The nature of the product to be discovered guides the reasoning to discover it. Biologists and medical researchers often search for mechanisms. The "new mechanistic philosophy of science" provides resources about the nature of biological mechanisms that aid the discovery of mechanisms. Here, we apply these resources to the discovery of mechanisms in medicine. A new diagrammatic representation of a disease mechanism chain indicates both what is known and, most significantly, what is not known at a given time, thereby guiding (...) the researcher and collaborators in discovery. Mechanisms of genetic diseases provide the examples. (shrink)

Early-Onset Schizophrenia (EOS) and Attention Deficit-Hyperactivity Disorder (ADHD) are early- onset neurodevelopmental disorders associated with cognitive deficits. The current study represents the first attempt to compare these groups on a comprehensive cognitive test battery in a longitudinal design over 25 years in order to enhance our knowledge of particular patterns resulting from the interaction between normal maturational processes and different illness processes of these disorders. In the baseline study, 19 adolescents with schizophrenia were compared to 20 adolescents with ADHD and (...) 30 healthy controls (HC), all between 12 and 18 years of age. After 13 years (T2) and after 25 years (T3) they were re-evaluated with the cognitive test battery. A cognitive Composite Score was used in a linear mixed model. The EOS group had a significant cognitive stagnation or deterioration from T1 to T2 compared to HC. However, the EOS group had the most positive change from T2 to T3, supporting a stable level of cognitive performance over the 25 year span. The ADHD group improved or had similar development as the HC group from T1 to T2. They continued to improve significantly compared to the HC group from T2 to T3. Individuals in the EOS group performed more impaired on the cognitive composite score compared to the HC group and the ADHD group at all three time points. Results might indicate a neurodevelopmental pathway of EOS with subnormal cognitive development specific in adolescence. In comparison, the ADHD group had a more consistent cognitive maturation supporting a maturational delay hypothesis of ADHD. (shrink)

Among the poems of the Greek Anthology is one (Anth. Pal.6.171) which purports to be the dedicatory inscription of the Colossus of Rhodes built to celebrate the Rhodians' successful resistance to the siege of their island by Demetrius Poliorcetes in the years 305–304b.c. It has long been assumed by scholars that this epigram represents the authentic dedicatory inscription carved on the base of the Colossus, which was completed in the 280s and stood for some sixty years before being destroyed by (...) an earthquake that rocked the island of Rhodes in the 220s. There are, however, strong reasons to doubt the epigram's authenticity, some of which come from considerations of the poem itself and others which come from a comparison with a closely related epigram (Anth. Pal.9.518) composed by Alcaeus of Messene to celebrate Philip V's military successes during his Aegean campaign of 203–200. Verbal and thematic parallels between the two epigrams make a connection certain. It is the aim of the present study to re-examine the Rhodian epigram and its relation toAnth. Pal.9.518 in order to propose a new date for the former in the context of Rhodes' defeat of Philip V and the advent of Rome in the affairs of the states ringing the Aegean. (shrink)

This article focuses on the relationship between democracy and the notwithstanding clause in s.33 of the Canadian Charter of Rights and Freedoms. A number of scholars argue that s.33 is inherently ‘democratic’, as it is an assertion of legislative supremacy. The most influential such theory is Jeremy Waldron’s. This article offers a democracy-based critique of Waldron’s democracy-based account of the notwithstanding clause. The argument that the notwithstanding clause is necessarily ‘democratic’ ignores the constitution of the legislature through elections and the (...) risk of self-dealing by the legislative branch, adopts an idealistic view of legislatures at odds with the reality of executive dominance and party discipline, and over-relies on the assumption that the electorate will ensure retrospective accountability for misuse of s.33. Contrary to Waldron and those who have adopted his arguments in Canada in the context of the Charter, the article argues we can be democrats and have faith in the capacities of legislators and voters while still maintaining skepticism about the uses to which the notwithstanding clause may be put. In short, s.33 is not inherently democratic. The political morality of each use of the notwithstanding clause—including whether it helps or harms democracy—must be assessed on a case-by-case basis. (shrink)

