BackgroundThe pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and scalable HIV cure, most of which are early translational research and experimental medicine. As HIV cure research increases, it is critical to identify and address the ethical challenges posed by this research.MethodsWe conducted a scoping review of the growing HIV cure (...) research ethics literature, focusing on articles published in English peer-reviewed journals from 2013 to 2021. We extracted and summarized key developments in the ethics of HIV cure research. Twelve community advocates actively engaged in HIV cure research provided input on this summary and suggested areas warranting further ethical inquiry and foresight via email exchange and video conferencing.DiscussionDespite substantial scholarship related to the ethics of HIV cure research, additional attention should focus on emerging issues in six categories of ethical issues: (1) social value (ongoing and emerging biomedical research and scalability considerations); (2) scientific validity (study design issues, such as the use of analytical treatment interruptions and placebos); (3) fair selection of participants (equity and justice considerations); (4) favorable benefit/risk balance (early phase research, benefit-risk balance, risk perception, psychological risks, and pediatric research); (5) informed consent (attention to language, decision-making, informed consent processes and scientific uncertainty); and (6) respect for enrolled participants and community (perspectives of people living with HIV and affected communities and representation).ConclusionHIV cure research ethics has an unfinished agenda. Scientific research and bioethics should work in tandem to advance ethical HIV cure research. Because the science of HIV cure research will continue to rapidly advance, ethical considerations of the major themes we identified will need to be revisited and refined over time. (shrink)

Secondary school teachers, trained as empowered mentors, were asked about their new role 2 years after the introduction of school-based initial teacher training. Kelly's repertory grid encouraged the development of personal constructs. The mentors demonstrated deep structure constructs which would not have been easily recognised by university tutors making relatively brief school visits. It is concluded that the mentors have reached a stage where continued experience in the role will not, per se, lead to improved skills. A number of tensions (...) within the role were highlighted, most of which are inherent in the school-based model, but some of which attach specifically to empowerment. Support for mentors not recognising such ambiguities is important. Mentor empowerment does appear to be a viable model of mentoring in school-based ITT, but continued training and changes in the type of support available is necessary. The place of appropriate theory at all stages of professional development was recognised. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Las preocupaciones sobre la mercantilización de la vida que supone la gestación subrogada comercial usualmente opacan la discusión ética sobre las formas de subrogación que no son comerciales. Rara vez se toman en cuenta los descubrimientos de las neurociencias y la evidencia empírica sobre el posible daño provocado al binomio materno-filial en la discusión ética sobre la subrogación. He realizado un estudio piloto revisando la literatura disponible sobre el impacto de la neurofisiología perinatal en el vínculo materno-filial y la evidencia (...) psicológica empírica, preguntando si la subrogación daña al binomio, haciéndola éticamente ilícita desde una perspectiva de la neuroética personalista. Estudios recientes sobre la fisiología del vínculo materno-filial sugieren una asociación entre éste y el bienestar psicológico materno. Sin embargo, las pruebas empíricas traslativas sobre las implicaciones clínicas de los acuerdos de subrogación tanto en las portadoras gestacionales como en los niños fueron limitadas y no concluyentes. Se necesita más investigación para formular una conclusión al respecto. (shrink)

This study investigates the distribution of traces and their antecedents. The first chapter outlines the Government and Binding theory, enabling those unfamiliar with this framework to understand the ensuing discussion. The second chapter concerns the Empty Category Principle. Argument/adjunct asymmetries are shown to follow from an independently motivated indexing algorithm, which entails that adjuncts display an impoverished indexing. The third chapter deduces the properties of A-chains from independently motivated principles, offering a thorough examination of Super-Raising, Improper Movement, and the Local (...) Binding Condition. The final chapter challenges the standard assumptions regarding Case requirements on traces. (shrink)

