Over the course of the last 1400 years, Islam has grown from a small band of followers on the Arabian peninsula into a global religion of over a billion believers. How did this happen? The usual answer is that Islam spread by the sword-that believers waged jihad against rival tribes and kingdoms and forced them to convert. Lamin Sanneh argues that this is far from the case.

This article aims to characterise the visions of ecologisation found within scientific approaches embraced by different epistemic communities, and which have inspired empirical work and public action on agrifood system transitions. Based on comparative readings of works anchored in our two disciplinary fields (ecology and sociology), we identified six large ensembles of epistemic communities as well as their points of convergence and divergence. We identify six ideotypical visions of ecologisation based on the types of 'relationships to nature' embedded in these (...) large sets of epistemic communities: protectionism, functionalism, structuralism, post-structuralism, relational and pragmatist-experience-based. We suggest that pragmatist-experience-based approaches allow us to transcend two classical oppositions: between realism and constructivism, and between a conception of nature as passive and external as opposed to active and relational. Without claiming to offer a detailed analysis of these approaches, we hope that our work can be used as a tool to support reflection among scientists and other actors involved in agrifood system transitions. (shrink)

Cet article discute la pertinence de plusieurs textes de Dewey, Le public et ses problèmes (1927), Ethics (1932), « Théorie de la valuation » (1939), L’art comme expérience (1934) et Une foi commune (1934), pour l’analyse sociologique du religieux dans un contexte de pluralité et d’inquiétude sur les identités. Ce pragmatisme permet d’aborder le religieux en acte, l’expérience et la construction de soi, en ne négligeant pas les affects. Il fournit un concept d’idéal, faisant part à l’intersubjectivité et au contexte, (...) permettant traiter du dépassement de soi. Enfin, Il éclaire la notion de commun, y compris construit à partir d’identités particulières, et nous fait préférer le concept pratique participation sociale à celui d’intégration. (shrink)

L'argumentation de la philosophie des valeurs repose, fondamentalement, sur la phénoménologie, dans son site de complexités et de vérités essentielles. Ce qui endure la conscience dans la réflexion de l'esprit à la création et à l'existence. Ainsi donc, la contraste Ciel/Terre est une unification de l'esprit à la Création, pour parfaire le Monde dans les Conditions de l'Existence, dans l'entité spirituelle, mais aussi dans l'entité politique.

Contrairement à Descartes, Spinoza refuse à l’esprit humain et par conséquent à l’homme le statut de substance : l’homme est défini comme l’union de deux modes, un corps et une âme. On ne peut donc plus comme chez Descartes distinguer une identité substantielle, conférée au corps par l’âme, et une identité modale, déterminée par le rapport du corps humain aux autres corps. Ces deux identités sont fondues dans une identité essentielle. L’objet de cet article est de mettre en évidence le (...) statut problématique de cette identité dans l’Éthique. L’esprit humain y est en effet déduit et défini comme l’idée du corps humain, c’est-à-dire le concept que Dieu forme du corps humain. Mais tantôt Spinoza identifie cette idée du corps humain à l’essence de l’esprit humain, tantôt il établit une distinction entre les deux. De même, tantôt en vertu du parallélisme des attributs il identifie l’idée du corps humain à l’idée de l’esprit humain, tantôt il distingue les deux. D’où des tensions qui travaillent le système de l’intérieur. (shrink)

We contribute to the study of offshoring and outsourcing by examining how stakeholders' ethical evaluations of these decisions are influenced by both their roles and the issues embedded within the decisions. Although offshoring and outsourcing have been studied from a transactional perspective, the moral issues embedded within these decisions can profoundly affect how the organization is perceived by outside stakeholders. First, we contend that investors use different moral paradigms compared with consumer stakeholders, as a result the stakeholder role an individual (...) occupies significantly influences their ethical evaluation of offshoring and outsourcing decisions. Next, we examine whether embedded issues of product quality and information security increase the moral intensity of offshoring and outsourcing decisions, thereby negatively influencing ethical evaluations. Using vignettes, we find that respondents viewed either offshoring or outsourcing less favorably than relocation. Surprisingly, respondents viewed offshoring with data security risks more negatively than offshore outsourcing with quality risks, suggesting that the issue of information security has a greater moral intensity than the issue of product or service quality for both consumer and investor stakeholders. Thus, we show that that embedded issues play a significant role in stakeholders' ethical judgments of business decisions, such as offshoring and outsourcing. (shrink)