ObjectiveTo examine subjective and objective socioeconomic status as predictors, cognitive abilities as confounders, and personal control perceptions as mediators of health behaviours.DesignA cross-sectional study including 197 participants aged 30–50 years, recruited from the crowd-working platform, Prolific.Main Outcome MeasureThe Good Health Practices Scale, a 16-item inventory of health behaviours.ResultsSSES was the most important predictor of health behaviours. Among the OSES indicators, education, but not income, predicted health behaviours. Intelligence and memory were negatively correlated with health-promoting behaviours, and the effect of memory (...) was upheld in the multivariate model. Personal control perceptions did not act as mediators.ConclusionSSES predicted health behaviours beyond OSES. The effect of socioeconomic indicators was not confounded by cognitive abilities. Surprisingly, cognitive abilities were negatively associated with health-promoting behaviours. Future research should emphasise SSES as a predictor of health behaviours. Delineating the psychological mechanisms linking SSES with health behaviours would be a valuable contribution toward improved understanding of socioeconomic disparities in health behaviours. (shrink)

The article explores digital literacy practices in children’s everyday lives at Norwegian preschools and some of the ways in which young children appropriate basic digital literacy skills through guided participation in situated activities. Building on an ethnomethodological perspective, the analyses are based on 70 hours of video recordings documenting the activities in which 45 children, aged 5-6, and eight preschool teachers participated. Through the detailed analysis of two categorization activities – identifying geometrical shapes and identifying feelings/thoughts –the use of digital (...) tools in the social organization of the activities are examined. The article finds that children’s digital literacy activities encompass visual, verbal, audio and embodied competencies that are made relevant, and thus accessible for learning, in interaction between the children and between the adults and children in the form of norms and guidelines for what constitutes correct categorizations (geometrical shapes and green and red feelings) in the situated activities, and that are appropriated and actualized by the children in interaction with their peers. The findings also show how the categorization practices in preschools deal with symbols and labels in ways that create and sustain socially organized ways of knowing, seeing and acting upon the world. Digital media are embedded in routines, procedures and socialites that are part of these categorization practices; they are part of how children are instructed to experience, interpret, understand and act in the world. Moreover, the different technologies created different conditions for the children’s participation. It was found that peer interaction was part of the digital literacy activities that involved such mobile technologies as smartphones and tablets, while when using non-mobile technologies, e.g. smartboards, the activities were structured more as ‘classic’ classroom activities, primarily guided by the teacher and the didactic material presented through the smartboard. (shrink)

Reason and Value collects 15 new papers by leading contemporary philosophers on themes from the work of Joseph Raz. Raz has made major contributions in a wide range of areas, including jurisprudence, political philosophy, and the theory of practical reason; but all of his work displays a deep engagement with central themes in moral philosophy. The subtlety and power of Raz's reflections on ethical topics make his writings a fertile source for anyone working in this area. Especially significant are his (...) explorations of the connections between practical reason and the theory of value, which constitute a sustained and penetrating treatment of a set of issues at the very center of moral philosophy as it is practiced today. The contributors to the volume acknowledge the importance of Raz's contributions by engaging critically with his positions and offering independent perspectives on the topics that he has addressed. The volume aims both to honour Raz's accomplishments in the area of ethical theorizing, and to contribute to an enhanced appreciation of the significance of his work for the subject. (shrink)

The aim of this paper is to contribute to the development of a theory of economic freedom. In this endeavor, we build our framework on the Hayekian notion of freedom because it explicitly embodies the obvious link between freedom and the state: freedom is an absence of state coercion except for that which enforces abstract, general rules known beforehand. We derive two propositions from this Hayekian thesis and elaborate on them, leading to a categorization of government actions from the viewpoint (...) of economic freedom in which the criterion against which coercive governmental actions must be evaluated is the rule of law, meaning a government’s reliance on general, abstract rules. As an implication, our framework allows us to argue for the imperative differentiation between “efficiency” and “economic freedom” as two separate criteria against which government actions can and must be evaluated. We also show that our framework may help explain the process through which economic freedom enhances growth. (shrink)

Félix Guattari mentioned an ‘ecology of the virtual’. This notion is developed in this article along two dimensions. The first dimension, which is conceptual, relates the mental or subjective ecology of The Three Ecologies to the ‘functors’ of Schizoanalytic Cartographies. The other dimension takes into consideration today’s context in Brazil, especially Amerindian struggles. I focus on how Guattari’s thinking of the virtual, in dialogue with other contemporary authors, opens the way to heterogenetic processes, with their own ecopolitical consequences.

1. köt. A Marx előtti filozófia története.--2. köt. Marxtól Lening.--3. köt. Lenintől napjainkig.

