Delusion is one of the most intriguing psychopathological phenomena and its conceptualization remains the subject of genuine debate. Claims that it is ill-defined, however, are typically grounded on essentialist expectations that a given definition should capture the core of every instance acknowledged as delusion in the clinical setting.

BackgroundAlthough values have increasingly received attention in psychiatric literature over the last three decades, their role has been only partially acknowledged in psychiatric classification endeavors. The review process of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders received harsh criticism, and was even considered secretive by some authors. Also, it lacked an official discussion of values at play. In this perspective paper we briefly discuss the interplay of some values in the scientific and non-scientific debate around (...) one of the most debated DSM-5 category proposals, the Attenuated Psychosis Syndrome. Then, we point out some ethical consequences of a facts-plus-values perspective in psychiatric classification.DiscussionDifferent stakeholders participated in the APS-debate and for analytical purposes we divided them into four groups: researchers in the field of high-risk mental states; the DSM-5 Psychotic Disorders Work Group; patient, carers and advocacy groups; and external stakeholders, not related to the previous groups, but which also publicly expressed their opinions about APS inclusion in DSM-5. We found that each group differently stressed the role of values we examined in the APS-debate. These values were ethical, but also epistemic, political, economic and ontological. The prominence given to some values, and the lack of discussion about others, generated divergent positions among stakeholders in the debate.SummaryAs exemplified by the APS discussion, although medicine is primarily an ethical endeavor, values of different kinds that take part in it also shape to a large extent the profession. Thus, it may be strategic to openly discuss values at play in the elaboration of diagnostic tools and classificatory systems. This task, more than scientifically or politically significant, is ethically important. (shrink)

Although values have increasingly received attention in psychiatric literature over the last three decades, their role has been only partially acknowledged in psychiatric classification endeavors. The review p..

In lieu of an abstract, here is a brief excerpt of the content:Deflating Psychiatric ClassificationClaudio E. M. Banzato (bio)Keywordsnosography, comorbidity, utility, pragmatismSystems of classification bring order into the world. They are a key part of the informational working infrastructure of the world we inhabit (Bowker and Star 1999). Thus, much of the human interaction hinges on these ordering—pattern identifying and creating—systems. Formal or informal, standardized or ad hoc, visible or invisible, enforced or optional, there are a myriad of classifications (...) we necessarily live by.Typically, classifications convey representations of states of affairs to make interventions on them feasible and, to some extent, predictable. In other words, classificatory systems and schemes try to confer intelligibility to the world. By succeeding in such task, they may provide rational grounds to human operation on reality (toward the most diverse ends). This account fully applies to medical classifications, which struggle to sort out all kinds of diseases, ailments, complaints, and sufferings that can possibly be targeted by medical interventions. This means classifications are instrumental to the ends pursued by medicine, quintessential modificatory activity. In sum, classifications are cognitive tools devised to build up knowledge by making relevant distinctions, which may prove helpful to guide human action.By working well, classifications eventually tend to become invisible. They end up looking just natural, as if they were carved by nature itself. But indeed purpose is the touchstone here. Even if a given class of objects fully qualifies as a 'natural kind' and necessary and sufficient criteria for class membership can be definitely established, it does not entail that it constitutes the best way to classify these objects irrespective of the context. Peter Zachar (2002) offers a compelling example from natural sciences, the utmost practical importance of distinguishing between hydrogen and its isotopes (hydrogen, deuterium, and tritium). In this case, the classificatory thrust stretches beyond the shared atomic number. In his words, "A crucial factor in recognizing them as distinct is that they are used in distinct activities and practices. We get a better neutron bounce with heavy water or D2O. Deciding what aspects of internal structure are important therefore cannot be isolated from external factors." (p. 220)In contemporary psychiatry, diagnostic classification has been center stage for several reasons. But before addressing them, however, a brief historical detour is necessary. Back in the nineteenth century, putting forward a new classification of mental diseases was taken somewhat as a token of psychiatric proficiency according to the witty remark by the French physician and publicist Philippe Buchez: "Upon believing that they have [End Page 23] completed their studies, rhetoricians will compose a tragedy and alienists a classification" (Berrios 1999, 152). By the middle of the twentieth century, many psychiatric classifications (based on diverse principles and underlying theoretical orientations) were still used across the world. The British psychiatrist Erwin Stengel (1959), in his influential report on classification of mental disorders, pointed out that the issue of difficulty of communication was then the order of the day for psychiatry, because it was widely perceived as one of the most serious obstacles to the progress in the field.The broad, worldwide survey carried out by Stengel made it clear that classifications of all shapes were used in different contexts, but they were seldom appealing outside the boundaries of the respective centers that generated them. Such diversity of classifications reflected not only different functions or purposes they were meant to serve, but also the role played by the history of a given problem within a particular medical tradition and cultural background. Thus, Stengel's aims for an acceptable statistical international classification were relatively modest: it should simply ground epidemiological work.Stengel's stance on classification was frankly pragmatic and utilitarian. He understood well the difficulties posed by the 'disease entity' assumption in psychiatry and asked the straight question: "Firstly, what do we classify in this field? Are we classifying diseases or people?", to which he offered a compromised answer: "It may be said that the material the psychiatrist has to classify consists neither of diseases nor of people but of a variety of disorders or reactions, a material which does not readily lend itself to classification" (Stengel 1959, 612). For him, the pursued agreement on the... (shrink)

