Colonialism, in its many forms and stages is often imposed as being central to the narratives of colonizedpeople and their cultures, as well as the genesis of their knowledge. In colonial discourse, lands and the occupants of these lands were ‘discovered’, further implying that colonized people did not have their own ways of knowing (nor even existence) before colonization. This narrative has been embedded within Euro‐American fields of study, including nursing, in which caring and healing practices that exist outside of (...) a colonial lens are dismissed and complicity with colonialism is downplayed or sanitized. This paper is a reflection on the current discourse on decolonizing nursing shaped by postcolonial, critical and Black feminist philosophies. After examining the decolonization discourse in nursing, I argue that current calls to decolonize nursing lack a clear description of the goals and process of doing so, making it unfeasible to hold those in the process of decolonizing accountable. In addition, the lack of intentionality in reckoning with past and current forms of colonialism embedded in nursing hinders the ability to engage with lessons that could shape the future. I conclude this discourse by discussing practical steps toward centrering diverse ways of knowing, and ensuring this process prioritizes communities and nurse scholars who have historically been silenced. (shrink)

Scholars of color have been instrumental in advancing nursing knowledge development but find limited spaces where one can authentically share their philosophical perspective. Although there is a call for antiracism in nursing and making way for more diverse and inclusive theories and philosophies, our voices remain at the margins of nursing theory and philosophy. In nursing philosophy, there continues to be a lack of racial diversity in those who are given the platform to share their scholarship. Five nurse scholars of (...) color attended the International Nursing Philosophy Conference in August 2022. We established a collective system of support by sharing our experiences as researchers, scholars, and educators with each other. The theory of emancipatory nursing praxis informed this process. In this dialogue, we reflected on what it is like to present at and attend predominantly white nursing conferences. We shared our experiences of how we exist as nurse scholars, our philosophical views, and our thoughts on how we create spaces where scholars of color can feel welcomed and acknowledged for their contributions to advancing nursing knowledge. (shrink)

This paper analyzes a model of sequential parimutuel betting described as a two-horse race with a finite number of noise bettors and a finite number of strategic and symmetrically informed bettors. For generic objective probabilities that the favorite wins the race, a unique subgame perfect equilibrium is characterized. Additionally, two explanations for the favorite–longshot bias—according to which favorites win more often than the market's estimate of their winning chances imply—are offered. It is shown that this robust anomalous empirical regularity might (...) be due to the presence of transaction costs and/or to strategic bettors' subjective attitude to probabilities. (shrink)

Kant’s claim that we must postulate the immortality of the soul is polarizing. While much attention has been paid to two standard arguments in its defense (one moral-psychological, the other rational), I contend that a favorite argument of Kant’s from the apogee of his critical period, namely, the teleological argument, deserves renewed attention. This paper reconstructs it and exhibits what makes it unique (though not necessarily superior) in relation to the other arguments. In particular, its form (as third-personal or descriptive, (...) beginning from observations) and related force of assent (as a subjectively universal reflective judgment) set it apart from the other arguments. My goal is to establish that any engagement with Kant’s immortality postulate must include equal consideration of the teleological argument in order to be complete. (shrink)

El presente estudio analiza cuándo y cómo audiodescribe la ONCE el lenguaje de la cámara en The Favourite (Yorgos Lanthimos, 2018) para identificar excesos y defectos por redundancia sonora que puedan comprometer la comprensión del mensaje y la experiencia artística en ciegos. Con este fin se han analizado los códigos visuales, el contexto de la producción, el sonido y las estrategias semánticas y lingüísticas utilizadas en su descripción. Los resultados demuestran que el texto ignora aspectos formales relacionados con la (...) transcripción de la realidad, la composición y el movimiento que afectan a la interpretación y percepción estética del filme. (shrink)

Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that in order to perform accurate and interesting comparative genomics, one first and foremost has to be able to recognize, postulate, and revise different evolutionary scenarios. After all, these studies lack a simple protocol, due to different proteins having different evolutionary dynamics and demanding different approaches. The authors here discuss this challenge from a practical (what are the observations?) (...) and conceptual (how do these indicate a specific evolutionary scenario?) viewpoint, with the aim to guide investigators who want to analyze the evolution of their protein(s) of interest. By sharing how the authors draft, test, and update such a scenario and how it directs their investigations, the authors hope to illuminate how to execute molecular evolution studies and how to interpret them. Also see the video abstract here https://youtu.be/VCt3l2pbdbQ. (shrink)

Injection of a peptide of 36 amino acids into virgin Drosophila females changes their reproductive properties drastically: males are rejected and egg laying is increased. The neuronal and physiological properties of the virgin state are replaced by a new pattern of behavior and stimulation of egg production and deposition. Under natural conditions, the peptide is synthesized by the male and transferred into the female during copulation. The sex‐peptide, therefore, can be considered as a pheromone. In this review, I shall limit (...) my discussion to Drosophila melanogaster. (shrink)

