Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

The paper reconstructs the key epistemological ideas of Merab Mamardashvili which form the bridge between his philosophy and phenomenology. He advances four key concepts in his sketch of a natural historical epistemology: the geometry of causal experience, the belonging to a certain time, the chronotype of a subject, and the ‘elaboration’ of the mind by consciousness. The concept of “fruitful tautology” leads Mamardashvili to a new aesthetics of thinking. The semiotics, rightfully included in Russian social sciences, assumes that the symbol (...) is a certain universal first element of psychic reality. (shrink)

Notwithstanding diverse opinions and debates about mixing methods, mixed methods research (MMR) is increasingly being used in sport and exercise psychology. In this paper, we describe MMR trends within leading sport and exercise psychology journals and explore critical realism as a possible underpinning framework for conducting MMR. Our meta-study of recent empirical mixed methods studies published in 2017–2019 indicates that eight (36%) of the 22 MMR studies explicitly stated a paradigmatic position (five drew on pragmatism, two switched paradigms between qualitative (...) and quantitative elements of the study, and one was situated in relativist-interpretivism). The remaining 14 (64%) studies did not report their underpinning research philosophical assumptions. Evaluating the merits and limitations of these positions against critical realist assumptions suggests that several paradigmatic disagreements are potentially reconcilable. These include (a) maintaining that ontological and epistemological concerns are important for methodological integrity of a mixed methods study; (b) switching between paradigms in the same study is problematic; and (c) refuting the qualitative-quantitative incommensurability thesis, therefore allowing mixed methods research without compromising philosophical coherence. From a critical realist position, we suggest that both quantitative and qualitative designs are justifiable in a mixed methods study because (1) they help corroborate, refine, or refute plausible explanations of phenomena (epistemological), but (2) with different methodologies utilised to perform different tasks in the same research design related to different psycho-social system features (ontological). We call for a collaborative engagement by researchers across paradigmatic positions to work towards the advancement of methodological pluralism in our research community. (shrink)

The aim of the article is to philosophically address and expand the contemporary discourse of the increasingly digitalized education by examining the problem of matter of education and its conceptualizations in this context. With the digital transformation of education a significant change occurs not only in terms of what is considered to be a matter of education, but also in the very principles of interaction between the subjects of education. In order to do this, in the first section several examples (...) of conceptual justifications of applying digital technologies in education are examined with the task of demonstrating how in such justifications the activity of education is reduced to the process of learning and what risks such instrumental interpretation engenders. Then, these issues are analyzed and contextualized utilizing the material of the philosophical discussion of the 20th century - the critique of the progressive education in the analytic philosophy of education. By outlining the relevance of the arguments of discussion on manner/matter to realities of digital education, the issue of the dominance of the logic of learning in current education is analyzed. In the last section several adjustments to the contemporary discourse on digitalization of education are proposed, aimed at finding a balance between individual and social dimensions of the problem of matter of education, given the current tendency of mass personalization in education. Particularly, the importance of the idea of education as a common good in the contemporary educational discourse is claimed. (shrink)

The article is devoted to the assessment of interconnection and interaction problems of an individual and a collective. The different definitions of personality are analyzed. There has been made a historical excursus to the theory of collective development during the soviet and post-Soviet period. There also have been set forth the views of interconnection and interaction of individual and a collective of outstanding pedagogues A. S. Makarenko and I. P. Ivanov. The modern psycho-pedagogical analysis of these theories confirms its actuality (...) and practical importance. (shrink)

The structure of Russian science of the XIX century was dominated by state forms of its organization. At the same time, there were also a few private (non-governmental) forms of research communities. One of the little-studied phenomena of scientific privacy is the so-called “kruzhok” (a little circle in Russian). The article examines the history of the formation and activity of one of such “kruzhoks”, formed in the 1880s–1890s around Grand Duke Nikolai Mikhailovich, who was seriously engaged in research in the (...) field of lepidopterology (the branch of entomology studying butterflies, Lepidoptera). The role and significance of this “kruzhok” for the development of descriptive entomology in the situation of its weak institutionalization in Russia at the end of the XIX century are briefly considered, the course of scientific research of the Grand Duke and his entourage and the reasons for the termination of their activity are discussed. The history of this informal association is interpreted by us as a manifestation of the purposeful life-making of the Grand Duke, who thus tried to professionalize his hobby and enter the scientific community of entomologists on an equal footing, without breaking with his social environment and without going beyond the behavioral norms established by society for persons of his status. It is shown that the Nikolai Mikhailovich’s “kruzhok” became not only an instrument of his life-making, but also an influential center of Russian lepidopterology, the development of which was thereby given a powerful impetus. (shrink)

