Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

Cultural evolution studies are characterized by the notion that culture evolves accordingly to broadly Darwinian principles. Yet how far the analogy between cultural and genetic evolution should be pushed is open to debate. Here, we examine a recent disagreement that concerns the extent to which cultural transmission should be considered a preservative mechanism allowing selection among different variants, or a transformative process in which individuals recreate variants each time they are transmitted. The latter is associated with the notion of “cultural (...) attraction”. This issue has generated much misunderstanding and confusion. We first clarify the respective positions, noting that there is in fact no substantive incompatibility between cultural attraction and standard cultural evolution approaches, beyond a difference in focus. Whether cultural transmission should be considered a preservative or reconstructive process is ultimately an empirical question, and we examine how both preservative and reconstructive cultural transmission has been studied in recent experimental research in cultural evolution. Finally, we discuss how the relative importance of preservative and reconstructive processes may depend on the granularity of analysis and the domain being studied. (shrink)

In Ockhamist branching-time logic [Prior 67], formulas are meant to be evaluated on a specified branch, or history, passing through the moment at hand. The linguistic counterpart of the manifoldness of future is a possibility operator which is read as `at some branch, or history (passing through the moment at hand)'. Both the bundled-trees semantics [Burgess 79] and the $\langle moment, history\rangle$ semantics [Thomason 84] for the possibility operator involve a quantification over sets of moments. The Ockhamist frames are (3-modal) (...) Kripke structures in which this second-order quantification is represented by a first-order quantification. The aim of the present paper is to investigate the notions of modal definability, validity, and axiomatizability concerning 3-modal frames which can be viewed as generalizations of Ockhamist frames. (shrink)

In 1996, the Royal College of Psychiatrists recommended that all psychiatric facilities in the UK develop policies concerning sexuality and sexual expression for persons contained in those facilities. This paper analyses the prevalence and content of such policies in English forensic psychiatric facilities. While the College recommends an individualised approach to sexual and emotional relationships, most hospitals in fact either prohibit or actively discourage such expression as a matter of policy. The paper considers the advantages and disadvantages of that approach. (...) The paper also considers the legal issues surrounding these policies, and in particular the legal authority for governing the sexual and emotional expression of hospital residents and the relevant human rights implications. (shrink)

A completeness theorem is established for logics with congruence endowed with general semantics (in the style of general frames). As a corollary, completeness is shown to be preserved by fibring logics with congruence provided that congruence is retained in the resulting logic. The class of logics with equivalence is shown to be closed under fibring and to be included in the class of logics with congruence. Thus, completeness is shown to be preserved by fibring logics with equivalence and general semantics. (...) An example is provided showing that completeness is not always preserved by fibring ligics endowed with standard (non general) semantics. A categorial characterization of fibring is provided using coproducts and cocartesian liftings. (shrink)

People’s awareness of tactile stimuli has been investigated in far less detail than their awareness of stimuli in other sensory modalities. In an attempt to fill this gap, we provide an overview of studies that are pertinent to the topic of tactile consciousness. We discuss the results of research that has investigated phenomena such as “change blindness”, phantom limb sensations, and numerosity judgments in tactile perception, together with the results obtained from the study of patients affected by deficits that can (...) adversely affect tactile perception such as neglect, extinction, and numbsense. The similarities as well as some of the important differences that have emerged when visual and tactile conscious information processing have been compared using similar experimental procedures are highlighted. We suggest that conscious information processing in the tactile modality cannot be separated completely from the more general processing of spatial information in the brain. Finally, the importance of considering tactile consciousness within the larger framework of multisensory information processing is also discussed. (shrink)

This major publication is a history of the semantic tradition in philosophy from the early nineteenth century through its incarnation in the work of the Vienna Circle, the group of logical positivists that emerged in the years 1925-1935 in Vienna who were characterised by a strong commitment to empiricism, a high regard for science, and a conviction that modern logic is the primary tool of analytic philosophy. In the first part of the book, Alberto Coffa traces the roots of (...) logical positivism in a semantic tradition that arose in opposition to Kant's theory that a priori knowledge is based on pure intuition and the constitutive powers of the mind. In Part II, Coffa chronicles the development of this tradition by members and associates of the Vienna Circle. Much of Coffa's analysis draws on the unpublished notes and correspondence of many philosophers. The book, however, is not merely a history of the semantic tradition from Kant 'to the Vienna Station'. Coffa also critically reassesses the role of semantic notions in understanding the ground of a priori knowledge and its relation to empirical knowledge and questions the turn the tradition has taken since Vienna. (shrink)