This article provides insight into one form of audience involvement with celebrities: parasocial relationships. To address several shortcomings in PSR research – focus on TV, confusion between PSI and PSR, use of student samples, neglect of socio-demographic variables – a representative online survey was conducted with 1000 Flemish adults who indicated 382 celebrities as favorites. A new scale reveals that PSR contain two important elements: emotional connections and an analogy with social relationships. Confirming previous research, most favorite celebrities are male, (...) and cultural proximity is especially important for older respondents. In one combined model, respondents’ and celebrities’ characteristics are included as potential PSR predictors. This model nuances previous research and reveals that people who are male, older, more lowly-educated, and interested in celebrity news have stronger PSR. Further, stronger PSR are found for local and religious, political, sports, and music celebrities than for film celebrities. (shrink)

This article closely reads “Chelsea Girls,” an autobiographical short story by Eileen Myles that depicts her experience caring for the diabetic, bipolar poet James Schuyler when she was a young writer getting started in East Village in the late 1970s. Their dependency relationship is a form of queer kinship, an early version of the caring relations between lesbians and gay men that HIV/aids would demand over the next two decades as chosen families emerged to nurture gay men and lesbians rejected (...) by their families of origin. The representation of queer kinship offers an alternative to more traditional portrayals of care in literature that focus on the heteronormative family, a site of care that feminist dependency theory also paradoxically privileges. This article synthesizes insights from queer theory and critical disability studies in order to expand our understanding of the roles participants in care can play, the ways they can feel, and the outcomes they can achieve. Myles and Schuyler’s dependency relationship was sustaining for both of them and also critical for her development as a pioneering lesbian poet in an art world still dominated by men. (shrink)

In The Problem of Punishment, David Boonin offers an analysis of punishment and an account of what he sees as ethically problematic about it. In this essay I make three points. First, pace Boonin's analysis, everyday examples of punishment show that it sometimes isn't harmful, but merely "discomforting." Second, intentionally discomforting offenders isn't uniquely problematic, given that we have cases of non-punitive intentional discomforture---and perhaps even harmful discomforture---that seem unobjectionable. Third, a notable fact about both non-harmful punishment and non-punitive intentional (...) discomforture is that they aim at improving the subject. This suggests that, if the prima facie wrongness of intentionally harming another person is the fundamental challenge for punishment, the "educative defense" is the royal road to justifying the practice. I conclude by outlining one version of the educative defense that exploits this advantage while avoiding some traditional objections to the approach. (shrink)

Trichoplax adhaerens is more simply organized than any other living metazoan. This tiny marine animal looks like a irregular “hairy plate” (“tricho plax”) with a simple upper and lower epithelium and some loose cells in between. After its original description by F.E. Schulze 1883, it attracted particular attention as a potential candidate representing the basic and ancestral state of metazoan organization. The lack of any kind of symmetry, organs, nerve cells, muscle cells, basal lamina and extracellular matrix originally left little (...) doubt about the basal position of T. adhaerens. Nevertheless, the interest of zoologists and evolutionary biologists suddenly vanished for more than half a century when Trichoplax was claimed to be an aberrant hydrozoan planula larva. Recently, Trichoplax has been rediscovered as a key species for unraveling early metazoan evolution. For example, research on regulatory genes and whole genome sequencing promise insights into the genetics underlying the origin and development of basal metazoan phyla. Trichoplax offers unique potential for understanding the minimal requirements of metazoan animal organization. BioEssays 27:1294–1302, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

“Let me begin with the standard stupid question: if I were allowed to take only one piece of music to a lone island, which one this would be? [...]”.

The gut protozoan parasite, Giardia duodenalis, is the best characterized example of the most ancient eukaryotes, which are anaerobic and appear to be primitively amitochondrial. Apart from its obvious medical importance, Giardia is fascinating in its own right. Its prokaryotic-like anaerobic metabolism renders it selectively sensitive to some bacterial drugs, especially the nitroimidazoles, which are activated to form toxic radicals. Other features, including an enzyme that reduces oxygen directly to water, cysteine as the keeper of redox balance, a plasmid, and (...) toxin-like genes are also distinctly prokaryotic-like. But, unlike prokaryotes, Giardia has a sophisticated, highly developed cytoskeleton, bounded nuclei, linear chromosomes capped with telomeric repeats, and telomere positional regulation of gene expression. BioEssays 20:256–263, 1998.© 1998 John Wiley & Sons, Inc. (shrink)

The gut protozoan parasite, Giardia duodenalis, is the best characterized example of the most ancient eukaryotes, which are anaerobic and appear to be primitively amitochondrial. Apart from its obvious medical importance, Giardia is fascinating in its own right. Its prokaryotic-like anaerobic metabolism renders it selectively sensitive to some bacterial drugs, especially the nitroimidazoles, which are activated to form toxic radicals. Other features, including an enzyme that reduces oxygen directly to water, cysteine as the keeper of redox balance, a plasmid, and (...) toxin-like genes are also distinctly prokaryotic-like. But, unlike prokaryotes, Giardia has a sophisticated, highly developed cytoskeleton, bounded nuclei, linear chromosomes capped with telomeric repeats, and telomere positional regulation of gene expression. BioEssays 20:256–263, 1998.© 1998 John Wiley & Sons, Inc. (shrink)

