BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to specific loci by RNAs during differentiation and development. A significant fraction of the genome-wide transcription of non-protein coding RNAs may be involved in this process, comprising a previously hidden layer of intermediary genetic information that (...) underpins developmental ontogeny and the differences between species, ecotypes and individuals. It is also evident that RNA editing is a primary means by which hardwired genetic information in animals can be altered by environmental signals, especially in the brain, indicating a dynamic RNA-mediated interplay between the transcriptome, the environment and the epigenome. Moreover, RNA-directed regulatory processes may also transfer epigenetic information not only within cells but also between cells and organ systems, as well as across generations. (shrink)

Há muitos pontos de concordância entre Frege e os neokantianos. Isso vale especialmente para os representantes do neokantismo da teoria do valor ou do Sudoeste alemão na tradição de Hermann Lotze. Não discutiremos aqui todos os aspectos dessa proximidade; de acordo com o tema que propomos, ficaremos restritos à filosofia da matemática. A primeira parte do artigo tratará da relação entre aritmética e geometria, mostrando surpreendentes semelhanças entre Frege e o neokantiano Otto Liebmann. A segunda parte discutirá as diferentes recepções (...) do logicismo de Frege por Jonas Cohn, Paul Natorp, Heinrich Rickert, Ernst Cassirer e Bruno Bauch. (shrink)

Trust is an attitude that an agent (the trustor) has toward an entity (the trustee), such that the trustor counts upon the trustee to act in a way that is benefi- cial w.r.t. to the trustor’s goals. The notion of trust is relevantly discussed both in in- formation science and philosophy. Unfortunately, we still lack a satisfying account for this concept. The goal of this article is to contribute to filling this gap. First, we take issue with some central tenets (...) shared by the main philosophical accounts, such as that there is just one relation of trust, that this relation has three argument places, and that trust is reliance plus some extra factor. Second, we provide a novel account of trust, also discussing different levels of trust. According to the account we put forth here, the logical form of trust sentences is expressed by a four-place relation. Further, we distinguish and characterize four kinds of trust relations and their connections. We also argue that trust and reliance are different phenomena. Third, on the basis of the proposed account, we extend the Reference Ontology of Trust (ROT). We call the new version of ROT that includes this extension ”ROT 3.0”. Finally, we discuss the implications of the new ontological definitions in the applications we have done of the concept of trust in other works, also pointing out future applications made possible by these novel accounts of trust. (shrink)

This paper investigates the effect of female representation on the board of directors on corporate response to stakeholders’ demands for increased public reporting about climate change-related risks. We rely on the Carbon Disclosure Project as a sustainability initiative supported by institutional investors. Greenhouse gas emissions measurement and its disclosure to investors can be thought of as a first step toward addressing climate change issues and reducing the firm’s carbon footprint. Based on a sample of publicly listed Canadian firms over the (...) period 2008–2014, we find that the likelihood of voluntary climate change disclosure increases with women percentage on boards. We also find evidence that supports critical mass theory with regard to board gender diversity. These findings reinforce initiatives being undertaken around the world to promote gender diversity in corporate governance while demonstrating board effectiveness in stakeholder management. (shrink)

ABSTRACT Banks provide a valuable but inherently unstable combination of deposit‐taking and lending functions that were successfully held together for several decades after the New Deal by tough banking rules. The weakening of the rules after the 1970s promoted the displacement of traditional relationship‐based banking with securitized, arms‐length alternatives that encouraged banks to undertake activities about which bankers lacked deep relationship‐based knowledge of the risks. Ironically, this risky behavior, encouraged by loosened regulation, was reinforced by progressively tightened securities regulation, which (...) promoted stock‐market liquidity but also deprived large banks (and other publicly traded companies) of oversight by investors with “insiders’” knowledge. Both the underregulation of banking and the overregulation of securities were underpinned by economic theories that favored blind diversification in liquid, anonymous markets, and that ignored the value of relationship‐based knowledge and case‐by‐case due diligence. (shrink)

The Nature of God explores a perennial problem in the philosophy of religion.

