BackgroundArtificial intelligence has been described as the “fourth industrial revolution” with transformative and global implications, including in healthcare, public health, and global health. AI approaches hold promise for improving health systems worldwide, as well as individual and population health outcomes. While AI may have potential for advancing health equity within and between countries, we must consider the ethical implications of its deployment in order to mitigate its potential harms, particularly for the most vulnerable. This scoping review addresses the following question: (...) What ethical issues have been identified in relation to AI in the field of health, including from a global health perspective?MethodsEight electronic databases were searched for peer reviewed and grey literature published before April 2018 using the concepts of health, ethics, and AI, and their related terms. Records were independently screened by two reviewers and were included if they reported on AI in relation to health and ethics and were written in the English language. Data was charted on a piloted data charting form, and a descriptive and thematic analysis was performed.ResultsUpon reviewing 12,722 articles, 103 met the predetermined inclusion criteria. The literature was primarily focused on the ethics of AI in health care, particularly on carer robots, diagnostics, and precision medicine, but was largely silent on ethics of AI in public and population health. The literature highlighted a number of common ethical concerns related to privacy, trust, accountability and responsibility, and bias. Largely missing from the literature was the ethics of AI in global health, particularly in the context of low- and middle-income countries.ConclusionsThe ethical issues surrounding AI in the field of health are both vast and complex. While AI holds the potential to improve health and health systems, our analysis suggests that its introduction should be approached with cautious optimism. The dearth of literature on the ethics of AI within LMICs, as well as in public health, also points to a critical need for further research into the ethical implications of AI within both global and public health, to ensure that its development and implementation is ethical for everyone, everywhere. (shrink)

Many moral philosophers tend to construe the aims of ethics as the interpretation and critique of ‘common-sense morality’. This approach is defended by Henry Sidgwick in his influential The Methods of Ethics and presented as a development of a basically Socratic idea of philosophical method. However, Sidgwick's focus on our general beliefs about right and wrong action drew attention away from the Socratic insistence on treating beliefs as one expression of our wider dispositions. -/- Understanding the historical contingency of Sidgwick's (...) approach to ethics can help us reflect on whether there are other ways in which modern ethics can be Socratic. (shrink)

Philippa Foot, like others of her philosophical generation, was much concerned with the status and authority of morality. How universal are its demands, and how dependent on the idiosyncrasies of individuals? In the early years of her career, she was persuaded that Kant and his twentieth-century followers had been wrong to insist on the centrality to morality of absolute and unconditionally binding moral imperatives. To that extent, she wrote, there was indeed ‘an element of deception in the official line about (...) morality’. In this paper, I shall explore her early alternative: a system of merely ‘hypothetical’ imperatives, imperatives that depend on the motivations of particular individuals. Could so contingent a system deserve to be termed a morality? How revisionary a proposal was this, and how serious its costs? And how might we reconcile ourselves to a morality stripped of what she called the ‘fictions’ that surrounded it? Foot's early answer, tentative and exploratory, remains of interest, long after she herself abandoned it. (shrink)

ABSTRACTThe Victorian period in Britain saw the curious emergence of the word ‘brick’ as a term of high praise, picking out for commendation certain qualities of character: reliability and a lack of whimsy. The novels and everyday conversation of the period were full of such phrases as ‘you’re a brick’ or ‘he’s a regular brick’. In this paper, I trace the history of this phrase in the respectable as well as popular literature of the period, including some ironic attempts to (...) claim for it a classical pedigree. I offer some hypotheses about how we might understand the metaphor of the brick in terms of the needs and values of mainstream British culture in the period. As an illuminating contrast, I consider the fate of a similar metaphor from mid-twentieth-century culture, ‘square’, which picks out roughly similar qualities of character but to reprove them. I conclude with some theoretical reflections on how the study of outdated colloquialisms might bring the resources of historical linguistics to bear on the study of the history of moral concepts. (shrink)

This paper proposes a qualitative study exploring anomalous self and world-experiences in individuals with high levels of depersonalization experiences. Depersonalization (DP) is a condition characterized by distressing feelings of being a detached, neutral and disembodied onlooker of one’s mental and bodily processes. Our findings indicate the presence of a wide range of anomalous experiences traditionally understood to be core features of DP, such as disembodiment and disrupted self-awareness. However, our results also indicate experiential features that are less highlighted in previous (...) work, such as faster time perception and blurriness of the self/other boundaries which may play a key role in altering one’s sense of self and sense of presence in the world. Our qualitative study provides an in-depth examination of self-reported disturbances of one’s relatedness to one’s self and the world, thereby shedding further light on the nature of altered subjective experiences in DP. In doing so, this paper draws attention to key aspects yet overlooked that may prove valuable for shedding further light into the phenomenon of depersonalization. We conclude by highlighting limitations of this study and a number of open questions that further work needs to address in the future. (shrink)

