Estrogen receptor α (ERα) is a ligand‐dependent transcription factor that regulates the expression of estrogen‐responsive genes. Approximately 70% of patients with breast cancer are ERα positive. Estrogen stimulates cancer cell proliferation and contributes to tumor progression. Endocrine therapies, which suppress the ERα signaling pathway, significantly improve the prognosis of patients with breast cancer. However, the development of de novo or acquired endocrine therapy resistance remains a barrier to breast cancer treatment. Therefore, understanding the regulatory mechanisms of ERα is essential to (...) overcome the resistance to treatment. This review focuses on the regulation of ERα expression, including copy number variation, epigenetic regulation, transcriptional regulation, and stability, as well as functions from the point of view post‐translational modifications. (shrink)

Several studies have shown that our visual system may construct a “summary statistical representation” over groups of visual objects. Although there is a general understanding that human observers can accurately represent sets of a variety of features, many questions on how summary statistics, such as an average, are computed remain unanswered. This study investigated sampling properties of visual information used by human observers to extract two types of summary statistics of item sets, average and variance. We presented three models of (...) ideal observers to extract the summary statistics: a global sampling model without sampling noise, global sampling model with sampling noise, and limited sampling model. We compared the performance of an ideal observer of each model with that of human observers using statistical efficiency analysis. Results suggest that summary statistics of items in a set may be computed without representing individual items, which makes it possible to discard the limited sampling account. Moreover, the extraction of summary statistics may not necessarily require the representation of individual objects with focused attention when the sets of items are larger than 4. (shrink)

We investigated whether the inferior parietal lobule (IPL) responds in real-time to multisensory inconsistency during movement. The IPL is thought to be involved in both the detection of inconsistencies in multisensory information obtained during movement and that obtained during self-other discrimination. However, because of the limited temporal resolution of conventional neuroimaging techniques, it is difficult to distinguish IPL activity during movement from that during self-other discrimination. We simultaneously conducted electroencephalography (EEG) and near-infrared spectroscopy (NIRS) with the goal of examining IPL (...) activity with a high spatiotemporal resolution during single reaching movements. Under a visual feedback-delay condition, gamma event-related synchronization (γ-ERS), i.e., an increase in gamma (31–47 Hz) EEG power, occurred during reaching movements. This γ-ERS is considered to reflect processing of information about prediction errors. To integrate this temporal information with spatial information from the NIRS signals, we developed a new analysis technique that enabled estimation of the regions that show a hemodynamic response characterized by EEG fluctuation present in the visual feedback-delay condition. As a result, IPL activity was explained by γ-ERS specific to visual feedback delay during movements. Thus, we succeeded in demonstrating real-time activation of the IPL in response to multisensory inconsistency. However, we did not find any correlation between either IPL activity or γ-ERS with the sense of agency. Therefore, our results suggest that while the IPL is influenced by prediction error signals, it does not engage in direct processing underlying the conscious experience of making a movement, which is the foundation of self-other discrimination. (shrink)

SUPERANNO A unique collection of photographs by WRA photographer Hikaru Iwasaki focuses on resettlement using photos of Japanese Americans following their release from WRA camps from 1943 to 1945. Author Lane Hirabayashi explores the use of photography in the WRA mission to encourage “loyal” Japanese Americans to return to society at large, and convince Euro-Americans this was safe. Hirabayashi also assesses the success of the WRA project, and the multiple uses of the photographs over time.

There is growing evidence that individuals with social anxiety show impaired cortisol recovery after experiencing social evaluative stressors. Yet, little is known regarding the cognitive processes underlying such impaired cortisol recovery. The present study examined the effect of post-event processing (PEP), referred to as repetitive thinking about social situations, on cortisol recovery following a social stressor. Forty-two non-clinical university students (23 women, 19 men, mean age = 22.0 ± 2.0 years) completed the Trier Social Stress Test (TSST), followed by a (...) thought sampling procedure which assessed the frequency of PEP reflecting the TSST. A growth curve model showed PEP and social anxiety interactively predicted cortisol recovery. In particular, PEP predicted impaired cortisol recovery in those with low levels of social anxiety but not in those with high levels of social anxiety, which contradicted the initial hypothesis. These findings suggest that PEP is differentially associated with cortisol recovery depending on levels of social anxiety. The possible mechanisms underlying these findings were discussed in terms of protective inhibition framework. (shrink)