Amphioxus represents the most basally divergent group in chordates and probably the best extant proxy to the ancestor of all chordates including vertebrates. The amphioxus, or lancelets, are benthic filter feeding marine animals and their interest as a model in research is due to their phylogenetic position and their anatomical and genetic stasis throughout their evolutionary history. From the first works in the 19th century to the present day, enormous progress is made mainly favored by technical development at different levels, (...) from spawning induction and husbandry techniques, through techniques for studies of gene function or of the role of different signalling pathways through embryonic development, to functional genomics techniques. Together, these advances foretell a plethora of interesting developments in the world of research with the amphioxus model. Here, the author review the discovery and development of amphioxus as a superb model organism in evolutionary and evolutionary‐developmental biology. (shrink)

A Paramecium cell has a stereotypically patterned surface, with regularly arranged cilia, dense‐core secretory vesicles and subplasmalemmal calcium stores. Less strikingly, there is also a patterning of molecules; for instance, some ion channels are restricted to certain regions of the cell surface. This design may explain very effective and selective responses, such as that to Ca2+ upon stimulation. It enables the cell to respond to a Ca2+ signal precisely secretion (exocytosis) or by changing its ciliary activity. These responses depend on (...) the location and/or type of signal, even though these two target structures co‐exist side‐by‐side, and normally only limited overlap occurs between the different functions. Furthermore, the patterning of exocytotic sites and the possibility of synchronous exocytosis induction in the sub‐second time range have considerably facilitated analyses, and thus led to new concepts of exocytotic membrane fusion. It has been possible to dissect complicated events like overlapping Ca2+ fluxes produced from external sources and from internal stores. Since molecular genetic approaches have become available for Paramecium, many different gene products have been identified only some of which are known from “higher” eukaryotes. Although a variety of basic cellular functions are briefly addressed to demonstrate the uniqueness of this unicellular organism, this article focuses on exocytosis regulation. BioEssays 24:649–658, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The chapter talks about Shel Silverstein's The Giving Tree, which is a favorite of many children, adults, and teachers. The story of a relationship between a boy and a tree is charming for, despite the vicissitudes of the relationship, the two end up together at the end, with the boy — now an old man — sitting contentedly on the tree — itself reduced to a mere stump. The book raises an important issue in the field of environmental ethics. It (...) asks us to recognize that between childhood and old age, people operating within the Western tradition of ethics are not mindful of the value that the non‐human beings in their environment have for them as well as for future generations. Harkening to such warnings, environmental ethicists have attempted to raise important issues about our relationship with the other beings that make up our world. (shrink)

The paper generalizes Van McGee's well-known result that there are many maximal consistent sets of instances of Tarski's schema to a number of non-classical theories of truth. It is shown that if a non-classical theory rejects some classically valid principle in order to avoid the truth-theoretic paradoxes, then there will be many maximal non-trivial sets of instances of that principle that the non-classical theorist could in principle endorse. On the basis of this it is argued that the idea of classical (...) recapture, which plays such an important role for non-classical logicians, can only be pushed so far. (shrink)

The answer is surprising, and what we're about to learn will wake us up to a reality most of us never knew existed.The reason we're so oblivious is because we've all been operating at human speed, relying on our own physical power and our five senses. But there is something extremely important we've all been missing. It holds the key to everything good--the key to life, success, happiness, peace of mind, and understanding beyond our wildest imagination. It's perhaps the best-kept (...) secret in the history of mankind and it packs a staggering, invigorating message that can change your life for the better--improving understanding, eliminating anxiety, and helping to extend your living years indefinitely. All we have to do is open our eyes and ears.We're all inundated with this secret at all times. It's present in our favorite songs and movies, the stories we tell our children, and even in every commercial campaign! The secret is broadcast in famous news stories including the coronavirus pandemic, the sinking of the Titanic, or the collapse of the World Trade Center on 9/11. It's in ordinary life activities such as breathing, sleeping, waking up, traveling, sex, and getting married and changing one's name.Now, bestselling author and award-winning journalist Joe Kovacs reveals the solution--cracking the divine code that shifts our minds from operating at slow, human speed and making the jump to the incredibly quick "God speed."Hundreds of ancient mysteries and prophecies are instantly unsealed as the master key that unlocks the mystery of everything is now in your hands. (shrink)

