Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum‐Golgi intermediate compartment (ERGIC). These membranous vesicular‐tubular clusters are found tightly juxtaposed to ER subdomains that are competent for the production of COPII‐coated transport carriers. In contrast to many unicellular systems, metazoan COPII carriers largely transit just a few hundred nanometers to the ERGIC, prior to COPI‐dependent transport on to the cis‐Golgi. The (...) mechanisms underlying formation and maintenance of ERGIC membranes are poorly defined. However, recent evidence suggests an important role for Trk‐fused gene (TFG) in regulating the integrity of the ER/ERGIC interface. Moreover, in the absence of cytoskeletal elements to scaffold tracks on which COPII carriers might move, TFG appears to promote anterograde cargo transport by locally tethering COPII carriers adjacent to ERGIC membranes. This action, regulated in part by the intrinsically disordered domain of TFG, provides sufficient time for COPII coat disassembly prior to heterotypic membrane fusion and cargo delivery to the ERGIC. -/- . (shrink)

Citrate, an organic trivalent anion, is a major substrate for generation of energy in most cells. It is produced in mitochondria and used either in the Krebs' cycle or released into cytoplasm through a specific mitochondrial carriers. Citrate can also be taken up from blood through different plasma membrane transporters. In the cytoplasm, citrate can be used ultimately for fatty acid synthesis, which is increased in cancer cells. Here, we review the ways in which citrate can be transported and (...) discuss the changes in transport and metabolism that occur in cancer cells. The primary focus is on the prostate gland, which is known to produce and release large amounts of citrate during its normal secretory function. The significant changes that occur in citrate‐related metabolism and transport in prostate cancer are the second focus. This review strives to relate these mechanisms to molecular biology on the one hand and to clinical applications on the other. (shrink)

Au Sud-Est du Cynthe, dans un paysage où prédomine le granit, on remarque une lentille de marbre blanc légèrement bleuâtre sur laquelle on peut observer les nombreuses marques d'une exploitation dans l'Antiquité. Les trois secteurs qui constituent cette carrière révèlent les traces du travail des carriers ; leur examen permet d'établir quelques hypothèses sur le fonctionnement de l'installation depuis les travaux préparatoires nécessaires à l'extraction jusqu'au levage et à l'embarquement des blocs prélevés pour leur transport par mer. L'utilisation (...) de ce marbre pour la construction de certains édifices déliens nous aide à préciser les dates de l'exploitation et permet de conclure que la carrière, dont le rendement semble avoir été faible, a connu une activité sporadique entre la première moitié du vie s. et la fin du IVe S. (shrink)

Physiological studies show that the driving force for long distance transport and the control of nutrient movement in plants resides largely in the regulated, membrane transport of a few carbohydrates, principally sucrose. The evidence is reviewed here and biochemical studies on sucrose carrier proteins are discussed.

Systems of urban transportation are largely shaped through planning practices. In transport economics, the benefits of infrastructure investments consist mainly of travel time savings calculated using monetary values of time. The economic interpretation of the value of travel time has significantly shaped our urban environment and transportation schemes. However, there is often an underlying assumption of transferability between time and money, which arguably does not sufficiently take into account the specific features of time. In this paper, we analyze the (...) various properties of time as an economic resource using findings in behavioral economics and psychology. Due to limitations in the standard model, it is proposed that an alternative model value should be investigated in which time rather than money is the primary carrier of and the basic features of such a model are outlined. An improved understanding the nature of time as a source of utility puts us in a better position to determine what aspects of time matter. Additionally, the analysis can be applied to further develop modeling where value of time plays a significant role; such as new models for the planning of urban transport. (shrink)

An entirely different mechanism and localization were recently proposed for the COPII coat complex, challenging its well‐accepted function to select and concentrate cargo into small COPII‐coated spherical transport vesicles. Instead, the COPII complex is suggested to form a dynamic yet stationary collar that forms a boundary between the ER and the ER export membrane domain. This membrane domain, the ER exit site (ERES), is the site of COPII‐mediated sorting and concentration of transport competent proteins. Subsequently, the ERES is (...) implicated to mature and bud to form a sizeable pleiomorphic transport carrier that translocate on microtubules to fuse with the Golgi apparatus. Despite this drastic mechanistic dogma shift, most of the underlying protein‐protein and protein‐membrane interactions remain unchanged. Here, we attempt to provide a detailed description of the newly proposed model of how ER to Golgi transport works by describing the role of several essential proteins of the transport machinery. (shrink)

