Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that in order to perform accurate and interesting comparative genomics, one first and foremost has to be able to recognize, postulate, and revise different evolutionary scenarios. After all, these studies lack a simple protocol, due to different proteins having different evolutionary dynamics and demanding different approaches. The authors here discuss this challenge from a practical (what are the observations?) (...) and conceptual (how do these indicate a specific evolutionary scenario?) viewpoint, with the aim to guide investigators who want to analyze the evolution of their protein(s) of interest. By sharing how the authors draft, test, and update such a scenario and how it directs their investigations, the authors hope to illuminate how to execute molecular evolution studies and how to interpret them. Also see the video abstract here https://youtu.be/VCt3l2pbdbQ. (shrink)

Simple mindfulness practices to help your child (ages 5-12) deal with anxiety, improve concentration, and handle difficult emotions—with a 60-minute audio CD of guided exercises Mindfulness—the quality of attention that combines full awareness with acceptance of each moment, just as it is—is gaining broad acceptance among mental health professionals as an adjunct to treatment. This little book is a very appealing introduction to mindfulness meditation for children and their parents. In a simple and accessible way, it describes what mindfulness is (...) and how mindfulness-based practices can help children calm down, become more focused, fall asleep more easily, alleviate worry, manage anger, and generally become more patient and aware. The book contains eleven practices that focus on just these scenarios, along with short examples and anecdotes throughout. Included with purchase is an audio CD with guided meditations, voiced by Myla Kabat-Zinn, who along with her husband, Jon Kabat-Zinn, popularized mindfulness-based stress reduction (MBSR) as a therapeutic approach. Continue your mindfulness practice with Eline Snel through her other mindfulness meditation titles, including Sitting Still Like a Frog Activity Book, which offers 75 fun mindfulness games and activities for children, and The Little Frog Awakes, which offers tools and advice for mindfully responding to younger children ages 18 months to 4 years. (shrink)

Parents of toddlers can find themselves overwhelmed and struggling with self-doubt when their child is willful, or is having trouble navigating difficult emotions and circumstances. Mindfulness can help! In The Little Frog Awakes, Eline Snel offers parents of children -ages 18 months--4 years--advice and tools for responding mindfully and effectively in the moment. These skills help us regain trust in ourselves and in the integral wholeness of our kids. And when we make mindfulness practice a part of daily life, (...) it gives our children a powerful message on how to recognize, name, and deal with emotions and situations. This practical guide will help you to connect with and respond mindfully to your own feelings as they arise; cultivate compassion for yourself as a parent; show you how to encourage serenity, self-confidence, and emotional regulation in your children; strengthen the bond with your kids and help all of you manage stress; be more fully present with your children, and more able to give them your undivided attention; embrace imperfection and focus on the things that really matter; and more The book and the accompanying audio include activities, practices, and stories for both you and for your toddler that cultivate mindful moments and action, and self-compassion. (shrink)

One of the central aims of autism research is to identify specific neurodevelopmental mechanisms that cause and explain the visible autistic signs and symptoms. In this short paper, I argue that the persistent search for autism-specific pathophysiologies has two fundamental difficulties. The first regards the growing gap between basic autism science and clinical practice. The second regards the difficulties with demarcating autism as a psychiatric condition. Instead of the unremitting search for the neurobiological basis of autism, I suggest that basic (...) autism research should focus on experiences of impairment and distress, and on how these experiences relate to particular behaviors in particular circumstances, regardless of whether we are dealing with an autism diagnosis or not. (shrink)

Although clinicians and researchers working in the field of autism are generally not concerned with philosophical categories of kinds, a model for understanding the nature of autism is important for guiding research and clinical practice. Contemporary research in the field of autism is guided by the depiction of autism as a scientific object that can be identified with systematic neuroscientific investigation. This image of autism is compatible with a permissive account of natural kinds: the mechanistic property cluster (MPC) account of (...) natural kinds, recently proposed as the model for understanding psychiatric disorders. Despite the heterogeneity, multicausality and fuzzy boundaries that complicate autism research, a permissive account of natural kinds (MPC kinds) provides prescriptive guidance for the investigation of objective causal mechanisms that should inform nosologists in their attempt to carve autism’s boundaries at its natural joints. However, this essay will argue that a mechanistic model of autism is limited since it disregards the way in which autism relates to ideas about what kind of behavior is abnormal. As historical studies and definitions of autism show, normative issues concerning disability, impairment and societal needs have been and still are inextricably linked to how we recognize and understand autism. The current search for autism’s unity in neurobiological mechanisms ignores the values, social norms and various perspectives on mental pathology that play a significant role in 'the thing called autism’. Autism research needs to engage with these issues in order to achieve more success in the effort to become clinically valuable. (shrink)

