We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate that these changes in gene expression play an essential role during regeneration by stimulating the anabolic pathways required for the reconstruction of a new appendage. We hypothesize that during regeneration, cells use leptin, slc2a3, proinsulin, g6pd, hif1α expression, receptor tyrosine kinase (RTK) signaling, and the production of reactive oxygen species (ROS) to (...) promote glucose entry into glycolysis and the pentose phosphate pathway (PPP), thus stimulating macromolecular biosynthesis. We suggest that this metabolic shift is integral to the appendage regeneration program and that the Xenopus model is a powerful experimental system to further explore this phenomenon.Also watch the Video Abstract. (shrink)

ENRIQUE BONETE: Neuroética práctica, Desclée de Brouwer, 2011, 192 pp.; JOSÉ MANUEL GIMÉNEZ AMAYA y SERGIO SÁNCHEZ-MIGALLÓN: De la Neurociencia a la Neuroética, Navarra, EUNSA 2010, 192 pp.; KATHINKA EVERS: Neuroética. Cuando la materia se despierta, Argentina- España, Katz, 2011, 208 pp.

En este artículo se presenta una ontología según la cual el mundo actual no es el único real, pero, al contrario que en la ontología de Lewis, no todos los mundos son reales, porque muchos de ellos siguen siendo mundos meramente posibles. Tras examinar cuidadosamente los pros y contras de los diferentes tipos de actualismo y posibilismo, esta nueva concepción posibilista (el multiposibilismo actual) es elaborada y defendida contra algunas objeciones. El punto de partida es que los mundos posibles sí (...) que incluyen individuos no actuales, y no únicamente estados de cosas no actualizados acerca de individuos actuales. Y el núcleo de la teoría consiste en conceder que muchos mundos son reales por igual, y ontológica y nomológicamente independientes entre sí, pero que la mayoría de ellos genera su propia serie de mundos posibles pero no actualizados inter-relacionados. De esta manera, permanecen intactas nuestras inuiciones metafísicas más profundas (como la identidad transmundana, la contingencia -tanto lógica como metafísica- del mundo actual, o los principios de la lógica clásica), pero existe una respuesta a la pregunta: "¿por qué precisamente el mundo actual es el real?" al negar que solamente él sea real. Al final del artículo se ponen de manifiesto algunas de las ventajas y del potencial ontológico y teológico de esta hipótesis. (shrink)

The systematic importance of the eidetic account of phantasy for Husserlian phenomenology in general is undisputed, but whether this account can be relevant for Aesthetics has often been put into question. In this paper I argue that Husserl’s rich phenomenology of phantasy, and in particular his account of perceptual phantasy, can nevertheless significantly enhance our understanding of how we recognize and imaginatively participate in artistic fictions. Moreover, I show how Husserl’s peculiar formulation of a non-intuitive phantasy at stake in artistic (...) representation anticipates some uses of the imagination in Aesthetics suggested by Ernst Gombrich and Kendall Walton. (shrink)

What does it mean to manage effectively? This paper discusses the historical problem of the criterion, stemming from skeptical thinkers, and applies it in a management environment. The aim is to highlight how awareness of criteria in judging outcomes may yield richer and more nuanced views of effectiveness. The argument begins by exploring the characterization of management actions and discusses how a distinguishing quality of those actions is that they’re oriented towards outcomes. The question is then how to assess outcomes (...) associated with effective management. The problem of the criterion, which identifies the multiple criteria used in judgments, is introduced and discussed in connection with outcomes. A guiding question is, What are the criteria used to assess whether outcomes are associated with effective management? A central point in the discussion is that the assessment of outcomes in effective management is contingent upon the criteria that are applied. These criteria function as part of a contextual and complex network. Thus what are seemingly simple and obvious answers may be seen in a different and more nuanced manner once various criteria are identified. The management vision that emerges is one in which management is more layered than simply ‘achieving results.‘ For although results do matter, the network of criteria used to assess outcomes may present those outcomes in new and different lights. Management is seen as the art of recognizing varied possibilities based on the criteria used to assess outcomes. (shrink)

