Results for 'CRISPR'

278 found
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  1. CRISPR/Cas9 genome editing – new and old ethical issues arising from a revolutionary technology.Martina Baumann - 2016 - NanoEthics 10 (2):139-159.
    Although germline editing has been the subject of debate ever since the 1980s, it tended to be based rather on speculative assumptions until April 2015, when CRISPR/Cas9 technology was used to modify human embryos for the first time. This article combines knowledge about the technical and scientific state of the art, economic considerations, the legal framework and aspects of clinical reality. A scenario will be elaborated as a means of identifying key ethical implications of CRISPR/Cas9 genome editing in (...)
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  2. Reproductive CRISPR does not cure disease.Tina Rulli - 2019 - Bioethics 33 (9):1072-1082.
    Given recent advancements in CRISPR‐Cas9 powered genetic modification of gametes and embryos, both popular media and scientific articles are hailing CRISPR’s life‐saving, curative potential for people with serious monogenic diseases. But claims that CRISPR modification of gametes or embryos, a form of germline engineering, has therapeutic value are deeply mistaken. This article explains why reproductive uses of CRISPR, and germline engineering more generally, do not treat or save lives that would otherwise have a genetic disease. Reproductive (...)
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  3. CRISPR as a Driving Force: The Model T of Biotechnology.Carlos Mariscal & Angel Petropanagos - 2016 - Monash Bioethics Review 34 (2):1-16.
    The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises several ethical concerns. Some bioethicists worry CRISPR is a prelude to a dystopian future, while others maintain it should not be feared because it is analogous to past biotechnologies. In the scientific literature, CRISPR is often discussed as a revolutionary technology. In this paper we unpack the framing of CRISPR as (...)
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  4.  56
    The CRISPR Revolution in Genome Engineering: Perspectives from Religious Ethics.Jung Lee - 2022 - Journal of Religious Ethics 50 (3):333-360.
    This focus issue considers the normative implications of the recent emergence in genome editing technology known as CRISPR (clustered regularly interspaced short palindromic repeats) or CRISPR‐associated protein 9. Originally discovered in the adaptive immune systems of bacteria and archaea, CRISPR enables researchers to make efficient and site‐specific modifications to the genomes of cells and organisms. More accessible, precise, and economic than previous gene editing technologies, CRISPR holds the promise of not only transforming the fields of genetics, (...)
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  5.  62
    CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-Making.Victor Lange & Klemens Kappel - unknown
    CRISPR is currently viewed as the central tool for future gene therapy. Yet, many prominent scientists and bioethicists have expressed ethical concerns around CRISPR gene therapy. This paper provides a critical review of concerns about CRISPR gene therapy as expressed in the mainstream academic literature, paired with replies also generally found in that literature. The expressed concerns can be categorised into three types depending on whether they stress risk/benefit ratio, autonomy and informed consent, or concerns related to (...)
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  6. CRISPR Critters and CRISPR Cracks.R. Alta Charo & Henry T. Greely - 2015 - American Journal of Bioethics 15 (12):11-17.
    This essay focuses on possible nonhuman applications of CRISPR/Cas9 that are likely to be widely overlooked because they are unexpected and, in some cases, perhaps even “frivolous.” We look at five uses for “CRISPR Critters”: wild de-extinction, domestic de-extinction, personal whim, art, and novel forms of disease prevention. We then discuss the current regulatory framework and its possible limitations in those contexts. We end with questions about some deeper issues raised by the increased human control over life on (...)
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  7.  23
    CRISPR/Cas9: A new tool for the study and control of helminth parasites.Xiaofeng Du, Donald P. McManus, Juliet D. French, Malcolm K. Jones & Hong You - 2021 - Bioessays 43 (1):2000185.
    Recent reports of CRISPR/Cas9 genome editing in parasitic helminths open up new avenues for research on these dangerous pathogens. However, the complex morphology and life cycles inherent to these parasites present obstacles for the efficient application of CRISPR/Cas9‐targeted mutagenesis. This is especially true with the trematode flukes where only modest levels of gene mutation efficiency have been achieved. Current major challenges in the application of CRISPR/Cas9 for study of parasitic worms thus lie in enhancing gene mutation efficiency (...)
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  8.  80
    CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology.Eugene V. Koonin - 2019 - Biology and Philosophy 34 (1):9.
    The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known (...)