In this article, I argue that the history and philosophy of autism need to account for two kinds of autism. Contemporary autism research and practice is structured, directed and connected by an ‘ontological understanding of disease’. This implies that autism is understood as a disease like any other medical disease, existing independently of its particular manifestations in individual patients. In contrast, autism in the 1950s and 1960s was structured by a psychoanalytical framework and an ‘individual understanding of disease’. This implied (...) that autism was not a distinct disease but an idiosyncratic and meaningful response of the child to a disturbed development of the ego. These two kinds of autism are embedded in and reveal two very different ‘styles of psychiatric thought’. (shrink)

Die Rezeption von Literatur ist von besonderen Herausforderungen gekennzeichnet. Einerseits gibt es erlernbare Techniken des Lesens und Deutens, andererseits gibt es das Wissen um eine dennoch verbleibende Deutungsvielfalt. Statt die Ungewissheiten bei der Deutung zu beklagen, besteht die (in der Moderne zunehmend wichtiger werdende) Möglichkeit, diese Ungewissheit als produktiv zu deuten und das Lesen von Literatur als einen ästhetisch eröffneten Spielraum zu fassen, in dem wir gefahrlos unsere Kenntnisse, Erwartungen und Überzeugungen einsetzen, erproben und erweitern können. Es werden zunächst grundlegende (...) Fragen des Lesens und der Fiktion angesprochen, eine Bestimmung literaturwissenschaftlicher Arbeit entwickelt, um dann philosophische und theologische Integrationsbemühungen literarischer Werke kritisch zu beleuchten. Am Beispiel der Deutungsbedürftigkeit des Todes wird die Relevanz und der Eigensinn des Literarischen aufgezeigt. (shrink)

Der Beitrag beleuchtet die Struktur und Funktion forschender Laborpraxis vor dem Hintergrund verschiedener erkenntnis- und wissenschaftstheoretischer Positionen. Das Labor kann in seiner Relevanz unterschätzt werden – mit Blick auf die darin verrichteten praktischen Tätigkeiten, auf dabei erforderliche Urteilsbildungen und nicht zuletzt auf unverzichtbare Impulse für die Wissenschaft. Die abstrakte Gegenüberstellung von Theorie und Praxis ist aufzugeben. Zugleich sollte Wissenschaft weder allein über das Labor noch über die Theoriebildung bestimmt werden. Abschließend plädiert der Beitrag dafür, die skizzierten Fragestellungen in die Labordidaktik (...) sowie in die Planung und Durchführung von Lernlaboren einzubeziehen. (shrink)

Die strittige ‚Faktizität des Todes‘ eröffnet die Frage, wie man sich zu ihr stellen soll. Der Beitrag bietet ein Panorama beispielhafter Ex-plikationen von Haltungen gegenüber dem Tod. Hierbei wird aufgewiesen, dass die bloße Bejahung des Todes unzureichend ist, wenn nicht zugleich die abträglichen und abgründigen Aspekte von Sterben und Tod wahrgenommen werden. Eine Abwägung der Effekte ist allerdings kaum durchführbar und das verbreitete Argument drohender Langeweile problematisch. Mit dem Hinweis auf Aristoteles und Kant werden Lektüremöglichkeiten aufgezeigt, die vertraute Topoi einer (...) Ars Moriendi aufbrechen und ein Verständnis gelingender Lebensführung entwickeln, die auf Fortsetzung drängt. Uto- pische Entwürfe der Überwindung des Todes werden zuletzt kritisch diskutiert. (shrink)

Performance measurement systems have the potential to improve organizational outcomes, but they often come at a cost. This commentary highlights the individual, organizational, and societal costs of performance measurement systems and explores how such costs could be reduced.

Review text: "Die gleichermaßen kenntnis- wie umfangreiche Studie gliedert sich in ausführliche Analysen einzelner literarischer Texte.... Bemerkenswert ist die subtile Aufmerksamkeit für temporale Aspekte des Stifter'schen Erzählens, welche in der Forschung nach wie vor häufig nur in Form des Klischees eines "Stillstands der Zeit" Erwähnung finden... "Elisabeth Strowick in: Monatshefte, Volume 103, 3/ 2011.

