We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

We propose a way in which Barsalou could strengthen his position and at the same time make a considerable dent in the category/abstraction problem (that he suggests remains unsolved). There exists a class of connectionist models that solves this problem parsimoniously and provides a mechanistic underpinning for the promising high-level architecture he proposes.

Physicians and other healthcare professionals are increasingly finding ways to use artificial intelligent decision support systems in their work. IBM Watson Health, for example, is a commercially available technology that is providing AI-DDS services in genomics, oncology, healthcare management and more.1 AI’s ability to scan massive amounts of data, detect patterns, and derive solutions from data is vastly more superior than that of humans. AI technology is undeniably integral to the future of healthcare and public health, and thoughtful consideration of (...) the legal, ethical and moral issues surrounding this technology is a must. The authors of the article, Responsibility, Second Opinions, and Peer-Disagreement—Ethical and Epistemological Challenges of Using AI in Clinical Diagnostic Contexts, provide an informed discussion of how AI-DSS may be used, both practically and ethically, to assist healthcare professionals in cooperative diagnostic processes2. The authors propose a process, whereby AI-DSS would provide a physician a second opinion, and when there is a mismatch between opinions, another physician would provide a third opinion. This approach maintains a ‘physician-in-charge’ perspective, and suggests that decision-making must ultimately be made by a person. This approach is also consistent with the ‘physician in-the-loop’ concept, such that even when increasingly autonomous AI-DSSs are put to use, physicians will still be providing checks and overseeing clinical decisions. The authors conceptualise AI as a replacement of human cognitive labour. That is, AI is used to supplant a human professional in particular functions …. (shrink)

Following other contributions about the MAX accidents to this journal, this paper explores the role of betrayal and moral injury in safety engineering related to the U.S. federal regulator’s role in approving the Boeing 737MAX—a plane involved in two crashes that together killed 346 people. It discusses the tension between humility and hubris when engineers are faced with complex systems that create ambiguity, uncertain judgements, and equivocal test results from unstructured situations. It considers the relationship between moral injury, principled outrage (...) and rebuke when the technology ends up involved in disasters. It examines the corporate backdrop against which calls for enhanced employee voice are typically made, and argues that when engineers need to rely on various protections and moral inducements to ‘speak up,’ then the ethical essence of engineering—skepticism, testing, checking, and questioning—has already failed. (shrink)

Controversy has long surrounded the complex relationship between King Victor Emmanuel III and the dictator Benito Mussolini in Fascist Italy. It is clear that the king played decisive roles in bringing Mussolini to power in 1922 and in removing him in 1943. In between, the two coexisted as Italy became a ‘dyarchy’, with two foci of power. The presence of the monarchy at once checked Fascist radicalism and persuaded many conservatives to adhere to the regime. Thanks especially to the monarchy, (...) the innovative thrust of Fascism was channelled in certain delimited directions, toward a statist economy, for example. Still, the relationship between the crown and Mussolini was often rocky, though the king’s reluctance did not prevent alliance with Nazi Germany, anti-Semitism, and war. Tensions were largely papered over by rhetoric and myth-making, as if the elements of Fascism fit together neatly. Despite his opposition to certain particulars, Victor Emmanuel identified with the overall Fascist project to some extent, and he worried that outright opposition to the regime would jeopardize the monarchy. But as the Second World War went badly for Italy, the king finally deposed Mussolini. Nevertheless, Italy soon voted to eliminate the monarchy, discredited by its association with fascism. (shrink)

Political science faces a challenge from a “Mr. Perestroika,” who decries the hegemony of formal and statistical analysis in the discipline. Although not connected with this movement, Bent Flyvbjerg makes the best case for a renewed dominance for qualitative and case study work throughout the social sciences. This article challenges Flyvbjerg’s call for a phronetic as opposed to an epistemic discipline. It challenges as well the unqualified call for pluralism advocated by many in the perestroika movement. It offers instead an (...) integrated tripartite method in which narrative, statistics, and formal modeling fill in a scientific frame. (shrink)

_Draws out numerous affinities between the sophists and Socrates in Plato's dialogues._.

There are numerous well-documented problems with the DSM’s polythetic-categorical approach to the delineation of mental disorders. However, the DSM-5 introduces an empirically based dimensional model of personality traits. These traits form a hierarchical structure that represents the organization of dispositions to common mental disorders. We connect emotions to this joint hierarchical structure using a modified set point model, which accommodates major theories linking personality and psychopathology—continuum, risk, scar, and pathoplasty—as well as more dynamic multivariate models. We argue that these traits (...) represent typical causal pathways that can be extracted from a complex web of equifinality and multifinality. Ultimately, research on mood disorders provides a stronger account of their underling traits than the variably endorsed symptoms of their polythetic criteria. (shrink)

Christian Exegesis of the Qurʾān: A Critical Analysis of the Apologetic Use of the Qurʾān in Select Medieval and Contemporary Arabic Texts. By J. Scott Bridger. American Society of Missiology Monograph Series, vol. 23. Eugene, OR: Wipf and Stock, 2015. Pp. xii + 188. $25.