Résumé : L’article propose une démarche méthodologique permettant d’identifier la réflexion professionnelle chez des stagiaires en formation à l’enseignement. En effet, la capacité d’analyser sa pratique de façon réflexive est une composante d’une compétence professionnelle à développer selon le Ministère de l’Éducation du Québec. Une certaine forme de réflexion chez les étudiants est donc à acquérir et, du point de vue des tuteurs de stage, à faire acquérir. Quels sont les critères implicites que les enseignants associés des écoles ou les (...) superviseurs universitaires identifient afin d’évaluer la présence ainsi que la qualité de la compétence réflexive chez le stagiaire ? L’étude identifie une dizaine de points de repère afin de favoriser chez les tuteurs de stage l’évaluation de la compétence réflexive de leurs stagiaires. L’article valide ces critères à partir d’un extrait de discours de stagiaire, puis confronte cet extrait à une autre approche, consistant à détecter des reconceptualisations chez les stagiaires pour dépister de la réflexion. Une certaine cohérence s’établit avec les critères empiriques d’identification de la réflexion identifiés par induction chez les tuteurs de stage. S’ensuit une discussion sur ces critères en lien avec les approches méthodologiques adoptées. La recherche utilise un devis qualitatif et s’appuie sur des entretiens semi-structurés. Abstract : This article proposes a methodological process aimed at identifying professional reflection among student teachers in teacher education. The ability to analyze one’s practice reflectively is a component of one of the professional competencies that must be developed according to Quebec’s Ministry of Education. A certain form of reflection must therefore be acquired by students, and, from the standpoint of practicum supervisors, it must be developed in students. What are the implicit criteria that mentor teachers in schools or university-based supervisors identify in order to assess the presence and quality of student teachers' reflective competence? This study identifies a dozen guideposts to assist supervisors in this direction. The article first validates these criteria based on an excerpt of a student teachers’ statements, then submits the same excerpt to another approach aimed at detecting the student teacher’s reconceptualizations with a view to pinpointing reflection. A certain degree of coherence is established with the empirical criteria for identifying reflection as identified inductively by practicum supervisors. A discussion follows on these same criteria in line with the methodological approaches adopted. This research is based on a qualitative study. (shrink)

In this work, a new intelligent control strategy based on neural networks is proposed to cope with some external disturbances that can affect quadrotor unmanned aerial vehicles dynamics. Specifically, the variation of the system mass during logistic tasks and the influence of the wind are considered. An adaptive neuromass estimator and an adaptive neural disturbance estimator complement the action of a set of PID controllers, stabilizing the UAV and improving the system performance. The control strategy has been extensively tested with (...) different trajectories: linear, helical, circular, and even a lemniscate one. During the experiments, the mass of the UAV is triplicated and winds of 6 and 9 in Beaufort’s scale are introduced. Simulation results show how the online learning of the estimator increases the robustness of the controller, reducing the effects of the changes in the mass and of the wind on the quadrotor. (shrink)

Athenian citizens deliberate in the assembly, but the theatre also becomes a place for public debate. In addition to being a consequence of economic or cultural aspects, democracy is a consequence of the development of a democratic imaginary. Located in that imaginary, Greek tragedies, regarded as «democratic myths», work to reaffirm Athenian democracy. Far from being dogmatic, the tragic myth explores the contradictions of social and personal life and implicitly or explicitly seeks their correction. This dramatic genre encourages participation from (...) the spectator (citizen) that greatly exceeds the schematic reduction in Aristotelian theory of catharsis. Greek tragedy proposes the existence of an «audience», of spectators who need a sufficient level of maturity to make that assessment. Democracy is a path, or perhaps an active utopia, which should combine the political order with a coherent culture and art.Los ciudadanos atenienses deliberaban en la asamblea, pero también el teatro se convierte en un lugar de debate público. Porque una democracia (también la ateniense) no solo es consecuencia de aspectos económicos o de orden cultural, sino también del desarrollo de un imaginario democrático. Y es en dicho imaginario donde se inscriben las tragedias griegas, consideradas como «mitos democráticos» que servían para reafirmar la democracia ateniense. Lejos de cualquier dogmatismo, el mito trágico explora las contradicciones de la vida social y personal, y se pregunta, de manera expresa o tácita, por su posible corrección. Este género dramático induce a una participación del espectador (ciudadano), que va más allá de la esquemática reducción de la teoría aristotélica de la catarsis. El teatro griego propone la existencia de un «público», de unos espectadores que precisan de una gran madurez para emitir ese juicio. La democracia es un camino, o quizás una utopía activa, que debe conjugar el orden político con una cultura y un arte coherentes. (shrink)

