It is argued that Kull’s approach to aesthetics complements a cognitive semiotic approach to culture. The concept of ‘ecological, semiotic fitting’ allows us to connect the three main concepts of beauty we encounter in discussions about the aesthetic, where the term beauty is, firstly, used to refer a positive experience in relation to what is perceived, or, secondly, to a positive experience in relation to an intentional action or, thirdly, to a positive experience in relation to a sense making process. (...) Kull makes a strong case for the ‘ecological, semiotic fitting’ being the common underlying structure of all three manifestations of the aesthetic. (shrink)

This volume contains a selection of essays presented at the international conference on Cultural Crises in Art and Literature, held in Groningen in November 2002, in a special session on the question of the autonomy of the arts. Do we witness, in western culture, the end of the autonomy of the arts as it has been conceptualized and institutionalized since the eighteenth century? Indeed, developments of quite a different nature seem to have contributed to a blurring of boundaries between art (...) and non-art, art and the market, art and politics or ethics, as well as between the arts themselves, and between 'high' and 'low' art. Although this volume does not pretend to map this complex process in its entirety - partly because it is impossible to step out of one's own history - it is meant as a contribution to the elucidation of the process itself, offering some challenging explanations as to the heat of the current debate. (shrink)

This book is about the interrelationship between nature, semiosis, metarepresentation and (self-)consciousness, and the role played by metarepresentation in ...

The comprehension of living organisms in all their complexity poses a major challenge to the biological sciences. Recently, systems biology has been proposed as a new candidate in the development of such a comprehension. The main objective of this paper is to address what systems biology is and how it is practised. To this end, the basic tools of a systems biological approach are explored and illustrated. In addition, it is questioned whether systems biology ‘revolutionizes’ molecular biology and ‘transcends’ its (...) assumed reductionism. The strength of this claim appears to depend on how molecular and systems biology are characterised and on how reductionism is interpreted. Doing credit to molecular biology and to methodological reductionism, it is argued that the distinction between molecular and systems biology is gradual rather than sharp. As such, the classical challenge in biology to manage, interpret and integrate biological data into functional wholes is further intensified by systems biology’s use of modelling and bioinformatics, and by its scale enlargement. (shrink)

In this paper, the process for firms to decide whether or not to invest in corporate social responsibility is treated from a real option perspective. We extend the Husted framework with an important extra parameter that allows us to understand the timing of CSR investment and explain why some companies drag their feet over CSR investments. Our model explicitly allows for the impact of the opportunity cost of delaying the CSR investment decision, providing firms with tools to determine the optimal (...) moment of exercising the CSR investment option. We illustrate our timing model through a case study and analyze governmental support strategies for CSR from a real options perspective. (shrink)

In this paper I argue that semiotic cognition is a distinctive form of cognition, which must have evolved out of earlier forms of non-semiotic cognition. Semiotic cognition depends on the use of signs. Signs are understood in terms of a specific organization, or structure, of the cognitive process. Semiotic cognition is a unique form of cognition. Once this form of cognition was available to humans, the semiotic provided the ground structure for an evolutionary development that was no longer strictly Darwinian, (...) but followed its own — semiotic — logic. In the increasingly abstract ways in which the ubiquitous difference is dealt with, we discover this logic of cultural evolution, which determines the course of long term cultural change. (shrink)

Report of the symposium 'Towards a Philosophy of Systems Biology' held at the Vrije Universiteit of Amsterdam (VUA), the Netherlands, from 2 to 3 June 2005.

Together with the city council elections, the citizens of Antwerp elected on 8 October 2000 nine district councils. This new decentralised political level is primarily initiated to restore the confidence of the citizens in the city government. By analysing the results of the city and the district elections we try to find indications whether citizens feel closer to their new district governments or not. Apparently district elections resulted neither in a higher voter turn-out, nor in less blank votes. Nevertheless, there (...) is a significant correlation of voter turn-out and blank votes with population of the districts. And although the differences between the electoral results of the city elections and the district elections are not huge, a different political landscape comes more or less into existence in the several districts. Quite surprisingly the number of list votes is higher on the district elections than on the city elections, while we would have expected a higher number of preferential votes. Correctingfor incumbents and famous candidates on the lists, our initial expectations hold much better. Generally spoken, we can conclude that the district elections do not give much proof of a closer connection between the citizens and the city government. Nevertheless we find some important differences between the districts. (shrink)

At the provincial council elections of the 13th of december 1987 only one of the three traditional political families made a general progress, namely the socialists. Mainly in Wallonia the socialists improved their position seriously. In this part of the country they are the only and absolute winners of these provincial elections. The christian-democrats and the liberals were subject of a severe decline. Por the christian-democrats this decline was mainly situated in Flanders. The liberals had a serious decline in W (...) allonia, that couldn't be counterbalanced by the small progress they made in Flanders. The ecologists made progress, mostly in the Flemish part of the country and in Brussels. By the federalist parties the Volksunie had a loss of three provincial council seats in Flanders, but the seperatistic and extreme right party Vlaams Blok won two seats. The communists disappeared totally from the provincial councils in Belgium. The results of the provincial council elections had a similar profile as these of the House of Representatives and the Senate which where held at the same day. (shrink)

About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping is the gold standard for the identification of “eloquent” areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity recorded with extraoperative electrocorticography during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha and beta bands could further (...) improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient’s degree of attention to the stimulus. We show that diagnostic ability can be increased by 3–5% by combining gamma and alpha and by 7.5–11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy. (shrink)