In this paper we present a model of vocational education and training (VET) that can be used to guide decisions relating to VET in Africa today. This model takes the critique of the neoclassical, neoliberal model of VET as its starting point. Guided by Bhaskar's Critical Naturalism, we use immanent critique to consider the adequacy of proposed alternatives to the neoclassical approach, such as: the heterodox approach, which foregrounds explanations based on human capital and political economy; and Hodgson and Spours' (...) social ecosystem model, which addresses some of the limitations of the heterodox account by including, social and ecosystem elements. Finally, we offer a version of the social ecosystem model that, according to our analysis, explains more of the empirical evidence than previous models. Our version of the social ecosystem model differs from earlier versions in terms of its explicit reference to the critical realist ideas of position- practices and emergence. (shrink)

The nuclear envelope has recently become the object of intense scrutiny because it is the site of nuclear transport and is possibly involved in the organization of the interphase genome, thereby affecting gene expression. The major structural support for the nuclear envelope is the nuclear lamina, composed of the nuclear lamin proteins. They lie on the surface of the inner nuclear membrane and are in direct contact with the chromatin at the edge of the nucleus. The structure of the nuclear (...) lamin proteins has recently been deduced from their cDNAs and shown to have remarkable homologies to the family of cytoplasmic intermediate filaments. However, the lamin proteins have been found to depolymerize in response to metaphase‐specific phosphorylation events, and reassemble around daughter chromosomes at the completion of cell division. Little is known of the mechanisms of these dynamics, nor of other post‐translational modifications evident in these proteins. In addition, we have as yet no concrete idea of the function of these highly conserved proteins in the cell. This review will summarize our present knowledge of nuclear lamin structure and the new experimental approaches designed to elucidate their function. (shrink)

The nuclear envelope shapes the functional organization of the nucleus. Increasing evidence indicates that one of its main components, the nuclear lamina, dynamically interacts with the genome, including the promoter region of specific genes. This seems to occur in a manner that accords developmental significance to these interactions. This essay addresses key issues raised by recent data on the association of nuclear lamins with the genome. We discuss how lamins interact with large chromatin domains and with spatially restricted regions on (...) gene promoters. We address the relationship between these interactions, chromatin modifications and gene expression outcomes. Lamin‐genome contacts are redistributed after cell division and during stem cell differentiation, with evidence of lineage specificity. Thus, we also speculate on a developmental role of lamin interactions with specific genes. Finally, we highlight how concepts arising from this recent work lay the foundations of future challenges and investigations. (shrink)

ABSTRACTThe United Nations Sustainable Development Goal 4.7 proposes that Education for Sustainable Development should be included at all levels of education, known as ‘mainstreaming’. Howeve...

Normal development of the nervous system is achieved through an elaborate program of guided neuronal migration and axonal growth. In the last few years, a flood of research has dissected the molecular bases of these phenomena, and several cell‐surface and extracellular matrix molecules, which are implicated in neuronal and axonal targeting processes, have been recognized. Taking this knowledge a step further, a recent paper by Tom Curran's group(1) reports the molecular cloning of the gene deleted in the autosomal recessive mouse (...) mutation reeler, affecting cortical neuronal migration. This gene encodes reelin, a novel extracellular matrix protein. (shrink)

Clinical success with human hematopoietic stem cell (HSC) transplantation establishes a paradigm for regenerative therapies with other types of stem cells. However, it remains generally challenging to therapeutically treat tissues after engineering of stem cells in vitro. Recent studies suggest that stem and progenitor cells sense physical features of their niches. Here, we review biophysical contributions to lineage decisions, maturation, and trafficking of blood and immune cells. Polarized cellular contractility and nuclear rheology are separately shown to be functional markers of (...) a hematopoietic hierarchy that predict the ability of a lineage to traffic in and out of the bone marrow niche. These biophysical determinants are regulated by a set of structural molecules, including cytoplasmic myosin‐II and nuclear lamins, which themselves are modulated by a diverse range of transcriptional and post‐translational mechanisms. Small molecules that target these mechanobiological circuits, along with novel bioengineering methods, could prove broadly useful in programming blood and immune cells for therapies ranging from blood transfusions to immune attack of tumors. (shrink)