In just the last decade, many conference proceedings have been published on Plato’s Timaeus and its influence on the history of philosophy. The present vo­lume, which is the result of a symposium held at Seoul National University in September 2011, testifies to the enduring and widespread interest the Platonic dia­logue is able to elicit. The nine studies here collected by Euree Song center on the figure of the demiurge as maker of the world and they all deal with authors who, (...) while having di... (shrink)

This open access book discusses individual, collective, and institutional responsibilities with regard to vaccination from the perspective of philosophy and public health ethics. It addresses the issue of what it means for a collective to be morally responsible for the realisation of herd immunity and what the implications of collective responsibility are for individual and institutional responsibilities. The first chapter introduces some key concepts in the vaccination debate, such as ‘herd immunity’, ‘public goods’, and ‘vaccine refusal’; and explains why failure (...) to vaccinate raises certain ethical issues. The second chapter analyses, from a philosophical perspective, the relationship between individual, collective, and institutional responsibilities with regard to the realisation of herd immunity. The third chapter is about the principle of least restrictive alternative in public health ethics and its implications for vaccination policies. Finally, the fourth chapter presents an ethical argument for unqualified compulsory vaccination, i.e. for compulsory vaccination that does not allow for any conscientious objection. The book will appeal to philosophers interested in public health ethics and the general public interested in the philosophical underpinning of different arguments about our moral obligations with regard to vaccination. (shrink)

The volume offers the first large-scale study of the teaching of Descartes' philosophy in the early modern age. Its twenty chapters explore the clash between Descartes' "new" philosophy and the established pedagogical practices and institutional concerns, as well as the various strategies employed by Descartes' supporters in order to communicate his ideas to their students. The volume considers a vast array of topics, sources, and institutions, across the borders of countries and confessions, both within and without the university setting (public (...) conferences, private tutorials, distance learning by letter) and enables us thereby to reconsider from a fresh perspective the history of early modern philosophy and education. (shrink)

The volume offers the first large-scale study of the teaching of Descartes' philosophy in the early modern age. Its twenty chapters explore the clash between Descartes' "new" philosophy and the established pedagogical practices and institutional concerns, as well as the various strategies employed by Descartes' supporters in order to communicate his ideas to their students. The volume considers a vast array of topics, sources, and institutions, across the borders of countries and confessions, both within and without the university setting (public (...) conferences, private tutorials, distance learning by letter) and enables us thereby to reconsider from a fresh perspective the history of early modern philosophy and education. (shrink)

The branching-time logic called Peircean by Arthur Prior is considered and given an infinite axiomatization. The axiomatization uses only the standard deduction rules for tense logic.

Temporal logic is one of the many areas in which a possible world semantics is adopted. Prior's Ockhamist and Peircean semantics for branching-time, though, depart from the genuine Kripke semantics in that they involve a quantification over histories, which is a second-order quantification over sets of possible worlds. In the paper, variants of the original Prior's semantics will be considered and it will be shown that all of them can be viewed as first-order counterparts of the original semantics.

In the tree-like representation of Time, two histories are undivided at a moment t whenever they share a common moment in the future of t. In the present paper, it will first be proved that Ockhamist and Peircean branching-time logics are unable to express some important sentences in which the notion of undividedness is involved. Then, a new semantics for branching-time logic will be presented. The new semantics is based on trees endowed with an indistinguishability function, a generalization of the (...) notion of undividedness. It will be shown that Ockhamist and Peircean semantics can be viewed as limit cases of the semantics developed in this paper. (shrink)

In order to present the philosopher Alberto Wagner de Reyna, we must first understand his life, then his work, and finally the force of his ideas; especially those which establish him within the history of philosophical ideas. This paper presents a synthesis of the conversation that the author..

The basic notions in Prior’s Ockhamist and Peircean logics of branching-time are the notion of moment and that of history (or course of events). In the tree semantics, histories are defined as maximal linearly ordered sets of moments. In the geometrical approach, both moments and histories are primitive entities and there is no set theoretical (and ontological) dependency of the latter on the former. In the topological approach, moments can be defined as the elements of a rank 1 base of (...) a non-Archimedean topology on the set of histories. In this paper, it will be shown that the topological approach, and hence the other approaches, can be reconstructed in a framework in which the basic notions are those of history and of relative closeness relation among histories. (shrink)

