Adenosine 5′-triphosphate (ATP) was identified in 1970 as the transmitter responsible for non-adrenergic, non-cholinergic neurotransmission in the gut and bladder and the term ‘purinergic’ was coined. Purinergic cotransmission was proposed in 1976 and ATP is now recognized as a cotransmitter in all nerves in the peripheral and central nervous systems. P1 (adenosine) and P2 (ATP) receptors were distinguished in 1978. Cloning of these receptors in the early 1990s was a turning point in the acceptance of the purinergic signalling hypothesis. There (...) are both short-term purinergic signalling in neurotransmission, neuromodulation and secretion and long-term (trophic) purinergic signalling of cell proliferation, differentiation and death in development and regeneration. Much is known about the mechanisms of ATP release and its breakdown by ectonucleotidases. Recently, there has been emphasis on purinergic pathophysiology, including neurodegenerative and neuropsychiatric disorders. Purinergic therapeutic strategies are being developed for treatment of gut, kidney, bladder, lung, skeletal and reproductive system disorders, pain and cancer. (shrink)

The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl (...) open this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

Extracellular ATP released from necrotic cells in inflamed tissues activates the P2X7 receptor, stimulates the exposure of phosphatidylserine, and causes cell lysis. Recent findings indicated that XK, a paralogue of XKR8 lipid scramblase, forms a complex with VPS13A at the plasma membrane of T cells. Upon engagement by ATP, an unidentified signal(s) from the P2X7 receptor activates the XK‐VPS13A complex to scramble phospholipids, followed by necrotic cell death. P2X7 is expressed highly in CD25+CD4+ T cells but weakly in CD8+ T (...) cells, suggesting a role of this system in the activation of the immune system to prevent infection. On the other hand, a loss‐of‐function mutation in XK or VPS13A causes neuroacanthocytosis, indicating the crucial involvement of XK‐VPS13A‐mediated phospholipid scrambling at plasma membranes in the maintenance of homeostasis in the nervous and red blood cell systems. (shrink)

CALHM1 was recently demonstrated to be a voltage‐gated ATP‐permeable ion channel and to serve as a bona fide conduit for ATP release from sweet‐, umami‐, and bitter‐sensing type II taste cells. Calhm1 is expressed in taste buds exclusively in type II cells and its product has structural and functional similarities with connexins and pannexins, two families of channel protein candidates for ATP release by type II cells. Calhm1 knockout in mice leads to loss of perception of sweet, umami, (...) and bitter compounds and to impaired gustatory nerve responses to these tastants. These new studies validate the concept of ATP as the primary neurotransmitter from type II cells to gustatory neurons. Furthermore, they identify voltage‐gated ATP release through CALHM1 as an essential molecular mechanism of ATP release in taste buds. We discuss these new findings, as well as unresolved issues in peripheral taste signaling that we hope will stimulate future research. (shrink)

Release of the ATP hydrolysis product ortophosphate (Pi) from the active site of myosin is central in chemo‐mechanical energy transduction and closely associated with the main force‐generating structural change, the power‐stroke. Despite intense investigations, the relative timing between Pi‐release and the power‐stroke remains poorly understood. This hampers in depth understanding of force production by myosin in health and disease and our understanding of myosin‐active drugs. Since the 1990s and up to today, models that incorporate the Pi‐release either (...) distinctly before or after the power‐stroke, in unbranched kinetic schemes, have dominated the literature. However, in recent years, alternative models have emerged to explain apparently contradictory findings. Here, we first compare and critically analyze three influential alternative models proposed previously. These are either characterized by a branched kinetic scheme or by partial uncoupling of Pi‐release and the power‐stroke. Finally, we suggest critical tests of the models aiming for a unified picture. (shrink)

Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

The process of protein folding in the cell is now known to depend on the action of other proteins. These proteins include molecular chaperones, Which interact non‐covalently with proteins as they fold and improve the final yields of active protein in the cell. The precise mechanism by which molecular chaperones act is obscure. Experiments reported recently(1) show that for one molecular chaperone (Cpn60, typified by the E. coli protein GroEL), the folding reaction is driven by cycles of binding and (...) class='Hi'>release of the co‐chaperone Cpn10 (known as GroES in E. coli). These alternate with binding and release of the unfolded protein substrate. These cycles come about because of the opposite effects of Cpn10 and unfolded protein on the Cpn60 complex: the former stabilises the ADP‐bound state of Cpn60, whereas the latter stimulates ADP‐ATP exchange. This model proposes that the substrate protein goes through multiple cycles of binding and release, and is released into the cavity of the Cpn60 complex where it can undergo folding without interacting with other nearby folding intermediates. This is consistent with the ability of Cpn60 proteins to enhance folding by blocking pathways to aggregation. (shrink)

Control of DNA supercoiling by the free-energy of hydrolysis of ATP that involves gene expression is analyzed in terms of three levels of unconnected metabolic pathways. These are synthesis and breakdown of topoisomerase mRNAs, synthesis and breakdown of topoisomerase proteins and supercoiling and relaxation of DNA. The so-called square-matrix method previously developed for the control of metabolic pathways, is extended to deal with this hierarchical control system. It turns out that also in this case, the matrix of control (...) coefficients is equal to the inverse of the so-called elasticity matrix, which contains all relevant elasticity coefficients as well as information about the structure and connectedness of the pathways involved. For a simpler case of a hierarchy of two systems, we demonstrate that the explicit matrix inversion method may be replaced by an implicit method in which the regulatory effects that run through the other level are described by an additional elasticy coefficient which may then be treated as if local. (shrink)

The Violence of Reading: Literature and Philosophy at the Threshold of Pain expounds the scene of reading as one that produces an overwhelmed body exposed to uncontainable forms of violence. The book argues that the act of reading induces a representational instability that causes the referential function of language to collapse. This breakdown releases a type of “linguistic pain” (Scarry; Butler; Hamacher) that indicates a constitutive wounding of the reading body. The wound of language marks a rupture between linguistic (...) reality and the phenomenal world. Exploring this rupture in various ways, the book brings together texts and genres from diverse traditions and offers close examinations of the rhetoric of masochism (Sacher-Masoch; Deleuze), the relation between reading and abuse (Nietzsche; Proust; Jelinek), the sublime experience of reading (Kant; Kafka; de Man), the “novel of the institution” (Musil; Campe), and literary suicide (Bachmann; Berryman; Okkervil River). (shrink)

In this contribution the author tries to formulate an approach to the art of living with technology based on Heidegger’s The Principle of Reason, a work often overlooked by contemporary commentators in the philosophy of technology. This approach couples the concept of releasement to insights hailing from Wolfgang Schirmacher concerning Heidegger’s nihilism.

This work interfaces the philosophies of Jean Baudrillard and Martin Heidegger. It hopes to contribute to both Heideggerian and Baudrillardian scholarship by employing Baudrillardian ideas in more effectively describing the historical happening of the so-called withdrawal of Being from man, which preoccupied much of Heidegger’s body of work. The work argues that by re-visiting an earlier idea of Baudrillard, which he termed as seduction, one finds a possible way of navigating the obscenity of the current epoch of Being. Akin to (...) Heidegger’s idea of Gelassenheit or releasement, Baudrillard’s concept of seduction invites one to allow the real to once again appear, no longer by way of subjective representation, but to let it appear in its very disappearance in hyperreality. (shrink)

The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as transmitter molecules, appeared very early in evolution: release mechanisms and ATP‐degrading enzymes are operative in bacteria, and the first specific receptors are present in single cell eukaryotic protozoa and algae. Further evolution of the purinergic signalling system resulted in the development of multiple classes of purinoceptors, several pathways for release of nucleotides and adenosine, and a system of ectonucleotidases controlling extracellular levels of purinergic transmitters. The purinergic (...) signalling system is expressed in virtually all types of tissues and cells, where it mediates numerous physiological reactions and contributes to pathological responses in a variety of diseases. (shrink)

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

On May 4, 1380, Cecily Chaumpaigne brought a deed of release into the Chancery of Richard II and had it enrolled on the close rolls . In this deed Chaumpaigne released the poet Geoffrey Chaucer from “all manner of actions such as they relate to my rape or any other thing or cause” . The deed had been witnessed three days earlier by several prominent members of the court of Richard II.