Brain evolution is a complex weave of species similarities and differences, bound by diverse rules and principles. This book is a detailed examination of these principles, using data from a wide array of vertebrates but minimizing technical details and terminology. It is written for advanced undergraduates, graduate students, and more senior scientists who already know something about “the brain,” but want a deeper understanding of how diverse brains evolved. The book's central theme is that evolutionary changes in absolute brain size (...) tend to correlate with many other aspects of brain structure and function, including the proportional size of individual brain regions, their complexity, and their neuronal connections. To explain these correlations, the book delves into rules of brain development and asks how changes in brain structure impact function and behavior. Two chapters focus specifically on how mammal brains diverged from other brains and how Homo sapiens evolved a very large and “special” brain. Key Words: basal ganglia; cladistics; development; hippocampus; homology; lamination; mammal; neocortex; neuromere; parcellation; primate. (shrink)

ABSTRACT Critical realist thought has theorised convincingly that epistemic relativism is constellationally embedded in ontological realism which in turn necessitates judgemental rationality. In social science, judgemental rationality involves acting upon plausible decisions about competing points of view. However, the tools for doing this are, as yet, under-articulated. This paper addresses this absence by articulating triangulation and depth-reflexivity as two tools for doing judgemental rationality in empirical research. It draws on the experiences of a diverse team working on an international comparative (...) research project on conversion to Islam in prisons. It demonstrates how epistemic and relational gaps between researchers and research subjects can be bridged by mobilising the ‘laminated’ properties and personal attributes of a diverse research team that factors in attributes that are absent as well as those present. The biographical experiences of the team are analyzed in a variety of intersecting dimensions: faith, ethnicity/ethno-culture, gender, class and professionality. (shrink)

In this article I present an original interpretation of Roy Bhaskar’s project in Dialectic: The Pulse of Freedom. His major move is to separate an ontological dialectic from a critical dialectic, which in Hegel are laminated together. The ontological dialectic, which in Hegel is the self-unfolding of spirit, becomes a realist and relational philosophical anthropology. The critical dialectic, which in Hegel is confined to retracing the steps of spirit, now becomes an active force, dialectical critique, which interposes into the ontological (...) dialectic at the ‘fourth dimension’ of a naturalistically reconfigured account of relational human nature, agency. This account allows Bhaskar to explain and vindicate the crucial role social criticism must play in any realistic project of self-emancipation, and to create a space that didn’t exist in Hegel for an open-ended concrete utopianism. Freedom is thus the actualization of human nature, but is not automatic: the relation of human nature to freedom is mediated historically through dialectical critique, which, informed by concrete utopianism, can have emancipatory power. Content Type Journal Article Category Article Pages 13-44 Authors Craig Reeves, Brunel University Journal Journal of Critical Realism Online ISSN 1572-5138 Print ISSN 1476-7430 Journal Volume Volume 12 Journal Issue Volume 12, Number 1 / 2013. (shrink)

Despite the seemingly neutral vantage of using nature for widely-distributed computational purposes, neither post-biological nor post-humanist teleology simply concludes with the real "end of nature" as entailed in the loss of the specific ontological status embedded in the identifier "natural." As evinced by the ecological crises of the Anthropocene—of which the 2019 Brazil Amazon rainforest fires are only the most recent—our epoch has transfixed the “natural order" and imposed entropic artificial integration, producing living species that become “anoetic,” made to serve (...) as automated exosomatic residues, or digital flecks. I further develop Gilles Deleuze’s description of control societies to upturn Foucauldian biopower, replacing its spacio-temporal bounds with the exographic excesses in psycho-power; culling and further detailing Bernard Stiegler’s framework of transindividuation and hyper-control, I examine how becoming-subject is predictively facilitated within cognitive capitalism and what Alexander Galloway terms “deep digitality.” Despite the loss of material vestiges qua virtualization—which I seek to trace in an historical review of industrialization to postindustrialization—the drive-based and reticulated "internet of things" facilitates a closed loop from within the brain to the outside environment, such that the aperture of thought is mediated and compressed. The human brain, understood through its material constitution, is susceptible to total datafication’s laminated process of “becoming-mnemotechnical,” and, as neuroplasticity is now a valid description for deep-learning and neural nets, we are privy to the rebirth of the once-discounted metaphor of the “cybernetic brain.” Probing algorithmic governmentality while posing noetic dreaming as both technical and pharmacological, I seek to analyze how spirit is blithely confounded with machine-thinking’s gelatinous cognition, as prosthetic organ-adaptation becomes probabilistically molded, networked, and agentially inflected (rather than simply externalized). (shrink)

ABSTRACTTyphoon Haiyan damaged around a million houses in the Philippines in November 2013. It especially affected the poor. Using a realist laminated ontology, this paper explains how multiple cau...