The basic notions in Prior's Ockhamist and Peircean logics of branching-time are the notion of moment and that of history. In the tree semantics, histories are defined as maximal linearly ordered sets of moments. In the geometrical approach, both moments and histories are primitive entities and there is no set theoretical dependency of the latter on the former. In the topological approach, moments can be defined as the elements of a rank 1 base of a non-Archimedean topology on the set (...) of histories. In this paper, it will be shown that the topological approach, and hence the other approaches, can be reconstructed in a framework in which the basic notions are those of history and of relative closeness relation among histories. (shrink)

Abortion is largely accepted even for reasons that do not have anything to do with the fetus' health. By showing that (1) both fetuses and newborns do not have the same moral status as actual persons, (2) the fact that both are potential persons is morally irrelevant and (3) adoption is not always in the best interest of actual people, the authors argue that what we call ‘after-birth abortion’ (killing a newborn) should be permissible in all the cases where abortion (...) is, including cases where the newborn is not disabled. (shrink)

Alireza Bagheri supports a policy on organ procurement where individuals could choose their own definition of death between two or more socially accepted alternatives. First, we claim that such a policy, without any criterion to distinguish accepted from acceptable definitions, easily leads to the slippery slope that Bagheri tries to avoid. Second, we suggest that a public discussion about the circumstances under which the dead donor rule could be violated is more productive of social trust than constantly moving the line (...) between life and death. (shrink)

This paper deals with structures ${\langle{\bf T}, I\rangle}$ in which T is a tree and I is a function assigning each moment a partition of the set of histories passing through it. The function I is called indistinguishability and generalizes the notion of undividedness. Belnap’s choices are particular indistinguishability functions. Structures ${\langle{\bf T}, I\rangle}$ provide a semantics for a language ${\mathcal{L}}$ with tense and modal operators. The first part of the paper investigates the set-theoretical properties of the set of indistinguishability (...) classes, which has a tree structure. The significant relations between this tree and T are established within a general theory of trees. The aim of second part is testing the expressive power of the language ${\mathcal{L}}$ . The natural environment for this kind of investigations is Belnap’s seeing to it that (stit). It will be proved that the hybrid extension of ${\mathcal{L}}$ (with a simultaneity operator) is suitable for expressing stit concepts in a purely temporal language. (shrink)

We experimentally investigated the influence of context-based biases, such as prestige and popularity, on the preferences for quotations. Participants were presented with random quotes associated to famous or unknown authors, or with random quotes presented as popular, i.e. chosen by many previous participants, or unpopular. To exclude effects related to the content of the quotations, all participants were subsequently presented with the same quotations, again associated to famous and unknown authors, or presented as popular or unpopular. Overall, our results showed (...) that context-based biases had no, or limited, effect in determining participants’ choices. Quotations preferred for their content were preferred in general, despite the contextual cues to which they were associated. We conclude discussing how our results fit with the well-known phenomenon of the spread and success of misattributed quotations, and we draw some more general implications for cultural evolution research. (shrink)

The association of resilience-related factors with frailty is a recent research topic. Dispositional optimism and context sensitivity are two psychological factors that differently contribute to individual resilience. This study aimed at investigating whether dispositional optimism and context sensitivity might contribute to a multifactorial model of frailty, together with established relevant factors such as cognitive and physical factors. This cross-sectional study involved 141 elderly outpatients aged ≥65 years, who were referred to the Geriatrics and Multidimensional Evaluation Clinic of the University Hospital (...) of Messina. We used the following measures: the Mini-Mental State Examination to screen for global cognitive functioning; 4-m gait speed and handgrip strength to measure physical performance; a 35-item Frailty Index to evaluate patients’ frailty status; the revised Life Orientation Test to gauge dispositional optimism; and the Context Sensitivity Index to measure context sensitivity. We found that LOT-R, CSI, and MMSE were all significantly associated with FI. Gait speed was only marginally associated with FI. The present study showed a novel association of dispositional optimism and context sensitivity with frailty among elderly outpatients. These preliminary findings support a multidimensional approach to frailty in which even peculiar psychological features might provide a significant contribution. (shrink)

We extend to the predicate frame a previous characterization of the maximal intermediate propositional constructive logics. This provides a technique to get maximal intermediate predicate constructive logics starting from suitable sets of classically valid predicate formulae we call maximal nonstandard predicate constructive logics. As an example of this technique, we exhibit two maximal intermediate predicate constructive logics, yet leaving open the problem of stating whether the two logics are distinct. Further properties of these logics will be also investigated.