In general terms there are only three primary energy sources: fossil fuels, renewable energy, and nuclear fission. For fueling road transportation, there has been much speculation about the use of hydrogen as an energy carrier, which would usher in the “hydrogen economy.” A parallel situation would use a simple battery to store electricity directly in order to power vehicles. The efficiency of these two different approaches has been compared and shows that the hydrogen and fuel cell system would consume nearly (...) three times the primary energy required by a battery storage system. Successful introduction into the marketplace of the plug-in hybrid vehicle would eliminate the need for road vehicles to use petroleum fuels, at least for the majority of miles traveled. If electricity were to be generated primarily from sustainable primary energy sources, then road transportation would also become sustainable, resulting in an “electricity economy” rather than a “hydrogen economy.”. (shrink)

This article summarizes the study of anion exchange mechanisms in bacteria. Along with defining at least two different families of anion exchange, an examination of such carrier‐mediated antiport reactions has led to techniques that considerably broaden the scope of biochemical methods for examining membrane proteins. Such advances have been exploited to show that anion exchange itself forms the mechanistic base of an entirely new kind of proton pump, one which may shed light on a variety of bacterial events, including methanogenesis. (...) Perhaps most important, the study of exchange provided the final link in a chain of evidence pointing to a structural [rhythm] that seems to characterize membrane carriers. These three issues ‐ a biochemical tool, a new proton pump, and a common structural rhythm ‐ are briefly examined in the context of their origins in the analysis of bacterial anion exchange. (shrink)

The recent discovery and structure determination of a novel ubiquitin‐like dimerization domain in protein kinase D (PKD) has significant implications for its activation. PKD is a serine/threonine kinase activated by the lipid second messenger diacylglycerol (DAG). It is an essential and highly conserved protein that is implicated in plasma membrane directed trafficking processes from the trans‐Golgi network. However, many open questions surround its mechanism of activation, its localization, and its role in the biogenesis of cargo transport carriers. In (...) reviewing this field, the focus is primarily on the mechanisms that control the activation of PKD at precise locations in the cell. In light of the new structural findings, the understanding of the mechanisms underlying PKD activation is critically evaluated, with particular emphasis on the role of dimerization in PKD autophosphorylation, and the provenance and recognition of the DAG that activates PKD. (shrink)

Food turns out to be not only the nutrient supplier for our body but also a carrier of regulatory information. Interestingly, a recent study made the discovery that some plant/food‐derived microRNAs (miRNAs) accumulate in the serum of humans or plant‐feeding animals, and regulate mammalian gene expression in a sequence‐specific manner. The authors provided striking evidence that miRNAs could function as active signaling molecules to transport information across distinct species or even kingdoms. Although the mechanism of how miRNAs are shuttled (...) between different organisms is still not well characterized, initial results point to the involvement of microvesicles and specific RNA‐transporter‐like proteins. These findings raise both speculation about the potential impact that plants may have on animal physiology at the molecular level, and an appealing possibility that food‐derived miRNAs may offer us another means to deliver necessary nutrients or therapeutics to our bodies. (shrink)

Auxin is a plant growth regulator involved in diverse fundamental developmental responses. Much is now known about auxin transport, via influx and efflux carriers, and about auxin perception and its role in gene regulation. Many developmental processes are dependent on peaks of auxin concentration and, to date, attention has been directed at the role of polar auxin transport in generating and maintaining auxin gradients. However, surprisingly little attention has focussed on the role and significance of auxin biosynthesis, (...) which should be expected to contribute to active auxin pools. Recent reports on the function of the YUCCA flavin monooxygenases and a tryptophan aminotransferase in Arabidopsis have caused us to look again at the importance of local biosynthesis in developmental processes. Many alternative and redundant pathways of auxin synthesis exist in many plants and it is emerging that they may function in response to environmental cues. (shrink)