This book provides a collection of sources, many of them fragmentary and previously scattered and hard to access, for the development of Peripatetic philosophy in the later Hellenistic period and the early Roman Empire. It also supplies the background against which the first commentator on Aristotle from whom extensive material survives, Alexander of Aphrodisias (fl. c. AD 200), developed his interpretations which continue to be influential even today. Many of the passages are here translated into English for the first time, (...) including the whole of the summary of Peripatetic ethics attributed to 'Arius Didymus'. (shrink)

Reason and Value collects 15 new papers by leading contemporary philosophers on themes from the work of Joseph Raz. Raz has made major contributions in a wide range of areas, including jurisprudence, political philosophy, and the theory of practical reason; but all of his work displays a deep engagement with central themes in moral philosophy. The subtlety and power of Raz's reflections on ethical topics make his writings a fertile source for anyone working in this area. Especially significant are his (...) explorations of the connections between practical reason and the theory of value, which constitute a sustained and penetrating treatment of a set of issues at the very center of moral philosophy as it is practiced today. The contributors to the volume acknowledge the importance of Raz's contributions by engaging critically with his positions and offering independent perspectives on the topics that he has addressed. The volume aims both to honour Raz's accomplishments in the area of ethical theorizing, and to contribute to an enhanced appreciation of the significance of his work for the subject. (shrink)

Recently, the second author, Briseid, and Safarik introduced nonstandard Dialectica, a functional interpretation capable of eliminating instances of familiar principles of nonstandard arithmetic—including overspill, underspill, and generalizations to higher types—from proofs. We show that the properties of this interpretation are mirrored by first-order logic in a constructive sheaf model of nonstandard arithmetic due to Moerdijk, later developed by Palmgren, and draw some new connections between nonstandard principles and principles that are rejected by strict constructivism. Furthermore, we introduce a variant of (...) the Diller–Nahm interpretation with two different kinds of quantifiers, similar to Hernest’s light Dialectica interpretation, and show that one can obtain nonstandard Dialectica by weakening the computational content of the existential quantifiers—a process called herbrandization. We also define a constructive sheaf model mirroring this new functional interpretation, and show that the process of herbrandization has a clear meaning in terms of these sheaf models. (shrink)

In this first paperback edition, a new introduction by Tom Burke establishes the ongoing importance of Sleeper's analysis of the integrity of Dewey's work and ...

Si le tragique n'est pas le propre de la tragédie grecque mais bien celui de 'l'être au monde de l'homme', sa conceptualisation n'advient qu'avec Wilderlin lorsque celui-ci s'approprie la question 'Comment lit-on la tragédie?', non plus selon son acception poétique, mais en tant que forme philosophique. Et si l'on suit sa réflexion, à la question 'Qu'est-ce que le tragique?', on notera qu'il est une façon d'être au monde de manière spéculative. L'union des contraires, de la poésie et de la sagesse, (...) voilà ce qui a tant plu à Empédocle, Hölderlin et Nietzsche. Si Je est un autre, la pensée tragique représente l'individu conscient de lui-même dans sa totalité. Mais, un personnage tragique n'est-il pas destiné à exister dans l'Histoire? Pour ces trois poètes, il s'agissait de traduire le monde du symbole, de la parabole, ou de l'allégorie en une nouvelle langue. En relisant de cette manière le tragique du monde, se découvre un sens qu'Empédocle, Hölderlin ou Nietzsche illuminèrent de leur regard: la mort dans les esquisses d'une tragédie pour Hölderlin et Nietzsche, ou la chute du démon chez Empédocle, traduisent la relation des oppositions dans l'absolu de la disparition"--Page 4 of cover. (shrink)

This book is not a study of Plato's philosophy, but a contribution to the literary interpretation of the dialogues, through analysis of their formal structure, ...

Le SMSI a affiché et promu une démarche de multipartenariat entre gouvernements, monde économique et société civile. Nous avons étudié la liste de diffusion électronique de l'un des caucus, « Civil Society - Internet Governance », au long d'une période clé de l'initiative onusienne. En analysant les modalités des échanges, nous nous sommes demandé quels types de tactiques et de stratégies émergent de ce dispositif, et dans quelle mesure il participe du débat public. Enfin, nous nous sommes interrogés sur les (...) limites du rôle effectif de la « société civile » dans un contexte international particulier.WSIS posted and promoted a multi-stakeholder approach between governments, civil society and business world. We studied the electronic mailing list of one of the caucus, "Civil Society - Internet Governance" during a key period of the UN initiative. By analyzing the terms of trade, we asked what kind of tactics and strategies emerge from this device, and how it participates in the public debate. Finally, we asked about the limits of the actual role of "civil society" in a particular international context. (shrink)