Paul Boyer shared a Nobel Prize in 1997 for his work on the mechanism of ATP synthase. His earlier work, though (which contributed indirectly to his triumph), included major errors, both experimental and theoretical. Two benchmark cases offer insight into how scientists err and how they deal with error. Boyer's work also parallels and illustrates the emergence of bioenergetics in the second half of the twentieth century, rivaling achievements in evolution and molecular biology.

This article attempts to analyze the deconstruction of the linear organization of legal systems into a plurality of organized networks conform a circular systemic organization. As we know, the process of systematization runs parallel to the evolution of the modern State and, in this sense, the structure constitutes a single and well defined corps. However, at present, the emergence of multiple legal networks has been seen to turn Law into a structure that translates into a plethora of information that is (...) hard to nuance. Finally, with respect to the emergence of reflexive law, such reflexivity is feasible only when the processes of democratization create discursive structures in social subsystems, so the main problem is to deal with is their identity within a dynamic process of inter-legalities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:720 Feminist Studies 42, no. 3. © 2016 by Feminist Studies, Inc. Julie R. Enszer “She Who Shouts Gets Heard!”: Counting and Accounting for Women Writers in Literary Grants and Norton Anthologies In 1979, the Coordinating Council of Literary Magazines (CCLM), a New York-based nonprofit that supported literary magazines through technical assistance and grant-making, announced a new program: CCLM editor fellowships.1 Editor fellowships came with a $5,000 grant. Members (...) of the literary community nominated editors to CCLM for the award. Adrienne Rich nominated Ellen Marie Bissert, editor of the feminist journal 13th Moon, and Mab Segrest, editor of Feminary: A Feminist Journal for the South Emphasizing the Lesbian Vision, for the editor fellowships. In 1979, the inaugural year of the prize, among the ten winners, not one was a woman. Bissert was one of three honorable mentions. Bissert rejected the distinction with a public letter to Maureen Owen, the only woman on the CCLM board of directors. Bissert deplored “the sexism inherent in the panelists’ decisions.”2 Several feminist publications reprinted Bissert’s letter while “the male small press gave it scant 1. The work of CCLM continues today, although now the organization is called the Council for Literary Magazines and Presses (CLMP). Under the leadership of Jeffrey Lependorf, the nonprofit organization continues to be a vital advocate for small magazines and publishers. 2. Open letter from Ellen Marie Bissert to Maureen Owen, June 28, 1980, CCLM Editors’ Grant 1980 folder, box 6, 13th Moon records, New York Public Library, Rare Books and Manuscripts Division (hereafter, CCLM folder). Julie R. Enszer 721 coverage.”3 As a result of Bissert’s objections, CCLM released the application statistics: 225 people were nominated, forty (18%) were women, and fifteen (7%) were non-white men. Of the 124 people who completed the applications, twenty-three (19%) were women and eleven (9%) were nonwhite men. There were thirty-three semifinalists, five (15%) women and four (12%) non-white men. These numbers shocked and outraged Bissert and other feminists. Adrienne Rich wrote to Maureen Owen, “I am appalled by the blatant sexism evidenced in the Council’s decision to fund ten male editors.”4 The attention that Bissert brought to the grant process resulted in a special meeting of the CCLM board to “discuss the controversy” and the awards.5 The next year, the CCLM editor fellowships went to five journals run by women and five run by men; one of the winners of the $5,000 award in 1980 was the editorial collective of Conditions, a magazine of writing by women with an emphasis on writing by lesbians.6 In a letter to readers of Conditions, the three editors, Elly Bulkin, Jan Clausen, and Rima Shore, noted that the “feminist protest following the announcement of the 1979 awards no doubt had an impact on the decision-making process” and that the award “represents the only substantial payment we have received, or seem likely to receive, for our editorial work, and we were greatly encouraged by it.”7 Maureen Owen acknowledged the importance of Bissert’s protests saying it “strengthened my position on the board at CCLM and the position of women editors and writers in general. She who shouts, get heard!”8 In 1979, Bissert, Rich, and other feminists demonstrated the importance of shouting about the inclusion of women in systems of literary appraisal; they recognized the important economic consequences of grants for feminist publishers and feminist authors. Thirty years later, in 2009, Cate Marvin and Erin Belieu founded VIDA: Women in Literary Arts to promote “conversations regarding the critical reception 3. Open letter from Bissert to Owen. 4. Rich to Owen, August 7, 1979, CCLM folder. 5. Open letter from Bissert to Owen. 6. Press release, June 11, 1980, CCLM folder. 7. Elly Bulkin, Jan Clausen, and Rima Shore, Conditions 7, unnumbered front matter. 8. Postcard from Owen to Bissert, undated, CCLM folder. 722 Julie R. Enszer of women’s creative writing in our current culture.”9 Each February or March since 2010, VIDA releases “the count”: a compilation of the gender breakdown of prizes, reviews, and literary journals in the United States. VIDA’s numbers demonstrate bias toward men in... (shrink)