The presence of Indians fundamentally altered the political, social and economic landscape of sugar producing nations. In most cases, race, which was used as an important signifier of difference by the colonising power, left these states with a colonial legacy of division and derision which they continue to endure and navigate in such diverse locations as the Caribbean, the West Indies, Fiji, Mauritius and parts of Africa. In the quest for recognition, equality and political status that allows the girmitiyas to (...) celebrate their past, embrace their present and imagine a future where they are enmeshed in the fabric of a new Fiji entail understanding why the declaration of girmit day on May 15th is such a powerful symbolic gesture on the part of the new coalition government. (shrink)

This paper examines the overwhelming desire of transnational adoptees to establish a connection with their origins in order to both come to terms with the past and develop an understanding of their identity. It considers the ethical ramifications of the commodification of human bodies. It is suggested that the idea of displacement is most helpful in approaching questions of transnational adoption. In this way, we can look at transnational adoption as a 'beginning' - one that disappears into the present moment, (...) becoming the constitutive reality underlying Derrida's concern with displacement - rather than its origin. For, what does the quest for a return to the point of origin entail? Transnational adoptees, when they embark on the journey of reclaiming their past, of coming to terms with their sense of loss, realise that there is no simple comfort in returning - that they are inevitably caught in the two worlds in which they co-exist. It is through this recognition of the traces that are contained in them, through this displacement, that they are able to negotiate identity. (shrink)

The concept of race is traced to the quest for the origins of language and the manner in which that led to the idea that a separate language indicated a separate racial origin. The Orientalist desire to know and dominate the other and to regard him or her as sub-human necessitated the invention of race. The notion of race is further traced through the slave trade and its contemporary usage in ‘race studies’.

This paper outlines a bicontextual account of fictional reports. A fictional report is a report on something that happens in a fiction, and a bicontextual account is an account that relativizes truth to two contexts. The proposal is motivated by two considerations. First, it explains the intuitive truth conditions of fictional reports without postulating hidden fiction operators. Second, it handles the problem of indexicals in fictional reports better than the standard accounts.

U mnogim etnickim konfliktima i gradjanskim ratovima u XX veku kulturne razlike izmedju sukobljenih strana su bile veoma male. Krvavi sukobi Srba, Hrvata i Bosnjaka tokom raspada Jugoslavije su jedan takav slucaj. Ovaj uvid je neke istrazivace vodio zakljucku da nedostatak objektivnih kulturnih markera izmedju grupa moze pogodovati izbijanju nasilja: kada se clanovi dve grupe tesko razlikuju, pribegava se nasilju da bi se stvorile identitetske granice medju njima. Jedna posebna verzija ove teorije poznata je pod imenom "narcizam malih razlika". Taj (...) izraz potice od Sigmunda Frojda koji ga je primenjivao kako u individualnoj psihologiji, tako i u svojoj filozofiji kulture. Ovaj koncept su u velikoj meri ignorisali psihoterapeuti-prakticari, ali su ga tokom poslednjih decenija otkrili novinari i drustveni naucnici i vise primenjivali u objasnjenju kolektivnog nego individualnog nasilja. U ovom radu ispitani su neke od studija i knjiga u kojima se koristi koncept "narcizma malih razlika" da bi se ocenila snaga i slabosti te teorije.. (shrink)

Lifestyle-induced diseases are becoming a burden on healthcare, actualizing the discussion on health responsibilities. Using data from the National Association for Heart and Lung Diseases ’s 2015 Health Survey, this study examined the public’s attitudes towards personal and social health responsibility in a Norwegian population. The questionnaires covered self-reported health and lifestyle, attitudes towards personal responsibility and the authorities’ responsibility for promoting health, resource-prioritisation and socio-demographic characteristics. Block-wise multiple linear regression assessed the association between attitudes towards health responsibilities and individual (...) lifestyle, political orientation and health condition. We found a moderate support for social responsibility across political views. Respondents reporting unhealthier eating habits, smokers and physically inactive were less supportive of health promotion policies. The idea that individuals are responsible for taking care of their health was widely accepted as an abstract ideal. Yet, only a third of the respondents agreed with introducing higher co-payments for treatment of ‘self-inflicted’ conditions and levels of support were patterned by health-related behaviour and left-right political orientation. Our study suggests that a significant support for social responsibility does not exclude a strong support for personal health responsibility. However, conditional access to healthcare based on personal lifestyle is still controversial. (shrink)

