Este estudio de relaciones médico-paciente en Mexico involucró entrevistas realizadas a 1700 pacientes inmediatamente de.\pués de salir de su consulta clínica. Se llevó a cabo entre los años 2004-05 en León, More ha, Guanajuato y en Charleston, West Virginia, USA. Los propósitos fueron: 1) establecer un base de datos como punto de referencia para investigaciones futuras en instituciones del cuidado de la salud con referencia a la comunicación médico-paciente, a la satisfacción de los pacientes y al consentimiento infórmado y, 2) (...) hacer una comparación entre las relaciones medico-paciente en Mexico y los Estados Unidos de America. Hicimos varias conclusiones sobre la comunicación médico-paciente, participación del paciente en decisiones con respecto a su cuidado de salud y el ambiente social de la consulta médica. Ofi-ecemos los datos y los cuestionarios completos por internet a cualquier investigador interesado para estudios futuros de acuerdo con sus propios intereses. Además, encontramos que no huho ninguna diferencia importante en las relaciones médico-pacientes con respecto al consentimiento infórmado y la satisfáccián del paciente entre México y los EEUU. (shrink)

Since most of the functions in cells are mediated by multimeric protein complexes, the determination of protein–protein interactions is an important step in the study of cellular mechanisms. Traditionally, after screening for possible target interactors by means of a yeast two‐hybrid screen, several methods are used to validate the initial result before carrying out functional experiments. Nowadays, non‐invasive fluorescence‐based methods like Bioluminescence Resonance Energy Transfer (BRET) and Fluorescence Resonance Energy Transfer (FRET) are widely used in the study of protein–protein interactions (...) in living cells. In the present review, we address the individual strengths and weaknesses of both RET approaches, providing information on their possible future use in the study of G protein‐coupled receptor oligomerization. BioEssays 30:82–89, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

El presente artículo propone una lectura paralela de dos narconovelas colombianas recientes: El ruido de las cosas al caer (2011) de Juan Gabriel Vásquez y El cielo a tiros (2018) de Jorge Franco. El objetivo del análisis consiste en identificar las convergencias entre ambas obras e interpretarlas a la luz de la evolución del paradigma narco vigente en la narrativa colombiana de los años 1990 y 2000.

Este artículo plantea un diálogo sobre la ficción y su relevancia narrativa dentro del relato histórico contemporáneo colombiano, a la luz de sus relaciones transversales. Tras el Acuerdo de Contribución a la Verdad Histórica y la Reparación y de la consolidación del trabajo llevado a cabo por el Centro Nacional de Memoria Histórica iniciado hace casi una década con su primer informe, es pertinente volver sobre algunas ideas relacionadas con la manera en la que se narra la historia en Colombia. (...) En este sentido, se constata el valor histórico de la ficción, así como la vitalidad de sus diversos actores sociales y culturales, en sus intersecciones y recorridos por la memoria colectiva, en su materialidad y en su reinvención histórica. Los textos de ficción, por tanto, ofrecen caminos de reinvención de los relatos históricos, que no los sustituyen, pero sí empoderan a sus participantes/enunciantes, sus lectores/receptores y sus versiones/ relatos dentro de los procesos de memorias nacionales y humanas de la Colombia de hoy. Lo significativo de esta propuesta radica en que estos relatos son inclusivos, plurales y carecen del juicio moral hecho por una voz narradora autoritaria y única. (shrink)

The aim of this study is to characterize the weak discussion about the Human Rights in Franco’s time, not in general, but by testing Vallet de Goytisolo’s works. This author is deeply influenced by the lectures of M. Villey, Parisinian philosopher well-known by his denial of Human Rights. A comparative study of these authors will be done focusing on two - faced aspects : the strength and fragility of their doctrines. Both authors are defined as supporters of the Methodical (...) Realism (Aristotelian-Thomist school), although their arguments and sources are very similar, their purposes and conclusions are different. Juan Vallet does not reject the Human Rights, but he prefers the denomination of ethical-legal principles, that is, moral categories that must guide the legislative and judicial praxis. The root of these ethical-legal principles is the ethical-natural principles extracted at natural order, and the duty of all authority is to adequate his rules to the nature of things, exactly as in Saint Thomas. In Vallet’s works, the theoretical reason for this rejection is that the notion of fundamental right is scientifically unsatisfactory to understand the complexity of the social reality. The practical reason defends that the Civil right should not be confused with the power or faculty of the individual, errors of nominalism, but the origin of these powers is to be found in the context of a particular legal relationship. However, in the end, this catalogue of rights will be not feasible for the citizen, since these rights are at the mercy of the legislator or the judge. They are liable to obey these principles, only morally. (shrink)