Meiotin‐1 is a protein found in developing microsporocytes of Lilium longiflorum, and immunological assays indicate that cognates exist in both mono‐ and dicotyledonous plants. Its temporal and spatial expression pattern, coupled with its unusual distribution in chromatin and the properties it shares with histone H1, encourages speculation that it is involved in regulating meiotic chromatin structure. Molecular analyses provide support for the hypothesis that meiotin‐1 arose from histone H1 by an exon shuffling mechanism, as meiotin‐1 is an H1‐like protein that (...) lacks the amino‐terminal domain shared by H1 molecules. We have proposed that meiotin‐1 serves to limit chromatin condensation in order to foster the unique cytological and molecular events which occur during meiotic prophase. As such, meiotin‐1 fits the role of a ‘meiosis readiness factor’, and its accumulation to a threshold level may commit mitotically dividing progenitor cells to differentiate into meiocytes. (shrink)

Thy‐1 is a small glycoprotein of 110 amino acids which, folded in the characteristic structure of an immunoglobulin variable domain1, are anchored to the plasma membrane via a glycophosphatidylinositol (GPI) tail(2,3) (Fig. 1). It is a major component of the surface of various cell types, including neurons, at certain stages of their development (4). These qualities doubtlessly appeal to certain cognoscenti, but it is not clear why they would raise Thy‐1 to the status of a favourite molecule. Indeed, few (...) scientists readily admit to having a favourite. We study individual molecules because science is rooted in specific observations; but we do so in order to discover mechanisms of general importance. A molecule's appeal is dependent on its ability to reveal novel aspects of how nature works.Thy‐1 has been unusual in this respect. It was the first lymphocyte surface antigen shown to be restricted to a functional subset of lymphocytes (T cells in the mouse), a finding crucial to the development of cellular immunology(5); it was one of the first cell surface molecules to be sequenced and indicated the importance of immunoglobulin domains and GPI anchors as structural motifs(1–3); it has been pivotal in studies demonstrating that GPI‐anchored molecules are able to signal across the membrane they do not span(6, 7). Thy‐1 has revealed this much, however, with the charm of an adroit stripper: it has always promised glimpses of things more exciting than that displayed. In particular, the function of this molecule has never emerged.Our current work on Thy‐1 in the nervous system is, we believe, finally prizing this last secret into the open. It suggests that Thy‐1 on the neuronal surface interacts with one of the main glial types of adult brain, the astrocyte, to restrict axonal growth(8). There is no current consensus that astrocytes do regulate such growth, and this is the wider question we are addressing from the perspective of Thy‐1. At issue also is how to progress from knowing the nature of a molecule to defining its function. This task has already been achieved with molecules which were harder to characterise than Thy‐1. The problem is a classic Catch 22 situation: Thy‐1 has been readily characterised because it is small and abundant it is ten times more abundant than any other surface glycoprotein on rat thymocytes(9); but since there is so much of it, whatever it does it must do rather badly (or there would be no need to have so much of it!). Defining a function based on low activity or affinity is not trivial.Here I describe two aspects of work on Thy‐1. One is long completed ‐ the research which led to Thy‐1 being isolated and characterised ‐ and included because it demonstrates features which are still applicable to much research using a antibodies today. The other is our ongoing work on the nervous system, which is at that exciting early stage where hypotheses are formed, but the answers are still coming in. (shrink)

As a traditional clothing symbol that is unique to the Chinese nation, the dragon symbol combines the distinctive features of the Chinese nation, reflecting the depth of mental changes and the historical context of Chinese culture. The image of the dragon has formed a kind of dragon pattern as a certain set of ideas about the culture that encoded all its changes. Therefore, in national clothing the dragon image has been one of the most favorite patterns for thousands of years. (...) With the interweaving of world cultures and the deepening of the concept of clothing design, the dragon pattern will incorporate fresh elements of Western culture while maintaining the essence of traditional Chinese culture, and show a new design image through the utilization of various innovative ideas and design methods. The following methods were used for the study: literature review, field research, analysis of design cases, analysis of fashion trends. Using these methods, the specifics of using dragon designs in the fashion industry in different seasons and years are analyzed, and the trend of their evolution in the field of high fashion is studied. In the article we analyzed modern trends of clothing design and gave their characteristics. The results of the study showed that even in modern youth fashion this national symbol is actively used, which indicates that the patterns and images of the dragon have real applicability and wide prospects of application in modern fashion design. Modern clothing design provides a rich cultural heritage for modern clothing to retain the characteristics of civilization on the basis of continuous innovation. The use of dragon motifs in modern clothing not only meets the aesthetic concepts of modern people, but also adds vitality to clothing design. (shrink)