What is a self? What does it mean to have selfhood? What is the relationship between selfhood and identity? These are puzzling questions that philosophers, psychologists, social scientists, and many other researchers often grapple with. -/- Self and Identity is a book that explores and brings together relevant ideas on selfhood and identity, while also helping to clarify some important and long standing scientific and philosophical debates. It will enable readers to understand the difference between selves in humans and other (...) animals, and the different selves that we come to possess from when we are born to when we become old. It also explains how and why the self might break down due to mental illness, thereby providing insight into how we might treat illnesses such as dementia and depression, both of which are conditions that fundamentally affect our selfhood. -/- Taking an important step towards clarifying our understanding of human selfhood and applying it to mental illness, this book will be of great interest to researchers and postgraduate students exploring philosophical questions of selfhood, as well as those examining the connection to clinical disorders. (shrink)

This article examines the philosophy of Gilles Deleuze and the poetry of Arthur Rimbaud in terms of the intersection between corporeality, temporality, and the political. The first part analyzes the deconstruction of lyrical subjectivity in Rimbaud’s verse in relation to the breakdown of the “sensory-motor link” described in the first volume of Deleuze’s Cinema; it discusses these homologous movements as a release of free-floating bodily potentiality. The second part shows how the shift from the first to the second (...) volume of Deleuze’s Cinema and the shift from verse to prose poetry in Rimbaud constitute the formal dimensions of a shared political project based on the transformation of bodily life, or a biopolitical transformation. This project can be understood as communist insofar as it attempts to liberate time from capital for the body and to produce a social form based on sharing the common. (shrink)

Due to the lack of a standard definition for the concept of corporate social responsibility, various discourse communities have assigned different meanings to it. Based on the intermedia agenda setting theory, this study examines the extent to which CSR-related news releases published by the two electricity providers in Hong Kong have influenced press coverage over a 6-year period between 2006 and 2011. A total of 202 news releases and 1,045 news articles were content-analyzed based on the following mutually exclusive categories (...) of CSR-related news events: operations, education, community, products and services, recognition, environment, and donations and sponsorships. This study found that operations-related and products and services-related news releases were more likely to be reported in the press. Recognition-related news releases were the least likely to be reported. Based on the findings, this study posits that two criteria would determine whether a CSR-related news release is likely to be covered in the press: the extent to which the news events are relevant to the core operations of the corporations and the extent to which the news events make an impact on society. (shrink)

ABSTRACT Through an exploration of a home invasion scene in Ingmar Bergman's Shame, this article explores the ways in which it is not only our own bodies that are vulnerable to assault but also the meaningful objects through which we expressively engage with the world, as well as the worldly context of these embodied engagements. First, I draw primarily on the work of Martin Heidegger and Maurice Merleau-Ponty in order to explore the ways in which things come to be incorporated (...) into our bodily experience and how our vulnerability as embodied individuals is thus extended into the life of these things. Second, I engage with phenomenological accounts of home and psychoanalytic accounts of childhood development in order to argue that our extended bodily vulnerability is coextensive with our creative openness to the world. Finally, I offer some reflections on the role played by breakdown in phenomenological experience, at the level of the things through which we are “at home” to expressively extend ourselves out into the world and at the level of the sense of “homelessness” alive in the experience of anxiety. (shrink)