This paper develops a theory of how democratic governance is possible. It analyses democracy as a laminated system consisting of three interdependent levels – the political/institutional, the socia...

Interleukin 1β‐converting enzyme (ICE)‐like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanisms of cell death. Diverse structural and regulatory proteins and enzymes, including protein kinase Cδ, the retinoblastoma protein (a protein involved in cell survival), the DNA repair enzyme DNA‐dependent protein kinase and the nuclear lamins, undergo specific and limited endoproteolytic cleavage by various caspases during apoptosis. Since individual caspases can (...) cleave multiple substrates, the consequences of cleavage of only a single substrate are still poorly understood. Nevertheless, proteolytic activation of protein kinase Cδ may be an important early step in the cell death pathway, and cleavage of the retinoblastoma protein could suppress its cell survival function, whereas proteolytic inactivation of DNA repair enzymes might compromise the ability of the cell to reverse DNA fragmentation. On the other hand, cleavages of nuclear and cytoplasmic structural proteins (e.g. the lamins and Gas2) appear to be required for or contribute to the dramatic rearrangements in cellular architecture that are necessary for the completion of the cell death process. An emerging theme is that parallel and sequential proteolytic activation and inactivation of key protein substrates occurs during the multiple steps of apoptosis. (shrink)

Building on foundational work in activity theory and cultural psychology, this article examines children's play to discern how biomedical practices and understandings of illness are negotiated, modeled, and reproduced among children dealing with a parent's cancer. Using discourse analytic methods, I analyze a videotaped playroom interaction involving three preschool-age girls, all of whom have a parent with cancer, and myself. The article employs notions of `frame' and `footing' to illustrate fantasy and reality as overlapping and embedded frames of experience that (...) organize children's playroom activities in distinctive ways. The shifting alignments and participation structures within the playroom environment illuminate the strategic ways in which children laminate personal experience onto the play frame. Through attention to children's talk and embodied action, I show how children key different interactional frames to expand the realm of epistemological and cognitive resources available to them as they seek cultural understanding. (shrink)

This paper studies the feature extraction and middle-level expression of Convolutional Neural Network convolutional layer glass broken and cracked at the scene of road traffic accident. The image pyramid is constructed and used as the input of the CNN model, and the convolutional layer road traffic accident scene glass breakage and crack characteristics at each scale in the pyramid are extracted separately, and then the depth descriptors at different image scales are extracted. In order to improve the discriminative power of (...) the depth descriptor, Hellinger kernel and Principal Component Analysis are used to perform nonlinear and linear transformations. Two aggregation strategies based on depth descriptors are proposed to form a global image representation. The classification experiment of the data set shows that Hellinger kernel, PCA transformation, and two aggregation strategies are all conducive to improving the classification accuracy. In addition, the convolutional layer road traffic accident scene glass breaking and crack feature coding can obtain better classification performance than the fully connected layer feature. We conducted dynamic impact tests on plate glass and Polyvinyl Butyral- laminated glass under different boundary conditions and studied the crack propagation and failure process of the glass under different impact speeds. The results show that there are radial cracks and circular cracks on the glass specimens under the impact load; the glass specimens show partial damage under high-speed impact and the characteristics of glass breaking and cracks at the scene of road traffic accidents; the four-frame plate glass is supported by sharp dagger-like fragments. This paper compares the energy absorption of glass specimens under different boundary conditions. The results show that the energy absorption effect of the four-point supporting glass specimen is generally stronger than that of the four-frame supporting glass. (shrink)