Best Book of June 2015 (The Christian Science Monitor) Book of the Year by the Conference on Christianity and Literature C. S. Lewis is the 20th century's most widely read Christian writer and J.R.R. Tolkien its most beloved mythmaker. For three decades, they and their closest associates formed a literary club known as the Inklings, which met every week in Lewis's Oxford rooms and in nearby pubs. They discussed literature, religion, and ideas; read aloud from works in progress; took philosophical (...) rambles in woods and fields; gave one another companionship and criticism; and, in the process, rewrote the cultural history of modern times. In The Fellowship, Philip and Carol Zaleski offer the first complete rendering of the Inklings' lives and works. The result is an extraordinary account of the ideas, affections and vexations that drove the group's most significant members. C. S. Lewis accepts Jesus Christ while riding in the sidecar of his brother's motorcycle, maps the medieval and Renaissance mind, becomes a world-famous evangelist and moral satirist, and creates new forms of religiously attuned fiction while wrestling with personal crises. J.R.R. Tolkien transmutes an invented mythology into gripping story in The Lord of the Rings, while conducting groundbreaking Old English scholarship and elucidating, for family and friends, the Catholic teachings at the heart of his vision. Owen Barfield, a philosopher for whom language is the key to all mysteries, becomes Lewis's favorite sparring partner, and, for a time, Saul Bellow's chosen guru. And Charles Williams, poet, author of "supernatural shockers," and strange acolyte of romantic love, turns his everyday life into a mystical pageant. Romantics who scorned rebellion, fantasists who prized reality, wartime writers who believed in hope, Christians with cosmic reach, the Inklings sought to revitalize literature and faith in the twentieth century's darkest years-and did so in dazzling style. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:484 BOOK REVIEWS faith. Yet faith-knowledge alone is insufficient to account for Jesus' extraordinary gifts as a teacher: for this we must appeal to a special charism along the lines of an infused knowledge. According to Torrell this knowledge is best understood by reference to Aquinas's mature teaching on prophecy: God equipped the prophets with an infused light (but not infused ideas) enabling them to communicate divine truths to (...) others. Likewise, God conferred on Jesus an infused light akin to that of the prophets, but with this qualitative difference: in him the lumen is a permanent feature of his cognitive life (a habitus), while it is given to the prophets only intermittently (per modum actus). The foregoing i;ummary will have served its purpose if it has conveyed to the reader some sense of the very rich historical, philosophical, and theological reflections that comprise this volume. The editorial team of the Revue thomiste is to be commended for the high caliber of this and the other special publications it has produced in recent years: the 1992 commemorative volume on the theological achievement of M.-M. Labourdette; th~ 1993 centenary index ("tables generales 1893-1992"); the Gilson issue of 1994; and most recently an issue devoted to Thomas Aquinas and the onto-theo-logy debate (1995). This reviewer eagerly waits for more. Fordham University Bronx, New York GREGORY M. REICHBERG The Divine Initiative: Grace, World-Order, and Human Freedom in the Early Writings of Bernard Lonergan. By J. MICHAEL STEBBINS. Toronto: University of Toronto Press, 1995. Pp. xxii + 399. $65.00 (cloth). Aquinas insists that the creator's primary intent is the "order of the universe," and Bernard Lonergan's dissertation on "operating grace" in Aquinas's writings managed to move beyond the stalemated discussion of "sufficient" and "efficacious" grace precisely because he displayed how any discourse about grace had to be connected with larger theorems of the creator's operation in creation. What speaking of the divine action called "grace" requires is a set of metaphysical skills adequate to speaking of the "order of the universe" as created. A tall order, whose scope the published edition of his dissertation-Grace and Freedom-so understated that its implications have been missed by many philosophers and theologians fascinated with such questions. Stebbins's careful reconstruction of that text reminds us of its daunting scope. And part of the reason it can do so is that he illustrates both the method and conclusions of Grace and Freedom through a later text which Lonergan had composed (in Latin) for a course on grace offered from 1947 to 1960: De ente supernaturali (which will appear in volume 16 [Early Latin Theology] of the Collected Works of Bernard Lonergan, published by BOOK REVIEWS 485 University of Toronto Press). The significance of this collateral source is that it can profit from and respond to Henri de Lubac's epochal Surnaturel (1946). For those not familiar with Grace and Freedom, as well as some who thought they were, a list of Stebbins's chapters manages to convey the scope of Lonergan's achievement: 1. The Role of Understanding in Theological Speculation; 2. The Principal Instance of Supernatural Being: The Created Communication of the Divine Nature; 3. Thirteenth-Century Breakthrough (The "Theorem" of the Supernatural); 4. Supernatural Transformation of Human Activity; 5. Obediential Potency and the Natural Desire to See God; 6. Molinist and Bannezian Systems; 7. Theoretical Perspective on Divine Concourse; 8. Contingence, Sin and Divine Efficacy. As always, Lonergan must actively reflect on method while executing a theological inquiry, so Stebbins rightly begins with his insistence that such inquiry must be more than "just a networks of concepts; it is primarily an act of understanding" (xix)-Chapter 1. Then, following the expository order of De ente supematurali, he shows how Lonergan roots the supernatural in the theorems developed to speak of the natural: of creation itself. ("Theorem," as we shall see, is a favorite word of Lonergan's, intimating what it takes to move beyond our imaginations to a set of propositions able to articulate the metaphysical issues at stake.) Following the analogy of nature, we can see how the "two operations by which creatures... (shrink)

