Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

Como objetivo se determinó la relación entre los factores motivacionales y el rendimiento académico. La investigación fue cuantitativa de diseño correlacional con corte transversal. La muestra fueron 315 estudiantes de en dos Facultades de la Universidad Central del Ecuador. Se aplicó un cuestionario de 27 preguntas con escala de Likert. Para los análisis estadísticos se utilizó el software SPSS V25. El resultado principal dio una correlación de Pearson de 0,827, siendo fuerte positiva entre las dos variables. Además, se analizó la (...) relación con las diferentes dimensiones de cada variable. En conclusión, la motivación mejora el rendimiento académico de los estudiantes. (shrink)

The aim of this article is to describe the social networks of the Maghrebis in Alicante, some of the problems they face in their daily life, and the role played by the “mosque” as a place not only of prayer but also of mutual help and support. At the same time, the analysis shows that Islamophobia has increased in the city, as it has done in other places in Spain and Europe following the Al-Qaeda terrorist attacks, with the resulting rejection (...) of the Maghrebis clearly seen in their relationship with local inhabitants and in some of the local authorities’ political decisions. (shrink)

Three‐dimensional structured illumination microscopy (3D‐SIM) has opened up new possibilities to study nuclear architecture at the ultrastructural level down to the ∼100 nm range. We present first results and assess the potential using 3D‐SIM in combination with 3D fluorescence in situ hybridization (3D‐FISH) for the topographical analysis of defined nuclear targets. Our study also deals with the concern that artifacts produced by FISH may counteract the gain in resolution. We address the topography of DAPI‐stained DNA in nuclei before and after (...) 3D‐FISH, nuclear pores and the lamina, chromosome territories, chromatin domains, and individual gene loci. We also look at the replication patterns of chromocenters and the topographical relationship ofXist‐RNA within the inactive X‐territory. These examples demonstrate that an appropriately adapted 3D‐FISH/3D‐SIM approach preserves key characteristics of the nuclear ultrastructure and that the gain in information obtained by 3D‐SIM yields new insights into the functional nuclear organization. (shrink)

Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...

Together, their work signals a new direction in the field and offers refreshingly original insights into a broad spectrum of texts.

We welcome Blumenthal-Barby’s et al. (2022) plaidoyer for the integration of philosophy in bioethics because of a perceived mutual benefit. Drawing on experience from a collaborative project, funde...

El blanco y el negro son más que colores, son claves de un contraste simbólico en islas que montaron su estructura social –desde los tiempos coloniales– sobre la esclavitud que racializó las relaciones sociales y generó con ellas modos diversos de discriminación que llegan hasta nuestros días. Uno de los importantes aportes del negro a las artes plásticas del Caribe, es su color, un signo visual en el universo de las tensiones raciales, nacidas en el seno mismo de la sociedad (...) moderno–colonial. Este trabajo se propone distinguir esa trayectoria de significaciones visuales, a través de una selección de obras que emplean el blanco y el negro a partir del soporte físico del cuerpo con todas sus capacidades expresivas. Uno de los textos más significativos del siglo XX sobre la cuestión, Piel negra, máscaras blancas (1952) de Frantz Fanon, será asumido como un recurso de interpretación crítica para el estudio de la selección de obras y autores del Caribe insular que se inscriben en los conflictos de la racialización e inferiorización de las corporalidades, para explorar formas de un humanismo decolonizador, devolver el hombre a su lugar, resituar su “yo” y revalorizar su sitio en la historia. (shrink)

Many of the classic theorems of first order classical logic can be interpreted in two ways, opposed generally. They could be seen like wealth of structures or poverty in the languaje expressive power. The objective of this article is to study three classic theorems of the first order logic: the ..

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

This article presents an impact assessment framework that allows for the evaluation of positive and negative local-level impacts that have resulted from "responsible trade" interventions such as fair trade and ethical trade. The framework investigates impact relating to (1) livelihood impacts on primary stakeholders; (2) socio-economic impacts on communities; (3) organizational impacts; (4) environmental impacts; (5) policies and institutional impacts; and (6) future prospects. It identifies relevant local-level stakeholders and facilitates the analysis of conflicting interests. The framework was developed in (...) the context of, and is applied in this article to, the fair trade coffee industry in northern Nicaragua. It was designed, however, so that it can be applied across commodity sectors and responsible trade initiatives. It is able to do this by accommodating for differences in the social, environmental, political and institutional contexts of different areas, and by taking into account the distinct nature of an initiative's overall objectives, different levels of intervention, and the full range of stakeholders involved. (shrink)