The collection presents a variety of promising new directions in Royce scholarship from an international group of scholars, including historical reinterpretations, explorations of Royce's ethics of loyalty and religious philosophy, and contemporary applications of his ideas in psychology, the problem of reference, neo-pragmatism, and literary aesthetics.

Super-substantivalism (of the type we’ll consider) roughly comprises two core tenets: (1) the physical properties which we attribute to matter (e.g. charge or mass) can be attributed to spacetime directly, with no need for matter as an extraneous carrier “on top of” spacetime; (2) spacetime is more fundamental than (ontologically prior to) matter. In the present paper, we revisit a recent argument in favour of super-substantivalism, based on General Relativity. A critique is offered that highlights the difference between (various accounts (...) of) fundamentality and (various forms of) ontological dependence. This affords a metaphysically more perspicuous view of what super-substantivalism’s tenets actually assert, and how it may be defended. We tentatively propose a re-formulation of the original argument that not only seems to apply to all classical physics, but also chimes with a standard interpretation of spacetime theories in the philosophy of physics. (shrink)

dolce, the first top-level ontology to be axiomatized, has remained stable for twenty years and today is broadly used in a variety of domains. dolce is inspired by cognitive and linguistic considerations and aims to model a commonsense view of reality, like the one human beings exploit in everyday life in areas as diverse as socio-technical systems, manufacturing, financial transactions and cultural heritage. dolce clearly lists the ontological choices it is based upon, relies on philosophical principles, is richly formalized, and (...) is built according to well-established ontological methodologies, e.g. OntoClean. Because of these features, it has inspired most of the existing top-level ontologies and has been used to develop or improve standards and public domain resources. Being a foundational ontology, dolce is not directly concerned with domain knowledge. Its purpose is to provide the general categories and relations needed to give a coherent view of reality, to integrate domain knowledge, and to mediate across domains. In these 20 years dolce has shown that applied ontologies can be stable and that interoperability across reference and domain ontologies is a reality. This paper briefly introduces the ontology and shows how to use it on a few modeling cases. (shrink)

Nowadays, a general agreement exists that European culture suffers from a severe type of economic and cultural crisis. In the first section of my contribution I intend to provide a comparison between Husserl's diagnosis of European crisis developed in the Vienna Lectures and Henry's account of barbarism in his book La barbarie. If, on the one hand, Husserl argues that such a critical condition compels Europe to choose between the sunset of its culture and its rebirth through a new foundation (...) of rationality, on the other hand Henry maintains that the barbarism prefigured by Husserl actually is the cultural horizon of our time. Under these premises, my core argument is that both Husserl and Henry suggest that Europe has the opportunity of overcoming its crisis through a new reflection about intersubjectivity, empathy, and social interaction. (shrink)

The œuvre of Portuguese photographer Jorge Molder can be construed as a series of series. These series are filled with a wealth of absent presences, of possibilities that arise and fade without ever reaching actualization or confirmation, thereby contributing to create a ‘detective-story’ atmosphere. This also proves to be true as regards Molder’s own body. Indeed, his face, his hands are recurrent “subjects” running through his 40 years of work. Even so, when we ask who the man is that we (...) see in Molder’s series, the answer is problematic. On the one hand, we know it is “him”, insofar as he himself is the model for his iconic “constructions”. On the other hand, Molder’s images are not “self-portraits” aiming to reveal the essence of his self, but rather “self-representations” creating a peculiar “character” who is and yet is not him: a double. (shrink)

This is the text of the Claudio Rozzoni's interview with Jorge Molder that took place in Portuguese on June 21, 2018, at the artist's atelier in Lisbon. English translation by Claudio Rozzoni.

