Although scholars have often settled upon 1686 as the year in which the central elements of Leibniz’s philosophy first appear in systematic form, certain of his positions appear to have been firmly in place at least ten years earlier. Papers written in 1676 reveal that Leibniz had already by that time established the fundamental feature of his single-substance metaphysics: the insubstantiality of matter. As he defines it, matter is a mode, but a mode of peculiar status, a sort of “top (...) mode,” which, together with change, is requisite to the existence of any other modes, or “things.” Things for Leibniz include all bodies and their qualities, and in some places also appear to include minds, although Leibniz for religious reasons equivocates here, and wants to resist. Nevertheless, Leibniz’s desire to move toward a version of the Aristotelian notion of matter as the principle of individuation is clearly in evidence as he works to set out a view which can accommodate mechanistic physics while avoiding the perceived atheistic threat inherent in both Cartesian dualism and Spinozistic monism. (shrink)
Abstract Angiogenesis is a complex morphogenetic process regulated by growth factors, but also by the force balance between endothelial cells (EC) traction stresses and extracellular matrix (ECM) viscoelastic resistance. Studies conducted with in vitro angiogenesis assays demonstrated that decreasing ECM stiffness triggers an angiogenic switch that promotes organization of EC into tubular cords or pseudo-capillaries. Thus, mechano-sensitivity of EC with regard to proteases secretion, and notably matrix metalloproteinases (MMPs), should likely play a pivotal role in this switching mechanism. While most (...) studies analysing strain regulation of MMPs used cell cultured on stretched membranes, this work focuses on MMP expression during self-assembly of EC into capillary-like structures within fibrin gels, i.e. on conditions that mimics more closely the in vivo cellular mechanical microenvironment. The activity of MMP-2 and MMP-9, two MMPs that have a pivotal role in capillaries formation, has been monitored in pace with the progressive elongation of EAhy926 cells that takes place during the emergence of cellular cords. We found an increase of the zymogen proMMP-2 that correlates with the initial stages of EC cords formation. However, MMP-2 was not detected. ProMMP-9 secretion decreased, with levels of MMP-9 kept at a rather low value. In order to analyse more precisely the observed differences of EAhy926 response on fibrin and plastic substrates, we proposed a theoretical model of the mechano-regulation of proMMP-2 activation in the presence of type 2 tissue inhibitor of MMPs (TIMP-2). Using association/dissociation rates experimentally reported for this enzymatic network, the model adequately describes the synergism of proMMP-2 and TIMP-2 strain activation during pseudo-capillary morphogenesis. All together, these results provide a first step toward a systems biology approach of angiogenesis mechano-regulation by cell-generated extracellular stresses and strains. Content Type Journal Article Category Regular Article Pages 1-20 DOI 10.1007/s10441-012-9147-3 Authors Minh-Uyen Dao Thi, Faculté de Médecine de Grenoble, DyCTiM team, UJF-Grenoble 1, CNRS, Laboratoire TIMC-IMAG UMR 5525, 38041 Grenoble, France Candice Trocmé, BEP/DBTP, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 9, France Marie-Paule Montmasson, Faculté de Médecine de Grenoble, DyCTiM team, UJF-Grenoble 1, CNRS, Laboratoire TIMC-IMAG UMR 5525, 38041 Grenoble, France Eric Fanchon, Faculté de Médecine de Grenoble, BCM team, UJF-Grenoble 1, CNRS, Laboratoire TIMC-IMAG UMR 5525, 38041 Grenoble, France Bertrand Toussaint, BEP/DBTP, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 9, France Philippe Tracqui, Faculté de Médecine de Grenoble, DyCTiM team, UJF-Grenoble 1, CNRS, Laboratoire TIMC-IMAG UMR 5525, 38041 Grenoble, France Journal Acta Biotheoretica Online ISSN 1572-8358 Print ISSN 0001-5342. (shrink)
Joseph Raz’s much discussed service conception of practical authority has recently come under attack from Stephen Darwall, who proposes that we instead adopt a second- personal conception of practical authority.1 We believe that the best place to start understanding practical authority is with a pared back conception of it, as simply a species of normative authority more generally, where this species is picked out merely by the fact that the normative authority in question is authority in relation to action, rather (...) than belief. We do not wish to deny that there might be properties of practical authority (as distinct from the species of authority that is concerned with belief) that are peculiar to it, but, unlike both Raz and Darwall, we do not believe that such features play a role in defining or delimiting practical authority. (shrink)