The Dynamics of Social Practice -- Introducing Theories of Practice -- Materials and Resources -- Sequence and Structure -- Making and Breaking Links -- Material, Competence and Meaning -- Car-Driving: Elements and Linkages Making Links -- Breaking Links -- Elements Between Practices -- Standardization and Diversity -- Individual and Collective Careers -- The Life of Elements -- Modes of Circulation -- Transportation and Access: Material -- Abstraction, Reversal and Migration: Competence -- Association and Classification: Meaning -- Packing and Unpacking -- (...) Emergence, Disappearance and Persistence -- Recruitment, Defection and Reproduction -- First Encounters: Networks and Communities -- Capture and Commitment: Careers and Carriers -- Collapse and Transformation: The Dynamics of Defection -- Daily Paths, Life Paths and Dominant Projects -- Connections Between Practices -- Bundles and Complexes -- Collaboration and Competition -- Selection and Integration -- Coordinating Daily Life -- Circuits of Reproduction -- Monitoring Practices-as-Performances -- Monitoring Practices-as-Entities -- Cross-Referencing Practices-as-Performances -- Cross-Referencing Practices-as-Entities -- Aggregation -- Elements of Coordination -- Intersecting Circuits -- Representing the Dynamics of Social Practice -- Representing Elements and Practices -- Characterizing Circulation -- Competition, Transformation and Convergence -- Reproducing Elements, Practices and Relations between Them -- Time and Practice -- Space and Practice -- Dominant Projects and Power -- Promoting Transitions in Practice -- Climate Change and Behaviour Change -- Basis of Action -- Processes of Change -- Positioning Policy -- Transferable Lessons -- Practice Theory and Climate Change Policy -- Configuring Elements of Practice -- Configuring Relations between Practices -- Configuring Careers: Carriers and Practices -- Configuring Connections -- Practice Oriented Policy Making. (shrink)

The blood‐brain barrier (BBB) is a complex structure formed by vascular endothelial cells, which serve to stabilize the homeostasic processes that are essential for neural functioning. The barrier relies on tight junctions between neighboring endothelial cells and a highly restricted passage of blood‐borne components through the endothelial lining. Selective transport mechanisms guarantee the essential import and export of metabolites through the BBB into and out of the neural microenvironment. The dual functions of barrier and carrier depend on distinct proteins, (...) some of which have been characterized in detail. (shrink)

A geometro-differential quantum theory of extended particles is presented. The geometrical selling is that of Hilbert fiber bundles whose base manifolds are pseudo-Riemannian space-times of points χ which are interpreted as partial aspects of physical reality (the extended particle). The fibers are carrier spaces of induced (internal configuration and momentum) representations of the structural group (the de Sitter group here). Sections of these bundles are seen as physical representations of the particle, and their values in the fibers are interpreted as (...) states of internally localized modes composing the particle. This geometrical structure is “analogous” to that of a geometro-stochastic quantization developed in recent years. The physical interpretation is a combination of those of an old functional quantum theory and of an induced representation scheme based on an interpretation of intertwining, between configuration and momentum representations, as localization, materialization, and propagation of particles. Our model is applied in two cases: (1) Induced representation is applied in both space-time and internal space: both have de Sitter symmetry whose connection is ignored. Intertwining is considered in both spaces in a composed fashion. (2) For generic spacetimes and when the connection is taken into account, intertwining is applied only in the internal space. Parallel transport is combined with intertwining for a redefinition of localization, materialization, and propagation (the latter in a path integral context inspired from geometro-stochastic quantization). (shrink)