Nuestra sociedad está siendo testigo de la creciente expansión de la industria del sexo convirtiéndose en un negocio transnacional de dimensión exagerada. La prostitución, la pornografía y la trata de mujeres con fines de explotación sexual (o más exactamente el sistema prostitucional), no paran de desarrollarse a través de formas diferentes, cada vez más toleradas y extendidas: turismo sexual, servicios de compañía, compra de esposas por catálogo procedentes de los países asiáticos, pornografía en Internet, pederastia, etc.

In this paper, we will analyse the language used by a group of Tourism ESP students on WhatsApp. The data will be analysed from different perspectives: a) the grammatical mistakes made, and b) the students´ degree of adaptation to the most common linguistic features in text messages. The results indicate that these students continue to make some basic grammatical mistakes they should have already overcome. Moreover, many linguistic features of text messages were encountered in their interventions such as punctuation overuse (...) and deletion and overuse of sounds. Finally, they insert many emojis in their messages to express different meanings. (shrink)

Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the editing and (...) design metaphors suggest. Such metaphors are therefore highly problematic phrases in the context of new gene technologies, for two reasons. On one hand, to design a child of choice by modifying the genome would require modifying any gene of choice, which is more than can be done with current gene technologies, such as CRISPR/Cas. On the other hand, a modification of genes would need to be enough to create any characteristic of choice in the future child. The latter presupposes the assumption of genetic determinism. Moreover, the CRISPR/Cas technology can not only be used in a potentially therapeutic manner at the germline level. In addition, there is the (more likely) scenario of a future clinical therapeutic use of these new gene technologies for modifying the DNA sequence of other cells of the body (somatic genome editing). There is also the option of modifying the epigenome, that is, the spatial configuration of DNA (epigenome editing) (see table 1). Like genetics and genome editing, epigenetics has been at the center of recent popular scientific and ethical discourse as well as scientific debates. The concept of epigenetics has given rise to very different notions of inheritability and responsibility for health, which, however, are oftentimes based on scientifically controversial basic assumptions. That there continues to be covert genetic determinism in the form of epigenetic determinism (see table 2) in debates about epigenetics has been pointed out in ethical analyses of epigenetics. Neither genetic determinism nor epigenetic determinism has been confirmed scientifically. It is therefore important to recognize the concepts that are discussed (and sometimes harshly criticized) in debates about genome editing and epigenetics—for example, concepts about the causal role of DNA for our own life course. This importance is based on the fact that if we understand such controversial concepts, we will be able to remain critical when evaluating scientific knowledge and ethical arguments about genome editing and epigenetics. This chapter, therefore, explains some of these concepts. For an ethical analysis of epigenetics as well as of genome editing, it is necessary to understand and critically reflect upon the underlying concepts of genetic determinism and other, related -isms. The following section offers a detailed introduction to these -isms (section 2; see also table 2). Section 3 provides an ethical analysis of genome editing and epigenetics based on the explanations in section 2. Section 3 focuses on inheritability and responsibility, justice, safety, the problem of consent, and the effects of genome editing and epigenetics on embryos and future generations. This section does not discuss in detail further points that can be found in ethical debates about epigenetics as well as in ethical debates about genome editing. These points include (among others): • fear that the findings of epigenetics and that the methods of genome editing are misused—this also with respect to eugenics and enhancement; • naturalness—an issue we mention in passing a few times in the following analysis; • a possible connection between the genome/epigenome and the concept of human dignity, and the derived danger of instrumentalization and infringement of autonomy when intervening in the genome or epigenome. Since current discourse about ethical issues associated with genome editing focuses mainly on germline interventions, which are, for instance, interventions into a human embryo’s genome, we mainly focus on germline interventions when comparing the debates on genome editing and on epigenetics in section 3. (shrink)

To carry out a bibliographic review of the factors associated with behavioral difficulties in children, but there are global data on these variables. Purpose: The purpose of this study was to review the literature on the factors associated with behavioral difficulties in boys and girls to identify the most influential countries, authors, magazines and institutions, their structures and research directions. Design: This review is based on bibliometric and network analysis of literature published in Scopus and Web of Science. A total (...) of 110 scientifically mapped articles were found in this area. (shrink)