Deep neural networks (DNNs) have had extraordinary successes in classifying photographic images of objects and are often described as the best models of biological vision. This conclusion is largely based on three sets of findings: (1) DNNs are more accurate than any other model in classifying images taken from various datasets, (2) DNNs do the best job in predicting the pattern of human errors in classifying objects taken from various behavioral datasets, and (3) DNNs do the best job in predicting (...) brain signals in response to images taken from various brain datasets (e.g., single cell responses or fMRI data). However, these behavioral and brain datasets do not test hypotheses regarding what features are contributing to good predictions and we show that the predictions may be mediated by DNNs that share little overlap with biological vision. More problematically, we show that DNNs account for almost no results from psychological research. This contradicts the common claim that DNNs are good, let alone the best, models of human object recognition. We argue that theorists interested in developing biologically plausible models of human vision need to direct their attention to explaining psychological findings. More generally, theorists need to build models that explain the results of experiments that manipulate independent variables designed to test hypotheses rather than compete on making the best predictions. We conclude by briefly summarizing various promising modeling approaches that focus on psychological data. (shrink)

While many models of ethical decision-making in marketing have been presented in the literature, no recent attempts have been made to explicitly account for ethical decision-making from a marketing research perspective. We present an ethical framework for marketing research, the various philosophies of ethics, and a few enduring marketing ethical decision-making models, thus laying the foundation for a descriptive model for ethics in marketing research. The authors then develop an integrated model of ethical decision-making that incorporates the perspectives of all (...) parties involved in the process of making ethical marketing research decisions, the various philosophies, and external variables. The proposed model is compared with some of the models considered in the literature and illustrated with a marketing research application. (shrink)

Mohandas Karamchand “Mahatma” Gandhi discussed corporate responsibility and business ethics over several decades of the twentieth century. His views are still influential in modern India. In this paper, we highlight Gandhi’s cross-level CR framework, which operates at institutional, organizational, and individual levels. We also outline how the Tata Group, one of India’s largest conglomerates, has historically applied and continues to utilize Gandhi’s concept of trusteeship. We then compare Gandhi’s framework to modern notions of stakeholder and stewardship management. We conclude that (...) trusteeship has strong potential to help firms and their stakeholders achieve shared value by considering the interactions between individual, organizational, and institutional factors, and paying attention to a range of multi-level stakeholder obligations. (shrink)

Traditional scholars of philosophy and religion, both East and West, often place a major emphasis on analyzing the nature of “the self.” In recent decades, there has been a renewed interest in analyzing self, but most scholars have not claimed knowledge of an ahistorical, objective, essential self free from all cultural determinants. The contributors to this volume recognize the need to contextualize specific views of self and to analyze such views in terms of the dynamic, dialectical relations between self and (...) culture.An unusual feature of this book is that all of the chapters not only focus on traditions and individuals, East and West, but include as primary emphases comparative philosophy, religion, and culture, reinforcing individual and cultural creativity. Each chapter brings specific Eastern and Western perspectives into a dynamic, comparative relation. This comparative orientation emphasizes our growing sense of interrelatedness and interdependency. Culture and Self includes many Asian and Western philosophical, religious, and cultural perspectives. Chapters focus on Vedanta, Samkhya-Yoga, and other Hindu approaches, as well as Buddhist, Confucian, Taoist and other Indian, Chinese, and Japanese perspectives. Studies present Cartesian and other dominant Western perspectives, as well as Marx, Nietzsche, Sartre, feminism, and other Western challenges to the dominant Western interpretations of culture and self.This volume will appeal to students and readers of philosophy, religious studies, Asian studies, and cultural studies. (shrink)

Combining classical and contemporary readings with original essays, Pathways to Philosophy offers an imaginative introduction to the art of philosophical reflection and wonderment. The collection reflects the inherent multidisciplinary nature of the field - revealing and exploring the connections between philosophy, science, and literature. All material is carefully chosen, edited, and coordinated to ensure its accessibility to readers of all levels. The result is a presentation that is engaging, provocative, and fun. There are four main sections divided into twelve chapters (...) held together by a common thread: analysis and exploration of concepts and dimensions of the Self. The readings cover Eastern as well as Western traditions, and include selections by both women and men. In the process, it provides coverage of a number of topics which, though important, are often omitted from introductory texts. (shrink)