Es una tesis admitida y común la que sostiene que Descartes introdujo la forma moderna del método y del quehacer filosófico, caracterizados ambos por su desconexión del terreno de la espiritualidad, del cuidado de sí, de la ascesis y de toda una forma de vida. Se considera que Foucault compartía esa tesis, lo que en su momento criticaría Pierre Hadot. En el presente trabajo tratamos de mostrar que la forma en que Descartes elaboró su método y su propuesta no se (...) ajusta a aquella tesis recibida. En él se mantiene la relación antigua entre filosofía y espiritualidad, método y paideía. Una vez mostrado esto, apuntamos finalmente cómo en él, sin embargo, se abrió la vía para que se diera la ruptura que él no practicó. (shrink)

RESUMEN Este trabajo pretende relacionar dos debates emparentados sobre cómo la lógica y el lenguaje influyen sobre el pensamiento. Existe un eje de discusión en relación a si hay una pluralidad de lógicas o un único sistema lógico como criterio de evaluación para cualquier contexto de razonamiento. En lingüística, el debate surgido a partir de las interpretaciones fuertes y débiles de la hipótesis Sapir-Whorf ha centralizado la discusión en torno al grado de influencia o determinación del lenguaje sobre el pensamiento. (...) Desde perspectivas y marcos teórico-conceptuales diferentes, lógica y lingüística delimitan y problematizan un campo de indagación y reflexión. El artículo, desde una mirada transdisciplinar, pretende dar cuenta y postular vasos comunicantes entre estos debates atendiendo a los matices de cada enfoque, así como proponer una hipótesis propia sobre la problemática planteada. ABSTRACT This paper aims to relate two debates about how logic and language influence thought. There is an axis of discussion about whether there exists a plurality of logic or a single logical system as an evaluation criterion for any reasoning context. In linguistics, the debate arising from the strong and weak interpretations of the Sapir-Whorf hypothesis has centralized the discussion around the degree of influence or determination of language on thought. From different perspectives and theoretical-conceptual frameworks, logic, and linguistics delimit and problematize a field of inquiry and reflection. The article, from a transdisciplinary perspective, intends to account for and postulate communicating vessels between these debates, considering the nuances of each approach. It also seeks to propose its own hypothesis on the problem raised. (shrink)

This paper introduces the theory QST of quasets as a formal basis for the Nmatrices. The main aim is to construct a system of Nmatrices by substituting standard sets by quasets. Since QST is a conservative extension of ZFA (the Zermelo-Fraenkel set theory with Atoms), it is possible to obtain generalized Nmatrices (Q-Nmatrices). Since the original formulation of QST is not completely adequate for the developments we advance here, some possible amendments to the theory are also considered. One of the (...) most interesting traits of such an extension is the existence of complementary quasets which admit elements with undetermined membership. Such elements can be interpreted as quantum systems in superposed states. We also present a relationship of QST with the theory of Rough Sets RST, which grants the existence of models for SQT formed by rough sets. Some consequences of the given formalism for the relation of logical consequence are also analysed. (shrink)

De manera analítica pretende exponerse aquí la respuesta de Simone Weil a la cuestión que dejara formulada en el inicio de la modernidad, Maquiavelo, la cuestión del uso del mal. Esta cuestión queda inscrita en toda la larga reflexión que la autora francesa hiciera sobre la lógica entre medios y fines que fatalmente rige nuestra cultura, y conduce a una constante inversión en la que los medios se convierten en el auténtico fin. Entendiendo que estas dos cuestiones constituyen el núcleo (...) de todo pensamiento político, que se ocupe de la organización de nuestra vida en común, Simone Weil no podía por menos de ocuparse intensamente en ello, de principio a fin de su obra. (shrink)