: Plato’s instructions entail that the line of Republic VI is divided so that the middle two segments are of equal length. Yet I argue that Plato’s elaboration of the significance of this analogy shows he believes that these segments are of unequal length because the domains they represent are not of equally clear mental states, nor perhaps of objects of equal reality. I label this inconsistency between Plato’s instructions and his explanation the “overdetermination problem.” The overdetermination problem has been (...) a perennial concern, and a substantial amount of work has been produced which attempts to deal with it. I offer a classification of approaches to the overdetermination problem as a way of documenting the problem’s significance, and show why these approaches are all inadequate as solutions. My novel resolution of the overdetermination problem rests upon a demonstration that the contradiction is intentional. The later recapitulation of the ratio at 534a reveals that Plato was himself aware that the middle two segments are equal. I argue that this contradiction is a sophisticated device designed to lead the reader of the Republic through the four epistemic stages represented by the line itself. Most significantly, recognition of this mathematical contradiction acts as a goad, spurring independent philosophical reflection just in the way that Plato advocates in the Republic more generally. (shrink)
The treatment of identical particles in quantum mechanics rests on two (related) principles: the spin-statistics connection and the Symmetrization Postulate. In light of recent theories (such as q-deformed commutators) that allow for ‘small’ violations of the spin-statistics connection and the Symmetrization Postulate, we revisit the issue of how quantum mechanics deals with identical particles and how it supports or fails to support various philosophical stances concerning individuality. As a consequence of the expanded possibilities for quantum statistics, we argue that permutation (...) symmetry is best formulated as a formal property of the state function describing the system of particles rather than as a property of the individual particles. 1 Introduction 2 Philosophical background 2.1 Important terminology 2.1.1 Identity 2.1.2 Indistinguishability 2.1.3 Indiscernibility 2.2 When are particles indistinguishable? 2.3 The Principle of the Identity of Indiscernibles and quantum mechanics 2.4 The Principle of the Identity of Indiscernibles and logic 2.5 Particle history 2.6 Transcendental individuality 3 Some quantum formalism 3.1 The Principle of Permutation Invariance and the Symmetrization Postulate 3.2 The configuration-space approach 3.3 Commutators and anticommutators, and identical particle statistics 3.4 Q-mutators 4 Identical particle statistics: a holistic point of view 5 Conclusions. (shrink)
The "Ibercorp affair" was front-page news in Spain at various times between 1992 and 1995. In itself, there was nothing particularly new about it: a newly formed financial group engaged in legally and ethically reprehensible behaviour that eventually came to light in the media, ruining the company (and the careers of those involved). What aroused public interest at the time was the fact that it involved individuals connected with Spanish public and political life, the media and certain business circles. Above (...) all, it demonstrated the personal, economic, social and political consequences of a business culture based on the pursuit of easy profits at any price (what came to be known as the cultura del pelotazo or "culture of the fast buck"). Again, this is all too familiar in business ethics. But it served to goad Spanish society into a rejection of such behaviour. This article describes the facts and their ethical implications. (shrink)
The "Ibercorp affair" was front-page news in Spain at various times between 1992 and 1995. In itself, there was nothing particularly new about it: a newly formed financial group engaged in legally and ethically reprehensible behaviour that eventually came to light in the media, ruining the company (and the careers of those involved). What aroused public interest at the time was the fact that it involved individuals connected with Spanish public and political life, the media and certain business circles. Above (...) all, it demonstrated the personal, economic, social and political consequences of a business culture based on the pursuit of easy profits at any price (what came to be known as the cultura del pelotazo or "culture of the fast buck"). Again, this is all too familiar in business ethics. But it served to goad Spanish society into a rejection of such behaviour. This article describes the facts and their ethical implications. (shrink)
Mary Anne Warren's claim that there is room for only one person with full and equal rights inside a single human skin ([1], p. 63) calls attention to the vast range of moral conflict engendered by assigning full basic moral rights to fetuses. Thereby, it serves as a goad to thinking about conflicts between pregnant women and their fetuses in a way that emphasizes relationships rather than rights. I sketch out what a care orientation might suggest about resolving gestational (...) conflicts. I also argue that the care orientation, with its commitment to the significance of the partial and the particular, cannot be absorbed within standard, impartialist moral theory. (shrink)