Examples of hypotheses about the number of planets are frequently used to introduce the topic of (actual) truthlikeness but never analyzed in detail. In this paper we first deal with the truthlikeness of singular quantity hypotheses, with reference to several ‘the number of planets’ examples, such as ‘The number of planets is 10 _versus_ 10 billion (instead of 8).’ For the relevant ratio scale of quantities we will propose two, strongly related, normalized metrics, the proportional metric and the (simplest and (...) hence favorite) fractional metric, to express e.g. the distance from a hypothetical number to the true number of planets, i.e. the distance between quantities. We argue that they are, in view of the examples and plausible conditions of adequacy, much more appropriate, than the standardly suggested, normalized absolute difference, metric. Next we deal with disjunctive hypotheses, such as ‘The number of planets is between 7 and 10 inclusive is much more truthlike than between 1 and 10 billion inclusive.’ We compare three (clusters of) general ways of dealing with such hypotheses, one from Ilkka Niiniluoto, one from Pavel Tichý and Graham Oddie, and a trio of ways from Theo Kuipers. Using primarily the fractional metric, we conclude that all five measures can be used for expressing the distance of disjunctive hypotheses from the actual truth, that all of them have their strong and weak points, but that (the combined) one of the trio is, in view of principle and practical considerations, the most plausible measure. (shrink)

Snježana Prijić-Samaržija’s book discusses the epistemic grounding of democracy, stressing the epistemic role of experts in her political-epistemological favorite, the project of “reliability democracy”. Her proposal, inspired by Christiano, lets citizens play an important role in setting the aims, whereas experts deliberate about means of reaching them. I argue that it is not easy to reach consensus about goals and values. What is needed is democratic deliberation in deciding, encompassing both experts and laypersons. We should retain the duality of less (...) ideal deliberation in real world and of hypothetical contractualist deliberation, within moral-political thought-experiments, in the tradition of Habermas and Scanlon in the ideal theory. I leave it open whether our author might ultimately agree with this picture of reliability democracy. (shrink)

The discovery of the signal peptides that direct proteins to localize at the nucleolus is described here. The nucleolar targeting signal termed the NOS consists of clustered basic amino acids organized such that a portion also functions as the nuclear transporting signal. Although a NOS has been identified within the regulatory genes of human retroviruses, HTLV‐I and HIV‐I, signals of similar function in cellular proteins – such as heat shock proteins – may be induced through the configurational change of protein (...) structure by heat or stress. (shrink)

This book challenges the notion that humans aren't any more important than, say, ants, and ethics and politics must be adjusted accordingly as not to rank human concerns as primary.

Kierkegaard is well known for his quick wit and sharp polemics against his opponents. One of his favorite targets was the poet, dramatist, and philosopher, Johan Ludvig Heiberg (1791 – 1860). Perhaps the best-known element of his critique was Heiberg’s outspoken Hegelian campaign. Before Kierkegaard’s famous criticisms of Heiberg, he learned the craft of literary polemics by reading the lively discussions in the Danish journals of the time. In this article it is argued that the role of the journal Kjøbenhavnsposten (...) for Kierkegaard has never been appreciated. This journal was edited by Andreas Peter Liunge (1798 – 1879), who was a great adversary of Heiberg and his Kjøbenhavns flyvende Post. The article shows that the often satirical use of Hegel by Kjøbenhavnsposten to criticize Heiberg anticipates Kierkegaard’s strategy of critique with regard to Heiberg and other figures in the Danish Hegelian movement. (shrink)