We show that classical two-valued logic is included in weak extensions of normal three-valued logics and also that normal three-valued logics are best viewed not as deviant logics but instead as strong extensions of classical two-valued logic obtained by adding a modal operator and the right axioms. This article develops a general method for formulating the right axioms to construct a two-valued system with theorems that correspond to all of the logical truths of any normal three-valued logic. The extended classical (...) system can then express anything that can be expressed in the three-valued logic, so there can be no reason to abandon two-valued logic in favor of three-valued logic. Moreover, the two-valued modal system is preferable, because it enables us to study interactions of different operators with different rationales. It also makes it easier to introduce quantifiers and iteration. Nothing is lost and much is gained by choosing the extended two-valued approach over normal three-valued logics. (shrink)

On several key issues we agree with the commentators. Perhaps most importantly, everyone seems to agree that psychology has an important role to play in building better models of human vision, and (most) everyone agrees (including us) that deep neural networks (DNNs) will play an important role in modelling human vision going forward. But there are also disagreements about what models are for, how DNN–human correspondences should be evaluated, the value of alternative modelling approaches, and impact of marketing hype in (...) the literature. In our view, these latter issues are contributing to many unjustified claims regarding DNN–human correspondences in vision and other domains of cognition. We explore all these issues in this response. (shrink)

Seeking to better understand how nonprofit organizations (NPOs) manage hybridity, we investigated what distinguishes NPOs that combine multiple logics in productive and unproductive ways. We collected and analyzed data from six case studies of NPOs delivering social services in Australia. Our findings reveal that organizational members of NPOs take a _perspective_ on their hybrid nature which comprises four elements: motivational framing, actor engagement, resourcing attitude, and governance orientation. NPOs that combine multiple logics in productive and unproductive ways, respectively, are distinguished (...) by (1) a compelling or confused motivational framing for combining logics; (2) actors having active and shared, or passive and isolated, engagement with multiple logics; (3) attitudes toward resourcing multiple logics that are either coherent or competitive; and (4) a governance orientation toward multiple logics as opportunities to leverage or problems to resist. Our findings contribute to the literature by deepening understanding of the interplay between complex constellations of multiple logics in NPOs, including religious and professional logics. We also develop a model of organizational perspectives on hybridity and their implications for distinguishing NPOs that productively harness tensions between logics. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

This paper presents a challenge to Eurocentric world history on the grounds that it reifies and exaggerates the role of the West in the creation of modernity, while simultaneously ignoring India's seminal contributions. The groundwork is prepared in the first three sections, which refute the parochial biases of Eurocentrism by revealing India's impressive early developmental record and its place near the center of a nascent global economy. The paper culminates in an approach that places the "dialogue of civilizations" center-stage of (...) progressive world history, which is formulated as an antidote to parochial Eurocentric world history. This entails an extensive discussion of two key contributions that India made in enabling the rise of the modern West. These comprise the dissemination of Indian industrial methods that enabled the British industrial revolution on the one hand, and the transmission of Indian mathematical ideas that helped promote the European scientific revolution on the other hand. Moreover, this discussion is coupled with two speculative counterfactual historical scenarios. They are: first, that in the absence of British imperialism which sought to "contain" Indian development, India might have gone on to make the breakthrough to modernity, and second, that in the absence of Indian (as well as Chinese, African and Middle Eastern) help, the West might not have made the breakthrough to modernity. But whatever the veracity of such counterfactuals may or may not be, the ultimate upshot of the argument presented in this paper reveals that Eurocentrism's central claim - that the West made the breakthrough to modernity all by itself - can no longer hold true. (shrink)

In the theory outlined in the target article, an animal forages continuously, making sequential decisions in a world where the amount of food and its uncertainty are fixed, but delays are variable. These assumptions contrast with the risk-sensitive foraging theory and create a problem for comparing the predictions of this model with many laboratory experiments that do not make these assumptions.

