Angiogenesis plays an essential role in tumor growth, invasion and metastasis. After initial pessimism about the usefulness of the antiangiogenic therapeutic approach for cancer, interest has increased in the development of antiangiogenic compounds after the first clinical approval of an antiangiogenic therapy. The anti‐vascular endothelial growth factor (VEGF) antibody bevacizumab has recently been approved for use in combination with chemotherapy for the treatment of metastatic colorectal and non‐small cell lung cancer patients. However, no survival benefit has been demonstrated in anti‐VEGF (...) monotherapy trials, probably due to the high complexity of tumor angiogenesis regulation. Experimental and clinical data, including the approval of the multitargeted drugs sunitinib and sorafenib, indicate that exciting results, including tumor regression, can be expected from the combined targeting of different pathways in the tumor angiogenesis scenario. Several obstacles, including the high cost of new molecular targeted drugs make this therapeutic approach difficult. BioEssays 29:1159–1168, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Perfectionism is a multidimensional construct with both positive and negative aspects. Recently, the concept of appearance-oriented perfectionism has been introduced, which is associated with body image dissatisfaction and weight and shape control behaviors. The Physical Appearance Perfectionism Scale is a 12-item two-factor instrument developed to assess this new dimension of perfectionism. The aim of the study is to validate the Spanish version of PAPS among a representative sample of 850 male university students in Spain. Exploratory and confirmatory factorial structure, internal (...) consistency, convergent and concurrent validity, and associated predictor variables analyses have been carried out. Results showed that the Spanish version of the PAPS maintains the original factor structure with all items and proves to be a reliable instrument. Physical appearance-oriented perfectionism is associated with general perfectionism, higher body dissatisfaction, Eating Disorders and Muscle Dysmorphia symptomatology, and compulsive exercise, particularly in the Worry about Imperfection subscale. These variables also act as predictors of physical appearance perfectionism. The use of the PAPS-S and the analysis of its subscales is recommended in the context of body image-related pathologies such as Eating Disorders and Muscle Dysmorphia. (shrink)

Ample attention is being paid in the higher education literature to promoting active learning among students. However, critical examination of educational purposes and ends is largely lacki...

Las fake news se suelen caracterizar como contenidos, de modo que prevalece el planteamiento semántico. Aquí se propone un enfoque pragmático, donde son actos comunicativos intencionales. Esto permite entender las fake news desde los actos locucionarios, ilocucionarios y perlocucionarios. Esta triple versión de intencionalidad comunicativa permite una mejor intelección de la mala información (misinformation) y de la desinformación (disinformation), que se refleja con claridad en el caso económico.Para mitigar o neutralizar los daños causados por las fake news en el tejido (...) social, se suele recomendar la contrastación de hechos (fact checking). La contribución de la Economía Experimental —y, en concreto, la aportación de Alvin Roth (Premio Nobel de Economía 2012)— puede ser especialmente relevante en dos direcciones: (a) la actividad económica y (b) la Economía como actividad entrelazada con otras. Esto supone el contrastar hechos partiendo de la intencionalidad en la actividad económica, en cuanto tal y en su nexo con otras actividades humanas. A este respecto, las fake news convergen con la toma de decisiones económicas, en cuanto que ambas están surcadas por la intencionalidad y, además, tienen lugar en un contexto donde adquieren un perfil orientado a fines. (shrink)

The purpose of professional education programs is to prepare aspiring professionals for the challenges of practice within a particular profession. These programs typically seek to ensure the acquisition of necessary knowledge and skills, as well as providing opportunities for their application. While not denying the importance of knowledge and skills, this paper reconfigures professional education as a process of becoming. Learning to become a professional involves not only what we know and can do, but also who we are (becoming). It (...) involves integration of knowing, acting, and being in the form of professional ways of being that unfold over time. When a professional education program focuses on the acquisition and application of knowledge and skills, it falls short of facilitating their integration into professional ways of being. In addition, through such a focus on epistemology (or theory of knowing), ontology (or theory of being) is overlooked. This paper explores what it means to develop professional ways of being where the focus is becoming, not simply knowing as an end in itself. (shrink)

Hailed by the Journal of the History of Astronomy as "charming and witty," this chronicle by a renowned physicist traces the development of scientific thought from the works of the "founding fathers" — Galileo, Huygens, and Newton — to the more recent discoveries of Maxwell, Boltzmann, and Gibbs. 1984 edition.

