC. A corollary of our formal result is that if every partial order extends to a total preorder while maintaining strict comparisons, then the Banach–Tarski Paradox holds. This yields an argument that incommensurability cannot be avoided in ambitious versions of decision theory. (shrink)

Consider the reasonable axioms of subjunctive conditionals if p → q1 and p → q2 at some world, then p → at that world, and if p1 → q and p2 → q at some world, then → q at that world, where p → q is the subjunctive conditional. I show that a Lewis-style semantics for subjunctive conditionals satisfies these axioms if and only if one makes a certain technical assumption about the closeness relation, an assumption that is probably (...) false. I will then show how Lewisian semantics can be modified so as to assure and even when the technical assumption fails, and in fact in one sense the semantics actually becomes simpler then. (shrink)

This paper argues that if creatures are to have significant free will, then God's essential omni-benevolence and essential omnipotence cannot logically preclude Him from creating a world containing a moral evil. The paper maintains that this traditional conclusion does not need to rest on reliance on subjunctive conditionals of free will. It can be grounded in several independent ways based on premises that many will accept.

Sceptical theism claims that we have vast ignorance about the realm of value and the connections, causal and modal, between goods and bads. This ignorance makes it reasonable for a theist to say that God has reasons beyond our ken for allowing the horrendous evils we observe. But if so, then does this not lead to moral paralysis when we need to prevent evils ourselves? For, for aught that we know, there are reasons beyond our ken for us to allow (...) the evils, and so we should not prevent them. This paralysis argument, however, shall be argued to rest on a confusion between probabilities and expected utilities. A connection between this paralysis argument and Lenman's1 discussion of the butterfly effect and chaos will be drawn, and the solution offered will apply in both cases. (shrink)