To what extent, if any, does Universal Grammar (UG) constrain second language (L2) acquisition? This is not only an empirical question, but one which is currently investigable. In this context, L2 acquisition is emerging as an important new domain of psycholinguistic research. Three logical possibilities have been articulated regarding the role of UG in L2 acquisition: The first is the hypothesis that claims that no aspect of UG is available to the L2 learner. The second is the hypothesis that claims (...) that only LI instantiated principles and LI instantiated parameter-values of UG are available to the learner. The third, called the hypothesis, asserts that UG in its entirety constrains L2 acquisition. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Fallen Nature, Fallen Selves: Early Modern French Thought IIDavid Cunning and Seth JonesMichael Moriarty. Fallen Nature, Fallen Selves: Early Modern French Thought II. Oxford-New York: Oxford University Press, 2006. Pp. xviii + 430. Cloth, $125.00.This book is the second of two volumes on a myriad of issues surrounding the early modern distinction between the embodied self and the immaterial self that is one of its components. One of (...) the theses of the book is that, although canonical philosophers like Descartes and Malebranche hold that it is in some sense the latter that is our true self, and although they expend a significant amount of their corpus trying to help us to touch base with it, they also offer well-developed and insightful views about our embodiment and about what we are to do as embodied beings. Another thesis of the book is that, even if early modern philosophers tend to think that we have unimpeded and transparent access to our psychological states after we have done enough reflection to keep our embodiment from restricting the view, a concomitant position in the period is that we otherwise have very little self-knowledge. A related thesis is that important elements of the psychoanalytic tradition of Freud and Lacan can be traced back to philosophers like Descartes and Malebranche and to the investigations that they inspire in their contemporaries and successors. The book is ambitious and is an extremely interesting and important contribution.Descartes holds that as a result of the bad habits of childhood we come to misrepresent external bodies as having qualities like color, smell, taste, and sound. Building on the work of volume one, Moriarty (5, 335–36, 372–73, 243–44) reminds us that Descartes also holds that we come to misrepresent our minds as in part tangible and corporeal (the Second Meditation, Second Replies) and that the Cartesian project of clarifying ideas is not restricted to the ideas of natural science. Indeed, Moriarty could also cite Descartes’s remark that there are circumstances in which we might report that we are thinking of our selves when in fact we are only thinking of our bodies (Principles of Philosophy I:12). Descartes seems to allow that if we are not sufficiently reflective and observant, our thinking is not transparent to us, and if so he is leaving open the view that we can mischaracterize our own psychological states. Descartes does not speak explicitly to this kind of mischaracterization, but in later writings (especially Passions of the Soul and the letters to Princess Elizabeth) he does speak to the importance of clearly defining the passions and distinguishing them, and to the importance of knowing the relationships between brain traces and particular passions so that we can understand our motivations and get a better handle on them (315). Moriarty then brings to the table a number of figures who develop these positions. In Nicole, we find the view that, from the first-person perspective, it can be very difficult to distinguish acting from charity and acting from self-love, and that we have a considerable interest in identifying ourselves as acting from the former (219–24). In La Rochefoucauld, we find the view that friendship is often a matter of wanting to see a certain image of ourselves reflected in and confirmed by others and that true friendship is very rare (243). We might focus on figures like Nicole insofar as they engage the more traditional questions of metaphysics and epistemology, but issues of embodiment and self-knowledge were also front and center in the early modern period, and the contributions of Nicole, Lamy, La Rochefoucauld, and Senault (just to name just a few) are enormous.Another strength of the book is that it highlights the systematic nature of early modern work on self-knowledge. For example, Moriarty not only considers the empirical psychology of thinkers like Nicole and Lamy, but also shows how their results are grounded in fully articulated views of habit, language, and imagination (361–63, 371–74). Of course, these views are Cartesian as well.The book also has some potential problems. Some philosophers might worry that it is a stretch... (shrink)

The target article advanced the null, unified and widely misinterpreted generative hypothesis regarding second language (L2) acquisition. Postulating that UG (Universal Grammar) constrains L2 knowledge growth does not entail identical developmental trajectories for L2 and first language (LI) acquisition; nor does it preclude a role for the L1. In embracing this hypothesis, we maintain a distinction between competence and performance. Those who conflate the two repeat fundamental and by no means unprecedented misconstruals of the generative enterprise, and more specifically, of (...) the empirical content of the null hypothesis regarding L2 linguistic knowledge growth. We hope to have identified certain common goals, the adoption of which might constitute a firm foundation for continued productive interdisciplinary development of contemporary theoretical and experimental L2 acquisition research. (shrink)