It weighs in at a bit more than five pounds; its dimensions demand a cradle. Yet this book is a handsome and welcome achievement despite its bulk. Its reproduction of the 1922 text, its maps and photos of 1904 Dublin; its list of minor characters in Ulysses; its bibliography of scholarship, both old and new; its timeline of Joyce's life, and its exemplary detailed annotations of the text: everything, harvested from the best sources, has been brought together to create the (...) largest volume dedicated to Joyce scholarship ever produced—a book that celebrates the first printing of Joyce's masterpiece. Given its weight and size, its classroom utility is likely limited; given its monumentality, it is a proper hundred-year tribute.What is wholly original about the book's contents are the essays that preface each of the eighteen episodes of the masterpiece. That Joycean scholarship grows upon itself is amply demonstrated by the sophistication and weight of learning the eighteen writers can now display. Almost fifty years have passed since Clive Hart and David Hayman edited a volume with a similar aim. Each of the new essays reveals just how much more there is now to know and say about Ulysses, how much more there is to praise in how Joyce conceived the book, how much more there is to teach, and how unlikely it is that Joycean scholarship will ever be diminished in either its curiosity or its energy. Given the increasing complexity and density of such accumulated knowledge, it is a pleasure to witness the economy and precision shown by so many of the writers. In particular, Robert Spoo's writing about “Nestor,” Maud Ellmann's writing about “Lotus Eaters,” and Vicki Mahaffey's writing about “Nausicaa” demonstrate how concision can make for valuable illumination.But there is a problem with where these essays are positioned. Coming before each of the episodes they introduce, they might condition the mind of a reader new to Ulysses to look upon those episodes as no more than demonstrations of what the scholars think. Catherine Flynn, the book's editor, emphasizes the need of such professional interpretation when she describes the plight of anyone “struggling through Ulysses” and “the key challenges facing the reader.” She is right about how hard it is for any new reader to “get” the book, but the placement of the essays is at odds with her claim that “grappling with the novel's challenges, the reader is pushed toward one of the most important rewards of reading Ulysses: thinking independently.” The prefaces may well impede the reader from thinking independently.Professor Flynn's focus on challenge and difficulty is widely shared throughout the Joycean community and has become a fundamental preoccupation in Joyce scholarship. Taking Joyce's mastery as a given, many Joyceans assume a Talmudic stance in believing, to quote Spinoza, that “the intellectual love of a thing consists in understanding its perfections.” Facing the formidable Joyce, they turn and turn again to explication. They subscribe to the dictum that the youthful Joyce himself, perhaps self-mockingly, set down: “A man of genius makes no mistake. His errors are volitional and are the portals of discovery.” But is Ulysses free of error?Fritz Senn, writing about “Ithaca,” does not put himself in opposition to Joyce but in opposition to the presumed inerrancy of Joyce. He argues that the episode displays a troubling disjunction between what Joyce intended to do in the episode and what he did. Joyce told his friend Frank Budgen that in the episode “not only will the reader know everything and know it in the baldest and coldest way, but Bloom and Stephen thereby become heavenly bodies, wanderers like the stars at which they gaze.” But readers do not, indeed, get to know all they should, or see all they should see. Senn notes that they “learn next to nothing about Bloom's mother, his birthday, or the exact nature of his father's suicide, although they do learn a lot about such things as the junk in a drawer, the Dublin water supply system, and the addresses of Dublin shops.” Senn asks: “What does the meeting of the two characters amount to? Will it change Stephen so that he might become the author of the book he is in? Does Bloom find a son? Does he become the father that Stephen is supposed to be looking for? The impassive episode does not seem to answer, or to care.” But these are questions about which many a reader might care.Joyce named “Ithaca” as his favorite among the episodes. Senn demonstrates by his care and attentiveness that he too admires it. But by not limiting himself to dutiful reverence, he instead critically examines the Joycean text. His tribute to Joyce is both unsparing and generous.Equally attentive and yet incisive is Katherine O'Callaghan in her examination of “Sirens.” She recognizes the experimental daring of Joyce's strategy of “conveying music through language” in that episode. But her analysis, as penetrating as it is learned, does not leave the reader persuaded that the episode is entirely successful. As she observes, “the reluctance of the musical art to bend to the critical written voice” is a “stumbling block.”Another problematic experiment, “Oxen of the Sun,” which Joyce himself described as “the most difficult episode... both to interpret and to execute,” presents its commentator, Sarah Davison, with the task of explaining how its grandiose mixture of parody, plagiarism, and sheer celebration of myriad English prose styles over the centuries can function without, as she says, “wrongfooting and dissatisfying readers” who assume that the episode “enacts a historical progression only to find themselves disorientated by so many different echoes and cadences.”Were Joycean scholars more devoted to critical judgment than to explication—even when they are faced with the spectacular imposition of genius—the common reader would more likely find fellowship, and less intimidation, when reading a book that is not a sacred text but a human document, written with the extraordinary self-imposed challenges, as well as the problematic results, that only a most extraordinary human could make. 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One can determine the nature of something by asking what it is for. For example one understands what a chair is when one understands it is for sitting on. This involves understanding its purpose. One type of corporation is the for-profit-corporation. This seems to indicate that this type of corporation, the business corporation, has as its purpose to make a profit. Is that as obvious as it first appears? The favorite way for philosophers to arrive at the "purpose" of anything (...) is to ask the question "Why?" But there are at least two answers to the question "Why"? when addressed to a social practice such as business. One might be asking for a psychological account (explanation) of "Why" a person does business, and this is primarily answered by discovering the motives behind business activity; or one might be asking for a justificatory reason (justification) for the practice – what purpose legitimates business as a human activity. These two answers are often conflated and thus the purpose of business is often considered to be answered by giving the psychological account of the self-interested profit-making motive. This paper will attempt to highlight the importance of making the distinction between motive and purpose clearly, show what confusions arise when the distinction is ignored, and hint at some of the structural philosophical reasons why the distinction got blurred in the first place. (shrink)

One of the principles on how to act under moral uncertainty, My Favourite Theory, says roughly that a morally conscientious agent chooses an option that is permitted by the most credible moral theory. In defence of this principle, we argue that it prescribes consistent choices over time, without relying on intertheoretic comparisons of value, while its main rivals are either plagued by moral analogues of money pumps or in need of a method for making non-arbitrary intertheoretic comparisons. We rebut (...) the arguments that have been levelled against My Favourite Theory and offer some arguments against intertheoretic comparisons of value. (shrink)