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  9.  64
    Altered Inheritance: Crispr and the Ethics of Human Genome Editing.Françoise Baylis - 2019 - Cambridge, Massachusetts: Harvard University Press.
    With the advent of CRISPR gene-editing technology, designer babies have become a reality. Françoise Baylis insists that scientists alone cannot decide the terms of this new era in human evolution. Members of the public, with diverse interests and perspectives, must have a role in determining our future as a species.
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  10. CRISPR/Cas9 and Germline Modification: New Difficulties in Obtaining Informed Consent.Joanna Smolenski - 2015 - American Journal of Bioethics 15 (12):35-37.
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  11.  31
    CRISPR-Cas9 and He Jiankui's Case: an Islamic Bioethics Review using Maqasid al-Shari'a and Qawaid Fighiyyah.Nimah Alsomali & Ghaiath Hussein - 2021 - Asian Bioethics Review 13 (2):149-165.
    The discovery of clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-mediated protein 9 (CRISPR-Cas9) immediately revealed numerous potential therapeutic applications. Although CRISPR-Cas9 will most likely be useful for addressing issues such as genetic diseases and related medical issues, use of this modality for germline modification generates complex ethical questions regarding the safety and efficacy, human genetic enhancement, and “designer” babies. In this article, the case of the He Jiankui affair is used as an example (...)
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  12.  62
    The Crispr Apple on the Tree of Knowledge Conference Highlights: Crispr in Science, Ethics, and Religion.Arvin M. Gouw - 2020 - Zygon 55 (2):409-420.
    The Institute on Religion in the Age of Science (IRAS) asked Ted Peters, an eminent theologian and bioethicist who was at the forefront of the cloning and stem cell debates in the past few decades, and myself, a molecular biologist, to invite scholars from various fields to brainstorm the religious and ethical implications of the CRISPR revolution. We invited keynote speakers, whose talks will be covered here, as well as other speakers and poster presentations. The conference also hosted question (...)
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  13.  77
    Will CRISPR Germline Engineering Close the Door to an Open Future?Rachel L. Mintz, John D. Loike & Ruth L. Fischbach - 2019 - Science and Engineering Ethics 25 (5):1409-1423.
    The bioethical principle of autonomy is problematic regarding the future of the embryo who lacks the ability to self-advocate but will develop this defining human capacity in time. Recent experiments explore the use of clustered regularly interspaced short palindromic repeats /Cas9 for germline engineering in the embryo, which alters future generations. The embryo’s inability to express an autonomous decision is an obvious bioethical challenge of germline engineering. The philosopher Joel Feinberg acknowledged that autonomy is developing in children. He advocated that (...)
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  14.  43
    CRISPR for Disabilities: How to Self-Regulate” or Something?Amanda Courtright-Lim - 2022 - Journal of Bioethical Inquiry 19 (1):151-161.
    The development of the CRISPR gene editing technique has been hyped as a technique that could fundamentally change scientific research and its clinical application. Unrecognized is the fact that it joins other technologies that have tried and failed under the same discourse of scientific hype. These technologies, like gene therapy and stem cell research, have moved quickly passed basic research into clinical application with dire consequences. Before hastily moving to clinical applications, it is necessary to consider basic research and (...)
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  15.  15
    CRISPR/Cas technology as a promising weapon to combat viral infections.Carmen Escalona-Noguero, María López-Valls & Begoña Sot - 2021 - Bioessays 43 (4):2000315.
    The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection (...)
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  16.  80
    Exploiting CRISPR / C as systems for biotechnology.Timothy R. Sampson & David S. Weiss - 2014 - Bioessays 36 (1):34-38.
    The Cas9 endonuclease is the central component of the Type II CRISPR/Cas system, a prokaryotic adaptive restriction system against invading nucleic acids, such as those originating from bacteriophages and plasmids. Recently, this RNA‐directed DNA endonuclease has been harnessed to target DNA sequences of interest. Here, we review the development of Cas9 as an important tool to not only edit the genomes of a number of different prokaryotic and eukaryotic species, but also as an efficient system for site‐specific transcriptional repression (...)
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  17.  63
    CRISPR-Cas immunity: beyond nonself and defence.Thomas Pradeu & Jean-François Moreau - 2019 - Biology and Philosophy 34 (1):6.
    In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements and tolerate exogenous elements. We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.