La posición de Foucault acerca de la ruptura que Descartes había representado respecto de la relación entre acceso a la verdad y transformación de sí, entre método y espiritualidad no fue unívoca. Sus formulaciones variaron, a veces de manera sorprendente. Foucault veía que el autor de las Meditaciones metafísicas mantenía una compleja relación con la tradición de la espiritualidad, lo que exigía precisar en más de un aspecto la conocida tesis de la ruptura. Aquí trataremos de examinar esa dificultad en (...) la que se encontró Foucault. (shrink)

Studying the neural correlates of conscious awareness depends on a reliable comparison between activations associated with awareness and unawareness. One particularly difficult confound to remove is task performance capacity, i.e. the difference in performance between the conditions of interest. While ideally task performance capacity should be matched across different conditions, this is difficult to achieve experimentally. However, differences in performance could theoretically be corrected for mathematically. One such proposal is found in a recent paper by Lamy, Salti and Bar-Haim [Lamy (...) D, Salti M, Bar-Haim Y. Neural correlates of subjective awareness and unconscious processing: an ERP study. J Cognitive Neurosci 2009,21:1435-46], who put forward a corrective method for an electroencephalography experiment. We argue that their analysis is essentially grounded in a version of High Threshold Theory, which has been shown to be inferior in general to Signal Detection Theory. We show through a series of computer simulations that their correction method only partially removes the influence of perfor- mance capacity, which can yield misleading results. We present a mathematical correction method based on Signal Detection Theory that is theoretically capable of removing performance capacity confounds. We discuss the limitations of mathemati- cally correcting for performance capacity confounds in imaging studies and its impact for theories about consciousness. (shrink)

The concept of scaffolding has wide resonance in several scientific fields. Here we attempt to adopt it for the study of development. In this perspective, the embryo is conceived as an integral whole, comprised of several hierarchical modules as in a recurrent circularity of emerging patterns. Within the developmental hierarchy, each module yields an inter-level relationship that makes it possible for the scaffolding to mediate the production of selectable variations. A wide range of genetic, cellular and morphological mechanisms allows the (...) scaffolding to integrate these modular variations into a functionally coordinate unit. A genetic scaffolding accounts for the inherited invariance of pattern formation during the embryo’s growth. At higher level, cells behave as agents endowed with the capacity to interpret any scaffolding variation as signs. The full hierarchy of a multi-level scaffolding is eventually attained when the embryo acquires the capacity to impose a number of developmental constraints on its constituting parts in a top-down direction. The acquisition of this capacity allows a semiotic threshold to emerge between the living cellular world and the underlying non-living molecular world. As this boundary is gradually defined during development, cells enter into new functional relationships, while, at the same time, are relieved from their physical determinism. The resulting constraints can thus become the driving forces that upgrade embryonic scaffolding from the simple molecular signalling to the complexity of sign recognition proper of a cellular community. In this semiotic perspective, the apparent goal directness of any developmental strategy should no longer be accounted for by a predetermined genetic program, but by the gradual definition of the relationships selected amongst the ones historically explored. (shrink)

1. Simultaneidade e presença ; O ser, o existir e o afirmar -- 2. Ensaios de axiologia realista-problemática ; Noções de moral realista-probemática ; Um novo banquete -- 3. Fragmentos filosóficos ; A anunciação de Emanuel ; Curso de filosofia realista-problemática -- 4. Uma análise realista-problemática dos absolutos ; Introdução à filosofia realista-problemática.