Resumen: En este artículo sostengo que los planteamientos de Jakob von Uexküll constituyen un apoyo científico decisivo para las reflexiones metafísicas de Martin Heidegger sobre el mundo, más allá de lo que el mismo Heidegger reconoce explícitamente. En particular, los estudios de Jakob von Uexküll enfatizan, de mejor manera que el mecanicismo y el vitalismo, la relación que existe entre el medio ambiente y el mundo interior del animal, lo que es fundamental para que Heidegger sostenga en su lección de (...) invierno de 1929 y 1930 que la esencia del animal es el "perturbamiento".: In this paper I argue that the scientific approaches of Jakob von Uexküll crucially support Martin Heidegger's metaphysical reflections about the world, beyond what Heidegger himself explicitly recognized. In particular, Jakob von Uexküll's studies emphasized, better than mechanicism and vitalism, the relationship between the environment and the inner world of the animal, which is crucial for Heidegger to claim in his winter 1929-1930 lessons that the essence of the animal is "disturbance". (shrink)

This article assesses an assumption pervasive in one strain of arguments in favor of stringent immigration controls. The assumption affirms that—for the case of regular admissions—to a certain extent states are permitted to prioritize the interests of their citizens and residents by issuing exclusionary immigration policies (call this the priority assumption). Using the normative methodology of applied international ethics, I suggest some broad constraints to this priority assumption that have a bearing on justifications for current practical immigration policy in Europe, (...) North America, and beyond. I do so by redefining borders as domestic-international institutions that open up borders not only to (internal) standards of justice but also to standards of international legitimacy. (shrink)

La relevancia del pensamiento de Emmanuel Levinas para comprender el surgimiento de la filosofía de la liberación –uno de los movimientos filosóficos más importantes de América Latina durante la segunda mitad del siglo XX– es innegable. En este artículo se analiza la interpretación geopolítica y analógica que Enrique Dussel realizó de los conceptos levinasianos de “Alteridad” y “Otro” para mostrar su equivocidad en el ámbito de lo político.

Se establecen las relaciones internas entre tres núcleos fundamentales del pensamiento de Newman: conciencia, fe y desarrollo de la doctrina cristiana; y se muestran, además, como claves interpretativas de su biografía, fundamentalmente hasta su conversión a la Iglesia Católica en 1845. La tesis es que la fe, como contenido de verdad, es la piedra clave que sostiene este edificio de pensamiento y vida. A ella tiende el mandato de la conciencia, el primero de los elementos que sostienen el acto libre (...) de la fe. El desarrollo de la doctrina cristiana establece el vínculo entre la fe revelada y el lugar donde esta fe vive, la Iglesia Católica Romana. (shrink)

Many biblical scholars have underlined the importance of Numbers 13-14, especially because these chapters are a reflection on Israel's greatest sin and rebellion against God in the desert. God's reaction to that sin is clear: of all the men who have put me to the test ten times already and have failed to heed my voice, not one shall see the land which I promised on oath to their fathers. It seems that the verbs 'see' and 'hear', both sentient verbs, (...) are important in both the statement of God and that of the Spies. This article focuses on this particular point and in the conclusions which can be drawn from it. It also considers the frustrating intercession of Moses before God on behalf of his people, on account of the threat to Israel about the promised land. (shrink)

El artículo versa sobre las fuentes inspiradoras del modelo antropológico presentado por Agustín en el libro I de las "Confesiones", que no son las de los filósofos neoplatónicos, sino las de la Antigua Academia, según la versión particular dada por Antíoco de Ascalón, entremezclado con muchos elementos peripatéticos y estoicos, y transmitido a la cultura latina por Cicerón y Varrón. Y para demostrarlo, se hace el estudio de diversos pasajes del libro I de las "Confesiones".