Se busca establecer una relación, no satisfactoriamente explorada, entre la fenomenología merleaupontiana del tiempo y un problema central de la “theory of time” analítica, la paradoja de McTaggart. Al clarificar, en polémica con Priest (1998), el auténtico sentido del “subjetivismo” merleaupontiano con respecto al tiempo, se señala cómo establecer una confluencia entre el acercamiento fenomenológico y las tesis desarrolladas por Michael Dummett como respuesta a la mencionada paradoja. Con los señalamientos de Dummett y la interpretación de Bimbenet acerca del “perspectivismo” (...) merleaupontiano, se intenta una solución “situacional” a la paradoja. (shrink)

Given two (positive) equivalence relations ∼ 1 , ∼ 2 on the set ω of natural numbers, we say that ∼ 1 is m-reducible to ∼ 2 if there exists a total recursive function h such that for every x, y ∈ ω, we have $x \sim_1 y \operatorname{iff} hx \sim_2 hy$ . We prove that the equivalence relation induced in ω by a positive precomplete numeration is complete with respect to this reducibility (and, moreover, a "uniformity property" holds). This (...) result allows us to state a classification theorem for positive equivalence relations (Theorem 2). We show that there exist nonisomorphic positive equivalence relations which are complete with respect to the above reducibility; in particular, we discuss the provable equivalence of a strong enough theory: this relation is complete with respect to reducibility but it does not correspond to a precomplete numeration. From this fact we deduce that an equivalence relation on ω can be strongly represented by a formula (see Definition 8) iff it is positive. At last, we interpret the situation from a topological point of view. Among other things, we generalize a result of Visser by showing that the topological space corresponding to a partition in e.i. sets is irreducible and we prove that the set of equivalence classes of true sentences is dense in the Lindenbaum algebra of the theory. (shrink)

Este artigo apresenta considerações sobre possíveis infl uências teóricas de Theodule A. Ribot sobre S. Freud por ocasião de suas formulações teóricas iniciais sobre o psiquismo. Infl uências a partir de noções como memória e consciência, mas especialmente de cerebração inconsciente. Essas serão investigadas especialmente nas obras Les maladies de la mémoire e Projeto de psicologia, respectivamente. Destacamos que essa influência se deu pela contribuição e mediação de J. M. Charcot, tal como apresentada em Leçons sur les maladies du système (...) nerveux faites a la Salpêtrière – Tome III, 1887), dedicada à abordagem da histeria psíquica/ideativa. Apresentaremos as duas primeiras obras destacando o que entendemos como infl uências, heranças e inclusive divergências entre os autores, mas especialmente destacando uma linha de continuidade entre eles, para a qual Charcot teve papel fundamental. Esperamos que nossa pesquisa proporcione melhor esclarecimento sobre o estatuto inicial do psiquismo concebido por Freud bem como sobre a emergência de uma explicação alternativa que propiciou a introdução de uma instância psíquica inconsciente tal como a conhecemos. (shrink)