This article considers the ambiguous translatability of the Christian doctrine of the Holy Trinity. The theme of the Trinity, as a central Christian doctrine, is brought into conversation with the so-called ‘translatability thesis’ regarding Christian history, which has been particularly expounded upon by Lamin Sanneh and Andrew Walls. Does the translatability of the gospel also imply the translatability of the Trinity, or is the equation not that straightforward? In answering this question, specific reference is made to early church formulation and (...) controversy surrounding the theme, as well as attention to specific attempts at translation or interpretation in the modern and contemporary forms of Christianity. The article acknowledges the problematic nature of Trinitarian translatability and concludes that such translatability is nonetheless possible as long as a static conception of Trinitarian doctrine could be avoided. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Five Poems DEBORAH WARREN Bugonia hic vero subitum dictu mirabile monstrum aspiciunt, liquefacta boum per viscera toto stridere apes utero et ruptis effervere costis. —Vergil, Georgics IV The covert’s dark, but Aristaeus sees —beyond it, in the oleandered meadow, walking to her wedding with her maids— Eurydice, as sweet as early windfall apples to the gods of the bitter dead. She runs, from shifting shade to sun to (...) shade until, in a shock of sudden sun, she sways, blinded, blundering into an adder’s kiss, and while the bridegroom waits by the bridal bed, she waits to be undressed by worms instead. But Aristaeus pays for the assault. The mead-gods visit on his apiaries wax-moth, mites, foulbrood and chalk-disease until an oracle orders a hekatomb: after nine days the myrtle-nymphs perform a miracle, and out of the carcases crawl fat new sun-furred drones to work the comb, a gift of the mead-gods who, with the poet, praise the teams of bright collaborating bees as little Romans—parvos Quirites. arion 27.1 spring/summer 2019 And what about Eurydice? The swarm goes humming on, a small Rome in a hive. The story’s not about Eurydice’s second chance, or whether she’ll survive. Eurydice’s a minor character; she’s only one girl, sui generis. Besides, no cattle-trick exists for her. The gods can let the apiaries thrive and armies—even empires—endure; one girl’s more complicated to replace. 44 five poems The Tithonus Club We can begin our visit with the Day Room where, in wheelchairs, some with canes or walkers, members sit: a fraternity so ancient that the confrères mostly ignore each other (club tradition). The dues are paid in decades; no one has an outstanding balance—Sir? Whoa, steady, there! Sit down... yes. Here’s your blanket. The badge of membership—the club regalia? Laminated ceremonial bracelets bear the motto Do Not Resuscitate (legend which, in practice, is seldom honored). Eleven-thirty, gentlemen; lunch is served, and now a little toast while the television mesmerizes the aides: Messieurs, your health! Deborah Warren 45 Aphrodite at the Old-Age Home —for Aphrodite Kalogeris “Honey,” the night nurse said to Aphrodite, “let me fix your bib. Look, Aphrodite! Here’s your juice and crackers, Aphrodite! “She doesn’t speak a blessed word of English,” the night nurse told us, “but she understands as good as if we spoke to her in Greek.” Aphrodite’s ears were as grotesque as the pore-coarse nose that bloomed across her face, but she heard her name: When Aphrodite rose and, beatific, dreamed across the room, traversing a happiness none of us could hear, she spoke a language older than herself but still her own—a dialect of beauty able to translate the fetid air. 46 five poems Climbing Etna We’d see the lava, nights, from the town square, as if the sun—an egg of fire—broke at dusk, threading its incandescent yolk down a mountain hanging in black air. Every night we’d scan the dark horizon looking for those streaks, and every night they took a while to find, however bright: Etna, it seemed, had spent the evening rising off the earth, to hover even higher, as if the mountain meant not to be found. And then, today, we ran the flows to ground, climbing up to the rolling burns of fire— closer, into the shimmering air and hiss that glanced up from the thick and red-flecked river —until our soles were smoking. But the lava sang, inside the mountain: Come, discover the fire’s origin and genesis; more—the heart of the world, in its enceinte of blind white heat. Seeing the lava course wasn’t enough, or watching the rock decant the sun; what brought us up here was the force— the hot loins—of a lightning god as dark as thunder; and, like Eve, like Semele, we wanted to approach. But there’s a spark, a jewel older than geology: stop shy of it—of finding the fire’s source, of closing in on what you shouldn’t see. Deborah Warren 47 Human Sucking strength... (shrink)

Insight is a cognitive feature that is usually regarded as being generated by the neocortex and being present only in humans and possibly some closely related primates. In this essay we show that especially corvids display behavioral skills within the domains of object permanence, episodic memory, theory of mind, and tool use/causal reasoning that are insightful. These similarities between humans and corvids at the behavioral level are probably the result of a convergent evolution. Similarly, the telencephalic structures involved in higher (...) cognitive functions in both species show a high degree of similarity, although the forebrain of birds has no cortex-like lamination. The neural substrate for insight-related cognitive functions in mammals and birds is thus not necessarily based on a laminated cortical structure but can be generated by differently organized forebrains. Hence, neither is insight restricted to mammals, as predicted from a “scala naturae”, nor is the laminated cortex a prerequisite for the highest cognitive functions. (shrink)