Children with developmental language disorder (DLD) served as a test case for determining the role of extant vocabulary knowledge, endogenous attention, and phonological working memory abilities in cross-situational word learning. First-graders (Mage = 7 years; 3 months), 44 with typical development (TD) and 28 with DLD, completed a cross-situational word-learning task comprised six cycles, followed by retention tests and independent assessments of attention, memory, and vocabulary. Children with DLD scored lower than those with TD on all measures of learning and (...) retention, a performance gap that emerged in the first cycle of the cross-situational protocol and that we attribute to weaknesses in initial encoding. Over cycles, children with DLD learned words at a similar rate as their TD peers but they were less flexible in their strategy use, demonstrating a propose-but-verify approach but never a statistical aggregation approach. Also, they drew upon different mechanisms to support their learning. Attention played a greater role for the children with DLD, whereas extant vocabulary size played a greater role for the children with TD. Children navigate the problem space of cross-situational learning via varied routes. This conclusion is offered as motivation for theorists to capture all learners, not just the most typical ones. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

On pp. 47-51, "Fifth Scenario: The Nazi and His Jew", discusses Adorno's theory of mimesis applied to the phenomenon of Nazi antisemitism. Influenced by Freud's theory, Adorno discussed in "Dialektik der Aufklärung" (1947) the Nazi phobic and distorted image of the Jew. In Adorno's interpretation, the imaginary portrait of the Jew created by the Nazis is in fact their self-portrait, expressing their longing for unlimited power and identification with an imaginary aggressor in order to be themselves the real aggressor.

A pesar de que Max Horkheimer en Eclipse de la razón había analizado los límites de la razón subjetiva, atendien- do a las posibilidades de retornar a la razón objetiva y a su función después del eclipse, a Jay le parecían aún insuficientes estas respuestas. Por ello, regresó al estudio de las conceptualizaciones filosóficas de los fundadores de la teoría crítica y de quienes se quedaron a cargo del Instituto de Investigación Social en Frankfurt. En este sentido, este texto podría (...) verse en continuidad y a distancia respecto a su primer li- bro: Dialectical Imagination. A History of the Frankfurt School and the Institute of Social Research, 1923-1950 (1973); producto de su trabajo de doctorado, enfocado en la formación del Instituto de Investigación Social; en sus principales integrantes: Herbert Marcuse, Max Horkheimer, Theodor Adorno, Leo Löwenthal, Walter Benjamin,Franz Neumann, Otto Kirchheimer, Henryk Grossmann, Erich Fromm, Karl August Wittfogel; en la integra- ción del psicoanálisis; en su exilio a América; en los estudios empíricos sobre el autoritarismo, la estética y la industria cultural. (shrink)

Corruption is a serious problem in Mexico and the available information regarding the levels of academic dishonesty in Mexico is not very encouraging. Academic integrity is essential in any teaching-learning process focussed on achieving the highest standards of excellence and learning. Promoting and experiencing academic integrity within the university context has a twofold purpose: to achieve the necessary learnings and skills to appropriately perform a specific profession and to develop an ethical perspective which leads to correct decision making. The objective (...) of this study is to explore the relationship between academic integrity and ethical behaviour, particularly workplace behaviour. The study adopts a quantitative, hypothetical and deductive approach. A questionnaire was applied to 1203 college students to gather information regarding the frequency in which they undertake acts of dishonesty in different environments and in regards to the severity they assign to each type of infraction. The results reflect that students who report committing acts against academic integrity also report being involved in dishonest activities in other contexts, and that students who consider academic breaches less serious, report being engaged in academic misconduct more frequently in different contexts. In view of these results, it is unavoidable to reflect on the role that educational institutions and businesses can adopt in the development of programmes to promote a culture of academic integrity which: design educational experiences to foster learning, better prepare students to fully meet their academic obligations, highlight the benefits of doing so, prevent the severity and consequences of dishonest actions, discourage cheating and establish clear and efficient processes to sanction those students who are found responsible for academic breaches. (shrink)

Este artículo tiene como objetivo revisar el concepto de emancipación en la obra de J. Rancière, particularmente como aparece desarrollado en El maestro ignorante y El espectador emancipado. De esta forma, se muestra que la emancipación no es el fin de un proyecto histórico sino un punto de partida a través de la igualdad de las inteligencias, y por lo tanto, cualquiera puede tener acceso a esta experiencia sin un proceso de concientización o un maestro explicador. Por último, reflexionamos sobre (...) los posibles retos y posibilidades del método de la igualdad. (shrink)