Universal Grammar (UG) can be interpreted as a constraint on the form of possible grammars (hypothesis space) or as a constraint on acquisition strategies (selection procedures). In this response to Herschensohn we reiterate the position outlined in Epstein et al. (1996a, r), that in the evaluation of L2 acquisition as a UG- constrained process the former (possible grammars/ knowledge states) is critical, not the latter. Selection procedures, on the other hand, are important in that they may have a bearing on (...) development in language acquisition. We raise the possibility that differences in first and second language acquisition pertaining to both attainment of the end-state and course of development may derive from differences in selection procedures. We further suggest that for these reasons age effects in the attainment of nativelike proficiency must necessarily be separated from UG effects. (shrink)

The theme of the third annual Spring workshop of the HUPO-PSI was proteomics and beyond and its underlying goal was to reach beyond the boundaries of the proteomics community to interact with groups working on the similar issues of developing interchange standards and minimal reporting requirements. Significant developments in many of the HUPO-PSI XML interchange formats, minimal reporting requirements and accompanying controlled vocabularies were reported, with many of these now feeding into the broader efforts of the Functional Genomics Experiment data (...) model and Functional Genomics Ontology ontologies. (shrink)

Ethical dimensions of friendship have rarely been explicitly addressed as aspects of friendship quality in studies of children's peer relationships. This study identifies aspects of moral virtue significant for friendship, as a basis for empirically investigating the role of ethical qualities in children's friendship assessments and aspirations. We introduce a eudaimonic conception of friendship quality, identify aspects of moral virtue foundational to such quality, review and contest some grounds on which children have been regarded as not mature enough to have (...) friendships that require virtue, and report a qualitative study of the friendship assessments and aspirations of children aged nine and ten. In focus group sessions conducted in ten schools across Great Britain, moral qualities figured prominently in children's assessments of friendship quality. The findings provide evidence of children having friendships exhibiting mutual respect, support, and valuing of each other's good character. (shrink)

Inspired by recent progress in multi-agent Reinforcement Learning (RL), in this work we examine the collective intelligent behaviour of theoretical universal agents by introducing a weighted mixture operation. Given a weighted set of agents, their weighted mixture is a new agent whose expected total reward in any environment is the corresponding weighted average of the original agents' expected total rewards in that environment. Thus, if RL agent intelligence is quantified in terms of performance across environments, the weighted mixture's intelligence is (...) the weighted average of the original agents' intelligences. This operation enables various interesting new theorems that shed light on the geometry of RL agent intelligence, namely: results about symmetries, convex agent-sets, and local extrema. We also show that any RL agent intelligence measure based on average performance across environments, subject to certain weak technical conditions, is identical (up to a constant factor) to performance within a single environment dependent on said intelligence measure. (shrink)

Held on Monday 12th October 2009, 5.30 - 7.00 pm, University of St Andrews, Scotland. Participants Dr Robert Sinnerbrink (Philosophy, Macquarie University, Sydney, Australia) Dr John Mullarkey (Philosophy, University of Dundee) Professor Berys Gaut (Philosophy, University of St Andrews) Dr David Martin-Jones (Film Studies, University of St Andrews) Dr William Brown (Film Studies, University of St Andrews)Over the course of at least the last hundred years the intellectual study of cinema has experienced a number of shifts towards and (...) away from theoretical or philosophical attempts to understand the moving image. The twenty-first century sees film-philosophy resurgent, in part due to the interest in cinema that has flourished recently in disciplines like philosophy, and in part due to the interdisciplinary nature of Film Studies. At a time when it is increasingly in vogue to return to theoretical questions previously pushed off the agenda by the dominance of historical approaches to cinema, such as the perennial "What is Cinema?", we are taking this opportunity to ask, "What is Film-Philosophy?" In a context that is witnessing the rise of digital cinema, the global dominance of multi-national media conglomerates, and the worldwide spread of "world cinemas", what role does theory or philosophy play in helping us understand cinema, and indeed, what role can cinema play in transforming philosophy? [The audio recording is of variable quality as we have had to remove a lot of background hiss and static. Please accept our apologies] Thanks to Rachel Brewster at Liverpool John Moores University for extracting the original audio. (shrink)

Can quantum theory provide examples of metaphysical indeterminacy, indeterminacy that obtains in the world itself, independently of how one represents the world in language or thought? We provide a positive answer assuming just one constraint of orthodox quantum theory: the eigenstate-eigenvalue link. Our account adds a modal condition to preclude spurious indeterminacy in the presence of superselection sectors. No other extant account of metaphysical indeterminacy in quantum theory meets these demands.