The development of AAC technologies is of critical importance to the many people who are unable to speak intelligibly due to a communication disorder, and to their many everyday interlocutors. Advances in digital technologies have revolutionized AAC, leading to devices that can “speak for” such individuals as aptly as it is illustrated in the case of the world famous physicist, Stephen Hawking. However, given their dependence on prefabricated language, current AAC devices are very limited in their ability to mediate everyday (...) interactions. We argue here that the limits of AAC are firstly theoretical — grounded in prosthetic models that imagine AAC devices as replacements for damaged body parts and in transmission models of language production as communication. In contrast, our multidisciplinary team aims to design pseudo-intelligent mediators of communication by blending strengths of human mediators with features of current AAC technologies. To inform the design process, we report here our initial situated studies focusing on the distributed nature of everyday communicative activities conducted with potential AAC/PIM users. Our analysis focuses on the discursive alignments of these participants and their interlocutors, attending especially to the various ways their personal aides function as human mediators. Specifically, we focus on mapping the communicative activity around each of these differently-abled individuals as they navigated a university campus. We profile the everyday interactional patterns within functional systems and across settings, and present close discourse analysis of one interaction to highlight the diverse roles personal aides adopted in mediating communication. Finally, we argue that attending to differently “abled” bodies as they move through everyday communicative environments pushes CHAT to more fully theorize physicality, individual mobilities, and the roles of bodies in the laminated assemblage of functional systems. (shrink)

Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we have now identified the translocation of phosphorylated p53 to the mitochondria and p53-dependent increases in the pro-apoptotic mitochondrial protein BAX leading to a loss of mitochondrial membrane potential as demonstrated by a 25% decrease in JC-1 red:green fluorescence ratio. Disruption of (...) mitochondrial membrane integrity was accompanied by efflux of the apoptosis inducing factor (AIF) from the mitochondria and translocation to the nucleus with a significant increase in reactive oxygen species (ROS) after 24 h of zinc deficiency. Measurement of caspase cleavage, mRNA, and treatment with caspase inhibitors revealed the involvement of caspases 2, 3, 6, and 7 in zinc deficiency-mediated apoptosis. Down-stream targets of caspase activation, including the nuclear structure protein lamin and polyADP ribose polymerase (PARP), which participates in DNA repair, were also cleaved. Transfection with a dominant-negative p53 construct and use of the p53 inhibitor, pifithrin- ␮, established that these alterations were largely dependent on p53. Together these data identify a cascade of events involving mitochondrial p53 as well as p53-dependent caspase-mediated mechanisms leading to apoptosis during zinc deficiency. (shrink)

The guides are shirt-pocket sized, easily folded, laminated for durability, and easy to read.

The prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins. The modification involves the covalent attachment of a 15‐carbon (farnesyl) or 20‐carbon (geranylgeranyl) isoprenoid moiety in a thioether linkage to a carboxyl terminal cysteine. The nature of the attached substituent is dependent on specific sequence information in the carboxyl terminus of (...) the protein. In addition, prenylation entrains other post‐translational modifications forming a reaction pathway. In this article, we review our current understanding of the biochemical reactions involved in prenylation and discuss the possible role of this modification in the control of cellular functions such as protein maturation and cell growth. (shrink)

In order to study drag reduction mechanism in mud parts’ operation of surface machine tools for paddy field, this paper takes floating plate, the main working part of laminating mechanism, as the research object and systematically analyzes the mechanism of action of elevation angle, curved angle, penetrating angle, and local microstructure of floating plate on working resistance and local fluid flow characteristics of the laminating structure based on VOF model in Fluent. Using ship mechanics theory and fluid lubrication theory, the (...) drag reduction mechanism under different structural parameters of the floating plate is analyzed. The results show that, compared with the ordinary floating plate, the pressure difference resistance can be reduced by increasing the elevation angle by 60°, curved angle by 20°, and mud separation angle by 20°. The increase of the concave nonsmooth bottom surface structure can reduce viscous frictional resistance, and the total working resistance after structural optimization is comparatively reduced by 48.3%, with lowered hilling height in the forward direction and improved lubrication condition of the bottom surface, forming liquid lubrication effect. This study can provide theoretical references for the optimization design of muddy soil mud parts, mud-machine interaction research, and the development of paddy field laminating mechanism. (shrink)