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  18.  94
    CRISPR and the Rebirth of Synthetic Biology.Raheleh Heidari, David Martin Shaw & Bernice Simone Elger - 2017 - Science and Engineering Ethics 23 (2):351-363.
    Emergence of novel genome engineering technologies such as clustered regularly interspaced short palindromic repeat has refocused attention on unresolved ethical complications of synthetic biology. Biosecurity concerns, deontological issues and human right aspects of genome editing have been the subject of in-depth debate; however, a lack of transparent regulatory guidelines, outdated governance codes, inefficient time-consuming clinical trial pathways and frequent misunderstanding of the scientific potential of cutting-edge technologies have created substantial obstacles to translational research in this area. While a precautionary principle (...)
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  19. Is CRISPR an Ethical Game Changer?Marcus Schultz-Bergin - 2018 - Journal of Agricultural and Environmental Ethics 31 (2):219-238.
    By many accounts, CRISPR gene-editing technology is revolutionizing biotechnology. It has been hailed as a scientific game changer and is being adopted at a break-neck pace. This hasty adoption has left little time for ethical reflection, and so this paper aims to begin filling that gap by exploring whether CRISPR is as much an ethical game changer as it is a biological one. By focusing on the application of CRISPR to non-human animals, I argue that CRISPR (...)
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  20.  15
    CRISPR-Cas9: el debate bioético más allá de la línea germinal.Dilany Vanessa Infante-López, Mileidy Fernanda Céspedes-Galvis & Ángela María Wilches-Flórez - 2022 - Persona y Bioética 25 (2):2529-2529.
    The CRISPR-Cas9 system is a genetic editing technology that, in addition to expanding the possibilities for scientific research, promotes reflections associated with human dignity, biological control, therapy, and genetic improvement. Bioethical discussions on the challenges and repercussions of the CRISPR-Cas9 system are reviewed. As a result, bioethical questions tend to problematize the application to non-human organisms, primary research, and the human somatic and germline. In brief, it is necessary to increase the levels of safety and effectiveness so that (...)
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  21.  35
    CRISPR Cautions: Biosecurity Implications of Gene Editing.Rachel M. West & Gigi Kwik Gronvall - 2020 - Perspectives in Biology and Medicine 63 (1):73-92.
    CRISPR, a recently developed gene-editing tool, has become synonymous with rapid biological advancement. While gene editing had been performed in life sciences research for decades, genetic engineering with CRISPR is much more straightforward, faster, and less expensive—and thus, the technology has been rapidly democratized. CRISPR was built on a natural mechanism, the method by which bacteria resist infections from viruses called bacteriophage. Once infected, bacteria may recognize specific genetic sequences of the invading bacteriophage virus and chop its (...)
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  22.  33
    Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation.Kang Hao Cheong, Jin Ming Koh & Michael C. Jones - 2019 - Bioessays 41 (7):1900032.
    Graphical AbstractRecent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented, focusing in particular on the stochastic nature of cellular control processes.
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  23.  22
    A Novel Eukaryote‐Like CRISPR Activation Tool in Bacteria: Features and Capabilities.Yang Liu & Baojun Wang - 2020 - Bioessays 42 (6):1900252.
    CRISPR (clustered regularly interspaced short palindromic repeats) activation (CRISPRa) in bacteria is an attractive method for programmable gene activation. Recently, a eukaryote‐like, σ54‐dependent CRISPRa system has been reported. It exhibits high dynamic ranges and permits flexible target site selection. Here, an overview of the existing strategies of CRISPRa in bacteria is presented, and the characteristics and design principles of the CRISPRa system are introduced. Possible scenarios for applying the eukaryote‐like CRISPRa system is discussed with corresponding suggestions for performance optimization (...)
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  24.  28
    Potential of the CRISPR‐Cas system for improved parasite diagnosis.Hong You, Catherine A. Gordon, Skye R. MacGregor, Pengfei Cai & Donald P. McManus - 2022 - Bioessays 44 (4):2100286.
    CRISPR‐Cas technology accelerates development of fast, accurate, and portable diagnostic tools, typified by recent applications in COVID‐19 diagnosis. Parasitic helminths cause devastating diseases afflicting 1.5 billion people globally, representing a significant public health and economic burden, especially in developing countries. Currently available diagnostic tests for worm infection are neither sufficiently sensitive nor field‐friendly for use in low‐endemic or resource‐poor settings, leading to underestimation of true prevalence rates. Mass drug administration programs are unsustainable long‐term, and diagnostic tools – required to (...)
