Cancer derives from a cell clone that has accumulated genetic and epigenetic changes that influence its phenotype and finally enable it to escape from the normal controls of proliferation. A recent paper shows that, in myc‐induced tumours, the inactivation of this oncogene produces the regression of the tumours and the differentiation of the tumour cells into mature osteocytes.1 In addition, a further reactivation of myc in these cells does not restore the malignant phenotype but induces apoptosis. This discovery could lead (...) to an innovative therapeutic strategy. BioEssays 25:104–107, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In Buddhism the idea of a transcendental or eternal self is denied as non-substantial and impermanent: a non-verifiable metaphysical entity that leads to grasping, craving and suffering. Buddhism posits that things continually change, are continually reducible and recyclable, and that no inherent existence or metaphysical “self” exists but rather a series of aggregates give rise to the experience so that consciousness itself is causally conditioned. As applied to the notion of no- self the one who is reborn and the one (...) who dies and the one who follows the path and the one who realizes enlightenment are neither the same nor different selves. With the Buddhist doctrine of impermanence an analysis of the notion of the “self” breaks down into layers to discover that the self does not exist independently at all. Because of simultaneous arising and falling of each moment the self exists as essentially empty. (shrink)

Alison Simmons, in Simmons (1999), argues that Descartes in Meditation Six offered a teleological account of sensory representation. According to Simmons, Descartes’ view is that the biological function of sensations explains both why sensations represent what they do (i.e., their referential content) and why they represent their objects the way they do (i.e., their presentational content). Moreover, Simmons claims that her account has several advantages over other currently available interpretations of Cartesian sensations. In this paper, I argue that Simmons’ teleological (...) account cannot be sustained for both theoretical and textual reasons and that it does not have the advantages it is claimed to have. (shrink)

This article focuses on the assessment of mechanistic relations with specific attention to medicine, where mechanistic models are widely employed. I first survey recent contributions in the philosophical literature on mechanistic causation, and then take issue with Federica Russo and Jon Williamson’s thesis that two types of evidence, probabilistic and mechanistic, are at stake in the health sciences. I argue instead that a distinction should be drawn between previously acquired knowledge of mechanisms and yet-to-be-discovered knowledge of mechanisms and that both (...) probabilistic evidence and manipulation are essential with respect to newly discovered mechanisms. (shrink)

This contribution claims that the two fundamental notions of causation at work in the health sciences are manipulative and mechanistic, and investigates what kinds of evidence matter for the assessment of causal relations. This article is a development of our 2007 article, ‘Plurality of Causality’, where we argue for a pluralistic account of causation with an eye to econometrics and a single medical example. The present contribution has a wider focus, and considers the notion of evidence within a whole range (...) of disciplines belonging to the health sciences. Section 1 addresses the relations between kinds of evidence and causal accounts, and it is shown how different notions of causation can be employed in various medical cases. Section 2 calls attention to issues crucial for any adequate epistemological theory of causation, such as the distinctions between types and tokens, observational and experimental regimes, explanation and prediction. Lastly, the notion of context is articulated, highlighted in its role in the assessment of causal links. All these issues are tackled in the framework of what we label a ‘bottom–up’ epistemology. (shrink)

The essay analyses utopia as a key concept to investigate modern politics. It argues that looking at the works of Machiavelli and More in order to retrace the utopia-realism nexus permits to develop a valuable analytical tool to interpret the outset of political modernity.

The notion of causal evidence in medicine has been the subject of wide philosophical debate in recent years. The notion of evidence has been discussed mostly in connection with Evidence Based Medicine and, more in general, with the assessment of causal nexus in medical, and especially research contexts. “Manipulative evidence” is one of the notions of causal evidence that has stimulated much debate. It has been defined in slightly different ways, attributed different relevance, and recently placed at the core of (...) Gillies’ “action-related theory of causality”, a view specifically meant to address causation in medicine. While in general sympathetic to Gillies’ account, and totally convinced of the relevance of manipulative evidence and different sorts of interventions in the biomedical sciences, we believe that some further qualifications are needed to allow the notion of manipulative evidence to better express features of medical practice. In particular, we provide some qualification of the role of “interventional evidence” proposed by Gillies, suggesting a distinction between “interventional evidence” and “evidence for interventions”. A case study from research on rare diseases is analyzed in depth and a multifaceted notion of manipulative evidence put forward that allows better understanding of what manipulations in medical contexts amount to and what their targets are. (shrink)

It is generally agreed that Parmenides’ fragment B3 posits some type of relation between “thinking” and “Being.” I critically examine the modern interpretations of this relation. Beginning with the ancient sources and proceeding into modern times, I try to show that the modern rationalist reading of fragment B3 conflicts with its grammatical syntax and the context of the poem as a whole. In my critique, I suggest that rather than a statement about epistemological relations, it is, as it was originally (...) understood, a religious assertion of metaphysical identity. (shrink)