The article deals with the breakdown of the co called „grand narratives“ and with processes that preceded it. The author focuses on the degradation of the traditional meaningful forms, such as myth and grand narrative, and their becoming a „story“. He offers a detailed examination of the essential characteristics of a story. He sees the particular forms of the codification of the world as related to following developments: the rise of grand narratives as related to the transition to linear (...) alphabetical codes, while their transformation into a story as connected with the rise of technological images. He sees this transition as a negative phenomenon, since this shift of the focus of human activities on images resulted in a significant reduction of our freedom. (shrink)

In the late Middle Ages the philosopher and mystic Meister Eckhart preached that to know the truth you must be the truth. But how to be the truth? Eckhart's answer comes in the form of an imperative: release yourself, let be. Only then will you be able to understand that the deepest meaning of being is releasement. Only then will you become who you truly are. This book interprets Eckhart's Latin and Middle High German writings under the banner of (...) an imperative of releasement, and then shows how the twentieth-century thinker Martin Heidegger creatively appropriates this idea at several stages of his career. Heidegger had a lifelong fascination with Eckhart, referring to him as "the old master of letters and life." Drawing on archival material and Heidegger's marginalia in his personal copies of Eckhart's writings, Moore argues that Eckhart was one of the most important figures in Heidegger's philosophy. This book also contains previously unpublished documents by Heidegger on Eckhart, as well as the first English translation of Nishitani Keiji's essay "Nietzsche's Zarathustra and Meister Eckhart," which he initially gave as a presentation in one of Heidegger's classes in 1938. (shrink)

To restructure and systematize the concept of personalization, in this study we introduce a two-dimensional and relational typology of personalization of political representation, comprising a horizontal as well as a vertical dimension, and put it to an empirical test. We concertedly utilize content analyses of political newspaper and television coverage as well as of party press releases during the 2008 Austrian election campaign. With regard to the Austrian case, the findings outline that personalization of political representation is not a universal (...) phenomenon; it rather appears as a context- and logic-sensitive communicational phenomenon. Political public relations shows significantly higher levels of horizontal as well as vertical diversification than the media by being more individualized and less monopolized by leaders and executive elites. Additionally, political representation in the tabloid press is more personalized than in quality papers, and the communication of catch-all parties is more individualized than of niche parties. (shrink)

Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated (...) Hh from the cell surface, and that another known upstream signaling modulator called Scube2 chaperones the dual‐lipidated morphogen to Ptc. By mechanistically and biochemically aligning this concept with established in vivo and recent in vitro findings, this reflection identifies remaining questions in lipidated Hh transport and evaluates additional mechanisms of Disp‐ and Scube2‐regulated release of a second bioactive Hh fraction that has one or both lipids removed. (shrink)

We introduce an Automatic Theorem Prover (ATP) of a dual tableau system for a relational logic for order of magnitude qualitative reasoning, which allows us to deal with relations such as negligibility, non-closeness and distance. Dual tableau systems are validity checkers that can serve as a tool for verification of a variety of tasks in order of magnitude reasoning, such as the use of qualitative sum of some classes of numbers. In the design of our ATP, we have introduced some (...) heuristics, such as the so called phantom variables, which improve the efficiency of the selection of variables used un the proof. (shrink)