ABSTRACT In The Longing for Total Revolution, Bernard Yack claims not to account for totalitarianism but simply to unearth a new, specifically modern mindset. Still, the problem of totalitarianism, and whatever connection it might have had with that mindset, lurks throughout his book. Yack convincingly posits a relationship between a troubling new sense of historical embeddedness and novel totalist thinking. But his sense of the range of responses to historicity proves too limited to illuminate the connection between the longing for (...) total revolution and the advent of totalitarianism. Another look at Yack’s two culminating figures, Marx and Nietzsche, suggests a more illuminating alternative. (shrink)

There are presently two modern critical editions of Proclus' commentary on the Parmenides. One, the edition of the Oxford Classical Texts, was completed under the auspices of Carlos Steel in 2009. The other, the Budé edition, under the editorship of Concetta Luna and the late Alain-Philippe Segonds, followed soon after, with the third of the first three books of the commentary having appeared in the early 2012. This most recent two-part volume of the Budé addresses, for the final time it (...) seems, the Budé's criticisms of the OCT edition. The first volume could be well described as a long philippic against the OCT and its editor and contributors, going well beyond the tone of measured academic discourse. Relentlessly, it imprecates the readings of the OCT, the length and tone of which criticisms will not weather time well. However, there is one disagreement between the two editions, perhaps the most textually significant one and certainly the largest, which is noted as a part of a comprehensive list by the Budé, but no discussion ensues. This is all the more curious because Steel had, in a separate article, directly raised objections to their solution to this passage. Why in this single case is the Budé suddenly so taciturn? (shrink)

"An admirable accomplishment.... Roberts provides valuable insights into the current debate on the nature of historical knowledge in our present 'postmodern' time. Anyone concerned with the philosophy of history will need to reckon with this book."--Allan D. Megill, author of "Prophets of Extremity".

Philosophers of language have drawn on metamathematical results in varied ways. Extensionalist philosophers have been particularly impressed with two, not unrelated, facts: the existence, due to Frege/Tarski, of a certain sort of semantics, and the seeming absence of intensional contexts from mathematical discourse. The philosophical import of these facts is at best murky. Extensionalists will emphasize the success and clarity of the model theoretic semantics; others will emphasize the relative poverty of the mathematical idiom; still others will question the aptness (...) of the standard extensional semantics for mathematics. In this paper I investigate some implications of the Gödel Second Incompleteness Theorem for these positions. I argue that the realm of mathematics, proof theory in particular, has been a breeding ground for intensionality and that satisfactory intensional semantic theories are implicit in certain rigorous technical accounts. (shrink)

Constructivism is based on the principle that our personalities, behavior, and society are organized by the ways in which we attribute meanings to events, and act upon those meanings. It provides a philosophy, an epistemology, and methods that are especially congruent with the central values of social work, particularly client self-determination. In this volume, Dr. David D.V. Fisher introduces social workers to constructivism, a perspective which is becoming increasingly popular in the social sciences, and which has already been embraced (...) by clinical psychologists, communication researchers, and cyberneticians. Fisher explains constructivism as an epistemology, shows the consequences of adopting a constructivist epistemology in contrast to operating from within the traditional objectivist epistemology, demonstrates the ethical appropriateness and practicality of constructivism for social work, and explicates a number of specific applications of constructivism to social work. The book is divided into two parts. The first part consists of an introduction and then explains and expands the theory of constructivism and its relationship to social work. The second part shows how constructivist principles may be applied in social work practices. Constructivist principles are applied to selected aspects of assessment, intervention, and interviewing--using immediate experience as a guide to action and the creation of professional responsibility. An Introduction to Constructivism for Social Workers will be of particular interest to social workers and psychologists involved in theory and research. (shrink)

For the past two decades, the humanistic disciplines have been dominated by poststructuralist theories and, more recently, a not unrelated curricular philosophy best defined as hardline multiculturalism, much discussed and often misunderstood. When linked together, they form an internal contradiction that is the moral challenge of liberal education today. Traditional political alignments cannot explain current divisions among the humanities professoriate. Ideological quarrels only obscure a deeper moral debate between an ascendant poststructuralism and a resurgent liberal humanism. It is important to (...) reappropriate liberal humanism in an effort to revitalize humanistic inquiry and renew its place in creative public discourse, and check a danger posed by poststructuralism's fascination with power and epistemological relativism which threaten to erase the ethical border between education and indoctrination. (shrink)

No writer or public intellectual of our era has been as sensitive to the role of faith in the lives of ordinary Americans as Robert Coles. Though not religious in the conventional sense, Coles is unparalleled in his astute understanding and respect for the relationship between secular life and sacredness, which cuts across his large body of work. Drawing inspiration from figures like Dietrich Bonhoeffer, Dorothy Day, and Simone Weil, Coles’s extensive writings explore the tug of war between faith and (...) doubt. As Coles himself admits, the “back-and-forthness between faith and doubt is the story of my life.” These thirty-one thought-provoking essays are drawn from Coles’s weekly column in the Catholic publication _America_. In them, he turns his inquisitive lens on a range of subjects and issues, from writers and painters to his recent reading and film viewing, contemporary events and lingering controversies, recollections of past and present mentors, events of his own daily life, and ordinary encounters with students, patients, neighbors, and friends. Addressing moral questions openly and honestly with a rare combination of rectitude and authorial modesty, these essays position Coles as a preeminent, durable, and trusted voice in the continuing national conversation over religion, civic life, and moral purpose. (shrink)