O presente artigo trata da concepção evolucionista da moral, considerando, primeiramente, duas análises que diferem quanto à maior ou menor importância atribuída à evolução. Discutimos, também, dois problemas filosóficos relacionados com a atribuição da origem evolutiva para moral: o determinismo e objetivismo moral. Defendemos que a vinculação entre evolução e moral não implica necessariamente o determinismo nem a exclusão de justificação e crítica. A perspectiva evolucionista pode, a nosso ver, cooperar para a ultrapassagem da oposição racionalismo e empirismo frente à (...) moralidade, ao levar em conta a influência dos sentimentos, mas sem desconsiderar a especificidade das normas morais. This article discusses the evolutionist conception of moral, considering two approaches, which differ in relation to the importance of evolution in understanding moral behavior. Moreover, it discusses two philosophical problems related to the association between moral and evolution: the determinism, and the problem of objectivity of morality. Evolutionist perspective does not always implicate in determinism. Indeed, it can overcome the opposition between rationalism and empiricism, because it considers the nature of the feelings, without denying the specificity of moral norms. (shrink)

En el siguiente trabajo expondré las características principales del materialismo de Alfred Schmidt, el cual, debe ser entendido en su vertiente: no dogmática, crítica y dialéctica. Me refiero a la primera característica, en el sentido de que Schmidt, deja de lado la lectura marxista ortodoxa de la ..

En el presente artículo se pretende dar cuenta de cómo opera el hábito en el cuerpo de las mujeres, particularmente con respecto a la relación amorosa heterosexual-patriarcal. Para ello, se recurrirá a Simone de Beauvoir y a Jean Paul Sartre, desde ahí explicar a qué nos referimos con cuerpo. También se tomará la noción de hábito de Pierre Bourdieu para señalar el orden simbólico patriarcal en las relaciones amorosas sexo-afectivas. En cuanto al abordaje de la idea del amor, se realizará (...) un recorrido histórico a partir del desarrollo de Marcela Lagarde, así como de su concepto de cautiverio, y, finalmente, apuntaremos algunas consideraciones de la ética del placer de Graciela Hierro a modo de conclusión. Palabras clave: hábito, cuerpo, relación amorosa, orden simbólico patriarcal, violencia simbólica. (shrink)

This article names some of the human under standings and ways of being that are fundamental to teaching and learning, which new educational tech nologies, especially the computer, tend to remake, reduce, or replace altogether in K-12 classrooms. The article asks questions and tells stories about students, teachers, and the authors themselves using computers for educational purposes, investigating three particular uses of technology in detail. The authors argue that new educational technologies change the meaning of words common to teachers' vocabularies, (...) especially words such as classroom community, knowing, and coming to know. The authors also argue that human senses used in learning are nullified, if not assaulted, by new educational technologies. (shrink)

Este ensayo da cuenta de la presencia del fenómeno camp como manifestación estética en el poema Strip Tease del escritor argentino Néstor Perlongher. Dicha manifestación estética aparece como un contradiscurso frente a los discursos de lo normativo y de lo permitido para dar cuenta de una manera de ser y de sentir mediante la escritura. Para el análisis del poema se partió de la relación que se puede establecer entre signos semióticos y a partir de los cuales una sintagmática actualiza (...) relaciones paradigmáticas. La razón de este análisis consiste en poder demostrar cómo se manifiestan las ideologías y en este caso, específicamente, la visión del mundo del amplio abanico de posibilidades genéricas que se han exteriorizado con la escritura, frente al denominado discurso gender. (shrink)

Este artículo tiene por objeto reflexionar sobre la articulación de la producción y la reproducción desde un plano normativo, a partir del movimiento de las que limpian. Para ello se analizará la lucha de las Kellys siguiendo la conceptualización de «luchas de frontera» de Nancy Fraser. Se examinarán las estrategias de invisibilización del trabajo de infraestructura del cuidado y su articulación entre lo público y lo privado, dando cuenta de sus contradicciones. Para concluir, poniendo el foco en el proceso de (...) visibilización de este colectivo, señalando las consecuencias sociopolíticas de su emergencia como sujeto político. (shrink)