Se busca establecer una relación, no satisfactoriamente explorada, entre la fenomenologia merleaupontiana del tiempo y un problema central de la "theory of time" analítica, la paradoja de McTaggart. Al clarificar, en polémica con Priest , el autêntico sentido del "subjetivismo" merleaupontiano con respecto al tiempo, se senala cómo establecer una confluencia entre el acercamiento fenomenológico y las tesis desarrolladas por Michael Dummett como respuesta a la mencionada paradoja. Con los senalamientos de Dummett y la interpretación de Bimbenet acerca del "perspectivismo" (...) merleaupontiano, se intenta una solución "situacional" a la paradoja. The article seeks to establish a relationship that has not yet been explored satisfactorily between Merleau-Ponty's phenomenology of time and a central issue of analytical "theory of time": McTaggart's paradox. By clarifying the authentic meaning of Merleau-Ponty's "subjectivism" regarding time, against Priest's interpretation , the article points out a convergence between the phenom-enological approach and Michael Dummett's theses developed in response to the abovementioned paradox. A "situational" solution to the paradox is attempted on the basis of Dummett's ideas and Bimbenet's interpretation of Merleau-Ponty's "perspectivism". Pretende-se estabelecer uma relação, não satisfatoriamente explorada, entre a fenomenologia merleau-pontiana do tempo e um problema central da "theory of time" analítica, o paradoxo de McTaggart. Ao esclarecer, em polémica com Priest , o autêntico sentido do "subjetivismo" merleau-pontiano a respeito do tempo, indica-se como estabelecer uma confluência entre a aproximação fenomenológica e as teses desenvolvidas por Michael Dummett como resposta ao mencionado paradoxo. Com as indicações de Dummett e a interpretação de Bimbenet sobre o "perspectivismo" merleau-pontiano, tenta-se uma solução "situacional" ao paradoxo. (shrink)

La presencia de Platón y del pensamiento platónico se ha mantenido de manera incesante a lo largo de la historia de la cultura. En esta historia, el siglo XX refleja el rechazo y la aceptación, la recepción, en suma, de un modo inusitado tal vez porque, durante este siglo, la humanidad se vio cara a cara con los infiernos que supo crear: un mundo en ruinas hacía imposible intuir la perfecta quietud de las Formas. La recepción de Platón en el (...) siglo XX bucea en la recepción de Platón en aquel mundo contradictorio: ¿cómo se integra su pensamiento fundacionalmente metafísico con la deconstrucción de la metafísica? ¿Cuáles son los alcances de la crítica que la teoría política hace, desde la época de los totalitarismos, al autor de la República? ¿Qué valor cognoscitivo y pedagógico puede tener en mito platónico para filósofos cristianos que se ocupan del pensamiento platónico? ¿Cómo recibe la poesía hispanoamericana su voz de demiurgo? Estas preguntas, de las que se ofrecen diversas respuestas en este libro, son tratadas con rigor académico y confrontadas doblemente con las fuentes: en primer término, con Platón y luego con quienes son estudiados en el presente volumen, aunque desde ángulos muy diversos: M. Heidegger, H. G. Gadamer, K. Popper, E. Cassirer, L. Marechal. La seguridad del tratamiento metodológico y lingüístico que se refleja en esta obra hace que sea altamente recomendable para alumnos de grado y de posgrado en Filosofía, Teoría Política, Literatura y Humanidades en general. (shrink)

Rule of law and constitutionalist ideals are understood by many, if not most, as necessary to create a just political order. Defying the traditional division between normative and positive theoretical approaches, this book explores how political reality on the one hand, and constitutional ideals on the other, mutually inform and influence each other. Seventeen chapters from leading international scholars cover a diverse range of topics and case studies to test the hypothesis that the best normative theories, including those regarding the (...) role of constitutions, constitutionalism and the rule of law, conceive of the ideal and the real as mutually regulating. (shrink)

The participation of vulnerable patients in clinical research poses apparent ethical dilemmas. Depending on the nature of the vulnerability, their participation may challenge the ethical principles of autonomy, non-maleficence, or justice. On the other hand, non-participation may preclude the building of a knowledge base that is a prerequisite for defining the optimal clinical management of vulnerable patients. Such clinical uncertainty may also incur substantial economic costs. We present the participation of pre-menopausal women with atrial fibrillation in trials of novel oral (...) anticoagulant drugs as a case study. Due to their non-participation in pivotal trials, it is uncertain whether for them, the risks that are associated with these drugs are outweighed by the advantages compared with conventional treatment. We addressed the question whether research of this new class of drugs in this subgroup would be appropriate from both, an ethical as well an economic perspective. We used the method of specifying norms as a wider framework to resolve the apparent ethical dilemma, while incorporating the question whether research of oral anticoagulants in premenopausal women with atrial fibrillation can be justified on economic grounds. For the latter, the results of a value-of-information analysis were used. Further clinical research on NOACs in premenopausal women with atrial fibrillation can be justified on both, ethical and economic grounds. Addressing apparent ethical dilemmas by invoking a method such as specifying norms can improve the quality of public practical reasoning. As such, the method should also prove valuable to committees that have formally been granted the authority to review trial protocols and proposals for scientific research. (shrink)