The historical trajectory of Central and Eastern Europe differed significantly from that of the West. The region became the periphery of a transforming West during the early modern centuries. The nineteenth and twentieth centuries were characterized by repeated attempts to catch up with the West. Romanticism brought in Western ideas and generated struggles for national independence and modernization. Failures paved the way for desperate revolts in the inter-war years. Left- and right-wing revolutions engulfed the region. Authoritarian, Fascist and Communist regimes (...) looked for short cuts to finish nation-building and industrialization. In the end, all versions of state-run modernization failed, and the region revolted against them. At least its western rim seems to be successfully returning to Europe at the turn of the millennium. (shrink)

Michel Foucault’s The Birth of Biopolitics is generally acknowledged as a pioneering study of neoliberalism, presenting it not merely as an economic theory but also as a mode of government. There is much debate, however, on Foucault’s intentions in analysing neoliberalism and the place of the genealogy in his broader critical project. The Birth of Biopolitics itself lacks both an explicit judgement of neoliberalism and an explicit ethical program. In this article, I maintain that Foucault’s genealogical work on neoliberalism is (...) complementary to his notions of agency. From this perspective, Foucault’s genealogy is not a judgement of neoliberalism in terms of right or wrong but rather serves as a breeding ground for ethical conduct. The notion of the critical attitude in particular shows that Foucault’s genealogical work stands in the service of the subject’s autonomy. However, Foucault is reluctant to fill in his ethical program too much because it should gain substance only in local struggles and through the subject’s own considerations. (shrink)

Michel Foucault’s The Birth of Biopolitics is generally acknowledged as a pioneering study of neoliberalism, presenting it not merely as an economic theory but also as a mode of government. There is much debate, however, on Foucault’s intentions in analysing neoliberalism and the place of the genealogy in his broader critical project. The Birth of Biopolitics itself lacks both an explicit judgement of neoliberalism and an explicit ethical program. In this article, I maintain that Foucault’s genealogical work on neoliberalism is (...) complementary to his notions of agency. From this perspective, Foucault’s genealogy is not a judgement of neoliberalism in terms of right or wrong but rather serves as a breeding ground for ethical conduct. The notion of the critical attitude in particular shows that Foucault’s genealogical work stands in the service of the subject’s autonomy. However, Foucault is reluctant to fill in his ethical program too much because it should gain substance only in local struggles and through the subject’s own considerations. (shrink)

The hopes and fears expressed in the debate on human enhancement are not always based on a realistic assessment of the expected possibilities. Discussions about extreme scenarios may at times obscure the ethical and policy issues that are relevant today. This paper aims to contribute to an adequate and ethically sound societal response to actual current developments. After a brief outline of the ethical debate concerning neuro-enhancement, it describes the current state of the art in psychopharmacological science and current uses (...) of psychopharmacological enhancement, as well as the prospects for the near future. It then identifies ethical issues regarding psychopharmacological enhancements that require attention from policymakers, both on the professional and on the governmental level. These concern enhancement research, the gradual expansion of medical categories, off-label prescription and responsibility of doctors, and accessibility of enhancers on the Internet. It is concluded that further discussion on the advantages and drawbacks of enhancers on a collective social level is still needed. (shrink)

In the Netherlands, Forensic Flexible Assertive Community Treatment is used as a specialized form of outpatient intensive treatment. This outreaching type of treatment is aimed at patients with severe and long lasting psychiatric problems that are at risk of engaging in criminal behavior. In addition, these patients often suffer from addiction and experience problems in different areas of their life. The aim of this exploratory study was to gain more insight into the characteristics of the ForFACT patient population. More knowledge (...) about these patients may enhance the effectiveness of ForFACT and therefore reduce the risk of recidivism. Data on 132 ForFACT patients were gathered by studying electronic patient records, criminal records, and by conducting semi-structured interviews with practitioners and patients. Additionally, as part of a cognitive screening, two screening instruments were conducted to gain insight into intelligence and possible mild cognitive impairments. This article gives a broad description of the ForFACT patient population, including demographic data and context variables, diagnostics, recidivism risk and offense history, and aspects related to care. Furthermore, several recommendations are given to further improve ForFACT. Based on the results it can be concluded that the ForFACT patient population shows a high degree of diversity in complex care needs and responsivity issues. Therefore, this article highlights the necessity for ForFACT to collaborate with other mental health institutions, as well as probation officers, and forensic or criminal justice institutions. Moreover, it is important to continually check the inclusion and exclusion criteria when admitting patients to ForFACT, and to examine whether ForFACT is still the most adequate care for patients or if they need to be referred. In addition, the results emphasize the importance of cognitive screening for forensic outpatients. Finally, this study zooms in on the interface between forensic psychiatric care and general mental health care. (shrink)