There are important similarities between moral thought and talk and thought and talk about gender: disagreements about gender, like disagreements about morality, seem to be intractable and to outstrip descriptive agreement; and it seems coherent to reject any definition of what it is to be a woman in terms of particular social, biological, or other descriptive features, just as it seems coherent to reject any definition of what it is to be good or right in terms of any set of (...) descriptive properties. These similarities give us reason to investigate the idea that, like moral thought and talk, gender thought and talk is inherently normative. This paper proposes a normative account of gender thought and talk in terms of fitting treatment. On this fitting treatment account, to judge that A is gender G is just to judge that it is fitting to treat A as a G. This account is a descriptive or hermeneutical account of our gender thought and talk rather than an ameliorative account of our gender concepts or a metaphysical account of gender properties in social metaphysics. This paper argues that other descriptive accounts of gender thought and talk face problems that the fitting treatment account overcomes. (shrink)

Este artigo começa por proceder à caracterização do Estado soberano, perspectivando-o como forma concreta e historicamente situada de organização política e inserindo-o no contexto dos demais modelos que o precederam. De seguida, constata a profunda crise que sobre ele se abateu, manifesta na incapacidade que apresenta, seja para explicar os fenómenos políticos com que nos deparamos diariamente, seja para constituir matriz adequada para a compreensão e explicação do mundo em que vivemos. Por último, lembra os direitos do homem desenvolvidos na (...) sequência da II Guerra Mundial do último século, explorando, por um lado, o carácter profundamente inovador que assumem e, por outro, a revolução que vêm introduzindo no sistema estatal de organização política. Tudo isto em apoio do principal argumento que se apresenta: quebrando o monopólio sobre o direito e o poder político que a modernidade havia consignado aos Estados, os direitos do homem emergem como uma das exigências mais eloquentes de um modelo novo de organização social e política, capaz de corresponder às necessidades que se fazem sentir, de universalidade, de solidariedade e de integração, também em termos jurídicos e políticos. /// This article opens with a characterization of the sovereign State, understood as a material and historically situated form of political organization and inserted in the context of the models that preceded it. In a second moment, it witnesses the profound crisis that has befallen it, evident in its incapacity, either to explain the political phenomenon we face daily, or to constitute an adequate framework for the under-standing and the explanation of the world we live in. Finally, it looks at human rights, as developed after the Second World War of the last century, exploring, on the one hand, their profoundly innovative character and, on the other, the revolution they are introducing in the State system of political organization. All of this in support of the main argument presented: breaking the monopoly over the law and political power that modernity had attributed to the States, human rights emerge as an eloquent demand for a new model of political organization, capable of corresponding to the demands of universality, solidarity and juridical and political integration that are felt in the contemporary world. (shrink)

Contributed articles with reference to India.

Multidimensional practical demand has made Islamology one of the most "trendy" branches of Oriental studies and has created a host of serious difficulties and problems associated with an adequate scientific response to the "Islamic challenge". Excessive politicization of the study of such a phenomenon as Islamic fundamentalism, radicalism in the world, undoubtedly, undermines the true scientific knowledge, preventing the specialists from understanding this complex phenomenon.

Many philosophers believe that there is a causal condition on perception, and that this condition is a conceptual truth about perception. A highly influential argument for this claim is based on intuitive responses to Gricean style thought experiments. Do the folk share the intuitions of philosophers? Roberts et al. (2016) presented participants with two kinds of cases: Blocker cases (similar to Grice’s case involving a mirror and a pillar) and Non-Blocker cases (similar to Grice’s case involving a clock and brain (...) stimulation). They found that a substantial minority agreed that seeing occurs in the Non-Blocker cases, and that in the Blocker cases significantly less agreed that seeing occurs. They thus hypothesized that folk intuitions better align with a no blocker condition than with a causal condition. This paper continues this line of enquiry with two new experiments. The paper investigates the generality and robustness of Roberts et al.’s findings by expanding the sense modalities tested from only vision to audition and olfaction as well. The paper also uses Gricean style thought experiments as a case study for investigating the “reflection defense” against the negative project in experimental philosophy. Our results replicate and extend Roberts et al.’s study and support their hypothesis that folk intuitions better align with a no blocker condition. They also provide an empirical reason to doubt the reflection defense. (shrink)