World Literature in Theory provides a definitive exploration of the pressing questions facing those studying world literature today. Coverage is split into four parts which examine the origins and seminal formulations of world literature, world literature in the age of globalization, contemporary debates on world literature, and localized versions of world literature Contains more than 30 important theoretical essays by the most influential scholars, including Johann Wolfgang von Goethe, Hugo Meltzl, Edward Said, Franco Moretti, Jorge Luis Borges, and (...) Gayatri Spivak Includes substantive introductions to each essay, as well as an annotated bibliography for further reading Allows students to understand, articulate, and debate the most important issues in this rapidly changing field of study. (shrink)

In this paper we discuss the notions of adequacy and truth functionality in quantum logic from the point of view of a non-deterministic semantics. We give a characterization of the degree of non-functionality which is compatible with the propositional structure of quantum theory, showing that having truth-functional connectives, together with some assumptions regarding the relation of logical consequence, commits us to the adequacy of the interpretation sets of these connectives. An advantage of our proof is that it is independent of (...) the number of truth values involved, generalizing previous works. We also show the failure of the adequacy of every Nmatrix that is a model of the non-distributive lattice of quantum propositions. En este trabajo discutimos las nociones de adecuación y veritativo-funcionalidad en la lógica cuántica, desde el punto de vista de una semántica no determinista. Damos una caracterización del grado de no-funcionalidad compatible con la estructura proposicional de la teoría cuántica, mostrando que tener conectivos veritativo-funcionales, junto con algunos presupuestos relativos a la relación de consecuencia lógica, nos compromete con la adecuación de los conjuntos de interpretación de estos conectivos. Un punto ventajoso de nuestra prueba es que se independiza de la cantidad de valores de verdad involucrados, generalizando trabajos previos. Probamos también que falla la adecuación de cualquier Nmatriz que sirva como modelo para el retículo no distributivo de proposiciones cuánticas. (shrink)

The definitive establishment of public-private governance has forced to abandon the theories of political autonomy that were valid until a few decades ago. In return, there has been a boom in the autonomy of the right conceived as a recovery of the natural law inherent to Human Rights. This article rescues from oblivion the two main criticisms made in the second half of the twentieth century to Human Rights: that of the conservative jurist Ernst Forsthoff and that of the Marxist (...) philosopher Antonio Negri. Although these thinkers are completely antagonistic from the point of view of their political projects, both agree that, in the current technical societies where collaborative work prevails, the liberal conception of right is no longer able to function as a guarantor of the freedoms and empowerment of citizens: it has lost all capacity for control and organization of material production relationships. (shrink)

RESUMEN Como reacción a la recuperación académica de un Marx completamente desvinculado de la tradición marxista-leninista realizada a finales del siglo XX, las dos últimas décadas han presenciado un nuevo intento, propiamente filosófico, de rescatar partes del pensamiento de Lenin, si bien se han llevado a cabo desde posiciones epistemológicas, y con objetivos políticos, altamente divergentes. El presente artículo analiza y compara las que consideramos que son las dos líneas principales de esta recuperación: La liderada por Slavoj Žižek desde posiciones (...) sociosimbólicas post-althusserianas, y la desarrollada por Antonio Negri y Michael Hardt a partir de la ontología deleuzo-guattariana y el post-operaísmo. ABSTRACT Towards the end of the 2oth century there took place an academic recovery of a Marx completely detached from the Marxist-Leninist tradition. As a reaction, in the last two decades there has been a new properly philosophical attempt to rescue pieces of Lenin's thinking. This recovery has been carried out from epistemological positions and with clearly divergent political objectives. This article analyzes and compares what we consider to be the two main lines of this recovery: the one led by Slavoj Žižek from post-Althusserian socio-symbolic positions, and the one developed by Antonio Negri and Michael Hardt from Deleuzo-Guattarian ontology and post-operaism. (shrink)

Introduction: Cartographies in becoming -- The happy depression -- Integrated world capitalism -- Planetary psychopathia -- Postmediatic affect -- User's manual-- Deleuze and the rhizomatic machine -- Why is anti-Oedipus the book of the '68 movement? -- Kafka, hypertext, and assemblages -- The tantric egg -- Chaosmosis -- The provisional eternity of friendship.

