Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection. However, most multicellular organisms have postmitotic tissues, with limited opportunity for selective removal of cells harboring persistent damage and deleterious mutations, which can therefore contribute to functional decline, disease, and death. Key in this process is the role of genome maintenance, the network of protein products that repair DNA damage and signal DNA damage response pathways. Genome maintenance is beneficial early (...) in life by swiftly eliminating DNA damage or damaged cells, facilitating rapid cell proliferation. However, at later ages accumulation of unrepaired damage and mutations, as well as ongoing cell depletion, promotes cancer, atrophy, and other deleterious effects associated with aging. As such, genome maintenance and its phenotypic sequelae provide yet another example of antagonistic pleiotropy in aging and longevity. (shrink)

Articles on Indian philosophy; a Marxist's viewpoint.

Článek analyzuje argument Pascalovy sázky a některé klíčové námitky proti ní – kritiku Antonyho Duffa, Alana Hájka a tradiční námitku mnoha Bohů. Pascalův argument je reformulován tak, aby těmto námitkám co nejlépe odolal. Analýza ukazuje, že revidovaná podoba sázky zůstává otevřeným problémem teorie rozhodování.The article analyzes some important reasons pro and contra Pascal`s wager argument. Many gods objection and objections by Antony Duff and Alan Hájek are discussed. A reformulation of Pascal`s wager is offered in order to make the case (...) for Pascal`s conclusion stronger. It is shown that some form of wager could still represent a serious problem for rational decision theory. (shrink)

In the late 19th century, T. G. Masaryk presented his national programme. This vision of modern Czech society rested on the ideals of humanity, thus infusing the national ethos with a universal dimension. The significance of T. G. Masaryk's thought is investigated by current Czech thinkers in this volume.

The Anthropocene concept arose within the Earth System science community, albeit explicitly as a geological time term. Its current analysis by the stratigraphical community, as a potential formal addition to the Geological Time Scale, necessitates comparison of the methodologies and patterns of enquiry of these two communities. One means of comparison is to consider some of the most widely used results of the ESS, the ‘planetary boundaries’ concept of Rockström and colleagues, and the ‘Great Acceleration’ graphs of Steffen and colleagues, (...) in terms of their stratigraphical expression. This expression varies from virtually non-existent to pronounced and many-faceted, while in some cases stratigraphical proxies may help constrain anthropogenic process. The Anthropocene concepts of the ESS and stratigraphy emerge as complementary, and effective stratigraphic definition should facilitate wider transdisciplinary communication. (shrink)

The concept of a socially extended mind suggests that our cognitive processes are extended not simply by the various tools and technologies we use, but by other minds in our intersubjective interactions and, more systematically, by institutions that, like tools and technologies, enable and sometimes constitute our cognitive processes. In this article we explore the potential of this concept to facilitate the development of a critical neuroscience. We explicate the concept of cognitive institution and suggest that science itself is a (...) good example. Science, through various practices and rules, shapes our cognitive activity so as to constitute a certain type of knowledge, packaged with relevant skills and techniques. To develop this example, we focus on neuroscience, its cultural impact, and the various institutional entanglements that complicate its influence on reframing conceptions of self and subjectivity, and on defining what questions count as important and what kind of answers will be valued. (shrink)

Does the real world, defined as a world of objects that exist independent of human interests, concerns, and cognitive activities, really exist? Jan Westerhoff argues that we have good reason to believe it does not. His discussion considers four main facets of the idea of the real world, ranging from the existence of a separate external and internal world, to the existence of an ontological foundation that grounds the existence of all the entities in the world, and the existence of (...) an ultimately true theory that provides a final account of all there is. As Westerhoff discusses the reasons for rejecting the postulation of an external world behind our representations, he asserts that the internal world is not as epistemically transparent as is usually assumed, and that there are good reasons for adopting an anti-foundational account of ontological dependence. Drawing on conclusions from the ancient Indian philosophical system of Madhyamaka Buddhism, Westerhoff defends his stance in a purely Western philosophical framework, and affirms that ontology, and philosophy more generally, need not be conceived as providing an ultimately true theory of the world. (shrink)

This paper makes the case for a sharper terminology regarding AIs cognitive abilities. In arguing that thinking requires more than content production, I offer a definition of meaning drawing on a clear distinction between living and machine intelligence. A pivotal argument is the re-use of the Turing Test (TT) for understanding which theories of meaning and consciousness are no longer plausible—because they have been reproduced by software without thereby gaining conscious experience. In following the few theories that have not (yet) (...) failed this reversed Turing Test (RTT), the focus turns towards rethinking the human condition in times of AI along the lines of three questions: What if a machine developed consciousness? What if AI proceeded without developing a consciousness? What, if machinic and human intelligence merged? These three questions in the end lead to examining three related possible futures of humanism as now determined by the relation between Human Intelligence and AI. (shrink)