A straightforward way to handle moral uncertainty is simply to follow the moral theory in which you have most credence. This approach is known as My Favourite Theory. In this paper, I argue that, in some cases, My Favourite Theory prescribes choices that are, sequentially, worse in expected moral value than the opposite choices according to each moral theory you have any credence in. In addition this, problem generalizes to other approaches that avoid intertheoretic comparisons of value, such (...) as My Favourite Option, the Borda Rule, Variance Normalization, and the Principle of Maximizing Expected Normalized Moral Value. (shrink)

In the last fifteen years, testing has attracted much attention in science and technology studies. Most researchers have focused almost exclusively on testing in the laboratory, specifically designed test locations, and, for medical technologies, the clinic. What counts as testing has largely been described in terms of the activities of scientific experts. This is not to say that science and technology studies have completely neglected other institutional discourses. Journalistic texts have been a favorite research site for scholars in science and (...) technology studies, particularly those seeking to understand the dynamics of public controversies on science and technology. Although most constructivist studies of science and media relations have treated journalistic texts as secondary to scientific texts, other scholars have dismissed this hierarchy. In this article, scientific texts and journalistic texts are considered equally important locations in which to analyze the testing of technologies. Based on a case study on the testing of a new contraceptive technology for men, the article shows that what counts as successful testing is not solely in the hands of scientific experts. In the case of male contraceptive technologies, journalists have contested the claims of scientific experts, particularly their claims about the cultural feasibility of the new technology. (shrink)

Provocative essays on real-world ethical questions from the world's most influential philosopher Peter Singer is often described as the world's most influential philosopher. He is also one of its most controversial. The author of important books such as Animal Liberation, Practical Ethics, Rethinking Life and Death, and The Life You Can Save, he helped launch the animal rights and effective altruism movements and contributed to the development of bioethics. Now, in Ethics in the Real World, Singer shows that he is (...) also a master at dissecting important current events in a few hundred words. In this book of brief essays, he applies his controversial ways of thinking to issues like climate change, extreme poverty, animals, abortion, euthanasia, human genetic selection, sports doping, the sale of kidneys, the ethics of high-priced art, and ways of increasing happiness. Singer asks whether chimpanzees are people, smoking should be outlawed, or consensual sex between adult siblings should be decriminalized, and he reiterates his case against the idea that all human life is sacred, applying his arguments to some recent cases in the news. In addition, he explores, in an easily accessible form, some of the deepest philosophical questions, such as whether anything really matters and what is the value of the pale blue dot that is our planet. The collection also includes some more personal reflections, like Singer’s thoughts on one of his favorite activities, surfing, and an unusual suggestion for starting a family conversation over a holiday feast. Now with a new afterword by the author, this provocative and original book will challenge—and possibly change—your beliefs about many real-world ethical questions. (shrink)

Among Rorty's most admired essays, and probably his most autobiographical, “Trotsky and the Wild Orchids” made its first appearance as a column in Common Knowledge during the journal's inaugural year. Here it is reprinted, thirty years later, in a symposium called “Whatever Happened to Richard Rorty?” He explains in this essay that, as a child, he loved things that would seem to others contradictory, for example the Trotskian socialism to which his family was committed and the wild orchids that he (...) would search for in the local mountains. Finding his own way between what appeared to others contrary kinds of demand or appeal, he never settled, as a philosopher and public intellectual, on syntheses that made good sense to his contemporaries. They were unable to locate him on their intellectual and political maps. As he writes, “If there is anything to the idea that the best intellectual position is one which is attacked with equal vigor from the political right and the political left, then I am in good shape.... The left's favorite word for me is ‘complacent,’ just as the right's is ‘irresponsible.’ ” The editors of Common Knowledge, a venue that Rorty helped to found, have reprinted this essay as a way of stating their view that nothing has “happened to Richard Rorty” in the past three decades that did not happen as well when he was active in his own self-defense. He was misconstrued but indispensable when alive, and has remained so in the decades since. (shrink)

It had to happen. After two full decades of intense energy, business ethicists and business practitioners may actually have succeeded in suppressing the feeblest joke of the profession: “Business Ethics. Isn’t that an oxymoron?” Har har har.In the early days of business ethics, the oxymoron had actual embodiments. “Business” was represented by hard-nosed, thicks-kinnedmanagers with no inclination to adopt academia’s language and critiques. “Ethics” was embodied by ivory-towered theoreticians with an undisguised contempt for profit makers. What a joke to think (...) of these two groups as conceptually productive partners. (shrink)

It had to happen. After two full decades of intense energy, business ethicists and business practitioners may actually have succeeded in suppressing the feeblest joke of the profession: “Business Ethics. Isn’t that an oxymoron?” Har har har.In the early days of business ethics, the oxymoron had actual embodiments. “Business” was represented by hard-nosed, thicks-kinnedmanagers with no inclination to adopt academia’s language and critiques. “Ethics” was embodied by ivory-towered theoreticians with an undisguised contempt for profit makers. What a joke to think (...) of these two groups as conceptually productive partners. (shrink)