In higher education, the conventional design of educational programs emphasises imparting knowledge and skills, in line with traditional Western epistemology. This emphasis is particularly evident in the design and implementation of many undergraduate programs in which bodies of knowledge and skills are decontextualised from the practices to which they belong. In contrast, the notion of knowledge as foundational and absolute has been extensively challenged. A transformation and pluralisation has occurred: knowledge has come to be seen as situated and localized into (...) various 'knowledges', and the status of the body has taken on renewed significance in epistemological debates. Rather than thinking of knowledge as transcending the body, the embodiment of knowledge has become a key factor in understanding the nature of knowledge and what it means to know. In this paper, we adopt a phenomenological perspective in exploring the notion of embodied knowing as it relates to higher education programs and, more specifically, the ways in which information and communication technologies (ICTs) are used in these programs. (shrink)

Le présent ouvrage comble une lacune. La recherche, en effet, n'avait jamais pris en vue de manière systématique et détaillée l'ensemble de la philosophie schellingienne dans son rapport à la théologie. (C'est d'autant plus surprenant si l'on se rappelle que la pensée de Schelling représente le dernier essai de grand style d'établir une médiation entre ces deux disciplines.) En pratiquant sur toute l'œuvre une coupe longitudinale - depuis les premiers écrits critiques sur le mal et le mythe, à travers la (...) spéculation théogonique des Ages du monde, jusqu'aux développements christologiques et ecclésiologiques de la dernière période - le livre retrace le devenir de la théologie de Schelling, s'intégrant dans sa pensée comme l'une de ses composantes. Cette méthode permet de mettre en évidence la façon dont le philosophe théologien s'est critiqué lui-même dans les diverses phases de sa longue carrière et a modifié ses positions initiales pour tenter d'échapper à la synthèse idéaliste de la foi et du savoir, sans parvenir toutefois à se dégager entièrement du schéma de l'identité. (shrink)

During the last decades the question of defining life has gained increased interest but, at the same time, the difficulty in reaching consensus on a possible answer has led many to skeptical positions. This, in turn, has raised a wider debate about why defining life is so hard and controversial. Such a debate introduces additional aspects to be considered, like the role and nature of a definition of life itself. In this paper, we will focus on those aspects, arguing that (...) progress can be made if we conceive definitions of life as open heuristic tools that contribute to develop specific research strategies in the biological sciences and, more generally, to increase our understanding of life’s complexity. In contrast with pragmatic or operationalist approaches, we will defend that definitions of life comprise a set of ontological assumptions, together with an inherent unifying vocation, so they should be subject to comparison and critical assessment, closely related to the success or failure of the corresponding research programs, but also to the success or failure in establishing well-grounded interconnections among the latter. We consider that the search for a more coherent, integrated and generalized theory of biology cannot be pursued without keeping an empirical standpoint, and the exercise of defining life should not be taken as an obstacle but as a valuable instrument to achieve that goal. (shrink)

This article offers a philosophical-empirical account of embodied skilful performance in the practice of plant biotechnology. Drawing on the work of Merleau-Ponty and others, we elaborate how skilful performance emerges from and through reciprocal relations encompassing the body-in-the-world and the world-in-the-body. The contribution of this article lies in offering an account of skilful performance that is attentive to a perceiving, motile, feeling body entwined with world. In genetically modifying plants, scientists direct their senses of touch and vision to manipulating plant (...) materials and matter, ‘reading’ subtle changes in tissue cultures, plantlets and so on. In rhythmic movements, they extend their bodies through skilful use of complex equipment, while calling on ‘intuition’ to guide their work. Skilful performance, then, relies on our lived body that is not merely a physical object among other objects, nor a passive instrument for the mind, but dynamic and inescapably entwined with people and things in a world in flux. Bringing to the fore how perceiving, motile, feeling bodies are implicated in skilful performance has significant implications for education and workplace training. (shrink)