Domino's Pizza is testing “Domicopter” drones to deliver pizzas, which will compete with Taco Bell's “Tacocopter” drones. Not to be outdone, Amazon is working on an army of delivery drones that will cut out the postal service. In Denmark, farmers use drones to inspect fields for the appearance of harmful weeds, which reduces herbicide use as the drones directly apply pesticides only where it is needed. Environmentalists send drones into glacial caves or into deep waters, gathering data that would be (...) too dangerous or expensive for human scientists to procure. Federal Express dreams of pilotless aerial and terrestrial drones that will transport goods more cheaply, reliably, and safely than vehicles operated by humans. Human rights activists deploy drones over conflict zones, intelligently searching for and documenting abuses for both rhetorical and legal purposes. Aid agencies send unmanned drones to villages deep in jungles or behind enemy lines, maneuvering hazardous terrain to bring food and supplies to endangered populations. Medical researchers are experimenting with injecting drone blood cells into humans that can mimic good cholesterol carriers or identify and neutralize cancerous cells. Parents in Vermont are using flying drones to accompany children to school, giving a whole new meaning to helicopter parenting. And Pilobolus, a New York dance company, has choreographed a dance in which drones and humans engage each other in the most human of acts: the creation of art. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 22 (2002) 207-208 [Access article in PDF] Society Cosponsors International Conference in Chiang Mai, Thailand Payap University and Payap University's Institute for the Study of Religion and Culture will be sponsoring a week-long International Academic Conference on "Religion and Globalization in Chiang Mai, Thailand" beginning the last week of July 2003. The conference is being cosponsored by the American Society for Buddhist-Christian Studies. Ruben Habito, vice-president of (...) the Society, is serving as a member of the planning committee and as the liaison between Payap University and the Society. Other members of the planning committee include Donald Swearer, Michael von Brueck, David Chappell, Wolfgang Schmidt, Parichart Suwanbubbha, Saeng Chandrangam, and John Butt. It is hoped that a large contingent of members of the American Society for Buddhist-Christian Studies will participate in the conference both by submitting academic papers and by attending.Other cosponsoring organizations include the International Network of Engaged Buddhists, the Museum of World Religions based in Taiwan, the International Buddhist-Christian Theological Encounter, the Church of Christ in Thailand (CCT), and a number of other academic and religious organizations from around the world and within Thailand.The conference will be held on the main Payap University campus beginning with dinner on Sunday evening, July 27. It will end with lunch on Saturday, August 2, 2003. Lodging will be provided at the four-star Amari Rincome Hotel located near the Payap campus. Following the conference, Payap is arranging for several optional post-conference excursions to important religious and historical sites in Thailand and neighboring countries for those wishing to extend their stay in Southeast Asia.The overall theme of the conference is "Religion and Globalization". Plenary speeches, academic papers, discussions, and workshops will be organized around three broad themes:Religious Diversity and Interfaith Relations in a Global Age This section will include topics concerning religious pluralism, missions, religious conflict and reconciliation, and religious dialogue.Religion and a Global Society This section will focus on specific topics related to issues of social and economic justice, such as the relation between religion and human rights, structural violence, gender, tourism, prostitution, HIV/AIDS, the natural environment, media, technology, arts, and culture. [End Page 207]Religious Reform and Reformulation for a Global Age This section will focus on the reformulation of religious teachings and doctrines as well as on reforms of religious rituals, practices, and institutions in relationship to globalization.Several reasons make Thailand an appropriate and attractive site for this conference. Thailand has the largest percentage of Buddhists of any country in the world. It also has significant Islamic, Christian, and Hindu minorities. Animistic beliefs and practices underlie the religious faith of most of the Thai people. Over the past century and especially during the past several decades the country and the region have experienced rapid and profound changes as a result of modernization and globalization. For all these reasons Chiang Mai presents an excellent venue for examining how the Theravada Buddhist tradition and other major religious traditions are affecting and being affected by globalization. In addition, the Chiang Mai area has been an important "crossroads" for various religious and cultural movements since the beginning of the Common Era. For over 2,000 years Thailand has been both a receiver and a sender of religious missions. Thus, Chiang Mai provides a superb locale for critically reexamining religious missions and interfaith relations.The complete cost for the seven-day conference (including all meals, lodging, local transportation, site visits, entertainment, and conference registration) will be $575 (U.S.). International air travel to Chiang Mai will be additional. But based on current fares, travel from the North America to Chiang Mai should be no more than between $800 and $1,200 (U.S.). The exact international travel cost will depend on the carrier and the place of origin. Optional post-conference excursions will involve some additional expense and will vary depending on the destination and length of the excursion.Details regarding procedure for registration and submitting papers, lodgings, the conference schedule, optional post-conference excursions, and travel... (shrink)