El artículo pretende demostrar que el pensamiento de san Agustín sobre el tema "acción y contemplación" se ve a la luz de un modelo antropológico que se remonta a Antíoco de Ascalón, y que Agustín conoce a través de las obras de Varrón y de Cicerón. Según tal modelo, el hombre está compuesto de alma y cuerpo y no sólo de alma racional; el alma es impulsada a la acción por un "appetitus" natural, como naturalmente es llevada también a vivir, (...) a conocer con los sentidos y el intelecto, en la vida humana, estos "appetitus" se satisfacen de manera diversa, según el progreso de la edad, de modo que en cada edad se alcanza o se debe alcanzar un acuerdo, una especie de "coniugium" entre los "appetitus" y el alma, y entre el conocimiento y la acción. (shrink)

Resumen Este artículo analiza la construcción de la infancia en las novelas El mercurio (1968), El río de la luna (1981) y Esta pared de hielo (2005), de José María Guelbenzu, a la luz de los conceptos mítico-simbólicos de Bachelard y Durand para demostrar que funciona como un absoluto primigenio al que se busca volver constantemente, pues resguarda a los personajes hasta el inminente choque con la realidad adulta. Esto para concluir que desde la adultez los personajes observan la infancia (...) con el anhelo de volver allí, lo que tiene una función paliativa mediante la memoria y la palabra, por ello, la narrativa de Guelbenzu plantea regresar al ámbito infantil desde las imágenes literarias y así conservar ese mundo de fantasía. Abstract This article analyzes the construction of childhood in the novels El mercurio (1968), El río de la luna (1981) and Esta pared de hielo (2005), by José María Guelbenzu, in the light of the mythical-symbolic concepts of Bachelard and Durand to demonstrate that it functions as a primitive absolute to which it is sought to return constantly, since it protects the characters until the imminent clash with adult reality. This to conclude that in their adulthood the characters observe childhood with the desire to return there, this has a palliative function through memory and word, therefore, Guelbenzu’s narrative proposes the return to the child environment trough literary images to preserve that world of fantasy. (shrink)

Resumen Este artículo es resultado de una investigación exploratoria sobre escrituras de mujeres mapuche entre 1935 y 1965 presentes en periódicos mapuche, así como en órganos de difusión de instituciones de educación y revistas de movimientos sociales. Los objetivos de esta investigación son revisar los elementos históricos que posibilitaron el surgimiento de esta prosa particular de mujeres y desglosar los aspectos centrales tratados en ella, en particular la relación con los derechos civiles, la demanda por la educación y la lucha (...) contra el racismo. El artículo nace de una investigación realizada en archivos de prensa en la Biblioteca Nacional de Chile y documentos en el Museo de la Educación Gabriela Mistral, así como una breve revisión en el Archivo Regional de La Araucanía. Abstract This paper is the result of an exploratory research about Mapuche women's writings between 1935 and 1965 available in Mapuche newspapers, as well as in educational institutions and journals of social movements. The goals of this research are to review the historical elements that allow the emergence of the women’s prose, and to break down the central aspects of these writings, specifically, the relationship with civil rights, the demand for education and the fight against racism. The article arises from a study carried out in press archives in the National Library of Chile and documents in the Gabriela Mistral Museum of Education, as well as brief research in the Regional Archive of Araucanía. (shrink)

This article investigates the characteristics of the phenomenon of fear in work relationships in contemporary society. In this sense, the first part describes the dynamics of current life, emphasizing the role of organizations, their bad reputation, and characterizing their operational center as a society of performance. The second part describes the phenomenon of fear, starting from some representative origins of the term, Martin Heidegger’s phenomenological perspective, and recent studies within the field of organizations. Finally, a survey conducted in the first (...) semester of 2023 with 160 workers from different sectors about their perception of fear in the organization is presented. The findings are interpreted in light of the studied perspectives connected with the ethical responsibility of institutions and the pursuit of comprehensive well-being in work relationships. (shrink)

The development in 1996 of a new generation of antiretroviral drugs was a major pharmaceutical advancement in the struggle against the epidemics of HIV and AIDS. However, due to high costs, access to these new drugs was almost impossible for most people living with HIV or AIDS. This situatiowhas been even more dramatic for those living with HIV/AIDS in poorer countries. Many of the organizations that are fighting for the rights of those with HIV have since developed human rights advocacy (...) and legal strategies to try to achieve universal access to treatment. These organizations are also fighting for states’ compliance with human rights obligations under health-related treatises and conventions. This paper draws upon the experience gained in Latin America, focusing on the legal strategies that have been explored in Venezuela and the legal consequences for domestic law. (shrink)