What counts as an intuitively plausible set theoretic content (notion, axiom or theorem) has been a matter of much debate in contemporary philosophy of mathematics. In this paper I develop a critical appraisal of the issue. I analyze first R. B. Jensen's positions on the epistemic status of the axiom of constructibility. I then formulate and discuss a view of intuitiveness in set theory that assumes it to hinge basically on mathematical success. At the same time, I present accounts of (...) set theoretic axioms and theorems formulated in non-strictly mathematical terms, e.g., by appealing to the iterative concept of set and/or to overall methodological principles, like unify and maximize, and investigate the relation of the latter to success in mathematics. (shrink)

The study relevance lies in understanding strategic objectives' content concerning intelligent technologies’ application. The development and application of artificial intelligence in various branches of human activity carry the potential for global changes in society, which, in methodological terms, increases the relevance of considering these problems. The study of ethical problems of artificial intelligence in the concept of sustainable development of society is connected with the dynamic development of innovative artificial intelligence (AI) technologies, which are considered a process of becoming a (...) new technosubject in the context of neuroscience development. The article emphasizes that the development of artificial intelligence acts as an innovative form of technology development when a new kind of human-machine technosubject is formed. The authors identify social problems of artificial intelligence application as the digitalization of life becomes a global anthropological challenge. Innovations of artificial intelligence are directly related to a number of ethical problems, as they contribute not only to the sustainable development of society but also cause dehumanization of relations between people and society. Based on the analysis of qualitative changes in scientific and technological research, using human-machine devices is becoming inevitable. Humankind must develop ethical guidelines for the application of AI systems. (shrink)

In this paper the author developes an account of the issues of post-modernism. This account is then used to discuss the difference between the concept of philosophy as knowledge or as "Weltanschauung". The author offers a critique of the post-modern philosophy and argues that, post-modernism does not distinguish epistemology from social ethics topics. All topisc are considered in relation to the situation of philosophy in Slovakia.

La thèse dont l’ouvrage de Laetitia Dion est issu examine l’influence de l’actualité politico-religieuse et des traditions narratives françaises et étrangères sur la transformation de la matière narrative autour du mariage. Nouvelles-fabliaux, nouvelles plus longues aux tonalités variées, avec ou sans histoire-cadre, récits longs ou formes encore hybrides de romans, des Cent Nouvelles nouvelles de P. de Vigneulles (v. 1515) aux Histoires tragiques de Pierre Boaistuau (1559), treize fictions n...

O presente artigo pretende uma reflexão acerca da relação entre filosofia platônica e poesia no século V a.C.. Mesmo que Platão tenha como objetivo banir as manifestações poéticas da pólis utópica, cuja teoria descreve magistralmente na República, o filósofo ateniense sabe da força que este tipo de representação ainda possui na formação do homem grego. No diálogo Íon, objeto deste estudo, percebemos a tentativa estratégica de Platão de desqualificar a poesia em nome do conhecimento. Para o cidadão ateniense de então, (...) a Musa inspirada perde força diante da argumentação científica filosófica. (shrink)

The Aleksanteri Institute of the University of Helsinki organized in 25–26 of September 2009 a special symposium Northern Lights — Facets of Enlightenment Culture with the aim to discuss form of Enlightenment thought in Sweden/Finland and Russia. The symposium, which was opened by Prof. Emeritus Matti Klinge, a renowned historian of 18th- and 19th-century Finland, had four participants from Russia, five from Finland and one from Germany; thus, it was yet a quite small event, but we hope that with it (...) the foundations of a fruitful co-operation, with annual symposia on questions of Enlightenment culture, will be laid. Of the speakers, Prof. Tatiana Artemyeva, Dr. Oili Pulkkinen and Prof. Vesa Oittinen focused on more general problems of study of Enlightenment ideas, while the other contributions dealt with different ―case studies‖ either in Sweden/Finland (Dr. Kimmo Sarje, Dr. Johan Sten), Russia (Prof. Mikhail Mikeshin, Dr. Johannes Remy, Dr. Larisa Agamalian), in France (Dr. Alla Zlatopolskaya) or Germany (Dr. Carola Häntsch). (shrink)