Editor's Preface Content Type Journal Article Pages 1-5 Authors David Jones Journal Comparative and Continental Philosophy Online ISSN 1757-0646 Print ISSN 1757-0638 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 / 2012.

It has recently been shown that stem and progenitor cells undergo population self‐renewal to maintain epithelial homeostasis. The fate of individual cells is stochastic but the production of proliferating and differentiating cells is balanced across the population. This new paradigm, originating in mouse epidermis and since extended to mouse oesophagus and mouse and Drosophila intestine, is in contrast to the long held model of epithelial maintenance by exclusively asymmetric division of stem cells. Recent lineage tracing studies have now shown that (...) wound responses vary between tissues, and that a stem cell reserve is not essential as cycling progenitors and even differentiating cells contribute to regeneration. (shrink)

This article explores the usefulness of Latin American philosopher Enrique Dussel's work for film-philosophy, as the field increasingly engages with a world of cinemas. The piece concludes with an analysis of two films with an ecological focus, Trolljegeren/Troll Hunter (2010) and The Hunter (2011). They are indicative of a much broader emerging trend in ecocinema that explores the interaction between humanity and the environment in relation to world history, and which does so by staging encounters between people and those ‘nonhuman’ (...) aspects of the Earth excluded by coloniality/modernity (e.g. animals, animal-spirits, mythological creatures, shaman, the very Earth itself). The interdisciplinary concerns of this work place it at the intersection of the latest research into a world of cinemas (in particular the various moves to understand films beyond the national paradigm now increasingly labelled the ‘transnational turn’; alongside growing concerns with how cinema helps us engage with ecology); and the need to broaden our philosophical grasp of the world. This latter point requires engagement with thinkers from beyond the Eurocentric canon of Western thought that currently dominates philosophy, and equally shapes film-philosophy. Dussel's philosophy is shown to provide a perspective capable of illuminating the intertwined nature of human and planetary history evident in these films, in a manner that is extremely pertinent to our global situation. Thus it is shown to be more useful than approaches to similar groupings of films which draw on, for example, speculative realism, when it comes to providing a cine-ethics appropriate to the Anthropocene. (shrink)

Peter Brunette _The Films of Michelangelo Antonioni_ Cambridge: Cambridge University Press, 1998 ISBN 0-521-38992-5 186 pp.

This chapter proposes a new and more coherent interdisciplinary prehistory of the Andes, based firstly on a long overdue re-examination of the relationships between the various regional ‘dialects’ within the Quechua language family; and secondly on a more satisfactory correlation with the archaeological record. The founding principle is that language families necessarily reflect past expansive processes, whose traces should also be clear in the archaeological record. It provides a logic by which to assess correspondences between archaeological and linguistic patterns, on (...) the three levels of when, where, and why particular language expansions occurred. In the Andes, the horizons thus offer the most natural explanations for the major Quechua and Aymara dispersals. With the Incas too late for the time-depth of either family, the Wari Middle Horizon emerges as the most plausible candidate for the first major expansion of Quechua, and not of the Aymara family, here tentatively associated with the Early Horizon instead. (shrink)

Introduction : deterritorializing Deleuze -- Spectacle I : attraction-image -- History : Deleuze after dictatorship -- Space : geopolitics and the action-image -- Spectacle II : Masala-image -- Conclusion : the continuing adventures of Deleuze and world cinemas.

Freud is often assumed to have given an explanation of how human beings acquire a morality, especially as it is manifested in the phenomenon of moral conscience. Freud himself certainly lends credence to such an interpretation of his theory, as the following passage testifies.