Meetings differ from ordinary conversation in that they have an agenda that specifies in advance the topics to be addressed during the meeting. However, the introduction of these topics needs to be locally accomplished and recognized by the participants as agenda items. This article presents some characteristic practices used for introducing agenda-based topics. It shows that they rely on the known-in-advance status of the items, and are presented by the chair as unilateral announcements. They exploit and invoke the written agenda (...) in several ways. The announcements are often short phrasal constructions, just citing the written title of the agenda point. Furthermore, a gaze down at the written document is used as a public display that the introduction is related to the agenda. In contrast to this practice of introducing agenda items, topics not specified by the agenda are introduced by suggestions and questions that present the introduction as contingent on acceptance by the co-participants. The analysis sheds light on the ways in which institutional talk-in-interaction is permeated by the formulations and logic of written documents. (shrink)

Nového knížka Filosof T. G. Masaryk (1994) má tři roviny, které se přirozeně neustále stýkají a prolínají: bilancování dosavadní masarykovské literatury s důrazem na rozbor literatury nejnovější, pokus o systematizaci Masarykova díla, postižení jeho vnitřní logiky a vřazení do evropských souvislostí (Brentano, Husserl), a konečně otevírání a řešení otázek, které je možné v užším slova smyslu označit za problémové a aktuální. Nový ukazuje, jak pomáhá Masarykovo myšlení vracet znovu otázku smyslu a řádu našeho usilování a tvoření.

In this paper we extend some techniques from the theory of conse- quences operations and logical matrices into the wider area of entailment relations.

This article considers the critical theory of the Frankfurt School in the context of decolonisation and asks whether it can have continuing relevance given its foundations in white, western traditions which bear the hallmarks of colonialism. Despite critical theory, particularly in its early radical figurations, situating itself as an alternative to traditional western philosophy it undoubtedly shares some of the myopic and Eurocentric traits of this tradition. Mindful of not wishing to perpetuate colonial impulses to appropriate Indigenous philosophies, this article (...) harnesses the twin ideas of a decolonial conversation and interacting in a third space, both of which foreground historical power imbalances and injustices. Only on that basis can a genuine engagement occur between western and Indigenous thought. My aim, as a western scholar, is to explore the relevance of critical theory in this decolonial age. By highlighting intersections, while acknowledging crucial differences, between critical theory and Indigenous philosophies I seek to show that critical theory can play a crucial role in how western scholars respond to and embrace the necessary and compelling movement of decolonialisation, but only first by acknowledging their own shortcomings, particularly in relation to race, racism and colonialism. (shrink)

While the history of science in Polish language has a long history, both intellectual and institutional, it became less visible internationally following the fall of the Iron Curtain. This article looks into the institutional state of history-of-science writing in Poland, and discusses several key focal points that emerged in recent years. By distinguishing between the core history of science, written at institutions devoted to this discipline, and broader academic discussions concerning science's past, I claim that, in recent decades, more important (...) topical and theoretical innovation has come from what we can term the “esoteric” circle (referring to Ludwik Fleck)—that is, scholars who do not identify themselves as historians of science. Given that those scholars from abroad who are interested in Polish history of science are in fact general historians, we get a strong impression that we are witnessing a deeper turn in the field, one with diminishing specialization and greater attention paid to situating science in a broader range of societal processes. (shrink)

The intention of this article is to make an educational analysis of Merleau-Ponty’s theory of experience in order to see what it implicates for educational practice as well as educational research. In this way, we can attain an understanding what embodied experience might mean both in schools and other educational settings and in researching educational activities. The analysis will take its point of departure in Merleau-Ponty’s analysis and criticism of empiricist and neokantian theories of experience. This will be followed up (...) by an introduction of some central concepts in Merleau-Ponty’s own understanding of experience with emphasis on their relevance for educational analysis. This way of presenting the theory of embodied experience has the advantage of being able to indicate the difference it makes in the field of theories of experience. (shrink)

Notes on the life of Adolf Lindenbaum, a complete bibliography of his published works, and selected references to his unpublished results.