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction (...) force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment. (shrink)

Grace a son interrogation incomparablement tenace et incisive sur le sens de l'etre, la pensee heideggerienne accede a une comprehension du sacre qui semble irreductible a tout autre, et qui, par son originalite et sa profondeur, compte parmi les plus significatives elaborees a notre epoque. Le present ouvrage etudie le rapport complexe entre cette notion du sacre et les eclaircissements heideggeriens sur le divin et la mediation poetique. Il s'articule en quatre parties, dont la premiere expose la genese de l'interpretation (...) heideggerienne du sacre. La deuxieme partie propose une etude thematique du nouveau lexique que Heidegger, au contact notamment de la poesie de Holderlin, introduit dans sa meditation du sacre. La troisieme partie entreprend une serie de discernements critiques, en se laissant instruire par les principaux travaux qui ont examine explicitement la comprehension heideggerienne du sacre, du divin, et du poete. Dans une perspective synthetique, la quatrieme partie, enfin, s'efforce de ressaisir l'approche de Heidegger par le biais de ce qui la deborde, en la faisant dialoguer avec d'autres pensees philosophiques et theologiques marquantes; ce qui conduit a considerer, entre autres, la difference du sacre et du Saint. Degage a partir des developpements diachroniques de la premiere partie, le triptyque du sacre, du divin, et du poete structure aussi bien les synchronisations thematiques de la deuxieme partie que les discernements critiques fournis par la troisieme, et il est assume, tout en etant "depasse", par les chapitres systematiques de la derniere partie. (shrink)

The study of agriculture in ancient societies is of vital importance for the understanding of their ecological basis. This article discusses data gathered from Alonso de Molina's dictionary, published in Mexico City in 1571. Molina's information on soil, rain, plants, technology, and human labor applied to agricultural activities gives a picture of the complexity of the several native agricultural systems practiced at that time. Since the Sixteenth Century, native agriculture was impacted by the introduction of new plants, animals, agricultural equipment, (...) and techniques from the Old World. A combination of the two agricultural models conform a new Mexican model of agriculture along the Colonial times. The knowledge of Sixteenth Century agricultural systems is fundamental for the understanding of the history and the conformation of contemporary agro-ecosystems. Recent studies on ecology and social anthropology agree on the necessity to take into account historical data for the discussion of ecological sustainability. (shrink)

El vocabulario en los niños con Trastorno del Desarrollo del Lenguaje (TDL) o con Retraso del Lenguaje (RL) es más pobre que en los niños con un desarrollo típico del lenguaje, por lo que se pretende conocer qué diferencias existen entre ellos. Han participado 66 infantes entre 3 y 5 años; se ha valorado que vocabulario conocen, se ha determinado que tienen menos vocabulario (52%) que sus homónimos (69%), a excepción de la categoría de transportes, en la que tienen los (...) mismos resultados. Finalmente, se determina el listado de categorías que más necesitan trabajar los niños con RL o TDL. (shrink)

This chapter contains sections titled: References.