Smart cities are now an established area of technological development and theoretical inquiry. Research on smart cities spans from investigations into its technological infrastructures and design scenarios, to critiques of its proposals for citizenship and sustainability. This article builds on this growing field, while at the same time accounting for expanded urban-sensing practices that take hold through citizen-sensing technologies. Detailing practice-based and participatory research that developed urban-sensing technologies for use in Southeast London, this article considers how the smart city as (...) a large-scale and monolithic version of urban systems breaks down in practice to reveal much different concretizations of sensors, cities, and people. By working through the specific instances where sensor technologies required inventive workarounds to be setup and continue to operate, as well as moments of breakdown and maintenance where sensors required fixes or adjustments, this article argues that urban sensing can produce much different encounters with urban technologies through lived experiences. Rather than propose a “grassroots” approach to the smart city, however, this article instead suggests that the smart city as a figure for urban development be contested and even surpassed by attending to workarounds that account more fully for digital urban practices and technologies as they are formed and situated within urban projects and community initiatives. (shrink)

" Notre Musique includes a lengthy sequence that involves a presentation by Godard on the relationship between text and image. The occasion of the lecture is a conference in Sarajevo titled European Literary Encounters, an annual event first organized in 2000. Godard gave his lecture in 2002 and the long middle-section of the film offers a "lightly fictionalized restaging" of his address and of other encounters surrounding the conference. The narrative setting of the majority of this film, then, is a (...) space of discourse (a conference and a lecture), but I suggest that the film is conceptually sited more generally and abstractly in the "space" or “frame” of discourse itself. Because it ponders various parameters—spatial, historical, conceptual—that allow or disallow discursive connection, I regard Notre Musique as an extended meditation on the possibilities for and barriers to discourse. By siting the film in Sarajevo, Godard is clearly highlighting a frame for this meditation—a frame that includes a history of violence and reconciliation. The conference is decidedly international and takes place in a city with a rich cosmopolitan and multi-ethnic history, even as it bears the scars of violence and ethnic division. Sarajevo, moreover, is a city with a complex relationship to the state—having been a nucleus to various formations of state and empire in the last century. In its history and in the present, Sarajevo is a site of discourse and discord; of the union and clash of influences (be they religious, political, or ethnic). Hence, Sarajevo’s relevance to the film is not merely one of documentary fidelity (because it was the host city for the conference). It is a perfect site for Godard to pursue a line of reflection on discourse and its breakdown in the frame of changing formations of power. Sarjevo as a site also calls attention to how the parties or constituencies for discourse remain in states of flux—either through processes of self-definition from within or misrecognition (or nonrecognition) from without...". (shrink)

We report evidence further supporting homology between proteins in the F1FO‐ATP synthetase and the bacterial flagellar motor (BFM). BFM proteins FliH, FliI, and FliJ have been hypothesized to be homologous to FO‐b + F1‐δ, F1‐α/β, and F1‐γ, with similar structure and interactions. We conduct a further test by constructing a gene order dataset, examining the order offliH,fliI, andfliJgenes across the phylogenetic breadth of flagellar and nonflagellar type 3 secretion systems, and comparing this to published surveys of gene order in the (...) F1FO‐ATP synthetase, its N‐ATPase relatives, and the bacterial/archaeal V‐ and A‐type ATPases. Strikingly, thefliHIJgene order was deeply conserved, with the few exceptions appearing derived, and exactly matching the widely conserved F‐ATPase gene orderatpFHAG, coding for subunits b‐δ‐α‐γ. The V/A‐type ATPases have a similar conserved gene order. Our results confirm homology between these systems, and suggest a rare case of synteny conserved over billions of years, predating the Last Universal Common Ancestor (LUCA). (shrink)

Background: When adolescent boys experience close, secure relationships with their parents and peers, the implications are potentially far reaching, including lower levels of mental health problems in adolescence and young adulthood. Here we use rare prospective intergenerational data to extend our understanding of the impact of adolescent attachments on subsequent postpartum mental health problems in early fatherhood.Methods: At age 17–18 years, we used an abbreviated Inventory of Parent and Peer Attachment to assess trust, communication, and alienation reported by 270 male (...) participants in their relationships with mothers, fathers, and peers. More than a decade later, we assessed the adult males, now fathers, at 12 months postpartum for symptoms of depression, anxiety, and stress. Logistic regression was used to examine the extent to which attachment dimensions predicted paternal postpartum mental health, adjusting for potential confounding, and with assessment for interactions between parent and peer attachments.Results: Trust in mothers and peers, and good communication with fathers during adolescence, were associated with 5 to 7 percentage point reductions in postpartum mental health symptoms in early fatherhood. Weak evidence of parent-peer interactions suggested secure attachments with either parent or peer may compensate for an insecure attachment with the other.Conclusions: Our results suggest that fostering trust and communication in relationships that adolescent boys have with parents and peers may have substantial effects on rates of paternal postpartum mental health problems. The protective benefits may be preventative in intergenerational cycles of risk for mental health problems. (shrink)