Due to existence of a huge amount of textual data either on the World Wide Web or in textual databases like PubMed, the development of novel automatic keyphrase extraction methods has emerged as one of the key research problems in recent past. Consequently, a number of machine learning techniques, mostly supervised, have been proposed to extract keyphrases from text documents. But, one of the main bottlenecks that hinders the success of such systems is the requirement of annotated corpora for training (...) purpose. In this paper, we propose the design of a deep text mining system to identify keyphrases in text documents that are either unstructured or semi-structured in nature. The novelty of our system lies in its applicability on a single document, instead of demanding a collection of annotated texts for training, to identify keyphrases embedded within it. The proposed system applies parsing techniques to identify candidate phrases. After mapping the original set of candidate phrases into a low-dimensional space using Singular Value Decomposition, the Markov Clustering technique is applied to cluster related sentences together. Finally, considering each cluster as a document, Latent Dirichlet Allocation is applied to identify feasible keyphrases that are presented to users in non-increasing order of their relevance score values. The efficacy of the proposed system is established through experimentation on datasets from two different domains. On comparative evaluation, we found that the proposed system outperforms KEA and KEA that apply the supervised machine learning approach for automatic keyphrase extraction from text documents. (shrink)

Why do human beings believe in divinities? Why do some seek eternal life, while others seek escape from recurring lives? Why do the beliefs and behaviors we typically call "religious" so deeply affect the human personality and so subtly weave their way through human society? Revised and updated in this second edition, Eight Theories of Religion considers how these fundamental questions have engaged the most important thinkers of the modern era. Accessible, systematic, and succinct, the text examines the classic interpretations (...) of religion advanced by theorists who have left a major imprint on the intellectual culture of the twentieth century. The second edition features a new chapter on Max Weber, a revised introduction, and a revised, expanded conclusion that traces the paths of further inquiry and interpretation traveled by theorists in the most recent decades.Eight Theories of Religion, Second Edition, begins with Edward Burnett Tylor and James Frazer--two Victorian pioneers in anthropology and the comparative study of religion. It then considers the great "reductionist" approaches of Sigmund Freud, Emile Durkheim, and Karl Marx, all of whom have exercised wide influence up to the present day. The discussion goes on to examine the leading challenges to reductionism as articulated by sociologist Max Weber and Romanian-American comparativist Mircea Eliade. Finally, it explores the newer methods and ideas arising from the African field studies of ethnographer E. E. Evans-Pritchard and the interpretive anthropology of Clifford Geertz. Each chapter offers biographical background, theoretical exposition, conceptual analysis, and critical assessment. This common format allows for close comparison and careful evaluation throughout. Ideal for use as a supplementary text in introductory religion courses or as the central text in sociology of religion and courses centered on the explanation and interpretation of religion, Eight Theories of Religion, Second Edition, offers an illuminating treatment of this controversial and fascinating subject. (shrink)

A literature search indicates an absence of research into boy’s experiences of physical education in classes in which there is a significant majority of girls. The aim of the study was to examine how boys in such classes experience their PE lessons. The methodological approach was qualitative, and data were collected with interviews of 13 boys in classes with more than 90% girls at a Norwegian high school. The data were analyzed with QSR NVivo 10, focused on creating categories of (...) meaning, in which students’ experiences were taken as subjectively true. The data are based on subjective constructions, which students constructed as part of their own interpretations and reflections on what had occurred in PE at the school. Results of the study came out in the form of three main findings. Two of those relate to a negative experience and the third to a positive experience of PE. The boys mostly felt that they are physically superior and have to consider the girls. Furthermore, the boys reported little challenge and feelings of mastery while being together with passive girls who are allowed to choose the activities. However, the boys found it easier to show off in front of the teachers and classmates when there were just a few boys in the class. The results are discussed in relation to gender-related theory on how the respondents are producing a traditional male gender in PE through their mastery, strength, and ambition to compete. We suggest a new approach of teaching that is more student-centered. A strategy could be to include other activities than sport-based activities into PE – activities that do not require strength and other athletic skills leading to feelings of hegemonic masculinity. A larger focus on social interactions during PE classes – activities in which students’ sex is not as important as in traditional teacher- and sport-centered PE classes, may be a good strategy. (shrink)