Studies associating interactions of 5-HTTLPR and life adversities with depression have yielded equivocal results. Studying endophenotypes may constitute a more powerful approach. In the current study, it was assessed whether interactions of 5-HTTLPR with childhood emotional abuse (CEA) and recent negative life events (RNLE) affect possible cognitive endophenotypes of depression, namely, attention-allocation bias and the ability to recognise others' mind states in 215 young adults of North-West European descent. The ability to classify others' negative mind states was found to be (...) increased with increasing RNLE in carriers of low-expressing Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) alleles. Carriers of two low-expressing alleles also preferentially oriented attention towards negative information. Gene-environment interactions were not observed for attention allocation bias. No effects involving CEA were observed. These results suggest that low-expressing 5-HTTLPR alleles may confer increased risk for depression through enhanced recognition of negative facial expressions following RNLE. (shrink)

The hemolysin toxin (HlyA) is secreted across both the cytoplasmic and outer membranes of pathogenic Escherichia coli and forms membrane pores in cells of the host immune system, causing cell dysfunction and death. The processes underlying the interaction of HlyA with the bacterial and mammalian cell membranes are remarkable. Secretion of HlyA occurs without a periplasmic intermediate and is directed by an uncleaved C‐terminal targetting signal and the HlyB and HlyD translocator proteins, the former being a member of a transporter (...) superfamily central to import and export of a wide range of substrates by prokaryotic and eukaryotic cells. The separate process by which HlyA is targetted to mammalian cell membranes is dependent upon fatty acylation of a non‐toxic precursor, proHlyA. This is achieved by a novel mechanism directed by the activator protein HlyC, which binds to an internal proHlyA recognition sequence and provides specificity for the transfer of fatty acid from cellular acyl carrier protein. (shrink)

Le trimètre ïambique gravé sur la base du Colosse fait simplement référence au fait, en soi remarquable, que cette base très lourde a été taillée dans le même marbre naxien que la statue : les dédicants tiennent à le rappeler parce que cette opération (travail en carrière et transport) représentait un supplément de dépense considérable, témoignage de leur piété envers le dieu. Un passage parallèle de Diodore de Sicile (I 47,3) vient à l'appui de cette interprétation.