In the third volume of his history of the phenomenological movement, Robert Denoon Cumming argues that their differences involve differences in method; whereas Husserl follows a "method of clarification," with which he eliminates ...

The following is an analysis of the relationship between incompatibility, conflict and breakdown. It is restricted to situations of a certain sort — to the isolation of the conditions under which breakdowns occur. These conditions are specific and defineable. Under certain circumstances incompatibilities and conflicts culminate in growth, under others in separation, under others in outright destruction of one of the incompatible elements, under others still in dominance-subserviance relationships and under others in breakdown. This is a matter of (...) some importance since influential current conceptions treat incompatibility and conflict as though they were uniform in outcome. The followers of Hegel regard them as always making for growth whereas certain contemporaries look upon them as the prime movers of breakdown and decline. The truth of the matter would seem to be that neither of these theories is correct. Conflicts vary, their consequences vary and the conditions under which they occur vary. For empirical analysis the important thing is the disengagement of the differences making for different culminations as well as the relations common to all; and the working out, as far as possible, of the way in which alterations in certain basic factors make for changes in result. A specific analysis of this sort may be valuable for foresight and even for a degree of control where the conditions are accessible to our manipulation. (shrink)

This article investigates how Plato thinks we secure necessary motivational conditions for inquiry. After presenting a typology of zetetic breakdowns in the dialogues, I identify norms of inquiry Plato believes all successful inquirers must satisfy. Satisfying these norms requires trust that philosophy will not harm but benefit inquirers overall. This trust cannot be secured by protreptic argument. Instead, it requires divine intervention—an extra-rational foundation for rational inquiry.

Heidegger's thinking in the decades following the publication of Being and Time is often deemed irreconcilable with that work. Critics contrast the notion of "resoluteness" in Being and Time with Heidegger's post-war account of "releasement" in an attempt to establish a discrepancy between the allegedly voluntarist humanism of his early work and the supposedly 'anti-humanist' thinking of his later work. By contrast, Mahon O'Brien argues for the structural and thematic coherence of Heidegger's movement from authenticity to the search for an (...) authentic free relation to the world - as captured by the term "releasement". By demonstrating the structural and thematic unity of Heidegger's thought in its entirety, O'Brien paves the way for a more measured and philosophically grounded understanding of the issues at stake in the Heidegger controversy. (shrink)

Recent advances in molecular genetics, plant physiology, and biochemistry have opened up the new biotechnology of herbicide resistant crops (HRCs). Herbicide resistant crops have been characterized as the solution for many environmental problems associated with modern crop production, being described as powerful tools for farmers that may increase production options. We are concerned that these releases are occurring in the absence of forethought about their impact on agroecosystems, the broader landscape, and the rural and urban economies and cultures. Many of (...) the benefits and risks associated with HRCs are not apparent to either the public, farmers, policy makers, or the scientific community. HRC technology raises moral issues in three areas: our duties toward the natural environment; our political and economic responsibilities to each other; and our communal character as one generation among many. We also need a rational basis on which to make evaluations of this new biotechnology. The technical aspects of their release require a logical guide to the ecological, environmental, and biological effects the release might have in sustainable agroecosystems. The initial step should include an assessment of the intrinsic qualities of the crop, the herbicide, and the resistance mechanisms. The second step should include an assessment of effects associated with population ecology, population genetics, environmental degradation, consumer health, and farm economic viability due to the resistant crop-herbicide pair. Herbicides have been used in crop production for nearly a half a century. There has been a tremendous increase in the use of these chemicals in that time. Society has seen the use of these chemicals not only help to feed many people, but also to bring costs not anticipated before the introduction of the chemicals. We need to draw on that long history of use and learn the lessons it can provide us as we approach the introduction and commercialization of the next generation of weed control technology, herbicide resistant crops. We also need to reflect on the lessons we missed during that half century because we spend more time imagining the possible benefits that would come from the technology than scrutinizing the possible harm. (shrink)