Classification learning is a preeminent human ability within the animal kingdom but the key mechanisms of brain networks regulating learning remain mostly elusive. Recent neuroimaging advancements have depicted human brain as a complex graph machinery where brain regions are nodes and coherent activities among them represent the functional connections. While long-term motor memories have been found to alter functional connectivity in the resting human brain, a graph topological investigation of the short-time effects of learning are still not widely investigated. For (...) instance, classification learning is known to orchestrate rapid modulation of diverse memory systems like short-term and visual working memories but how the brain functional connectome accommodates such modulations is unclear. We used publicly available repositories (openfmri.org) selecting three experiments, two focused on short-term classification learning along two consecutive runs where learning was promoted by trial-by-trial feedback errors, while a further experiment was used as supplementary control. We analyzed the functional connectivity extracted from BOLD fMRI signals, and estimated the graph information processing in the cerebral networks. The information processing capability, characterized by complex network statistics, significantly improved over runs, together with the subject classification accuracy. Instead, null-learning experiments, where feedbacks came with poor consistency, did not provoke any significant change in the functional connectivity over runs. We propose that learning induces fast modifications in the overall brain network dynamics, definitely ameliorating the short-term potential of the brain to process and integrate information, a dynamic consistently orchestrated by modulations of the functional connections among specific brain regions. (shrink)

This study examined the differences in the level of physical fitness and academic performance among male middle-school children based on different body status categories. A total of 69 male children [age: 12.4 ± 0.7 years; body mass: 58.5 ± 7.2 kg; height: 1.62 ± 0.09 m; and body mass index : 22.4 ± 3.3 kg/m2] participated and were divided into BMI age-adjusted groups. Height, mass, BMI, stork test of static balance, 10 and 15 m sprint as an indicator for speed, (...) hand-grip strength test, agility T-half test, medicine ball throw, and the Yo-Yo Intermittent Recovery Test level 1 were assessed. School records were retrieved for grade point averages of mathematics, science, and Arabic. We found significant group differences regarding anthropometric, physical, and academic performance parameters. The largest difference correlation between parameters of different dimensions was found. In conclusion, the highest BMI group exhibited similar physical and academic performances than the lowest group. Thus, these data emphasize the importance and appropriateness to engage young Qatari schoolchildren in physical activity as it associates with superior academic performance. (shrink)

Background Genomic research on neurodevelopmental disorders (NDDs), particularly involving minors, combines and amplifies existing research ethics issues for biomedical research. We performed a review of the literature on the ethical issues associated with genomic research involving children affected by NDDs as an aid to researchers to better anticipate and address ethical concerns. Results Qualitative thematic analysis of the included articles revealed themes in three main areas: research design and ethics review, inclusion of research participants, and communication of research results. Ethical (...) issues known to be associated with genomic research in general, such as privacy risks and informed consent/assent, seem especially pressing for NDD participants because of their potentially decreased cognitive abilities, increased vulnerability, and stigma associated with mental health problems. Additionally, there are informational risks: learning genetic information about NDD may have psychological and social impact, not only for the research participant but also for family members. However, there are potential benefits associated with research participation, too: by enrolling in research, the participants may access genetic testing and thus increase their chances of receiving a (genetic) diagnosis for their neurodevelopmental symptoms, prognostic or predictive information about disease progression or the risk of concurrent future disorders. Based on the results of our review, we developed an ethics checklist for genomic research involving children affected by NDDs. Conclusions In setting up and designing genomic research efforts in NDD, researchers should partner with communities of persons with NDDs. Particular attention should be paid to preventing disproportional burdens of research participation of children with NDDs and their siblings, parents and other family members. Researchers should carefully tailor the information and informed consent procedures to avoid therapeutic and diagnostic misconception in NDD research. To better anticipate and address ethical issues in specific NDD studies, we suggest researchers to use the ethics checklist for genomic research involving children affected by NDDs presented in this paper. (shrink)

