Although epistemic values have become widely accepted as part of scientific reasoning, non-epistemic values have been largely relegated to the "external" parts of science (the selection of hypotheses, restrictions on methodologies, and the use of scientific technologies). I argue that because of inductive risk, or the risk of error, non-epistemic values are required in science wherever non-epistemic consequences of error should be considered. I use examples from dioxin studies to illustrate how non-epistemic consequences of error can and should be considered (...) in the internal stages of science: choice of methodology, characterization of data, and interpretation of results. (shrink)

Minors are generally considered incompetent to provide legally binding decisions regarding their health care, and parents or guardians are empowered to make those decisions on their behalf. Parental authority is not absolute, however, and when a parent acts contrary to the best interests of a child, the state may intervene. The best interests standard is the threshold most frequently employed in challenging a parent''s refusal to provide consent for a child''s medical care. In this paper, I will argue that the (...) best interest standard provides insufficient guidance for decision-making regarding children and does not reflect the actual standard used by medical providers and courts. Rather, I will suggest that the Harm Principle provides a more appropriate threshold for state intervention than the Best Interest standard. Finally, I will suggest a series of criteria that can be used in deciding whether the state should intervene in a parent''s decision to refuse medical care on behalf of a child. (shrink)

This paper examines the relationship between organizational ethical culture in two large international CPA firms, auditors'' personal values and the ethical orientation that those values dictate, and judgments in ethical dilemmas typical of those that accountants face. Using an experimental task consisting of multiple judgments designed to vary in "moral intensity" (Jones, 1991), and unique as well as tried-and-true approaches to variable measurements, this study examined the judgments of more than three hundred participants in our study. ANCOVA and path analysis (...) results indicate that: (1) Ethical judgments in situations of high moral intensity are affected by personal values and by environmental variables, such as the professional code of conduct (direct and indirect effects) and previous ethics instruction (direct effect only). (2) Corporate ethical culture, and a relatively strong firm rules-orientation, affect auditors'' idealism but not relativism, and therefore indirectly affect ethical judgments. Jones'' (1991) moral intensity argument is supported: differences in the characteristics of specific judgment tasks apparently result in different decision processes. (shrink)

In this first modern, critical assessment of the place of mathematics in Berkeley's philosophy and Berkeley's place in the history of mathematics, Douglas M. Jesseph provides a bold reinterpretation of Berkeley's work. Jesseph challenges the prevailing view that Berkeley's mathematical writings are peripheral to his philosophy and argues that mathematics is in fact central to his thought, developing out of his critique of abstraction. Jesseph's argument situates Berkeley's ideas within the larger historical and intellectual context of the Scientific Revolution. (...) Jesseph begins with Berkeley's radical opposition to the received view of mathematics in the philosophy of the late seventeenth and early eighteenth centuries, when mathematics was considered a "science of abstractions." Since this view seriously conflicted with Berkeley's critique of abstract ideas, Jesseph contends that he was forced to come up with a nonabstract philosophy of mathematics. Jesseph examines Berkeley's unique treatments of geometry and arithmetic and his famous critique of the calculus in The Analyst. By putting Berkeley's mathematical writings in the perspective of his larger philosophical project and examining their impact on eighteenth-century British mathematics, Jesseph makes a major contribution to philosophy and to the history and philosophy of science. (shrink)

SUMMARYThis paper discusses the scientific instruments made and used by the microscopist Antony van Leeuwenhoek. The immediate cause of our study was the discovery of an overlooked document from the Delft archive: an inventory of the possessions that were left in 1745 after the death of Leeuwenhoek's daughter Maria. This list sums up which tools and scientific instruments Leeuwenhoek possessed at the end of his life, including his famous microscopes. This information, combined with the results of earlier historical research, gives (...) us new insights about the way Leeuwenhoek began his lens grinding and how eventually he made his best lenses. It also teaches us more about Leeuwenhoek's work as a surveyor and a wine gauger.A further investigation of the 1747 sale of Leeuwenhoek's 531 single lens microscopes has not only led us to the identification of nearly all buyers, but also has provided us with some explanation about why only a dozen of this large number of microscopes has survived. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

Synthese: An International Journal for Epistemology, Logic and Philosophy of Science, 157, 2007, 197-240. Published version available at: http://www.springerlink.com/content/q9402gv46t415504/fulltext.pdf.