Dit boekt brengt negen opstellen samen van Gentse filosofen en godsdienstwetenschappers. Etienne Vermeersch, Freddy Mortier, Johan Braeckman met Stefaan Blancke, Rik Pinxten, Patrick Loobuyck, Balagangadhara Rao met Sarah Claerhout, Benjamin Biebuyck, Nel Grillaert, en Danny Praet leveren, elk vanuit hun eigen interesses en expertises, kritische bijdragen over de complexe relatie tussen christendom en filosofie: wijsgerige kritiek op het christendom en christelijk gebruik van de filosofie. Vanuit het ruimere perspectief van de interactie tussen wijsbegeerte, wereldbeeld en wetenschappen bestrijken de elf (...) auteurs de volledige periode van het vroege christendom tot het hedendaagse fundamentalisme. Het boek bevat zowel historische als theoretische benaderingen. Drie bijdragen hebben het werk en de impact van Nietzsche tot thema, drie bespreken verschillende aspecten van het fundamentalisme. Thema’s zoals het geloof in een hiernamaals, de relatie tussen christenen en niet-christenen, de impact van het christendom op het westerse wereldbeeld en de benadering van andere culturen, en de radicale kritiek van filosofen op het theïsme en de christelijke moraal maken van deze bundel een uitzonderlijk rijke collectie die lezers met diverse interesses zal aanspreken. (shrink)

At the provincial council elections of the 13th of October 1985 in Belgium two of the three traditional politie al families made a general progress, namely the socialists and the christian democrats. The liberals had a serious decline in Flanders, but for the greater part this was counterbalanced by the liberal progress in Wallonia. The ecologists also made progress, mostly in the Flemish part of the country. Beside the Flemish liberals, the big losers of these elections were the regional parties, (...) namely the Flemish nationalists and for sure the Walloon Rally who disappeared from the electoral scene. (shrink)

Pastoral power and techniques of the self: Foucault and the asceticism of the Desert Fathers This article argues that Foucault would probably have wanted to discuss a number of subjects and texts which are now almost completely lacking: the novelistic texts known as the Apocryphal Acts of the Apostles and some hagiographical sources. The Christian views on sexuality were sometimes less ‘orthodox’ and more extreme than what Foucault presented, probably under the influence of Paul Veyne. The Life of Anthony by (...) Athanasius contains a passage which is not analyzed thoroughly in the volume as it was published but which is a key text for the development of Christian hermeneutics and pastoral power. (shrink)

Via a historical reconstruction, this paper primarily demonstrates how the societal debate on genetically modified organisms (GMOs) gradually extended in terms of actors involved and concerns reflected. It is argued that the implementation of recombinant DNA technology out of the laboratory and into civil society entailed a “complex of concerns.” In this complex, distinctions between environmental, agricultural, socio-economic, and ethical issues proved to be blurred. This fueled the confusion between the wider debate on genetic modification and the risk assessment of (...) transgenic crops in the European Union. In this paper, the lasting skeptical and/or ambivalent attitude of Europeans towards agro-food biotechnology is interpreted as signaling an ongoing social request – and even a quest – for an evaluation of biotechnology with Sense and Sensibility. In this (re)quest, a broader-than-scientific dimension is sought for that allows addressing the GMO debate in a more “sensible” way, whilst making “sense” of the different stances taken in it. Here, the restyling of the European regulatory frame on transgenic agro-food products and of science communication models are discussed and taken to be indicative of the (re)quest to move from a merely scientific evaluation and risk-based policy towards a socially more robust evaluation that takes the “non-scientific” concerns at stake in the GMO debate seriously. (shrink)

I define serendipity as the art of making an unsought finding. And I propose an overview of my collection of serendipities, the largest yet assembled, chiefly in science and technology, but also in art, by giving a list of ‘serendipity patterns’. Although my list of ‘patterns’ is just a list and not a classification, it serves to introduce a new and possibly stimulating perspective on the old subject of serendipity. Knowledge of these ‘serendipity patterns’ might help in expecting also the (...) unexpected and in finding also the unsought. * I acknowledge A. D. de Groot, R. C. M. Noordam, B. P. van Heusden, T. Pinkster, C. J. van den Berg, T. A. F. Kuipers, A. Wegener Sleeswijk and my referee for their suggestions and I dedicate this article to T. A. van Kooten. Cases and studies of serendipidy are welcome. À propos: a travelling serendipity exhibition is available, also for ‘new democracies’: ‘Freedom of opportunity as developed by democracy is the best human reaction to divergent phenomena. We may, in fact, define ‘freedom’ as ‘the opportunity to profit from the unexpected.’ (Langmuir [1956]). (shrink)

The title of this collection of essays reflects the confusing complexity of the issues at stake. “Arts,” “Beyond Art,” and “Art”: what “art” are we talking about? In the introductory chapter, the editors follow, among others, the analyses of Arthur Danto and Pierre Bourdieu, concluding that “art,” as a series of canonical art works that reflect and legitimize the taste of an elite and defines the content of arts education, has come to an end. More specifically, the focus should change (...) from the qualities of works of art to the processes of imaginative consciousness and to other cognitive processes that give form to the “artistic” as a dimension of life. In his concluding essay, Barend van Heusden... (shrink)

Keuze van artikelen uit het werk van de Vlaamse filosoof over wetenschap, milieu, en medische en biologische ethiek.

Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Is it wrong to say Heidegger developed a metaphysics of technology? It doesn't seem to be so. The distinction he makes between technology and the essence of technology, a distinction that proves to be the core of his philosophy of technology, is clearly a metaphysical one: what appears is rooted in something else that does not appear . This is peculiar, for Heidegger is commonly known of course as a thinker who tenaciously tried to overcome metaphysics. In this paper, I (...) wish to examine to what extent Heidegger's philosophy of technology is metaphysical, and to what extent it isn't. In doing so, I want to make clear how Heidegger could arrive at the statement that the essence of technology jeopardizes the essence of man, and why according to him insight can bring salvation here. (shrink)