In this article, other-repetition after informing statements is investigated in a corpus of institutional encounters between native Norwegian clerks and non-native clients. Such repetition is used to display receipt of information. A plain repeat with falling intonation is described as a display of hearing, whereas a repeat plus a final response particle, ‘ja’, constitutes a claim of understanding. Repeats with high-tone response particles in addition display emotional stance, such as surprise or interest, and these are primarily exploited for the purposes (...) of topic organization. In the cross-linguistic context of the current encounters, the native speakers are shown to use receipts as embedded corrections of the non-native speaker’s utterances. The repeats also have certain formal features that are characteristic of the situation, such as less pronominalization and ellipsis, and this is explained as a procedure to ensure the joint construal of linguistic form. (shrink)

Respecting Persons in Theory and Practice is a collection of essays of the moral and political philosophy of Jan Narveson. The essays in this collection share a consistent theme running through much of Narveson's moral and political philosophy, namely that politics and morals stem from the interests of individual people, and have no antecedent authority over us. The essays in this collection, in various ways and as applied to various aspects of the scene, argue that the ultimate and true point (...) of politics and morals is to enable us to make our lives better, according to our varied senses of what that might mean. (shrink)

Are the political ideals of liberty and equality compatible? This question is of central and continuing importance in political philosophy, moral philosophy, and welfare economics. In this book, two distinguished philosophers take up the debate. Jan Narveson argues that a political ideal of negative liberty is incompatible with any substantive ideal of equality, while James P. Sterba argues that Narveson's own ideal of negative liberty is compatible, and in fact leads to the requirements of a substantive ideal of equality. Of (...) course, they cannot both be right. Thus, the details of their arguments about the political ideal of negative liberty and its requirements will determine which of them is right. Engagingly and accessibly written, their debate will be of value to all who are interested in the central issue of what are the practical requirements of a political ideal of liberty. (shrink)

Background The ownership status of individual-level health data affects the manner in which it is used. In this paper we analyze two competing models of the ownership status of the data discussed in the literature recently: private ownership and public ownership. Main body In this paper we describe the limitations of these two models of data ownership with respect to individual-level health data, in particular in terms of ethical principles of justice and autonomy, risk mitigation, as well as technological, economic, (...) and conceptual issues. We argue that undifferentiated application of neither private ownership nor public ownership will allow us to resolve all the problems associated with effective, equitable, and ethical use of data. We suggest that, instead of focusing on data ownership, we should focus on the institutional and procedural aspects of data governance, such as using Data Access Committees (DACs) or equivalent managed access processes, which can balance the elements of these two ownership frameworks. Conclusion Undifferentiated application of the ownership concept (private or public) is not helpful in resolving problems associated with sharing individual-level health data. DACs or equivalent managed access processes should be an integral part of data governance. They can approve or disapprove data access requests after considering the potential benefits and harms to data subjects, their communities, primary researchers, and the wider society. (shrink)

BackgroundSexual boundary violations in healthcare are harmful and exploitative sexual transgressions in the professional–client relationship. Persons with mental health issues or intellectual disabilities, especially those living in residential settings, are especially vulnerable to SBV because they often receive long-term intimate care. Promoting good sexual health and preventing SBV in these care contexts is a moral and practical challenge for healthcare organizations.MethodsWe carried out a qualitative interview study with 16 Dutch policy advisors, regulators, healthcare professionals and other relevant experts to explore (...) their perspectives on preventing SBV in mental health and disability care organizations. We used inductive thematic analysis to interpret our data.ResultsWe found three main themes on how healthcare organizations can prevent SBV in mental health and disability care: setting rules and regulations, engaging in dialogue about sexuality, and addressing systemic and organizational dimensions.ConclusionOur findings suggest that preventing SBV in mental health and disability care organizations necessitates setting suitable rules and regulations and facilitating dialogue about positive aspects of sexuality and intimacy, as well as about boundaries, and inappropriate behaviors or feelings. Combining both further requires organizational policies and practices that promote transparency and reflection, and focus on creating a safe environment. Our findings will help prevent SBV and promote sexual health in mental health and disability care organizations. (shrink)