"The development of the calculus during the 17th century was successful in mathematical practice, but raised questions about the nature of infinitesimals: were they real or rather fictitious? This collection of essays, by scholars from Canada, the US, Germany, United Kingdom and Switzerland, gives a comprehensive study of the controversies over the nature and status of the infinitesimal. Aside from Leibniz, the scholars considered are Hobbes, Wallis, Newton, Bernoulli, Hermann, and Nieuwentijt. The collection also contains newly discovered marginalia of Leibniz (...) to the writings of Hobbes."--BOOK JACKET. (shrink)

In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap (...) between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages. (shrink)

: Errors in science range along a spectrum from those relatively local to the phenomenon (usually easily remedied in the laboratory) to those more conceptually derived (involving theory or cultural factors, sometimes quite long-term). One may classify error types broadly as material, observational, conceptual or discoursive. This framework bridges philosophical and sociological perspectives, offering a basis for interfield discourse. A repertoire of error types also supports error analytics, a program for deepening reliability through strategies for regulating and probing error.

There is a burgeoning scientific and ethical literature on the use of biomarkers—such as genes or brain scan results—and biological interventions to predict and prevent crime. This literature on biopredicting and biopreventing crime focuses almost exclusively on crimes that are physical, violent, and/or sexual in nature—often called blue-collar crimes—while giving little attention to less conventional crimes such as economic and environmental offences, also known as white-collar crimes. We argue here that this skewed focus is unjustified: white-collar crime is likely far (...) costlier than blue-collar crime in money, health, and lives lost. Moreover, attempts to biopredict and bioprevent blue-collar crime may entail adopting potentially unfair measures that target individuals who are already socio-economically disadvantaged, thus compounding pre-existing unfairness. We argue, therefore, that we ought to extend the study of bioprediction and bioprevention to white-collar crime as a means of more efficiently and fairly responding to crime. We suggest that identifying biomarkers for certain psychopathic traits, which appear to be over-represented among senior positions in corporate and perhaps political organisations, is one avenue through which this research can be broadened to include white-collar crime. (shrink)

_ Source: _Volume 29, Issue 1, pp 66 - 85 This paper will deal with the notion of _conatus_ and the role it plays in Hobbes’s program for natural philosophy. As defined by Hobbes, the _conatus_ of a body is essentially its instantaneous motion, and he sees this as the means to account for a variety of phenomena in both natural philosophy and mathematics. Although I foucs principally on Hobbesian physics, I will also consider the extent to which Hobbes’s account (...) of _conatus_ does important explanatory work in his theory of human perception, psychology, and political philosophy. I argue that, in the end, there are important limitations in Hobbes’s account of _conatus_, but that Leibniz adapted the concept in important ways in developing his science of dynamics. (shrink)

PrefaceList of AbbreviationsChapter One: The Mathematical Career of the Monster of MalmesburyChapter Two: The Reform of Mathematics and of the UniversitiesIdeological Origins of the DisputeChapter Three: De Corpore and the Mathematics of MaterialismChapter Four: Disputed FoundationsHobbes vs. Wallis on the Philosophy of MathematicsChapter Five: The "Modern Analytics" and the Nature of DemonstrationChapter Six: The Demise of Hobbesian GeometryChapter Seven: The Religion, Rhetoric, and Politics of Mr. Hobbes and Dr. WallisChapter Eight: Persistence in ErrorWhy Was Hobbes So Resolutely Wrong?Appendix: Selections from (...) Hobbes's Mathematical WritingsReferencesIndex Copyright © Libri GmbH. All rights reserved. (shrink)

A well-known ``overdetermination''argument aims to show that the possibility of mental causes of physical events in a causally closed physical world and the possibility of causally relevant mental properties are both problematic. In the first part of this paper, I extend an identity reply that has been given to the first problem to a property-instance account of causal relata. In the second, I argue that mental types are composed of physical types and, as a consequence, both mental and physical types (...) may be causally relevant with respect to the same physical effect, contrary to the overdetermination argument. In further sections, I argue that mental types have causal powers, consider some objections and reject an alternative version of part-whole physicalism. Throughout I assume that causal relata are tropes and property types are classes of tropes. (shrink)