The archive of Gustav Shpet contains scattered preparatory materials for his “Lectures on the Theory of Cognition” and his major philosophical work History as a Problem of Logic. Some of these handwritten rough notes are devoted to Kant, indeed some of them have already seen the light of day in the “Kant­ian Journal” (2022, № 3). The notes published below continue to acquaint the reader with Shpet’s creative laboratory. His method of work with the concepts and ideas is instructive in (...) that it enables us to raise questions about the meaning of “positive critique”, its difference from Kant’s own “critical method” and why contemporary historical-philosophical attempts to actualise Kant’s concept of critique have more to do with Shpet’s rather than Kant’s methodology. Of particular relevance today is the authors’ attempt to immerse the Kantian understanding of critique in the context of Shpet’s phenomenologically oriented hermeneutic methodology. (shrink)

The new industrial paradigm Industry 4.0, or smart industry, is at the core of contemporary debates. The public debate on Industry 4.0 typically offers two main perspectives: the technological one and the one about industrial policies. On the contrary, the discussion on the social and organizational effects of the new paradigm is still underdeveloped. The article specifically examines this aspect, and analyzes the change that workers are subject to, along with the work organization, smart digital factories. The study originates from (...) an empirical survey conducted by the author together with a multidisciplinary research group between 2014 and 2015 in some of the largest Italian factories.In particular, the article analyzes the links between digital society, digital culture and Industry 4.0, focusing on the issue of people’s participation in the process of change, within a specific case study from the railway sector.Many elements of the Industry 4.0 paradigm are widespread outside the factory, in society; they are not only technological elements but also cultural. One of the key aspects of the analysis is the question of participation and the “person-centered” culture. The subject is addressed critically by presenting both the RE-personalization processes and the new processes of DE personalization caused by digital automation. (shrink)

The relevance of the topic of research of humanitarian capital as a set of values of social sciences today plays an exceptional role, because human capital is a great character and its goal is the process of mastering the world through the development of humanistic knowledge and methods of cultural education, aimed at personality formation. The Central problem for modern conditions is management education with a view that human capital formed by all humanist-oriented sciences, must be directed to the development (...) and fulfillment of personality. The main task of higher school is the identification, preservation and effective use of human knowledge as a set of humanistic values, which together constitute the human capital needed to ensure a comprehensive and creative personality. The article explains the essence, objectives and main directions of human capital with the aim to form comprehensive and creative personality, based on cultural development of man as his self-development and self-actualization. Objectives of the study are the conceptualization of human capital as a set of humanitarian values, which are implemented in practice of educational process of higher school. The methodological basis for the formation of humanitarian capital in the information society is a synergetic methodology aimed at revealing the intellectual and creative personality, which incorporates all the values of the Humanities, presented by specific synergistic tools. Conclusions – management of education in modern conditions should be directed on formation of mechanisms of human capital as a set of values created by mankind and implemented by social sciences and disciplines. (shrink)

In the paper the joint Logic of Proofs and Provability is presented that incorporates both the modality □ for provability 287–304) and the proof operator tF representing the proof predicate “t is a proof of F” . The obtained system naturally includes both the modal logic of provability GL and Artemov's Logic of Proofs . The presence of the modality □ requires two new operations on proofs that together with operations of allow to realize all the invariant operations on proofs (...) admitting description in the modal propositional language. Logic is proved to be decidable and complete with the intended provability semantics. (shrink)

Modern individuals grapple with a paradoxical reality: their lives are characterized by a strong feeling of independence as well as by an intense social interconnection. This article argues that despite an increased discussion of dependence in contemporary social and political philosophy, current ways of theorizing it have disregarded the concrete form that our social dependence takes under capitalist relations. I maintain that without integrating the critique of political economy, we risk offering a defense of dependence that remains unaware of important (...) axes of domination. In particular, I suggest recuperating Marx’s notion of objective dependence, which has been insufficiently discussed in the existing literature. Finally, drawing on recent developments in critical theory, I put forward a normative critique of dependence. I contend that the issue with modern societies is that they promote alienated and reified relations of dependence, transforming the basis of our social freedom into an objective form of domination. -/- . (shrink)