Some people report that they argue for play. We question whether and how often such arguments are mutually entertaining for both participants. Play is a frame for arguing, and the framing may not always be successful in laminating the eristic nature of interpersonal argumentation. Previous research and theory suggest that playfulness may be associated with aggression. Respondents supplied self - report data on their arguing behaviors and orientations. We found support for the hypothesis that self - reported playfulness and aggression (...) are directly associated. We found less evidence for our hypothesized inverse association between self - reported playfulness and indices of cooperation and avoidance. Self - reports of playfulness are not significantly associated with expert coders ’ ratings of either playfulness or aggressiveness. The claim that an argument is playful should be met with skepticism, although playful arguments are possible. (shrink)

Mammalian telomeres have evolved safeguards to prevent their recognition as DNA double‐stranded breaks by suppressing the activation of various DNA sensing and repair proteins. We have shown that the telomere‐binding proteins TRF2 and RAP1 cooperate to prevent telomeres from undergoing aberrant homology‐directed recombination by mediating t‐loop protection. Our recent findings also suggest that mammalian telomere‐binding proteins interact with the nuclear envelope to maintain chromosome stability. RAP1 interacts with nuclear lamins through KU70/KU80, and disruption of RAP1 and TRF2 function result in (...) nuclear envelope rupture, promoting telomere‐telomere recombination to form structures termed ultrabright telomeres. In this review, we discuss the importance of the interactions between shelterin components and the nuclear envelope to maintain telomere homeostasis and genome stability. (shrink)

Ruins, their evocations and enigmas, have been a source of fascination since the advent of civilization. Both coordinating and distressing the relations of space and time, ruins are unparalleled catalysts of cultural analysis, as both history and adumbration. Ruins, and the concept of ruin on which they ‘rest’ and through which they decay, can be regarded in space, as strata, in time, as sedimenta, and in dynamic terms, as lamina. This essay works down through each focusing on the forceof ruin (...) occurring between them. The essay itself is a lamination: Anselm Kiefer's exploration of ruins as artefacts, in recent works such as ‘Falling Star’, shown at Paris’ Grand Palais in the summer of 2007 as the first installation in its Monumenta series, plays across many dimensions of ruins’ themes; Derrida's exploration of the very idea of ruin – not ruins but ruin, as artefacture – conceptualizing ruins’ liminal nature, at the very limit of phenomenology, in Mémoires d'aveuglesand elsewhere; the ruin-caught-in-motion of the virtually unknown French-Italian painter ‘Monsù Desiderio’; and the linguistic ruin of Samuel Beckett's ‘D'un ouvrage abandonné’ and ‘Sans’. Each contributes to the others as ruins and ruin accumulate. Finally, ruin's decay passes into and through a passe partout into the uninhabitable. (shrink)

Touching on Nancy and Derrida offers a glimpse not only into the thesis both of Jean-Luc Nancy's critique of touch and of Derrida's Le Toucher, but also into the threshold of a technology of (the) sense to come. This glimpse is an interrogation, and one that is both historic and historical, in the sense that Derrida, in addressing Jean-Luc Nancy's work, has presented us with an encyclopedic history of touch in the philosophic tradition from Aristotle to Nancy, one in which (...) what Derrida calls “transcendental archifacticity” is accorded its proper value, and within which any seeming anthropological privilege, as an inherent aspect of the Phenomenological Reduction is, as Derrida says, ‘overshadowed.’ Such an overshadowing is both strategic, in terms of a historical phenomenological project, and tactical, in Derrida's investigative sense: tactical in terms of implementation, manifestation, manipulation (i.e. through the application of the hand, manus) and in terms of tact, tactility; to which must be tacked on, à la Nancy, con-tact, ‘with touch,’ a ‘with-touch’ in which a béance, a gash or dash, opens out in-between, ‘at the very point’ to use Derrida's repeated specification, of bifurcation and of con-tact, at the junction point of the ‘spacing out’ of a laminated différance con-noting more than it has or had ever done in Derrida's work itself. *. (shrink)