It is generally agreed that Parmenides’ fragment B3 posits some type of relation between “thinking” and “Being.” I critically examine the modern interpretations of this relation. Beginning with the ancient sources and proceeding into modern times, I try to show that the modern rationalist reading of fragment B3 conflicts with its grammatical syntax and the context of the poem as a whole. In my critique, I suggest that rather than a statement about epistemological relations, it is, as it was originally (...) understood, a religious assertion of metaphysical identity. (shrink)

This is a personal recollection of Lyman Tower Sargent that stresses his enormous contribution—personal and academic—to the community of utopian studies. After a brief recollection of our academic interactions, the short contribution pays homage to a “social dreamer” who is aware that utopia can be dangerous but is equally sure that it is absolutely essential if we are to survive.

Polarity Items are linguistic expressions known for being a ‘lexically controlled’ phenomenon. In this paper we show how their behavior can be implemented in a deductive system. Further- more, we point out some possible directions to recast the deductive solution into a Tree Ad- joining Grammar system. In particular, we suggest to compare the proof system developed for Multimodal Categorial Grammar (Moot & Puite, 1999) with the Partial Proof Trees proposed in (Joshi & Kulick, 1997).

A theater that heals is not a theater that offers answers and ?medicines? that guarantee to cure weaknesses and fragilities people meet but it is an open organization, which questions itself, which brings out ambivalence and ambiguity, diversity, weaknesses, and which leaves room for possible interpretations and narratives, the play of imagination, and the development of innovative and creative processes of people in society.

In the last few years, avatars have been increasingly used in treating persistent persecutory auditory verbal hallucinations. The digital representation (an avatar) of persecutory hallucinations is voiced by the therapist and engages the patient in a dialogue, progressively conceding its power and, hence, reducing the stress experienced by the patient. Such attempts at integrating digital representations and cognitive behavior therapy raise a range of philosophical questions, which this chapter tackles along two trajectories. From an epistemological standpoint, we inquire what notion (...) of mental disorder can underlie the use of avatar therapy, and how our understanding of psychiatric diseases can be affected by the implementation of such a therapy. Relatedly, from an ethical standpoint, we reflect on some of the controversial issues posed by such therapeutic strategies. Discussing selected epistemological and ethical aspects stemming from the latest relevant literature both in philosophy and in psychiatry, the chapter aims to provide a tentative evaluation of trade-offs between the promises of and the limits to this therapeutic option. (shrink)

Current research on choice overload has been mainly conducted with choice options not associated with specific brands. This study investigates whether the presence of brand names in the choice set affects the occurrence of choice overload. Across four studies, we find that when choosing among an overabundance of alternatives, participants express more positive feelings (i.e., higher satisfaction/confidence, lower regret and difficulty) when all the options of the choice set are associated with familiar brands, rather than unfamiliar brands or no brand (...) at all. We also find that choice overload only appears in the absence of brand names, but disappears when all options contain brand names—either familiar or unfamiliar. Theoretical and practical implications are discussed. (shrink)

This paper uses a partially ordered set of syntactic categories to accommodate optionality and licensing in natural language syntax. A complex but well-studied data set pertaining to the syntax of quantifier scope and negative polarity licensing in Hungarian is used to illustrate the proposal. The presentation is geared towards both linguists and logicians. The paper highlights that the main ideas can be implemented in different grammar formalisms, and discusses in detail an implementation where the partial ordering on categories is given (...) by the derivability relation of a calculus with residuated and Galois-connected unary operators. (shrink)

Adolescence involves a profound number of changes in all domains of development. Among others, adolescence yields an enhanced awareness and responsibility toward the community, representing a critical age to develop prosocial behaviors. In this study, the mediation role of Trait Emotional Intelligence was detected for the relationship between the dark triad and prosocial behavior based on altruism and equity. A total of 129 healthy late adolescents filled in the Dark Triad Dirty Dozen, measuring Machiavellianism, psychopathy, and narcissism; the Altruistic Action (...) Scale, evaluating behaviors directed at helping others; the Equity Scale, assessing behaviors directed at equity in different forms; and the TEI Questionnaire-Short Form. Results showed that TEI mediated the negative effects of the three dark triad traits on both altruism and equity. This finding suggests that TEI, which relies on a set of dispositions, might reduce the malevolent effects of the dark triad on altruism and equitable behavior in late adolescence. This led to assume that intervention programs focused on improving emotional skills, also in late adolescence, can promote prosociality. (shrink)