1.1 A distinctive feature of our agency is the ability to bind our future conduct by making future-directed decisions. The bond of decisions is not one of mere physical constraint. A decision is not the trigger of some mechanism that takes control of the agent at the future time f and physically forces her to φ. When the agent φ’s out of her past decision to do so, she is in rational control of her conduct at the time of action.1 (...) Decisions appear to have rational authority over the agent’s future conduct. When the time of action comes, the agent is normally guided by no other rational consideration but her past decision. She is guided, not goaded, by it.2 Unlike manipulative forms of distal self-control such as precommitments, decisions do not seem to alter the future situation of choice by introducing features extraneous to the original merits of the case.3 Decisions appear nonetheless to make some kind of difference at the time of action. Were it not so, they would not be effective at influencing future conduct. A successful theory of future-directed decisions must account for the distinctive rational guidance of decisions and show how they can be effective without being manipulative.4 A theory of this kind does not deny that decisions might play a causal role in the agent’s psychology and that their effectiveness is in part a causal matter. But it rejects the suggestion that genuine future-directed decisions operate as mere time-delay devices such as lit-fuses, that is, by way of mechanisms of brute, non-rational.. (shrink)
Friedrich Nietzsche is one of the most popular and controversial philosophers of the last 150 years. Narcissistic, idiosyncratic, hyperbolic, irreverent--never has a philosopher been appropriated, deconstructed, and scrutinized by such a disparate array of groups, movements, and schools of thought. Adored by many for his passionate ideas and iconoclastic style, he is also vilified for his lack of rigor, apparent cruelty, and disdain for moral decency. In Living with Nietzsche, Solomon suggests that we read Nietzsche from a very different point (...) of view, as a provocative writer who means to transform the way we view our lives. This means taking Nietzsche personally. Rather than focus on the "true" Nietzsche or trying to determine "what Nietzsche really meant" by his seemingly random and often contradictory pronouncements about "the Big Questions" of philosophy, Solomon reminds us that Nietzsche is not a philosopher of abstract ideas but rather of the dazzling personal insight, the provocative challenge, the incisive personal probe. He does not try to reveal the eternal verities but he does powerfully affect his readers, goading them to see themselves in new and different ways. It is Nietzsche's compelling invitation to self-scrutiny that fascinates us, engages us, and guides us to a "rich inner life." Ultimately, Solomon argues, Nietzsche is an example as well as a promulgator of "passionate inwardness," a life distinguished by its rich passions, exquisite taste, and a sense of personal elegance and excellence. (shrink)
The Bishop of Questoriana has recently asked for a pontifical document ‘furnishing a doctrinal foundation of love and respect for life existing on the earth’. Mainstream moralists have urged, since the Axial Era, that it is human life that most demands love and respect. We realize and perfect our own humanity by recognizing humanity in every other, of whatever creed or race. Realizing that biological species are not natural kinds, more recent moralists have hoped to found moral decency either on (...) a respect for ‘rationality’ which excludes many of our conspecifics, or on simple loyalty to our immediate kin. Neither option is without its costs, and Catholic moralists in particular have often been suspicious of a morality that seems to lead to contempt for ordinary human life. Neither advocacy of ‘animal rights’ nor utilitarian calculation of animal pains and pleasures sit well with a traditional Catholic morality. Conversely, many of those who defend traditional practices such as hunting, farming or goading animals to fight, themselves suppose that ‘human’ and ‘animals’ may sometimes inhabit the same moral universe, that there are virtues that both may display in ‘noble action’. Developing this thought, it is possible to locate decency elsewhere than in an over-intellectual respect for ‘reason’. Decent treatment of animals (as of others) is that form of life which lets us live together ‘humanely’, in appreciation of the actual beings they are. Virtue, as Aristotle argued, lies less in acting nobly than in appreciating nobility. Those who claim to appreciate such nobility in beasts must learn to live humanely. (shrink)
The kind of commitment to moral rules that characterizes effective interaction between persons in, among others places,manufacturing and commercial settings is characteristically treated by economists and game theorists as a public good, the securing ofwhich requires the expenditure of scarce resources on surveillance and enforcement mechanisms. Alternatively put, the view is that,characteristically, rational persons cannot voluntarily guide their choices by rules, but can only be goaded into acting in accordancewith such rules by the fear of social and formal sanctions. On (...) this way of thinking, rational individuals are condemned to having to settlefor the "second-best" results that are thereby implied. This conclusion rests not only on an appeal to a consequentialist perspective, butalso a separability principle. Against this, it is argued that consequentialism itself offers a basis for the rejection of the separability principle, and a defense of the thesis that, for a wide range of realistic cases, being disposed to voluntarily guide one's choice by rules (on the condition that others can be expected to do so as well) is a necessary condition of engaging in rational interaction. (shrink)