The impact of _Harukanaru Sanga ni_ upon its publication in 1947 was immediate and dramatic- -the impetus, many have argued, for a post-war peace movement in Japan that has lasted over half a century. Now the text is available for the first time in English as _In the Far Away Mountains and Rivers_, a heart-wrenching and thought-provoking collection of letters, journal entries, and essays written by University of Tokyo students as they were drafted to fight in World War II. Many (...) of these students faced certain death as pilots in the kamikaze squads. Many of them deplored the war, and many were simply motivated by a sense of duty to their families and their country. They turned to poetry, philosophy, and religion—all in an attempt to make sense of the universal tragedy of war. (shrink)

The subject of Western environmental ethics has been widely written about and discussed but the same can not be said of 'Japanese' environmental ethics. This discipline has not been covered in any branch of Japanese philosophy nor has there been sufficient pressure exerted by ecologists on Japanese thinkers and writers to explain how the Japanese code addresses environmental concerns. Although some Japanese scholars have in the past articulated their ideas on working with the natural world, the field covering the spirit (...) and core of Japanese environmental ethics remains largely unexplored. This paper examines and compares the discipline of Japanese environmental ethics, a 'bottom up process', with that of the Western model, a 'top down process'. It defines, and presents a new insight into environmental ethics from the Japanese perspective where the concept of 'living with nature' is more sensitive towards the environment than is the Western one of 'taming nature'. (shrink)

Cytoskeletal organization in embryonic skeletal muscle cells has been examined by transmission electron microscopy; the technique involves preparation using the platinum replication method of freezedried samples, with and without cryofracture. The cytoskeletons in developing muscle cells appear to play a role in preserving cell shape as well as in anchoring myofibrils to cell membrane.

This work examines Japanese government policies that impact on the environment in order to determine whether they incorporate a sufficient ethical substance. In the enquiry into the ethics of the policies, Kagawa-Fox explores how Western philosophers combined their theories to develop a 'Western environmental ethics code'; she also reveals the existence of a unique 'Japanese environmental ethics code' built on Japan's cultural traditions, religious practices, and empirical experiences. The discovery of the distinctive Japanese code is not only important for what (...) it discloses as a new philosophy, but most importantly how it can be used to analyse the ethical framework of the Japanese policies. In spite of the positive contributions that Japan has shown towards the global environment, the government has failed to show a corresponding moral obligation to the world ecology in its global environmental policy. The policies examined in the three case studies comprising whaling, nuclear energy, and forestry, have also been found wanting in ecological ethical considerations, both from a Western and Japanese perspective. The main reason for this is that the integrity of the policies has been compromised by Japanese vested interest groups; business and political interests ensure that the policies are primarily focused on maintaining sustainable economic growth. Whilst Japan's global environmental policy initiatives are the key to its economic survival into the 21st century, and these initiatives may achieve their aim, they do however fail the Japanese code of environmental ethics."--Publisher's description. (shrink)

The standing screens on the title is the oldest work extant of KANO Motonobu's work as folding screens of thick colored flowers and birds with golden background. This thesis designates that the scenery and the motif of the work are in correspondence with both descriptions of the scenery of Pure Land in several Buddhist scriptures and the design of actual gardens. Firstly, a peacock on the right hand screen is focused to indicate the bird connotes the elements of auspicious birds (...) in Buddhism, such as Mahamayuri and Kalavinka.Secondly, the elements of the scenery in the work, such as the four seasons at the same time ∼ the depiction of perpetuity ∼ and the existence of a pond, are identified with the description of Pure Land in Kwan-mu-liang-shou-ching and Ta-wuliang-shou-ching. These elements of the garden in the work are placed similarly to the Pure Land style gardens, which are illustrated in "Center and Surrounds of Kyoto" 's. In consideration of the above factors, the conclusion that, in the work, KANO Motonobu succeeded to portray the ideal garden by combining the scenery of Pure Land and that of actual gardens, is drawn. (shrink)