The thesis of the paper is that the root cause of clash or reconciliation among civilizations is housed in the drama of consciousness! Two models of consciousness that highlight this drama are put forward here. First is Jean Gebser’s view, which asserts that the history of human civilization is nothing more than the manifestations of the development of consciousness. This development has taken place through five distinct stages: the archaic, magical, mythic, mental and integrative. Clash in civilizations is due to (...) the fixation on the first four stages whereas reconciliation is possible through the use of the integrative stage. The second is the Tantric Yoga view of consciousness in terms of the seven chakras or wheels of consciousness. These chakras are spread out in the body like seven colors of the rainbow—starting with the base of the spine to the genitals, the belly button, the heart, the throat, the forehead and ending in the crown of the head. Clash in civilizations is due to the fixation on the first three levels (chakras) of consciousness whereas reconciliation is possible through the use of the upper fourwheels of consciousness (chakras), which are focused at developing universal consciousness. Since religion and civilization are intimately connected and several of the prominent civilizational clashes have been due to the religious differences, religious consciousness will be taken as the paradigm of this paper.How can humanity move from clash towards reconciliation? Such a possibility is suggested by both Gebser and Tantric Yoga whose theories point towards the development of an integrative universal consciousness: an encompassing consciousness that will transcend as well as incorporate all limited religious consciousness perspectives in its fold! The views of Vivekananda, a scholar-monk of India, on “one religion/one spirituality” are of particular interest in this context. They indicate an approach, which might lead to a possible future solution thus paving a path towards one-world-spiritual-peaceful order! (shrink)

With its promise of personal improvement, physical well-being and spiritual enrichment, yoga is enjoying a resurgence in popularity at the turn of the third millennium. To unravel the mystery of the discipline, its philosophies and relevance in contemporary life, the original text of the Yoga Sutras of Patanjali must be explored. This book offers the first accessible translation and commentary on Patanjali's Yoga Sutras. An introductory section examines the multidimensional aspects of yoga as philosophy, psychology, science, and religion, as well (...) as exploring popular versions of yoga in the West. The core of the book offers a new translation of the entire text of the Yoga Sutras, in a language that is clear and comprehensible to students. Commentaries are presented to highlight the meaning of various statements and key themes are outlined via sectional summaries. A full glossary of key words and names is also provided. Concluding chapters look at yoga in contemporary life, revealing the popularity of yoga in the 21st century through Star Wars, and exploring yoga's connection to health and science, contrasting yoga's holistic view of healing with that of the limited view of present day medical science. Sample physical, breathing and meditation exercises are provided. An Introduction to Yoga Philosophy offers a comprehensive introduction to the Yoga Sutras text of Patanjali to all students and interested readers of Indian philosophy and religion, world religions, east-west psychology, and mysticism. (shrink)

Steven Pinker presents four ideals of Enlightenment in his popular book Enlightenment Now: The Case for Reason, Science, Humanism, and Progress. He argues his case brilliantly and convincingly through cogent arguments in a language comprehensible to the reader of the present century. Moreover, whether it is reason or science or humanism or progress, he defends his position powerfully. He justifies his views by citing 75 graphs on the upswing improvement made by humanity in terms of prosperity, longevity, education, equality of (...) men and women, health, political freedom and medical breakthroughs. Though Pinker makes an excellent case for the positive contributions of Enlightenment; however he ignores the negative aspects that are responsible for causing a great schism between the white race and others who are black and brown. The paper highlights some of these negative comments made by such Enlightenment thinkers as Montesquieu, Voltaire, Chambers, Down and Down and others. Through their literary and scientific writings, these scholars and researchers downgraded the black and brown races, thus causing a rift that led to slavery, colonialism and apartheid. The paper reveals these negative aspects ignored by Pinker in his otherwise well-researched book on Enlightenment. Since Pinker presents a one-sided case by including only the positive contributions of Enlightenment, I recommend that he should write a sequel to his present work outlining the negative aspects responsible for numerous political, social and environmental problems facing humanity today. By using dialectical logic in place of logic of contraries, he might be able to synthesize both the positive and negative aspects of Enlightenment. He can then argue that humanity might be propelled to make progress more efficiently at a faster pace toward humanism and world peace. (shrink)

The activation of leukocytes by bacterial cell wall lipopolysaccharide (LPS) contributes to the pathogenesis of septic shock. It is well established that, in the presence of plasma LPS‐binding protein (LBP), LPS binds with high affinity to CD14. The binding of LPS to CD14 has been associated with the activation of cells, although available evidence indicates that CD14 itself does not transduce intracellular signalling. The physiological function of this interaction is to promote host defense mechanisms of cells to combat the infection (...) and clear LPS from the circulation. At higher concentrations of LPS, however, the activation of cells can take place in the absence of LBP and CD14, presumably through a distinct low‐affinity signalling LPS receptor. On the evidence published by us and others, we propose that in neutrophils, and possibly other leukocytes, L‐selectin can act as a low‐affinity LPS receptor. (shrink)