United Nations (UN) leaders suggest that the world is not on track to meet the Sustainable Development Goals (SDGs) by 2030. The purpose of this paper is to explore whether the SDGs provide a valuable platform to call for a basic income (BI) globally. Adopting a critical historical studies approach, the article traces the evolution of ‘development’, including the UN decades of development, the Millennium Development Goals, and the SDGs. It subsequently describes the structural adjustment and poverty reduction efforts by (...) the World Bank and International Monetary Fund, and then outlines why the SDG framework may be helpful in advancing a BI. We argue that as climate-related disasters increase, a BI will be vital in providing a modicum of security in an increasingly unstable world. Calls for BI must be anchored to a broader change agenda that recognizes the causes of poverty and income inequality, and seeks their dismantling and redress. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 38.2 (2004) 80-87 [Access article in PDF] The Beauty of Henri Matisse David Carrier Because beauty has for a long time now been politically incorrect (at least among certain influential critics and academic historians) the art of Henri Matisse has recently suffered from a kind of benign neglect. His goals were luxury, calm, and voluptuousness, not social critique. He painted female nudes, and was (...) preoccupied with artistic tradition. Celebrated in his own lifetime, he died a rich man. Matisse's famous identification of the work of art with a good armchair is another provocation. His paintings, after all, are very expensive armchairs. Liberated from any vital connection with everyday life, they often seem merely escapist. In her recent book, On Beauty and Being Just, Elaine Scarry remarks, "Matisse never hoped to save lives. But he repeatedly said that he wanted to make paintings so serenely beautiful that when one came upon them, suddenly all problems would subside."1 That some of Matisse's paintings succeed in being serenely beautiful seems self-evident to Scarry, to me, and to a great many other art lovers. What is perhaps worth exploring at greater length, however, is precisely how Matisse's paintings succeed in achieving their unfashionable goal. What is it that makes the work of Matisse so serenely beautiful?To start, consider The Painter and His Model (1918-1921), made just after his move from Paris to Nice. Like other works from this period of his career, this picture raises special problems, even for many commentators who admire his earlier experimentation. At the left, we see the painter working on a canvas of a nude. "Expression, for me," Matisse wrote, "does not reside in passions glowing in a human face."2 Like most of his models, this one appears expressionless. She poses at the center of the picture, beneath a window that admits the light filling the room. A flowering palm, a symbol of fertility, is the only object visible from the world outside the studio.Leaving behind his family and the luxury of his Paris home, Matisse lived and worked in a small room like this one. The entire picture is filled [End Page 80] with patterns — a red tablecloth on the left, orange wallpaper on the right, blue stripes on the painter's shirt, a red grid on the floor. A dark painting hangs above flowers on the table. The Painter and His Model shows the artist hard at work, but the composition appears effortlessly spontaneous. Matisse, who lived only to paint during his time in Nice, concealed the endless effort required to make his beautiful pictures. A man from North France, he discovered the power of light. There is nothing special about this room, but under the spell of his model Matisse makes it appear ravishing. Intense Mediterranean sunlight transforms ordinary patterns into a world of visual luxury.We know that The Painter and His Model is beautiful because we get great pleasure seeing the model in the golden room. Her skin is close in tone to, or in harmony with the colors of the walls; her curves harmonize with the two vases, and play against the spreading linear grids. As we move our eyes easily from the model to the entire picture, we experience a kind of sublimated erotic pleasure. In "Notes of a Painter," Matisse gave an apt description of his approach in The Painter and His Model. Suppose I want to paint a woman's body: first of all I imbue it with grace and charm, but I know that I must give something more. I will condense the meaning of this body by seeking its essential lines. The charm will be less apparent at first glance, but it must eventually emerge from the new image which will have a broader meaning, one more fully human. (MA, 36) He does not use the word "beauty," but speaks instead about expression and harmony. When he published this manifesto, Matisse was painting very different sorts of pictures — portraits, scenes of nudes in utopian settings, and... (shrink)

We examined the affective consequences of everyday attention lapses and memory failures. Significant associations were found between self-report measures of attention lapses , attention-related cognitive errors , and memory failures , on the one hand, and boredom and depression , on the other. Regression analyses confirmed previous findings that the ARCES partially mediates the relation between the MAAS-LO and MFS. Further regression analyses also indicated that the association between the ARCES and BPS was entirely accounted for by the MAAS-LO and (...) MFS, as was that between the ARCES and BDI-II. Structural modeling revealed the associations to be optimally explained by the MAAS-LO and MFS influencing the BPS and BDI-II, contrary to current conceptions of attention and memory problems as consequences of affective dysfunction. A lack of conscious awareness of one’s actions, signaled by the propensity to experience brief lapses of attention and related memory failures, is thus seen as having significant consequences in terms of long-term affective well-being. (shrink)

Although significant literature and jurisprudence has amassed on rights-based climate litigation over recent years, less research and case law has emerged on poverty-related court cases and the fulfilment of economic, social, and cultural rights (ESCR) in Canada. Fewer still are studies exploring the interlinkages between these areas of inquiry. The purpose of this paper is to explore, using Canada as a case study, rights-based developments in climate litigation cases and how these could impact the innovative advancement of ESCR (e.g. to (...) food, housing and water). Typically, issues of justiciability and standing emerge, impeding the realization of such rights. Given the grave threats we now face, climate cases and social movements must be brought together to better hold state actors accountable for their rights obligations. We implore the legal community to explore ways to traverse juridical obstacles to realize the interdependencies of human rights and protect the planet from calamitous climate change. (shrink)

Ah, emojis ☺. Some enthusiastically speak of them as a new universal language. In 2015, the Oxford English dictionary crowned one of them as its word of the year. Sixty million are exchanged daily on Facebook. Along with emoticons and various other smileys, emojis are now part of daily communications. Visual add-ons or superscript, they are meant to indicate intent or add emotions to written messages, which do not benefit from the tone or body language of the interlocutor. As such, (...) they present themselves as tools for clarification, but one can wonder if they do not, too, introduce uncertainty in language. Aimed at barristers as well as jurilinguists, this paper seeks to underline some design and perception biases that can hinder communication, with a focus on rules of evidence and legal methodology. Empirically rooted in Canadian case law, the findings resonate in other jurisdictions, as emojis, indeed, are a global phenomenon. (shrink)