The existence of superstition and religious beliefs in most, if not all, human societies is puzzling for behavioral ecology. These phenomena bring about various fitness costs ranging from burial objects to celibacy, and these costs are not outweighed by any obvious benefits. In an attempt to resolve this problem, we present a verbal model describing how humans and other organisms learn from the observation of coincidence (associative learning). As in statistical analysis, learning organisms need rules to distinguish between real patterns (...) and randomness. These rules, which we argue are equivalent to setting the level of α for rejection of the null hypothesis in statistics, are governed by risk management as well as by comparison to previous experiences. Risk management means that the cost of a possible type I error (superstition) has to be traded off against the cost of a possible type II error (ignorance). This trade-off implies that the occurrence of superstitious beliefs is an inevitable consequence of an organism’s ability to learn from observation of coincidence. Comparison with previous experiences (as in Bayesian statistics) improves the chances of making the right decision. While this Bayesian approach is found in most learning organisms, humans have evolved a unique ability to judge from experiences whether a candidate subject has the power to mechanistically cause the observed effect. Such “strong” causal thinking evolved because it allowed humans to understand and manipulate their environment. Strong causal thinking, however, involves the generation of hypotheses about underlying mechanisms (i.e., beliefs). Assuming that natural selection has favored individuals that learn quicker and more successfully than others owing to (1) active search to detect patterns and (2) the desire to explain these patterns mechanistically, we suggest that superstition has evolved as a by-product of the first, and that belief has evolved as a by-product of the second. (shrink)

A major part of police work consists in providing services and information to the general public. A stated goal of such police work is to be service-minded and contribute to a positive encounter. This article analyses service requests in calls to the duty desk of a large police station and focuses on how officers deal with requests that have to be rejected. It reveals a general pattern in which officers produce the rejection in a dispreferred format and include displays of (...) empathy, accounts for the rejection and suggestions for alternative solutions. However, in certain types of requests the rejections are not infrequently produced in a direct and unmitigated fashion, without accounts or explanations.This is especially notable in requests that touch upon institutional constraints, such as professional secrecy. And in certain cases the rejections are even delivered in an aggravated form, involving an explicit or implicit challenge to the legitimacy of the request. These rejections cast the caller in an oppositional role, infringing the professional constraints of the police. However, the constraints in question may not be accessible to the callers. The officers will consequently be experienced as hostile and will subvert their own objectives of showing service-mindedness. (shrink)

Relevance drives our actions and channels our attention; it shapes how we make sense of the world and communicate with each other. Irrelevance spreads a twilight which blurs the line between information we do not want to access and information we cannot access. In disciplines as diverse as philosophy, sociology, the information sciences and linguistics, “relevance” has been proposed as a key concept. This book is the first to bring together the often unrelated traditions. Researchers from different fields discuss relevance (...) and relate it to the challenges of “irrelevance”, which have so far been neglected despite their significance for our chances of making well-informed decisions and understanding others. The contributions focus on theoretical and conceptual questions, on specific factors and fields, and on practical and political implications of relevance and irrelevance as forces which are even stronger when they remain in the background. (shrink)

Im Jahre 1994 organisierte der Lehrstuhl für Wirtschaftsgeschichte und Geschichte der Wirtschaftslehre an der Universität Łódz eine wissenschaftliche Konferenz, die der 100-jährigen Entwicklung der Soziallehre der Kirche gewidmet war. Als aktiver Teilnehmer dieser zweitägigen Konferenz hörte ich mit grossem Interesse 11 Referate und die ihnen folgenden Diskussionen an. Einen größeren Teil der Referenten stellte die Universität Łódz - die anderen kamen aus verschiedenen akademischen Zentren Polens. Fünf von ihnen waren akademische Lehrer an kirchlichen Hochschulen.

Die vorliegende Publikation wurde zum Jubiläumsjahr 2000 von Sozialwissenschaftlern am Lehrstuhl für Wirtschaftsgeschichte und Geschichte der Wirtschaftslehre der staatlichen Universität Łódz vorbereitet. Das Buch hat vor allem ein theoretisches Ziel. Die Autoren, ausschließlich Wissenschaftler die diesem Lehrstuhl angehören, wollen die logische Struktur der päpstlichen Lehre, ihre Methode, Prinzipien und letztlich ihr Verhältnis zur empirischen Realität beschreiben.

Lars von Trier's movies can be seen as a series of iterations in an infinitely repeated prisoner's dilemma. After testing the logic of this game, at the core of which is the dilemma of cooperation or conflict, at the middle level at which an individual confronts a community up till Dogville, he has transposed the game to the level of social systems in Manderlay and the level of the minimal social unit, the couple in Anti-Christ. The story is the Oedipus (...) myth reversed and fit into the logic of the prisoner's dilemma which is, one could argue, the mathematical model of a Hobbesian world view. In that sense it could be called Von Trier's Anti-Oedipus. Moreover, this is the first film in which Von Trier fully embraces digital technologies. It is as if he as a filmmaker acts like the male protagonist in Anti-Christ, and assumes the role of the Anti-Christ in order to become a Savior, since digital technologies and special effects are aligned with 'evil' in this movie. (shrink)