This chapter seeks to contribute to the eco-feminist dialogue concerning the still present need for global advances in the status of both women and nature. Beginning with a cross-cultural comparative analysis of ancient myth, I propose to revive a dynamic “biophilic” ethics of interconnectedness and eco-justice. An examination of modern relationships between women and land leads us to conclude that our institutions and practices are woefully destructive. This situation is symptomatic of the fundamental oppression inherent to the dominant patriarchal paradigm. (...) Practices imbedded and deeply rooted within societal customs, traditions and attitudes frequently prevent women from equal access to land and deny women the right of being recognized as producers. By reclaiming our ancient goddess myths and indigenous sense of sacredness, we can heal some of the schisms of planetary oppression. Respecting women’s rights to land and their relationships with the earth, and encouraging women’s ownership of land, is a pragmatic, double-pronged step towards changing destructive thinking patterns about women and our planet. Women’s access and title tenure to land is a solution towards empowering women, adjusting ideologies and promoting global and ecological sustainability. (shrink)

Research represents an essential component of the response to infectious disease outbreaks and to other public health emergencies, whether they are localised, of international concern, or global. Research conducted in such contexts also comes with particular ethics challenges, the awareness of which has significantly grown following the Ebola outbreak in West Africa, the Zika outbreak in Latin America and the COVID-19 pandemic. These challenges include the need for implementing meaningful community engagement with the researched communities, not just to build unidirectional (...) trust towards the research team, but to achieve a genuine and mutually respectful partnership before, during and after the research. Here, we describe the real-life experience of 10 well-established research clinics in Nairobi, where a successful experience of community engagement linking prevention and care to research was interrupted during the COVID19 pandemic. We contrast this experience with the concept and processes of community engagement as described in selected scientific manuscripts and guidelines, to formulate some conclusions and recommendations. We contend that more action is needed, from research ethics committees and other key-research stakeholders, to align policies and practices with ethics guidance and with evidence-based recommendations from the academic literature, to achieve meaningful community engagement during emergency research, irrespective of the scale and location of an outbreak or public health crisis. Failure to do so, will aggravate the (postcolonial) asymmetries of power in global health and local systems. (shrink)

ABSTRACTThe quality of medicines is generally adequately assured by manufacturers and regulatory authorities for well-resourced settings, while the implementation of existing quality standards is challenged in many low- and middle-income countries. This situation of multiple pharmaceutical standards raises the question whether it could ever be ethically justified to compromise on the quality assurance of medicines depending on what individuals, communities, or societies can afford. In this paper, we contend that ethically, any unjustified exceptions to medicines’ quality assurance represents a violation (...) of the principles of beneficence and non-maleficence. Exceptions are only acceptable in exceptional and temporary circumstances, if based on a meaningful quality risk assessment, guided by a rigorous ethical framework built on the principles of independence, technical competence, transparency, and accountability. We also discuss how such exceptional and temporary circumstances should be defined/justified.... (shrink)

This paper studies the influence of an organization’s time perspective on triple bottom line deployment through sustainable innovativeness. Although academics increasingly consider sustainable innovation to be an essential element in deploying the triple bottom line, the degree of an organization’s sustainable innovativeness remains limited. Using ten inductive case studies based on the triangulation of data from multiple-respondent interviews and secondary data, this study shows that an organization’s time perspective plays a crucial role in explaining the organization’s degree of sustainable innovativeness (...) and improvement of triple bottom line outcomes. Specifically, organizations with a longer planning horizon, higher tolerance of uncertainty, and greater ability to learn from the past develop a higher and increasing degree of sustainable innovativeness, allowing trade-offs between triple bottom line dimensions to be mitigated. (shrink)

After its rise, in the years of the George W. Bush Jr.’s presidency, neoconservatism seemed to collapse under the weight of its utopian ambition to dictate the new rules of the internal and international political order, to stem the conflicts and processes of disruption of the liberal order as it had been defined since the Second World War. Going through the various contributions of the monographic issue, this introduction highlights the historical and political reasons that make neoconservatism an idea whose (...) parable and movements are of great importance to understand the crisis of liberalism and the current role of the neoliberalism. (shrink)

This article focuses on the significance of space in the display of hegemonic power in the La Scala opera house in the years 1776–1850s. More specifically, it traces the changes in the use of space from Napoleon’s attempt to “democratise” La Scala by attacking the display of hegemonic hierarchy and subverting the status quo, to the Habsburgs’ attempt to “restore” a display of hegemonic rule. The analysis of primary findings demonstrates that the space of the opera house was reshaped not (...) only physically through renovation but also by imposing rules and structuring attendance during performances. The social significance of La Scala’s theatrical space is also explored by identifying the means the Habsburg authorities used to control it as part of their response to the rise of the Risorgimento. The article thus traces the historical shifts in the political functions of space in La Scala from its early role of displaying aristocratic authority through the period of Napoleonic democratisation and finally the Hapsburgs’ restoration politics of surveillance. (shrink)