Breakdown and Breakthrough examines the essential role of regression in the patient's recovery from mental illness. In light of this Nathan Field reassesses the role of the therapist tracing psychotherapy back to its earliest spiritual roots and comparing modern analytic methods with ancient practices of healing and exorcism. The author uses vivid examples from his psychotherapeutic practice to show how, with the apparent breakdown of the therapeutic method itself, patients can break through to a new level of functioning. (...) The book goes on to consider how psychotherapy has been affected by fundamental developments in twentieth century science, such as the move from old, classical assumptions of linear causation to non-linear complexity from reductionism to a holistic systems approach and from mental mechanisms to acknowledging the mysteries of unconscious interaction. Taking up the radical vision originally proposed by Carl Jung and later fostered by eminent psychotherapists such as Winnicott and Bion, the author shows how psychotherapy can be reframed to admit the existence of a psychological fourth dimension. Nathan Field reappraises ideas of health and pathology, psychoanalysis and healing, sex and spirituality in light of a dramatic shift in the way we understand ourselves. How this shift alters the shape of psychotherapy in the twenty-first century is the challenge the practitioners, teachers and trainees must all address. (shrink)

What is behind the upsurge of virulent nationalism and intransigent politics across the globe today? In Fear of Breakdown, Noëlle McAfee contends that politics needs something that only psychoanalysis has been able to offer: an understanding of how to work through anxieties, ambiguity, fragility, and loss.

Transcription factor (TF) signaling regulates gene transcription and requires a complex network of proteins. This network includes co‐activators, co‐repressors, multiple TFs, histone‐modifying complexes, and the basal transcription machinery. It has been widely appreciated that pioneer factors, such as FoxA1 and GATA1, play an important role in opening closed chromatin regions, thereby allowing binding of a secondary factor. In this review we will focus on a newly proposed model wherein multiple TFs, such as steroid receptors (SRs), can function in a pioneering (...) role. This model, termed dynamic assisted loading, integrates data from widely divergent methodologies, including genome wide ChIP‐Seq, digital genomic footprinting, DHS‐Seq, live cell protein dynamics, and biochemical studies of ATP‐dependent remodeling complexes, to present a real time view of TF chromatin interactions. Under this view, many TFs can act as initiating factors for chromatin landscape programming. Furthermore, enhancer and promoter states are more accurately described as energy‐dependent, non‐equilibrium steady states. (shrink)

In this essay I offer a qualified defence of Axel Honneth's recognition-theoretical critique of reification. This defence begins by engaging with a cross-section of the recent critical responses to Honneth's theory. In response to these criticisms I develop a reading of the recognition-theoretical critique of reification which illuminates both the intentional structure and pre-ethical nature of affective recognition whilst also reconstructing the existential contours of reification, understood as the “forgetfulness of recognition.” The paper concludes by taking the problem of “forgetfulness” (...) in a novel direction by drawing on the theory of double reflection expounded by Kierkegaard's pseudonymous author Johannes Climacus in the Concluding Unscientific Postscript. In this final discussion I argue that the recognition-theoretical application of the theory of double reflection provides a conceptual model which allows one to think through the social, cultural and political mediations which inhibit, or wholly.. (shrink)

We find here a translation for the first time of the sanskrit philosophical work entitled Pancaprakriya which belongs to the relatively early Advaita Vedanta thinker Sarvajnatman and a thematic analysis of the contents of that work. The Pancaprakriya is a menual of Advaita Vedanta philosophy of language which for Sarcajnatman is reduced to the discernment of the proper meaning of certain great Upanisadic statements or mahavakyss such as Iam Brahman and That thou art. Through the approprition of such a proper (...) understanding which resorts to the secondary of implied usafe of language the qualifies striver after enlghtenment obtains release from bondage int he world. (shrink)