En el presente trabajo abordamos el papel desempeñado por el exilio padecido por Hilario de Poitiers y su relación con los obispos homeusianos en su comprensión de la realidad teológica del episcopado oriental. Su toma de contacto con las corrientes doctrinales con las que se familiariza durante su estancia en Oriente y la relación que traba con los obispos en los sínodos a los que asiste le llevan a constatar la existencia de más puntos en común que divergencias. Centrándose en (...) la explicación ofrecida a sus colegas galos en De synodis de que el credo del concilio de Ancira de 358 y el homoioúsios no difieren sustancialmente de la comprensión que tienen los partidarios del homooúsios de la relación entre Padre e Hijo aboga por un entendimiento conjunto contra el enemigo común. (shrink)

We present a preliminary high-level formal theory, grounded on knowledge representation techniques and foundational ontologies, for the uniform and integrated representation of the different kinds of (quali- tative and quantitative) knowledge involved in the designing process. We discuss the conceptual nature of engineering design by individuating and analyzing the involved notions. These notions are then formally charac- terized by extending the DOLCE foundational ontology. Our ultimate purpose is twofold: (i) to contribute to foundational issues of design; and (ii) to support (...) the development of advanced modelling systems for (qualitative and quantitative) representation of design knowledge. (shrink)

This paper attempts to answer whether the property of “efficacy” can be attributed to constitutive rules. In particular, according to Di Lucia, I will point out some problems that the “semantic conception of efficacy” has concerning constitutive and regulative rules. Then, the main goal of the paper will be to reflect on the possibility of the efficacy of constitutive rules by means of a complex case that the semantic conception seems to disregard: The case of the cheater. Does the action (...) of the cheater show the inefficacy of constitutive rules? Does she play the game while breaking the rule? Can the semantic conception of efficacy explain this situation, or do we need a more flexible concept of efficacy that takes nomotropism into account? These are some of the questions I will try to answer. (shrink)

En 1993 y 2012 la poeta irlandesa Mary O’Malley publicó Valparaiso y Where the Rocks Float que edificó alrededor de la figura del mar y de la zona costera irlandesa donde nació. En ambas colecciones, la figura del mar se transforma en un potente agente activo que denuncia el rol de la mujer en la sociedad irlandesa y la explotación de los espacios azules con fines de consumo. Utilizando el análisis de Donna Haraway en Manifiesto cíborg (1985), este artículo analizará (...) una selección de textos de ambos poemarios para estudiar el vínculo entre mujer y mar como agentes activos contra la opresión patriarcal y la explotación capitalista. (shrink)

La investigación presentada explora el método Painting Dialogues, llevado a cabo en la Universidad de Cádiz, durante la estancia postdoctoral de su creadora, Małgorzata Karczmarzyk, con estudiantes de Educación Infantil.A partir de la experiencia de creación compartida y del análisis y reflexión conjunta de la huella gráfica originada a modo de cartografía, el diálogo pictórico se presenta como proceso clave de aprendizaje. Esta forma de comunicación ayuda a comprender e interiorizar el conocimiento, potenciando la expresividad, la sensorialidad, la intuición, la (...) confianza y la escucha hacia uno mismo y hacia el otro. (shrink)

Product structures are represented in engineering models by depicting and linking components, features and assemblies. Their understanding requires knowledge of both design and manufacturing practices, and yet further contextual reasoning is needed to read them correctly. Since these representations are essen- tial to the engineering activities, the lack of a clear and explicit semantics of these models hampers the use of information systems for their assessment and exploita- tion. We study this problem by identifying different interpretations of structure rep- resentations, (...) and then discuss the formal properties that a suitable language needs for representing components, features and combinations of these. We show that the representation of components and features require a non-standard mereology. (shrink)

The purpose of professional education programs is to prepare aspiring professionals for the challenges of practice within a particular profession. These programs typically seek to ensure the acquisition of necessary knowledge and skills, as well as providing opportunities for their application. While not denying the importance of knowledge and skills, this paper reconfigures professional education as a process of becoming. Learning to become a professional involves not only what we know and can do, but also who we are. It involves (...) integration of knowing, acting, and being in the form of professional ways of being that unfold over time. When a professional education program focuses on the acquisition and application of knowledge and skills, it falls short of facilitating their integration into professional ways of being. In addition, through such a focus on epistemology, ontology is overlooked. This paper explores what it means to develop professional ways of being where the focus is becoming, not simply knowing as an end in itself. (shrink)