Familial amyloidotic polyneuropathy (FAP) is an inherited systemic amyloidosis, characterized by the extracellular deposition of fibrillar amyloid protein, i.e. a variant type of prealbumin, and by prominent peripheral nerve involvement. We recently established the basis of FAP, using a cloned human prealbumin cDNA, restriction endonuclease(s) and Southern blot procedures. This approach clearly revealed a direct link between mutation in the prealbumin gene and FAP; individuals with FAP are heterozygous for the prealbumin gene, carrying one normal and one mutant gene. Molecular (...) analysis of the prealbumin gene yielded pertinent data on the genetic basis for FAP. (shrink)

This study investigates the influence of a robot's speech rate. In human communication, slow speech is considered boring, speech at normal speed is perceived as credible, and fast speech is perceived as competent. To seek the appropriate speech rate for robots, we test whether these tendencies are replicated in human-robot interaction by conducting an experiment with four rates of speech: fast, normal, moderately slow, and slow. Our experimental results reveal a rather surprising trend. Participants prefer normal and moderately slow speech (...) to fast speech. A robot that provides normal or moderately slow speech is perceived as competent. We further study how context affects this perception. In a situation where the robot and participants talk while walking, we found that slow speech was the most comprehensible. In addition, slow speech is subjectively perceived as good as moderately slow and normal speech. Keywords: Human-robot interaction; speech rate. (shrink)

This study investigates the influence of a robot’s speech rate. In human communication, slow speech is considered boring, speech at normal speed is perceived as credible, and fast speech is perceived as competent. To seek the appropriate speech rate for robots, we test whether these tendencies are replicated in human-robot interaction by conducting an experiment with four rates of speech: fast, normal, moderately slow, and slow. Our experimental results reveal a rather surprising trend. Participants prefer normal and moderately slow speech (...) to fast speech. A robot that provides normal or moderately slow speech is perceived as competent. We further study how context affects this perception. In a situation where the robot and participants talk while walking, we found that slow speech was the most comprehensible. In addition, slow speech is subjectively perceived as good as moderately slow and normal speech. Keywords: Human-robot interaction; speech rate. (shrink)

This special issue explores the significance of collectivism in modern and contemporary Japanese art. Japanese artists banded together throughout the twentieth century to work in collectives, reflecting and influencing each evolution of their culture. Illuminating the interplay between individual and community throughout Japan’s tumultuous century, the contributors to this issue examine both the practical internal operations of the collectives and the art that they produced. One contributor studies the art societies of prewar imperial Japan, whose juried art salons defined a (...) new _nihonga_ painting tradition. While recent scholarly work on art produced during World War II has tended to neglect the collectivist tradition, this issue covers wartime groups like the Art Unit for Promoting the Munitions Industry and the important questions they pose about the relationship between artists and the state. Art collectives in post-occupation Japan gained prominence working in the experimental vanguard of the global art scene in painting, sculpture, design, and intermedia projects. Adding a crucial dimension to the study of Japanese art and modernism, this issue explores how these groups attempted to accommodate the creative paradox of individualism within collectivism. _Contributors: Maki Kaneko, Kuroda Raiji, John Szostak, Miwako Tezuka, Ming Tiampo, Reiko Tomii, Alicia Volk, Midori Yoshimoto Reiko Tomii_ is an independent art historian and curator in New York. She is coauthor of _Xu Bing_. _Midori Yoshimoto_ is Associate Professor of Art History and curator of two galleries at New Jersey City University. She is the author of _Into Performance: Japanese Women Artists in New York_. (shrink)

Political developments in Japan from the latter part of 2000 to the year 2001 were highlighted by the executive transition from unpopular Yoshiro Mori to exceptionally popular Junichiro Koizumu as the nation's leader.

Young children generally learn words from other people. Recent research has shown that children can learn new actions and skills from nonhuman agents. This study examines whether young children could learn words from a robot. Preschool children were shown a video in which either a woman or a mechanical robot labeled novel objects. Then the children were asked to select the objects according to the names used in the video. The results revealed that children in the human condition were more (...) likely to select the correct objects than those in the robot condition. Nevertheless, the five-year-old children in the robot condition performed significantly better than chance level, while the four-year olds did not. Thus there is a developmental difference in children’s potential to learn words from a robot. The results contribute to our understanding of how children interact with non-human agents. Keywords: developmental cybernetics; word learning; social cognition; cognitive development. (shrink)