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  25.  66
    CRISPR/Cas9-mediated Editing of Human?-globin Gene in Human Cells: A Commentary on the Research Ethics.Norman K. Swazo - 2015 - Bangladesh Journal of Bioethics 6 (1):22-26.
    Recently, Chinese researchers published the results of their research using a gene-editing technology on abnormal human zygotes. The research team believes this research has prospective clinical application, viz., for gene therapy for?-thalassemia, a white blood cell disorder, and plan to persist with further studies, despite technical problems in this experiment. The research has elicited international criticism from both scientific and bioethics domains, because it innovates beyond the current global consensus against human germ line modification. This paper comments on some ethical (...)
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  26. Enter CRISPR: Jennifer Doudna's Autobiographical Assessment of the Science and Ethics of CRISPR/Cas9.Hub Zwart - 2018 - Ethics in Biology, Engineering and Medicine 9 (1):59-76.
  27.  48
    CRISPR Becomes Clearer.Andrew W. Torrance - 2017 - Hastings Center Report 47 (5):5-6.
    In this pivotal year for gene editing, the breakthrough molecular system CRISPR–Cas9 has advanced on three fronts. In under seven months, an influential scientific body—the National Academies of Sciences, Engineering, and Medicine the National Academies of Sciences, Engineering, and Medicine—cracked open the door to human germline gene editing, ownership of patents covering CRISPR–Cas9 came into much sharper focus as a result of a dispute between two parties, and experiments showing proof of concept of the most controversial of uses—altering (...)
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  28.  35
    CRISPR and the Ethics of Gene Drive in Mosquitoes.Tina Rulli - 2018 - In David Boonin (ed.), Palgrave Handbook of Philosophy and Public Policy. Cham: Palgrave Macmillan. pp. 509-521.
    CRISPR Cas9-powered gene drive allows for the rapid alteration of malaria-causing mosquitoes to spread an infertility gene or resistance to malaria among their species. Malaria eradication would be a great boon to human health. But many are concerned with driving genetic changes through a natural species. This chapter catalogs objections to the use of gene drive in mosquitoes for eradicating malaria. In-principle objections to gene drive use are not compelling. The most urgent concerns are related to the safety of (...)
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  29.  99
    Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework.Niklaus H. Evitt, Shamik Mascharak & Russ B. Altman - 2015 - American Journal of Bioethics 15 (12):25-29.
    CRISPR germline editing therapies hold unprecedented potential to eradicate hereditary disorders. However, the prospect of altering the human germline has sparked a debate over the safety, efficacy, and morality of CGETs, triggering a funding moratorium by the NIH. There is an urgent need for practical paths for the evaluation of these capabilities. We propose a model regulatory framework for CGET research, clinical development, and distribution. Our model takes advantage of existing legal and regulatory institutions but adds elevated scrutiny at (...)
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  30.  26
    CRISPR Images: Media Use and Public Opinion About Gene Editing.Paul R. Brewer, James Bingaman, Ashley Paintsil & Wyatt Dawson - 2022 - Bulletin of Science, Technology and Society 42 (1-2):11-18.
    As gene editing technologies such as CRISPR have become increasingly prominent, so have media portrayals of them. With this in mind, the present study builds on theoretical accounts of framing effects, cultivation effects, and genre-specific viewing effects to examine how different forms of media use predict attitudes toward applications of gene editing. Specifically, the study tests how news use, overall television viewing, and science fiction viewing are related to such attitudes. The analyses draw on original data from two surveys (...)
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  31.  46
    CRISPR-Cas changing biology?Janella Baxter - 2019 - Biology and Philosophy 34 (1):15.
    Eugene V. Koonin argues that fundamental research of CRISPR-Cas mechanisms has illuminated “fundamental principles of genome manipulation.” Koonin's discussion provides important philosophical insights for how we should understand the significance of CRISPR-Cas systems. Yet the analysis he provides is only part of a larger story. There is also a human element to the CRISPR-Cas story that concerns its development as a technology. Accounting for this part of CRISPR's history reveals that the story Koonin provides requires greater (...)
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  32. La técnica CRISPR-Cas9 unos años después.Gilberto A. Gamboa-Bernal - 2021 - Persona y Bioética 2 (25):e2521.
