Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)
What counts as an intuitively plausible set theoretic content (notion, axiom or theorem) has been a matter of much debate in contemporary philosophy of mathematics. In this paper I develop a critical appraisal of the issue. I analyze first R. B. Jensen's positions on the epistemic status of the axiom of constructibility. I then formulate and discuss a view of intuitiveness in set theory that assumes it to hinge basically on mathematical success. At the same time, I present accounts of (...) set theoretic axioms and theorems formulated in non-strictly mathematical terms, e.g., by appealing to the iterative concept of set and/or to overall methodological principles, like unify and maximize, and investigate the relation of the latter to success in mathematics. (shrink)
In this paper the author developes an account of the issues of post-modernism. This account is then used to discuss the difference between the concept of philosophy as knowledge or as "Weltanschauung". The author offers a critique of the post-modern philosophy and argues that, post-modernism does not distinguish epistemology from social ethics topics. All topisc are considered in relation to the situation of philosophy in Slovakia.
This paper, based on ideas of a cognitive anthropologist Dan Sperber, provides a concise introduction to how to construct a naturalistic causal explanation in social sciences. Its author starts with critical remarks concerning the philosophy of social sciences as presented in the previously published article by Tatiana Sedova. The author provides argumets in favor of a view that all the plausible explanations in social sciences should be based on the naturalistic, material processes. Furthermore the author presents a set of (...) examples showing how to build a naturalistic explanation in cognitive anthropology. The conclusion is that the reconceptualization of all too abstract concepts of social sciences is urgently needed so that the ontology of social sciences could become consequently materialistic.properties of social phenomena are likely to be explained as either effects of or epistemological constructions derived from the material processes. (shrink)
This book is a translation of W.V. Quine's Kant Lectures, given as a series at Stanford University in 1980. It provide a short and useful summary of Quine's philosophy. There are four lectures altogether: I. Prolegomena: Mind and its Place in Nature; II. Endolegomena: From Ostension to Quantification; III. Endolegomena loipa: The forked animal; and IV. Epilegomena: What's It all About? The Kant Lectures have been published to date only in Italian and German translation. The present book is filled out (...) with the translator's critical Introduction, "The esoteric Quine?" a bibliography based on Quine's sources, and an Index for the volume. (shrink)
This paper presents new constructions of models of Hume's Principle and Basic Law V with restricted amounts of comprehension. The techniques used in these constructions are drawn from hyperarithmetic theory and the model theory of fields, and formalizing these techniques within various subsystems of second-order Peano arithmetic allows one to put upper and lower bounds on the interpretability strength of these theories and hence to compare these theories to the canonical subsystems of second-order arithmetic. The main results of this paper (...) are: (i) there is a consistent extension of the hyperarithmetic fragment of Basic Law V which interprets the hyperarithmetic fragment of second-order Peano arithmetic, and (ii) the hyperarithmetic fragment of Hume's Principle does not interpret the hyperarithmetic fragment of second-order Peano arithmetic, so that in this specific sense there is no predicative version of Frege's Theorem. (shrink)
The following essay reconsiders the ontological and logical issues around Frege’s Basic Law (V). If focuses less on Russell’s Paradox, as most treatments of Frege’s Grundgesetze der Arithmetik (GGA)1 do, but rather on the relation between Frege’s Basic Law (V) and Cantor’s Theorem (CT). So for the most part the inconsistency of Naïve Comprehension (in the context of standard Second Order Logic) will not concern us, but rather the ontological issues central to the conflict between (BLV) and (CT). These ontological (...) issues are interesting in their own right. And if and only if in case ontological considerations make a strong case for something like (BLV) we have to trouble us with inconsistency and paraconsistency. These ontological issues also lead to a renewed methodological reflection what to assume or recognize as an axiom. (shrink)
The ‘continuous’ and the ‘discrete’ in nature and in science live and fight forever. The questionnaires and the Lickert scales are indispensable and widely used tools in social sciences research. Vougiouklis & Vougiouklis bar is a new tool introduced as an alternative to Lickert scales. We believe that such an alternative might offer some solutions to problems that crop up during the fight between continuous and discrete. Nevertheless, the greatest contribution of the V&V bar is that it offers the researchers (...) freedom in all stages of the research procedure using a questionnaire. (shrink)
It is argued that Convention T and Basic Law V of Frege’s Grungesetze share three striking similarities. First, they are universal generalizations that are intuitively plausible because they have so many obvious instances. Second, both are false because they yield contradictions. Third, neither gives rise to a paradox.