The landscape of social theory has changed significantly over the three decades since the publication of Anthony Giddens and Jonathan Turner’s seminal Social Theory Today. Sociologists in the twenty-first century desperately need a new agenda centered around central questions of social theory. In Social Theory Now, Claudio E. Benzecry, Monika Krause, and Isaac Ariail Reed set a new course for sociologists, bringing together contributions from the most distinctive sociological traditions in an ambitious survey of where social theory is today (...) and where it might be going. The book provides a strategic window onto social theory based on current research, examining trends in classical traditions and the cutting edge of more recent approaches. From distinctive theoretical positions, contributors address questions about how social order is accomplished; the role of materiality, practice, and meaning; as well as the conditions for the knowledge of the social world. The theoretical traditions presented include cultural sociology, microsociologies, world-system theory and post-colonial theory, gender and feminism, actor network and network theory, systems theory, field theory, rational choice, poststructuralism, pragmatism, and the sociology of conventions. Each chapter introduces a tradition and presents an agenda for further theoretical development. Social Theory Now is an essential tool for sociologists. It will be central to the discussion and teaching of contemporary social theory for years to come. (shrink)

This book explores how Modernist movements all across the Mediterranean basin differed from those of other regions. The chapters show how the political and economic turmoil of a period marked by world war, revolution, decolonization, nationalism, and the rapid advance of new technologies compelled artists, writers, and other intellectuals to create a new hybrid Mediterranean Modernist aesthetic which sought to balance the tensions between local and foreign, tradition and innovation, and colonial and postcolonial.

We present a new viable nonlinear chaotic paradigm. This paradigm has four nonlinear terms. The essential features of the new paradigm have been investigated. Our new system is confirmed to have chaotic behaviors by calculating its Lyapunov exponents. The relations of the system states are displayed by a suggested new signal flow graph. The proposed SFG is discussed via some graph theory tools, and some of its hidden features are calculated. In addition, the system is realized via constructing its electronic (...) circuit which helps in the real applications. Also, a robust controller for the system is designed with the aid of a genetic algorithm. (shrink)

Dondeyne, A. Pluriformiteit en eenheid van de filosofie.--Peperzak, A. Wegwijzers naar een dialogiek?--Boer, T. de. De eindigheid van de mens en de oneindigheid van de waarheid.--Hollak, J. Wijsgerige reflecties over de scheppingsidee : St. Thomas, Hegel en de Grieken.--Plat, J. Kants kritiek op de rationele psychologie.--Melsen, A. van. Wijsgerige antropologie en de ontwikkeling van natuurwetenschap en techniek.--Buytendijk, F. Het pathisch aspect van de eindigheid.--Struyker Boudier, H. 's Bergbeklimmers einder.

Coaching is a systematic and goal-oriented one-on-one intervention by a coach aimed to guide clients in their professional and personal development. Previous research on coaching has demonstrated effects on a number of positive outcomes, including well-being and performance, yet little is known about the processes that underlie these outcomes, such as the type of questions coaches use. Here, we focus on three different types of coaching questions, and aim to uncover their immediate and sustained effects for affect, self-efficacy, and goal-directed (...) outcomes, using a between-subjects experiment. One hundred and eighty-three medical residents and PhD students from various medical centers and healthcare organizations in the Netherlands were recruited to participate in a self-coaching writing exercise, where they followed written instructions rather than interacting with a real coach. All participants were randomly allocated to one of three conditions: either one of two solution-focused coaching conditions or a problem-focused coaching condition. Self-report questionnaires were used to measure key outcomes of coaching, that is positive and negative affect, self-efficacy, goal orientation, action planning and goal attainment. Two follow-up measurements assessed if the effects of the self-coaching exercise led to problem-solving actions within an initial follow-up period of 14 days and a subsequent follow-up period of 10 days. Findings showed that participants experienced more positive affect, less negative affect, and higher approach goal orientation after the solution-focused coaching exercise compared to the problem-focused coaching exercise. In all conditions, goal attainment increased as a consequence of the self-coaching intervention. We discuss the implications of our findings for the science and practice of contemporary coaching. (shrink)