The infamous difficulty of Lacan's writing has its own, very apt synecdoche: the matheme. What makes this ‘little letter’ that structures the signifier so apposite a device is how it stymies even those sophisticated readers for whom Lacan is as close-readable as Mallarm e. The proposition offered here is that this crisis of reading is not the consequence of either some terrible mistake or egregious failing in character, but rather a typically Lacanian move by which his text stages the very (...) theory it is presumably explicating. This article suggests that by striving to read the matheme, instead of seizing upon excuses to avoid it, we can begin to understand what Lacan meant when he said that everything emerges from the structure of the signifier. (shrink)

Alexander Rosenberg (1983) has argued, contrary to his previous work in the philosophy of economics, that economics is not science, and it is merely mathematics. The following paper argues that Rosenberg fails to demonstrate either of these two claims. The questions of the predictive weakness of modern economics and the cognitive standing of abstract economic theory are discussed in detail.

It is argued that Hellman's arguments purporting to demonstrate that constructive mathematics cannot cope with unbounded operators on a Hilbert space are seriously flawed, and that there is no evidence that his thesis is correct.

The first part of the paper introduces the varieties of modern constructive mathematics, concentrating on Bishop's constructive mathematics (BISH). it gives a sketch of both Myhill's axiomatic system for BISH and a constructive axiomatic development of the real line R. The second part of the paper focusses on the relation between constructive mathematics and programming, with emphasis on Martin-L6f 's theory of types as a formal system for BISH.

'Natural class' trope nominalism makes a trope's being of a certain sort--its nature--a matter of its membership in a certain natural class of actual tropes. It has been objected that on this theory had even a single member of the class of red tropes not existed, for example, then the type 'being red' would not have been instantiated and nothing would have been red. I argue that natural class trope nominalism can avoid this implication by way of counterpart theory as (...) applied to properties. (shrink)

Western science teaches that our beings are governed by the laws of physics and our minds play no part. There are, however, flaws in this thinking, most prominently unexplained paranormal phenomena that defy explanation by modern theories of physics. Collected by a handful of renegade scientists who call themselves parapsychologists, these data include extrasensory perception (ESP), poltergeist occurrences, and psychokinesis. Much of the current data in parapsychology and their implications for understanding the true nature of the self are examined here. (...) Beginning with a consideration of several instances of spontaneous psi, the book examines the theoretical explanations of paranormal phenomena. It also covers the hypothesis and evidence that minds contain the so-called hidden variables that determine the outcomes of the quantum process, thus interweaving parapsychology with modern physics. The minds fate upon the death of the physical body is discussed; the reader is forced to consider in detail the relationship between the conscious mind and the physical brain and the evidence that minds survive the death of bodies. (shrink)

I argue in this paper that philosophers have not clearly introduced the concept of a body in terms of which the problem of other minds and its solutions have been traditionally stated; that one can raise fatal objections to attempts to introduce this concept; and that the particular form of the problem of other minds which is stated in terms of the concept is confused and requires no solution. The concept of a "body" which may or may not be the (...) body of a person, which is required to state the traditional problem, is, on close examination, incoherent and cannot be introduced into a reasonable philosophical discussion. Also published in The Philosophy of the Body, Rejections of Cartesian Dualism, ed. Stuart F. Spicker. (shrink)

This chapter is concerned with the foundations of Hobbes’s natural philosophy, notably his account of space and time, as well as an inertial law the author terms the “persistence principle” and a mechanistic principle of action by contact. The author argues that these foundational concepts and principles serve as a framework that places constraints upon the kinds of hypotheses that may figure in the explanation of phenomena, but they do not uniquely determine how natural philosophy is to be developed. In (...) particular, the author shows that Hobbes took questions about the infinitude and uniqueness of the world as unanswerable in principle, although he regarded the question of the vacuum as an empirical matter that could be settled by experiment. Hobbes did, however, hold that certain doctrines were incoherent and should be rejected on a priori grounds. (shrink)

The nature of modern constructive mathematics, and its applications, actual and potential, to classical and quantum physics, are discussed.