    En 2016 se hizo pública una nueva técnica para editar genes: la CRISPR-Cas9. Cinco años después es posible dar una mirada que desde la Bioética examine el desarrollo de esta biotecnología. Es constatable que la técnica de edición de genes en la línea somáticas se ha difundido y está empezando a mostrar algunos resultados. Sin embargo, a pesar de ellos no es posible extender ese trabajo a las líneas germinales a través de la edición hereditaria del genoma humano. Se (...)
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  33.  25
    A Crispr Revolution: The Brave New World of Cut-and-Paste Genetics.Sahotra Sarkar - 2021 - Rowman & Littlefield Publishers.
    The emergence of CRISPR/Cas9 technology has revolutionized gene editing and made both gene therapy and eugenic control of future human evolution plausible. This accessible book puts these developments in their historical and scientific contexts and analyzes the policy and ethical challenges they raise. It presents the case for altering the human germ-line to eliminate a large number of genetic diseases controlled by a single or few genes, while pointing out that gene therapy is likely to ineffective for diseases with (...)
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  34.  10
    La técnica CRISPR-Cas9 unos años después.Gilberto A. Gamboa-Bernal - 2022 - Persona y Bioética 25 (2):2521-2521.
    In 2016, a new technique to edit genes was made public: the CRISPR-CAS9. Five years later, we can examine the advancement of this biotechnology from bioethics. It is evident that the gene-editing technique on the somatic line has been disseminated and is starting to show some results. Nonetheless, it is impossible to extend this work to the germlines through heritable human genome editing. Two documents are studied, the International Commission for the Clinical Use of Human Germline Genome Editing report (...)
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  35.  47
    Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion.Noor Munirah Isa, Nurul Atiqah Zulkifli & Saadan Man - 2020 - Science and Engineering Ethics 26 (1):309-323.
    The recent development of CRISPR/Cas9 technology has rekindled the ethical debate concerning human germline modification that has begun decades ago. This inexpensive technology shows tremendous promise in disease prevention strategies, while raising complex ethical concerns about safety and efficacy of the technology, human dignity, tampering with God’s creation, and human genetic enhancement. Germline gene editing may result in heritable changes in the human genome, therefore the question of whether it should be allowed requires deep and careful discussion from various (...)
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  36.  24
    CRISPR: Beyond the Excitement.Khaled Moustafa - 2024 - Journal of Bioethical Inquiry 21 (1):7-9.
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  37. CRISPR / case technology : ending disease, designer babies, eternal youth, and 'crimes against the species'.Inez Braber - 2020 - In Caroline Fournet & Anja Matwijkiw (eds.), Biolaw and international criminal law: towards interdisciplinary synergies. Boston: Brill Nijhoff.
     
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  38.  42
    Introducing the Brave New Crispr World.Arvin M. Gouw - 2020 - Zygon 55 (2):421-429.
    Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has been the buzzword for genome editing in the past few years, especially with the birth of Lulu and Nana, twin girls who were genetically edited using the CRISPR/Cas system. To discuss this, a group of scientists, theologians, and ethicists gathered at the 2019 Institute on Religion in the Age of Science (IRAS) conference to discuss the implications of CRISPR gene editing. It became quickly apparent through our discussions that this (...)
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  39.  94
    CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the Patient, Not the Germ Line.Ante S. Lundberg & Rodger Novak - 2015 - American Journal of Bioethics 15 (12):38-40.
  40. “Editing”: A Productive Metaphor for Regulating CRISPR.Ben Merriman - 2015 - American Journal of Bioethics 15 (12):62-64.
    The metaphor of “gene editing” has been employed widely in popular discussions of CRISPR technology. The editing metaphor obscures the physical mechanism of action in CRISPR techniques, and understates the present frequency of off-target effects. However, the editing metaphor may be a useful means to think about approaches to regulating the future use of CRISPR. Conceiving of CRISPR as an information technology recalls the highly computational, information-oriented context of genomic research in which CRISPR has emerged. (...)
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  41.  21
    Managing New Technology When Effective Control is Lost: Facing Hard Choices With CRISPR.Joel Andrew Zimbelman - 2022 - Journal of Religious Ethics 50 (3):433-460.
    This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats‐associated protein 9 (CRISPR‐Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in the context of 150 years of formal exploration of heredity and genetics. I describe CRISPR's structure and explain how it functions as a useful engineering tool. The contemporary international and domestic regulatory environment governing human (...)