A comparison is given between two conditions used to define logical constants: Belnap's uniqueness and Hacking's deducibility of identicals. It is shown that, in spite of some surface similarities, there is a deep difference between them. On the one hand, deducibility of identicals turns out to be a weaker and less demanding condition than uniqueness. On the other hand, deducibility of identicals is shown to be more faithful to the inferentialist perspective, permitting definition of genuinely proof-theoretical concepts. This kind of (...) analysis is driven by exploiting the Curry–Howard correspondence. In particular, deducibility of identicals is shown to correspond to the computational property of eta expansion, which is essential in the characterization of propositional identity. (shrink)

This note makes a contribution to the issue raised in a paper by Popper and Miller (1983) in which it was claimed that probabilistic support is purely deductive. Developing R. C. Jeffrey's remarks, a new general approach to the crucial concept of "going beyond" is here proposed. By means of it a quantitative measure of the inductive component of a probabilistic inference is reached. This proposal leads to vindicating the view that typical predictive probabilistic inferences by enumeration and analogy are (...) purely inductive. (shrink)

Este trabalho, apresentado em forma de ensaio filosófico e pedagógico, propõe experimentar modos outros de escrever e interpretar os conceitos de Michel Foucault. Para desenvolver a analítica, parte-se de três conceitos basilares: saber, poder e subjetividade. A tese que se instaura é que a interpretação se dá na articulação entre movimentos recíprocos de interioridade e exterioridade do sujeito –constituído pelos discursos, pelos jogos de poder e pelas tecnologias de si – que, para significar o mundo, dá nomes e, assim, sentido (...) para a existência. Como resultado, o trabalho propõe pensar a hermenêutica foucaultiana como transgressora, não pelo seu caráter subversivo, mas pela possibilidade de funcionar como ferramenta teórica e metodológica. Interpretar é, nessa perspectiva, projetar o espaço-outro, o tempo-outro e a vida-outra, indagando o impacto da crise anti-intelectualista e negacionista. (shrink)

We describe a form of moral artificial intelligence that could be used to improve human moral decision-making. We call it the “artificial moral advisor”. The AMA would implement a quasi-relativistic version of the “ideal observer” famously described by Roderick Firth. We describe similarities and differences between the AMA and Firth’s ideal observer. Like Firth’s ideal observer, the AMA is disinterested, dispassionate, and consistent in its judgments. Unlike Firth’s observer, the AMA is non-absolutist, because it would take into account the human (...) agent’s own principles and values. We argue that the AMA would respect and indeed enhance individuals’ moral autonomy, help individuals achieve wide and a narrow reflective equilibrium, make up for the limitations of human moral psychology in a way that takes conservatives’ objections to human bioenhancement seriously, and implement the positive functions of intuitions and emotions in human morality without their downsides, such as biases and prejudices. (shrink)

We argue that individuals who have access to vaccines and for whom vaccination is not medically contraindicated have a moral obligation to contribute to the realisation of herd immunity by being vaccinated. Contrary to what some have claimed, we argue that this individual moral obligation exists in spite of the fact that each individual vaccination does not significantly affect vaccination coverage rates and therefore does not significantly contribute to herd immunity. Establishing the existence of a moral obligation to be vaccinated (...) despite the negligible contribution each vaccination can make to the realisation of herd immunity is important because such moral obligation would strengthen the justification for coercive vaccination policies. We show that two types of arguments—namely a utilitarian argument based on Parfit’s Principle of Group Beneficence and a contractualist argument—can ground an individual moral obligation to be vaccinated, in spite of the imperceptible contribution that any single vaccination makes to vaccine coverage rates. We add a further argument for a moral obligation to be vaccinated that does not require embracing problematic comprehensive moral theories such as utilitarianism or contractualism. The argument is based on a “duty of easy rescue” applied to collectives, which grounds a collective moral obligation to realise herd immunity, and on a principle of fairness in the distribution of the burdens that must be borne to realise herd immunity. (shrink)

Spartan institutions were pictured as a model of political stability from the Classical period onwards. The so-called Spartan ‘mirage’ did not involve only its constitutional order but also social and economic institutions. Xenophon begins hisConstitution of the Lacedaemoniansby associating Spartan fame with thepoliteiaset up by Lycurgus, which made the Laconian city the most powerful (δυνατωτάτη) and famous (ὀνομαστοτάτη)polisin Greece (Xen.Lac.1.1). In Aristotle'sPolitics, in which the assessment of Sparta is more complex and nuanced, one finds a critique of contemporary Spartan institutions (...) as well as praise for Lycurgus as a great lawgiver who established the laws of Sparta (Arist.Pol.2.1269a69, 2.1273b20). Most other ancient sources often remark upon the unchangeable features of some Spartan institutions as a key aspect of Spartan εὐνομία. Thucydides maintains that, after a long period of war andstasis, the Dorians established excellent laws and Sparta employed the same constitution for more than four hundred years (Thuc. 1.18.1: τετρακόσια καὶ ὀλίγῳ πλείω ἐς τὴν τελευτὴν τοῦδε τοῦ πολέμου ἀφ᾽ οὗ Λακεδαιμόνιοι τῇ αὐτῇ πολιτείᾳ χρῶνται). (shrink)