: This paper investigates the influence of Galileo's natural philosophy on the philosophical and methodological doctrines of Thomas Hobbes. In particular, I argue that what Hobbes took away from his encounter with Galileo was the fundamental idea that the world is a mechanical system in which everything can be understood in terms of mathematically-specifiable laws of motion. After tracing the history of Hobbes's encounters with Galilean science (through the "Welbeck group" connected with William Cavendish, earl of Newcastle and the "Mersenne (...) circle" in Paris), I argue that Hobbes's 1655 treatise De Corpore is deeply indebted to Galileo. More specifically, I show that Hobbes's mechanistic theory of mind owes a significant debt to Galileo while his treatment of the geometry of parabolic figures in chapter 16 of De Corpore was taken almost straight out of the account of accelerated motion Two New Sciences. (shrink)

Investigating the concepts and material realities of energy coursing through the arts: a foundational text. This book investigates energies—in the plural, the energies embedded and embodied in everything under the sun— as they are expressed in the arts. With contributions from scholars and critics from the visual arts, art history, anthropology, music, literature, and the history of science, it offers the first multidisciplinary investigation of the concepts and material realities of energy coursing through the arts. Just as Douglas Kahn's (...) earlier books helped introduce sound as a category for study in the arts, this new volume will be a foundational volume for future explorers in a largely uncharted domain. The modern concept of energy is only two hundred years old—an abstraction grounded in extraction—but this book takes a more expansive view. It opens with a clap: the sonic energies in a ceremony of the indigenous Goolarabooloo people of Australia. Other chapters explore the energies of photography; responses of artists in the early twentieth century—including Marcel Duchamp—to scientific discoveries in electricity and electromagnetism; the aestheticization of entropy in works by Hans Haacke and Robert Smithson; free-jazz musician Milford Graves's cross-cultural engagement with music, science, and spiritualism; energy field performance; and the self-generating energy of rumor and gossip as artwork. Contributors include such leading scholars as Linda Dalrymple Henderson, John Tresch, and Caroline A. Jones. Practicing artists and students of art history will find Energies in the Arts an essential work. Contributors Susan Ballard, Jennifer Biddle, Marcus Boon, Joan Brassil, Steven Connor, Milford Graves, Daniel Hackbarth, Linda Dalrymple Henderson, Caroline A. Jones, Douglas Kahn, David Mather, Stephen Muecke, James Nisbet, Daniela Silvestrin, Michael Taussig, John Tresch, Melissa Warak. (shrink)

This investigation joins recent research on problems with ambiguity in two fields, argumentation and computing. In argumentation, there is a concern with fallacies arising from ambiguity, including equivocation and amphiboly. In computing, the development of agent communication languages is based on conversation policies that make it possible to have information exchanges on the internet, as well as other forms of dialogue like persuasion and negotiation, in which ambiguity is a problem. Because it is not possible to sharply differentiate between problems (...) arising from ambiguity and those arising from vagueness, obscurity and indeterminacy, some study of the latter is included. The semantic web is based on what are called ontologies, or systems of classification of concepts, shown to be useful tools for dealing with these problems. (shrink)

In the shadowy world between philosophy of science and ethics lie the paired concepts of underdetermination and incommensurability. Typically, scientific evidence underdetermines the hypotheses tested in research studies, providing neither proof nor disproof. As a result, scientists must judge the weight of the evidence, and in doing so, bring scientific and extrascientific values to bear in their approaches to assessing and interpreting the evidence. When different scientists employ very different values, their views are said to be incommensurable. Less prominent differences (...) represent partial incommensurabilities. The definitions and analyses provided by McMullin and by Veatch and Stempsey lay the foundation for the description of partial incommensurabilities in the current practice of assessing and interpreting epidemiologic evidence. This practice is called "causal inference" and is undertaken for the purpose of making causal conclusions and public health recommendations from population-based studies of exposures and diseases. Following the work of Bayley and Longino, several suggestions are examined for dealing with the partial incommensurabilities found in the general practice of causal inference in contemporary epidemiology. Two specific examples illustrate these ideas: studies on the relationship between induced abortion and breast cancer and those on the relationship between moderate alcohol consumption and breast cancer. (shrink)

This article examines Hobbes’s conception of mathematical method, situating his methodological writings in the context of disputed mathematical issues of the seventeenth century. After a brief exposition of the Hobbesian philosophy of mathematics, it investigates Hobbes’s attempts to resolve three important mathematical controversies of the seventeenth century: the debates over the status of analytic geometry, disputes over the nature of ratios, and the problem of the “angle of contact” between a curve and tangent. In the course of these investigations, Hobbes’s (...) account of mathematics and its method is contrasted with the those of Descartes, Isaac Barrow, John Wallis, and Christopher Clavius. (shrink)