Often understood as synonymous with “oral history” in Indigenous title and rights cases in Canada, “oral tradition” as theorized by Jan Vansina is complexly imbricated in the European genealogy of “scientific history” and the archival science of Diplomatics with roots in the development of property law and memory from the time of Justinian. Focusing on Tsilhqot’in Nation v. British Columbia, which resulted in the first declaration of Aboriginal title in Canada, this paper will discuss Tsilhqot’in law in the context of (...) the court’s deployment of Vansina’s theory and its genealogy, and conclude that “oral tradition” functions as a legal fiction enabling the court to remain in the familiar archive of its own historiography while claiming to listen to the Elders. (shrink)
I attempt to clarify the connection between two late texts by V.S. Solov'Ã«v: Justification of the Good and Theoretical Philosophy. Solov'Ã«v drew attention to the intrinsic connection between moral and intellectual virtues. Theoretical Philosophy is the initial -- unfinished -- sketch of the dynamism of mind seeking truth as a good. I sketch several parallels and analogies between the doctrine of moral experience set out in Justification and the account of the intellect's dynamism based on immediate certitude set out in (...) Theoretical Philosophy. Solov'Ã«v can thus be considered as a âvirtue epistemologistâ in the current meaning given to this description. I conclude by suggesting that Solov'Ã«v's position on these questions does not easily cohere with the âimpersonalismâ he appears to defend in Theoretical Philosophy. (shrink)
As one of the preeminent philosophers of the twentieth century, W. V. Quine made groundbreaking contributions to the philosophy of science, mathematical logic, and the philosophy of language. This collection of essays examines Quine's views, particularly his holism and naturalism, for their value to feminist theorizing today. Some contributors to this volume see Quine as severely challenging basic tenets of the logico-empiricist tradition in the philosophy of science—the analytic/synthetic distinction, verificationism, foundationalism—and accept various of his positions as potential resources for (...) feminist critique. Other contributors regard Quine as an unrepentant empiricist and, unlike feminists who seek to use or extend his arguments, they interpret his positions as far less radical and more problematic. In particular, critics and advocates of Quine's arguments that the philosophy of science should be "naturalized"—understood and pursued as an enterprise continuous with the sciences proper—disagree deeply about whether such a naturalized philosophy is "philosophy enough." Central issues at stake in these disagreements reflect current questions of special interest to feminists and also bridge the analytic and postmodern traditions. They include questions about whether and how the philosophy of science, as a form of practice, is or can be normative as well as questions concerning the implications of Quine's philosophy of language for the transparency and stability of meaning. In representing feminist philosophy centrally engaged with the analytic tradition, this volume is important not only for what it contributes to the understanding of Quine and naturalized epistemology but also for what it accomplishes in working against restrictive conceptions of the place of feminism within the discipline. Aside from the editors, the contributors are Kathryn Pyne Addelson, Louise M. Antony, Richmond Campbell, Lorraine Code, Jane Duran, Maureen Linker, Phyllis Rooney, and Paul A. Roth. (shrink)
In this paper, the so-called V-chip is analysed from the perspective of responsibility. The V-chip is a technological tool used by parents, on a voluntary basis, to prevent children from watching violent television content. Since 1997 in the United States, the V-chip is installed in all new televisions sets of 12″ and larger. We are interested in the question whether and how the introduction of the V-chip affects who is to be considered responsible for children. In the debate, it has (...) been argued that the V-chip reduces parents’ responsibility for children, but it has also been argued that it gives parents a tool to exercise their responsibility. It may appear as though all debaters are discussing the same thing and merely have different opinions. However, we argue that there are at least three notions of responsibility underlying these claims and that these should be kept separate. First, arguments on responsibility may refer to responsibility as task distribution. Second, they can refer to responsibility as control. Finally, a thicker concept of parental responsibility understood as a virtue may be referred to. It becomes clear that whereas task distribution changes to some extent and the possibilities for control are increased, only certain parts of parental responsibility as a virtue are affected. The finding that there appear to be different notions of responsibility involved in a debate that prima facie is about one issue, indicates that discussions on other technologies and how they affect responsibility may suffer from the same conceptual lack of clarity. (shrink)