Drawing from both theoretical and empirical research, the literature on basic income (BI) is now voluminous, pronouncing both its merits and its limitations. Burgeoning research documents the impacts of un/conditional cash transfers and negative income tax programs, with many studies highlighting the effectiveness of these programs in reducing poverty, and improving a host of social, economic and health outcomes. We consider possible avenues for BI architecture to be adopted within Canada’s existing constellation of income security programs, to the benefit of (...) disadvantaged groups in society. Identifying key federal and provincial (i.e., Ontario) transfer and tax benefit programs, we highlight which programs might best be maintained or converted to a BI. While opponents decry the (alleged) exorbitant costs of BI schemes, we suggest that the existing approach not only produces an ineffective system—which actually engenders poverty and the health and social problems that accompany it—but an excessively costly one. (shrink)

I argue that sentences ascribing beliefs to non-human animals have the same logical form as sentences of the "perceives that" variety. Pace D.M. Armstrong, I argue that animal belief sentences can be referentially opaque, just as perception sentences containing a propositional clause are. In both cases, referential opacity requires our assuming that the animal believer and the human perceiver has each identified the object of the belief or perception.

I argue that the time-gap argument poses no objection to Direct Realism. In the case of exploded stars many light years from us, what we see is no longer the star, but its light. I argue that in all cases of seeing we see light, but only when physical objects exist at the time of our seeing do we see them.

An introduction to the new area of ignorance studies that examines how science produces ignorance—both actively and passively, intentionally and unintentionally. We may think of science as our foremost producer of knowledge, but for the past decade, science has also been studied as an important source of ignorance. The historian of science Robert Proctor has coined the term agnotology to refer to the study of ignorance, and much of the ignorance studied in this new area is produced by science. Whether (...) an active or passive construct, intended or unintended, this ignorance is, in Proctor's words, “made, maintained, and manipulated” by science. This volume examines forms of scientific ignorance and their consequences. A dialogue between Proctor and Peter Galison offers historical context, presenting the concerns and motivations of pioneers in the field. Essays by leading historians and philosophers of science examine the active construction of ignorance by biased design and interpretation of experiments and empirical studies, as seen in the “false advertising” by climate change deniers; the “virtuous” construction of ignorance—for example, by curtailing research on race- and gender-related cognitive differences; and ignorance as the unintended by-product of choices made in the research process, when rules, incentives, and methods encourage an emphasis on the beneficial and commercial effects of industrial chemicals, and when certain concepts and even certain groups' interests are inaccessible in a given conceptual framework. Contributors Martin Carrier, Carl F. Cranor, Peter Galison, Paul Hoyningen-Huene, Philip Kitcher, Janet Kourany, Hugh Lacey, Robert Proctor, Londa Schiebinger, Miriam Solomon, Torsten Wilholt. (shrink)

ISBN-13: 978-0-8229-4317-4 (cloth : alk. paper) ISBN-10: 0-8229-4317-4 (cloth : alk. paper) 1. Science — Philosophy. 2. Science — Social aspects. 3. Values. 4. Science and civilization. I. Carrier, Martin. II. Howard, Don, professor. III. Kourany ...

I address options for providing scientific policy advice and explore the relation between scientific knowledge and political, economic and moral values. I argue that such nonepistemic values are essential for establishing the significance of questions and the relevance of evidence, while, on the other hand, such social choices are the prerogative of society. This tension can be resolved by recognizing social values and identifying them as separate premises or as commissions while withholding commitment to them, and by elaborating a plurality (...) of policy packages that envisage the implementation of different social goals. There are limits to upholding the value-free ideal in scientific research. But by following the mentioned strategy, science can give useful policy advice by leaving the value-free ideal largely intact. Such scientific restraint avoids the risk of appearing to illegitimately impose values on the public and could make the advice given more trustworthy. (shrink)