The thesis of the paper is that the root cause of clash or reconciliation among civilizations is housed in the drama of consciousness! Two models of consciousness that highlight this drama are put forward here. First is Jean Gebser’s view, which asserts that the history of human civilization is nothing more than the manifestations of the development of consciousness. This development has taken place through five distinct stages: the archaic, magical, mythic, mental and integrative. Clash in civilizations is due to (...) the fixation on the first four stages whereas reconciliation is possible through the use of the integrative stage. The second is the Tantric Yoga view of consciousness in terms of the seven chakras or wheels of consciousness. These chakras are spread out in the body like seven colors of the rainbow—starting with the base of the spine to the genitals, the belly button, the heart, the throat, the forehead and ending in the crown of the head. Clash in civilizations is due to the fixation on the first three levels (chakras) of consciousness whereas reconciliation is possible through the use of the upper fourwheels of consciousness (chakras), which are focused at developing universal consciousness. Since religion and civilization are intimately connected and several of the prominent civilizational clashes have been due to the religious differences, religious consciousness will be taken as the paradigm of this paper.How can humanity move from clash towards reconciliation? Such a possibility is suggested by both Gebser and Tantric Yoga whose theories point towards the development of an integrative universal consciousness: an encompassing consciousness that will transcend as well as incorporate all limited religious consciousness perspectives in its fold! The views of Vivekananda, a scholar-monk of India, on “one religion/one spirituality” are of particular interest in this context. They indicate an approach, which might lead to a possible future solution thus paving a path towards one-world-spiritual-peaceful order! (shrink)

The author examines the relationships between civilization and organized religion. A new theory of religion spawning civilization instead of vice versa is discussed, as well as the influence of the great organized religions on the development of modern cultures and civilizations. The history of the various large organized religions, including their origins, spread and mindsets are all examined, and the major differences between the Abrahamic and Indic religions are remarked upon as well.

Clinical Pharmacology is a specialty with many attributes and our association with the subject has allowed us to acquire, apply and disseminate myriad aspects of research and practice. Though clinical pharmacologists are conspicuous by virtue of their small number, recent years have shown a growing need for the course. In the review below we navigate through several aspects of the subject as we encountered them from time to time. From critical appraisal of literature, to application of knowledge of drugs, to (...) clinical practice; moving on to clinical and basic research, to drug development process, to policy making - these are but a few of the many fields which constitute the scope of clinical pharmacology. The importance of the subject lies in allowing a trainee to develop a broad overview of the entire process, from drug generation to drug distribution to drug utilization, a process meant for the greater common goal of better health for all. We foresee a bright future for the subject though with a slight skepticism thrown in. In the present article, we make use of personal experiences and reference from literature to help you get a broad view of what clinical pharmacology means to us. (shrink)

The COVID-19 pandemic has shaken the world. After liberalization in 1991, microfinance became a panacea for poor people without collateral and information asymmetry. The higher cost of microfinance and debt traps highlighted the need for the state to intervene in resource redistribution. In addition, national lockdowns and COVID-19 restrictions have made it difficult for emerging economies like India to achieve this sustainable development goal. The Reserve Bank of India introduced self-help group (SHG) bank linkage to ensure the financial inclusion of (...) the poor. The difference-in-difference method examined how SHGs affect entrepreneur households’ income. CMIE Consumer Pyramid dx data were used for analysis. The data establish that SHGs have increased the income of the households, and demographic factors such as education, income level and gender also impact the financial inclusion of the poor. (shrink)

This volume is a critical investigation into the contemporary phenomenon of the dissensus of the globe and the planet, and the new terrains of consciousness that need to be negotiated towards a possibility for transformation. It examines the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview. The book explores themes like philosophical posthumanism and planetary concerns; disruption of cultural and intellectual inequality; bodily movement through nomadic subjectivity; dystopic spatialities of (...) game(re)play; globalization, and speculative imaginaries of the body; and theory of multiplicity. It also discusses impact of COVID on human beings, role of the neoliberal media, the question of rights of robots and cyborgs in sci-fi movies, and representation of refugees in literature. This book will be of interest to scholars and researchers of English literature, political philosophy, cultural studies, literary cultures, post-colonial studies, critical theory, and social anthropology. (shrink)

This book presents a critical analysis of sense-making practices through an exploration of acoustic, creative, and artistic spaces. It studies how local cultures of sight, hearing, smell, taste, and touch are impacted by global discourses and media, such as television, popular music, digital media, and literature. The authors look at sense-making practices and spatial discourses through an interconnected discussion on thought and experience that seeks to present a multidimensional cartography of the global, the local, and the glocal, to closely analyze (...) the phenomenon of globalization. The volume is an investigation of the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview that challenges the disparity of its fragments while speculating on their synesthetic conditionality. A unique contribution, the book will be of interest to scholars and researchers of English literature, media studies, cultural studies, literary cultures, post-colonial studies, globalization studies, philosophy, critical theory, sociology, and social anthropology. (shrink)