Normative case studies are designed to offer richly detailed “worlds of possibility” that invite complex reflection and discussion about authentic ethical dilemmas in education. In this essay, Tatiana Geron and Meira Levinson argue that authors' choices of what details to include in a case are themselves ethical decisions that require significant ethical responsibility. Case details can shape which avenues of ethical inquiry are open to readers, whether and how institutional and structural conditions get considered, whose perspectives are included and (...) legitimized, and what political issues are understood as “open” or “closed.” At its best, case “world-building” can help readers understand the full complexity of ethical decision-making in education. However, for this to occur, case authors must seek out expert and dissenting perspectives, field test the case with diverse audiences, and remain reflexive about their own perspectives and how these shape their world-building decisions. (shrink)

Introduction. The condition of fixed assets and their rational management largely determine the competitiveness of an enterprise. Updating the production base is possible both at the expense of their own funds and at the expense of borrowed funds. When choosing sources of financing for renovating fixed assets, it is important to assess the impact of the chosen acquisition method on cash flows and the financial result of an enterprise. The purpose of the article is to assess the impact of the (...) chosen method of financing the acquisition of fixed assets on the company’s financial results and cash flow. Methods. Comparison, induction, analysis, synthesis, direct counting, the author’s methodology for assessing the impact of the source of renovation on the financial result of the enterprise and cash flow. Scientific novelty of the research. The authors propose an additional criterion for assessing the efficiency of managing fixed assets of an enterprise: choosing the most optimal method of acquisition, based on assessing its impact on the financial results of activities, and they also proposed to supplement the options for renovating the main environments using leases, since, depending on the economic situation, this option may have financial advantages over credit, loan and leasing. Results. The authors predict the influence of the method of financing the acquisition of fixed assets (credit, leasing, rent, own funds) on the financial result of an enterprise and cash flows; develop the general approaches to the method of choosing the optimal source of financing for the renovation of fixed assets. Conclusions. The acquisition of ownership of fixed-capital assets is not always advisable. The article shows that not only credit or leasing operations, but also rent are comparable in efficiency. When choosing a source of financing for renovating fixed assets, it is necessary to compare the costs of acquiring property and their distribution by periods, to analyze the impact of the method of acquiring them on the financial result of the enterprise and cash flow. (shrink)

This article aims to make public part of the research on the concept of ‘light’ in the theological and, above all, liturgical tradition of the Greek Orthodox Church, based on its representation of the concept of ‘hypostasis’. Taking as a point of departure the interpretation of the expression ‘light of light’ [φῶς ἐκ φωτός (phôs ek phōtos)] of the text of the Niceno-Constantinopolitan Symbol, the article presents a proposal for the interpretation of the concept of ‘representation’ for this specific case, (...) based on the idea of apomímesis, and applies this concept to a reading of the place of ‘light’ in the Holy Scripture, in the Patrology and in the Greek Eastern Liturgies. (shrink)

WINNER OF THE SIMON HAILWOOD ESSAY PRIZE. This paper discusses the problem of alienation from nature, considered through the phenomena of reification and de-objectification. I propose understanding alienation as the result of a distorted relation between the subjective and the objective and I suggest a tentative solution via the combination of two ethico-political practices: releasement and reappropriation. In doing so, I put forward a structural-ethical critique and response to our current ecological crisis.

This paper argues that the impact of individual higher education institutions’ strategies on system diversity should be explored. By looking at how universities respond strategically to governmental policies as well as to the actions of other (competing) institutions, our understanding of determinants of diversity can be enriched. A conceptual framework focusing on institutional positioning is explained using the dimensions deliberateness of organizational actions versus environmental influence, on the one hand, and differentiation versus compliance, on the other. We posit institutional positioning (...) as the mechanism through which organizational and environmental levels are linked. Our model features multiple dimensions and relations reflecting how higher education institutions locate themselves in specific niches, i.e. positions where they are able to gather the necessary resources for their core activities. The implications for research on diversity and for policymaking are discussed. (shrink)