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  42. Regulating CRISPR : A Quest to Foster Safe, Ethical, and Equitable Innovation.Andrew C. Heinrich - 2024 - In Neal Baer (ed.), The promise and peril of CRISPR. Baltimore: Johns Hopkins University Press.
     
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  43.  45
    CRISPR's Twisted Tales: Clarifying Misconceptions about Heritable Genome Editing.Marcy Darnovsky & Katie Hasson - 2020 - Perspectives in Biology and Medicine 63 (1):155-176.
    In the year since He Jiankui announced the birth of twin girls whose genes were edited as embryos, reactions and revelations have continued, including the recent announcement that He and two colleagues have been sentenced to jail time and hefty fines. But what of Nana and Lulu, now infants, whose lives and futures are often missing in discussions of He's ethical violations? Their status remains a mystery. Other than learning that they were born prematurely by emergency C-section, we know nothing (...)
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  44. CRISPR-Cas9 Human Genome Editing: Challenges, Ethical Concerns and Implications.Otieno Mo - 2015 - Journal of Clinical Research and Bioethics 6 (6).
  45.  49
    Shaping the CRISPR Gene-Editing Debate: Questions About Enhancement and Germline Modification.Josephine Johnston - 2020 - Perspectives in Biology and Medicine 63 (1):141-154.
    When the use of CRIsPR-Cas9 to edit DNA was first reported in 2012, it was quickly heralded by scientists, policymakers, and journalists as a transformative technology. CRISPR-Cas9 provides the means to change DNA in ways that either were not generally possible using previous genetic technologies or that were orders of magnitude more laborious or inefficient to undertake. CRISPR's possible applications were readily apparent and seemingly endless, from supercharging laboratory research to modifying insects that transmit disease to eliminating (...)
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  46.  80
    Trust in Science: CRISPR–Cas9 and the Ban on Human Germline Editing.Stephan Guttinger - 2018 - Science and Engineering Ethics 24 (4):1077-1096.
    In 2015 scientists called for a partial ban on genome editing in human germline cells. This call was a response to the rapid development of the CRISPR–Cas9 system, a molecular tool that allows researchers to modify genomic DNA in living organisms with high precision and ease of use. Importantly, the ban was meant to be a trust-building exercise that promises a ‘prudent’ way forward. The goal of this paper is to analyse whether the ban can deliver on this promise. (...)
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  47.  67
    Ethical Issues of Using CRISPR Technologies for Research on Military Enhancement.Marsha Greene & Zubin Master - 2018 - Journal of Bioethical Inquiry 15 (3):327-335.
    This paper presents an overview of the key ethical questions of performing gene editing research on military service members. The recent technological advance in gene editing capabilities provided by CRISPR/Cas9 and their path towards first-in-human trials has reinvigorated the debate on human enhancement for non-medical purposes. Human performance optimization has long been a priority of military research in order to close the gap between the advancement of warfare and the limitations of human actors. In spite of this focus on (...)
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  48.  45
    Lamarckian realities: the CRISPR-Cas system and beyond.Eva Jablonka - 2019 - Biology and Philosophy 34 (1):14.
    In his target article, Koonin discusses the insights into the evolution of bacterial genomes provided by the CRISPR-Cas system. This evolved defense system is based on intrinsic processes of genome engineering which, as he argues, enable Lamarckian inheritance. In this commentary I discuss some historical and conceptual issues that pertain to Koonin’s analysis of this aspect of the CRISPR-Cas system, extending and qualifying his discussion.
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  49.  11
    From CRISPR to Conscience: Ethical Dilemmas in Gene Editing and Genetic Selection.Shu Ishida & Tsutomu Sawai - 2024 - American Journal of Bioethics 24 (8):67-70.
    Volume 24, Issue 8, August 2024, Page 67-70.
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  50.  47
    A justice‐based argument for including sickle cell disease in CRISPR/Cas9 clinical research.Marilyn S. Baffoe-Bonnie - 2019 - Bioethics 33 (6):661-668.
    CRISPR/Cas9 is quickly becoming one of the most influential biotechnologies of the last five years. Clinical trials will soon be underway to test whether CRISPR/Cas9 can edit away the genetic mutations that cause sickle cell disease (SCD). This article will present the background of CRISPR/Cas9 gene editing and SCD, highlighting research that supports the application of CRISPR/Cas9 to SCD. While much has been written on why SCD is a good biological candidate for CRISPR/Cas9, less has (...)
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