Conscientious objection in health care is a form of compromise whereby health care practitioners can refuse to take part in safe, legal, and beneficial medical procedures to which they have a moral opposition (for instance abortion). Arguments in defense of conscientious objection in medicine are usually based on the value of respect for the moral integrity of practitioners. I will show that philosophical arguments in defense of conscientious objection based on respect for such moral integrity are extremely weak and, if (...) taken seriously, lead to consequences that we would not (and should not) accept. I then propose that the best philosophical argument that defenders of conscientious objection in medicine can consistently deploy is one that appeals to (some form of) either moral relativism or subjectivism. I suggest that, unless either moral relativism or subjectivism is a valid theory—which is exactly what many defenders of conscientious objection (as well as many others) do not think—the role of moral integrity and conscientious objection in health care should be significantly downplayed and left out of the range of ethically relevant considerations. (shrink)

The present paper investigates the seventeenth-century debate on whether the agreement of all human beings upon certain notions—designated as the “common” ones—prove these notions to be innate. It does so by focusing on Descartes’ and Locke’s rejections of the philosophy of Herbert of Cherbury, one of the most important early modern proponents of this view. The paper opens by considering the strategy used in Herbert’s arguments, as well as the difficulties involved in them. It shows that Descartes’ 1638 and 1639 (...) reading of Herbert’s On Truth—both the 1633 second Latin edition and Mersenne’s 1639 translation—was instrumental in shaping Descartes’ views on the issue. The arguments of Locke’s Essay opposing Herbert’s case for innatism are thus revealed to be ineffective against the case which Descartes makes for this same doctrine, since Descartes had in fact framed his conception of innateness in opposition to the very same theses as Locke was arguing against. The paper concludes by explaining how two thinkers as antithetical as Locke and Descartes came to agree on at least one point, and a truly crucial one: namely, that universal consent counts as a criterion neither for innatism nor for truth. (shrink)

Últimamente se viene hablando mucho de “guerra cultural” si bien pocas veces se concreta su significado. Tiene que ver con la batalla por el relato, pero no se limita a este campo. En todo caso, conviene diferenciar este concepto del legítimo debate e intercambio de ideas en pos de la mejora social. Nos encontraríamos por el contrario más cerca de la guerra híbrida, psicológica, cognitiva y el arte de la propaganda llevados a cabo por unos Estados contra otros, pero también (...) por determinados agentes con poder suficiente para imponer la cultura que les interesa y acabar con la del contrario. (shrink)

El libro es una obra colectiva coordinada por el catedrático de filosofía de la Universidad de Alcalá Francisco Castilla Urbano, quien también redacta el capítulo introductorio. El resto son doce capítulos a manos de otros tantos profesores, nueve de ellos en universidades de EEUU, y tres en Universidades españolas: Pública de Navarra, Sevilla y Francisco de Vitoria. Comentar un libro colectivo, y más con tantos autores, resulta siempre una tarea dificultosa, en lo que es una recensión de extensión necesariamente limitada.

I argue that there are significant moral reasons in addition to harm prevention for making vaccination against certain common infectious diseases compulsory. My argument is based on an analogy between vaccine refusal and tax evasion. First, I discuss some of the arguments for compulsory vaccination that are based on considerations of the risk of harm that the non‐vaccinated would pose on others; I will suggest that the strength of such arguments is contingent upon circumstances and that in order to provide (...) the strongest defence possible of compulsory vaccination, such arguments need to be supplemented by additional arguments. I will then offer my additional argument for compulsory vaccination: I will argue that in both cases of vaccine refusal and of tax evasion individuals fail to make their fair contribution to important social and public goods, regardless of whether each individual contribution ‘makes a difference’. While fairness considerations have sometimes been used to support a moral duty to vaccinate, they have not been appealed to in order to argue for a legal duty to vaccinate. I will suggest that this is due, among other things, to a misapplication of the principle of the least restrictive alternative in public health. Finally, I will address nine possible objections to my argument. (shrink)