Few figures of the Middle Ages command the attention of so many modern disciplines as Robert Grosseteste (c. 1170-1253). Theology, Philosophy, History, and Science are all areas which his life and thought continue to have significance and to inspire re-interpretation. Accompanied by a series of original commentaries, this new edition of Grosseteste's work, with English translation, draws together the perspectives of modern scientists and medieval specialists. Volume I of a six volume series, Knowing and Speaking presents two of the earliest (...) of Grosseteste's works, the treatises On the Liberal Arts and On the Generation of Sounds. These are accompanied by a significant Middle English treatise on the Seven Liberal Arts whose anonymous fifteenth-century author translated and excerpted passages from Grosseteste's treatises in a re-imagining of their structure and function.0Each work is treated separately within the volume, which is constructed in three parts. On the Liberal Arts sets Grosseteste's thoughts on the arts subjects and emphasises moral concerns about the purpose of learning. On the Generation of Sounds builds on the theories and statements of On the Liberal Arts in connection to the production of sound, elaborating the earlier position, relating the generation of sounds to human vocal and speech production. (shrink)

PurposeTo explore the mindfulness practice, its long-term effects, facilitators and barriers, in clinical clerkship students 2 years after participation in an 8-week mindfulness-based stress reduction training.MethodA qualitative study was performed by semi-structured in-depth interviews with 16 clinical clerkship students selected by purposive sampling. Students had participated in a MBSR training 2 years before and were asked about their current mindfulness practice, and the long-term effects of the MBSR training. Thematic analysis was conducted using the constant comparison method. Data saturation was (...) reached after 16 interviews.ResultsMost interviewees were still engaged in regular, predominantly informal, mindfulness practice, although some discontinued mindfulness practice and reported an “unchanged lifestyle.” Three main themes came forward; “focused attention and open awareness” during daily activities as core elements of long-term mindfulness practice; “changes in behavior and coping” that resulted from taking a pause, reflecting, recognizing automatic behavioral patterns and making space for a conscious response; “integration in personal and professional life” by enhanced enjoyment of daily activities, improved work-life-balance and making different career choices. Barriers and facilitators in starting and maintaining mindfulness practice were understanding and intention as “pre-conditions”; practical, personal, and professional factors of students in maintaining practice.ConclusionTwo years after participation in a MBSR training, many interviewees were still engaged in mindfulness practice contributing to both personal and professional changes. In light of the high clerkship demands, MBSR training could be a valuable addition to medical curricula, supporting medical students in developing necessary competencies to become well-balanced professionals. (shrink)

The paper aims at developing the idea that the standard operator of noncontingency, usually symbolized by Δ, is a special case of a more general operator of dyadic noncontingency Δ(−, −). Such a notion may be modally defined in different ways. The one examined in the paper is __Δ__(B, A) = df ◊B ∧ (A ⥽ B ∨ A ⥽ ¬B), where ⥽ stands for strict implication. The operator of dyadic contingency __∇__(B, A) is defined as the negation of __Δ__(B, (...) A). Possibility (◊A) may be then defined as __Δ__(A, A), necessity (□A) as __∇__(¬A, ¬A) and standard monadic noncontingency (__Δ__A) as __Δ__( \({\textsf{T}}\), A). In the second section it is proved that the deontic system KD is translationally equivalent to an axiomatic system of dyadic noncontingency named KDΔ 2, and that the minimal system KΔ of monadic contingency is a fragment of KDΔ 2. The last section suggests lines for further inquiries. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Mechanistic models are built using knowledge as the primary information source, with well-established biological and physical laws determining the causal relationships within the model. Once the causal structure of the model is determined, parameters must be defined in order to accurately reproduce relevant data. Determining parameters and their values is particularly challenging in the case of models of pathophysiology, for which data for calibration is sparse. Multiple data sources might be required, and data may not be in a uniform or (...) desirable format. We describe a calibration strategy to address the challenges of scarcity and heterogeneity of calibration data. Our strategy focuses on parameters whose initial values cannot be easily derived from the literature, and our goal is to determine the values of these parameters via calibration with constraints set by relevant data. When combined with a covariance matrix adaptation evolution strategy, this step-by-step approach can be applied to a wide range of biological models. We describe a stepwise, integrative and iterative approach to multiscale mechanistic model calibration, and provide an example of calibrating a pathophysiological lung adenocarcinoma model. Using the approach described here we illustrate the successful calibration of a complex knowledge-based mechanistic model using only the limited heterogeneous datasets publicly available in the literature. (shrink)