The judgment in Qarase v. Bainimarama provided a legal basis for the 2006 military coup in Fiji and stated that the President was entitled to grant authority to the military to act outside of the powers prescribed by the written Constitution. According to the ruling, the Royal Prerogative powers that remained in government following British rule could be utilised by the President at any time that he considered it necessary. This paper explores the rationale for that judgment and the role (...) that Royal Prerogative powers may play in the governance of countries that were previously subject to British rule. It further considers the impact of this judgment upon democracy in Fiji and the future protection of human rights for its citizens. (shrink)
This Companion brings together a team of leading figures in contemporary philosophy to provide an in-depth exposition and analysis of Quine’s extensive influence across philosophy’s many subfields, highlighting the breadth of his work, and revealing his continued significance today. Provides an in-depth account and analysis of W.V.O. Quine’s contribution to American Philosophy, and his position as one of the late twentieth-century’s most influential analytic philosophers Brings together newly-commissioned essays by leading figures within contemporary philosophy Covers Quine’s work across philosophy of (...) logic, philosophy of language, ontology and metaphysics, epistemology, and more Explores his work in relation to the origins of analytic philosophy in America, and to the history of philosophy more broadly Highlights the breadth of Quine’s work across the discipline, and demonstrates the continuing influence of his work within the philosophical community. (shrink)
This chapter first surveys general issues in the epistemic internalism / externalism debate: what is the distinction, what motivates it, and what arguments can be given on both sides. -/- The second part of the chapter will examine the internalism / externalism debate as regards to the specific case of the epistemology of memory belief.
The article is devoted to the memory of Vyacheslav Semenovich Stepin and Nikita Nikolaevich Moiseev, whose multifaceted work was integrally focused on philosophical, interdisciplinary and transdisciplinary research of the key ideas and principles of universal human-dimensional evolutionism. Other remarkable Russian scientists V.I. Vernadsky, S.P. Kurdyumov, S.P. Kapitsa, D.S. Chernavsky worked in the same tradition of universal evolutionism. While V.I. Vernadsky and N.N. Moiseev had been the originators of that scientific approach, V.S. Stepin provided philosophical foundations for the ideas of those (...) remarkable scientists and thinkers. The scientific legacy of V.S. Stepin and N.N. Moiseev maintained the formation of a new quality of research into the philosophy of science and technology as well as into the philosophy of culture. This new quality is multidimensional and it is difficult to define unambiguously, but we presume the formation of those areas of philosophical knowledge as constructively oriented languages of interdisciplinary and transdisciplinary co-participation of philosophy in the convergent-evolutionary development of scientific knowledge in general. In this regard, attention is paid to V.S. Stepin’s affirmations about non-classical nature of modern social and humanitarian knowledge. Quantum mechanics teaches us that the reality revealed through it is a hybrid construct, or symbiosis, of both mean and object of cognition. Therefore, the very act of cognitive observation constructs quantum reality. Thus, it is very close to the process of cognition in modern sociology and psychology. V.S. Stepin insisted that these principles are applicable to all complex selfdeveloping systems, and such are all “human-dimensional” objects of modern humanities. In all the phases of homeostasis changes, or crises, there is necessarily a share of chaos, instability, uncertainty in the selection process of future development scenarios, which is ineliminably affected by our observation. Therefore, a cognitive observer in the humanities should be considered as a concept of post-non-classical rationality, that is as an observer of complexity. (shrink)