Sostenemos la tesis de que el concepto de hegemonía que desarrolló Gramsci es deficiente en dos puntos claves: en dar cuenta de los modos de integración característicos de las sociedades complejas, y en su proyección respecto a la construcción de la sociedad futura. Los dos aspectos están relacionados en cuanto que uno y otro remiten a la concepción de una totalidad ética, vertebrada por una concepción del mundo. El concepto de hegemonía, según esto, debiera superar su honda dimensión eticista. Para (...) la exposición de esta tesis hacemos una confrontación de la posición gramsciana con las observaciones de la gran sociología clásica (Durkheim, Weber) y particularmente con los enfoques de Habermas y Rawls. (shrink)

_ Source: _Volume 29, Issue 1, pp 86 - 102 The aim of this paper is to give an overview of the place that Hobbes assigns to optics in the context of his classification of sciences and disciplinary boundaries. To do this, I will begin with an account of Hobbes’s conception of philosophy or science, and particularly his distinction between true and hypothetical knowledge. I will also show that in his demarcation between mathematics or geometry and natural philosophy Hobbes was (...) influenced by Galileo’s _Dialogue_. I then analyse the consequences of this distinction for optics, and conclude by clarifying its status among the scientific disciplines. (shrink)

Cell communication plays a key role in multicellular organisms. In developing embryos as in adult organisms, cells communicate by coordinating their differentiation through the establishment and/or renewal of a variety of cell communication channels. Under both these conditions, cells interact by either receptor signalling, surface recognition of specific cell adhesion molecules or transfer of cytoplasmic components through junctional coupling. In recent years, it has become apparent that cells may also communicate through the extracellular release of microvesicles. They may originate as (...) either exosomes from the endosomal compartment upon fusion of multivesicular bodies with the plasma membrane or be shed directly from the plasma membrane via extensions of the cell surface. Microvesicles may disperse over long distances through body fluids and deliver their molecular cargo onto a variety of target cells. As a general rule, the metabolic fate of these cells is determined by the molecular nature of the vesicular cargo, while targeting itself depends on the affinity of the molecules expressed on the enclosing membrane. In this paper, we will be arguing that intercellular vesicular transfer is substantially different from other types of cell communication, allowing cells and molecules to interact on varying levels. Cells interacting via ligand signalling owe their specificity to the steric coupling with cognate receptor molecules. As such, it is a pure molecular process that affects target cells only upon integration into their responding repertoire. In this relationship, coupled cells are reciprocally adapted to each other through the selection of their respective signalling capacities, following exploration of their receptor specificity. Interaction by intercellular vesicles realizes a substantially different type of cell communication. Vesicular traffic allows donor cells to carry out a horizontal type of gene transfer and target this information over long distances via independently controlled mechanisms. Because of this independence, cells interacting via vesicular traffic are not expected to adapt their signalling correspondences, but to control instead the efficiency of their cargo delivery irrespective of the receptor repertoire expressed by the target tissue. In this paper, the multifaceted functions of the intercellular vesicular traffic will be discussed in a multilevel biosemiotic perspective with the aim of unravelling the cellular mechanisms devised by nature to accomplish communication. (shrink)

It happens when you travel -- The rules for doing nothing -- Other people's rules -- There's someone knocking at the door -- Turbulent hearts -- An ordinary ethics -- Is it really a morality? -- What sort of morality is this? -- A parenthesis -- Taboos -- Cambia, todo cambia -- Lágrimas, tormentos -- Other torments (more familiar this time) -- A question of scale : still the local mind? -- Rights : human? -- Ordinary ethics and aesthetics -- (...) Impertinence. (shrink)

En el presente trabajo expondremos y analizaremos algunos de los aspectos más significativos del pensamiento de John Ruskin. Comprobaremos que sus reflexiones sobre el arte en general y sobre la arquitectura en particular están íntimamente conectadas con sus ideas morales, religiosas y sociopolíticas. Fue un enemigo declarado de la civilización industrial, responsabilizándola de haber convertido el mundo en un lugar inhóspito, cruel y feo. Debía comprenderse en toda su profundidad el abismo que media entre la belleza sagrada de una torre (...) gótica y la insufrible fealdad de una chimenea fabril. Pero Ruskin no fue un esteta despreocupado de lo social. Contempló con horror la miseria material y espiritual de esas muchedumbres hacinadas inhumanamente en los suburbios urbanos, la creciente devastación de la naturaleza, el endiosamiento del dinero, la degradación del gusto artístico y el desfallecimiento de las artes. Todos esos fenómenos o procesos estaban ocasionados por una misma lógica económica, injusta y absurda. (shrink)