The most influential philosopher in the analytic tradition of his time, Willard Van Orman Quine changed the way we think about language and its relation to the world. His rejection of the analytic/synthetic distinction, his scepticism about modal logic and essentialism, his celebrated theme of the indeterminacy of translation, and his advocacy of naturalism have challenged key assumptions of the prevailing orthodoxy and helped shape the development of much of recent philosophy.This introduction to Quine's philosophical ideas provides philosophers, students, and (...) generalists with an authoritative analysis of Quine's lasting contributions to philosophy. The major themes covered include the adaptation of the language of modern logic to formulate a criterion of ontological commitment; Quine's own ontological commitments; Duhemian-Holistic empiricism and the attendant rejection of a priori knowledge; the nature and grounds of logical truth; Quine's criticisms of such notions as meaning, synonymy, analyticity, and necessity; the conjecture of the indeterminacy of translation; modal logic; propositional attitudes; and Quine's work on naturalized epistemology.Quine's ideas throughout are contrasted with more traditional views, as well as with contemporaries such as Frege, Russell, Carnap, Davidson, Field, Kripke, and Chomsky, enabling the reader to grasp a clear sense of the place of Quine's views in twentieth-century philosophy and the important criticisms of them. (shrink)
The article discusses the affinity of the ideas of two prominent Russian scholars N.N. Moiseev and V.S. Stepin. This affinity of their ideas is above all expressed in the global scale of their thinking, in their orientation toward the search for the ways of mankind development. Both thinkers sought a way out of the limitations and crisis of technological civilization through the promotion of basic values of harmony in the evolution of society and the biosphere. They made an enormous contribution (...) to the development of both humanitarian and natural sciences areas of knowledge related to social management and development, techonology, economics, law, medicine, ecology, education, etc. They worked in an interdisciplinary areas and were successful integrators of natural science and humanities. Simultaneously with the scientific work, Moiseev and Stepin were excellent teachers and mentors of both young and mature researchers. They have created successful scientific schools that include many dozens of outstanding scientists. They devoted much attention and much time to social work, primarily in various structures of the Russian Academy of Sciences. The affinity of Moiseev’s and Stepin’s ideas is shown in four areas of their activities: overcoming the crisis of technological civilization and the limitations of the concept of sustainable development, research into socio-humanitarian cybernetics, development of advanced education models, implementation of successful scientific diplomacy projects. The author of this article participated in joint research projects with Moiseev and Stepin, the personal communication with them and their ideas significantly influenced author’s life path, interests and research results. (shrink)
We ought to combine the predicative and veridical readings of estin. Plato’s view involves a parallelism between truth and being: when we know, we grasp a logos which is completely true and is made true by an on which is completely (F). Opinion takes as its object a logos which is no more true than false and which concerns things which are no more (F) than not (F). This view, I argue, is intelligible in the context of the presuppositions which (...) underlie Socratic ‘What is F?’ questions. (shrink)
The paper summarizes the main points of Quine's epistemology and philosophy of language: empiricism, holism, semantic behaviourism, inscrutability of reference, indterminacy of translation and the rejection of analyticity.
Here are ten essays written by a happily balanced mixture of younger and of more senior Quine scholars commenting on the philosophy of Willard Van Orman Quine, and collected in honor of his seventieth birthday, June 1978.
The comparative analysis of the approaches to philosophy and philosophizing by the two prominent Russian thinkers of the Soviet era: Evald V. Ilyenkov and Merab K. Mamardashvili. The author discusses specific methodological and conceptual features of Ilyenkov's dialectic and Mamardashvili's phenomenology, showing their theoretical and topical affinity.
Echoing Beardsley's trinity of unity, complexity, and intensity, Perkins develops three interrelated criteria on which to base an evaluation of film: credibility, coherence, and significance. I assess whether Perkins criteria of credibility serves as a useful standard for film criticism. Most of the effort will be devoted to charitably reconstructing the notion of credibility by bringing together some of Perkins' particular comments. Then I will briefly examine whether Perkins has successfully achieved his goal of developing standards of judgment by holding (...) credibility up to his own criteria of successful meta-criticism: "The clarification of standards should help to develop the disciplines of criticism without seeking to lay obligations on the film-maker" (p. 59). Although I argue that Perkins fails to achieve his goal, his criterion of credibility remains a useful mechanism for evaluating artistic attempts to achieve a particular end, namely spectator immersion. A limited domain of application for his criteria might seem to leave us with little more than an idiosyncratic expression of his classicist artistic taste, but Film as Film also contains valuable insights relevant to the so called "problem of imaginative resistance.". (shrink)