Enzymes that degrade nucleic acids are emerging as important players in the pathogenesis of inflammatory disease. This is exemplified by the recent identification of four genes that cause the childhood inflammatory disorder, Aicardi‐Goutières syndrome (AGS). This is an autosomal recessive neurological condition whose clinical and immunological features parallel those of congenital viral infection. The four AGS genes encode two nucleases: TREX1 and the hetero‐trimeric Ribonuclease H2 (RNase H2) complex. The biochemical activity of these enzymes was initially characterised 30 years ago (...) but a role in neurological inflammation was entirely unanticipated until they were found to be mutated in AGS. This has led to a hypothesis that accumulation of intracellular nucleic acids occurs as a consequence of mutation in these enzymes and triggers an inflammatory response through activation of innate immune pattern recognition receptors. ©2007 Wiley Periodicals, Inc BioEssays 30:833–842, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Reflection Principles are commonly thought to produce only strong axioms of infinity consistent with V = L. It would be desirable to have some notion of strong reflection to remedy this, and we have proposed Global Reflection Principles based on a somewhat Cantorian view of the universe. Such principles justify the kind of cardinals needed for, inter alia , Woodin’s Ω-Logic.

This essay finds room for scepticism in the context of a Reformed understanding of how we come to know, and participate in, the work of God in the world. To disallow scepticism in the face of the impossible things God has promised is to impede the work of bringing God’s Kingdom to earth as it is in heaven. This work is done only when we step into that which is beyond anything we can ask or imagine. I develop this argument (...) first by considering how we might do a better job of including and conversing with sceptics in our midst. I then explore three theological themes in the Reformed tradition that suggest the potential value of scepticism. Finally, I suggest that scepticism secures a place for wonder in the face of God’s Kingdom, a place from which we can effectively work for God’s impossible promises to come to fruition. (shrink)

The president of APA's Division Two suggests that those who teach psychology can make contributions to psychologist-scholars in theoretical and philosophical psychology. She indicates that members of Division Two could use some help in learning to think differently about the psychology they teach and specifically about the ways in which they try to teach theoretical and philosophical issues in psychology. For Division Two's part, she believes that their members could reciprocate with additional insights that might help Division 24's students learn. (...) 2012 APA, all rights reserved). (shrink)

This timely collection of essays by leading international scholars across religious studies and the environmental humanities advances a lively discussion on materialism in its many forms. While there is little agreement on what 'materialism' means, it is evident that there is a resurgence in thinking about matter in more animated and active ways. The volume explores how debates concerning the new materialisms impinge on religious traditions and the extent to which religions, with their material culture and beliefs in the Divine (...) within the material, can make a creative contribution to debates about ecological materialisms. Spanning a broad range of themes, including politics, architecture, hermeneutics, literature, and religion, the book brings together a series of discussions on materialism in the context of diverse methodologies and approaches. The volume investigates a range of issues including space and place, hierarchy and relationality, the relationship between nature and society, human and other agencies, and worldviews and cultural values. Drawing on literary and critical theory, and queer, philosophical, theological and social theoretical approaches, this ground-breaking book will make an important contribution to the environmental humanities. It will be a key read for postgraduate students, researchers and scholars in religious studies, cultural anthropology, literary studies, philosophy and environmental studies. (shrink)

Inleidend overzicht van de wijsgerige ethiek.

Scientific realists have suggested that changes in our scientific communities over the course of their history have rendered those communities progressively less vulnerable to the problem of unconcieved alternatives over time. I argue in response not only that the most fundamental historical transformations of the scientific enterprise have generated steadily mounting obstacles to revolutionary, transformative, or unorthodox scientific theorizing, but also that we have substantial independent evidence that the institutional apparatus of contemporary scientific inquiry fosters an exceedingly and increasingly theoretically (...) conservative form of that inquiry. I conclude that contemporary scientific communities are actually more vulnerable to the problem of unconceived alternatives than their historical predecessors, and I briefly suggest how we might seek to pursue scientific inquiry in a less theoretically conservative way. (shrink)

Alexithymia is a dimensional trait characterized by difficulties identifying and describing feelings and an externally oriented thinking (EOT) style. Here, we explored interrelationships between alexithymia and measures assessing how individuals process and regulate their responses to environmental and body-based cues. Young adults (N= 201) completed self-report questionnaires assessing alexithymia, sensory processing sensitivity (SPS), interoceptive accuracy (IA), sensory processing styles, and current levels of depression, anxiety, and stress. Whereas EOT was related to low orienting sensitivity, problems with emotional appraisal (difficulties identifying (...) feelings/difficulties describing feelings) were related to heightened sensory sensitivity. In addition, features of SPS improved the prediction of alexithymia above and beyond that accounted for by IA. We suggest that EOT is linked to problems maintaining a representation of one’s emotions in working memory and that low IA and problems with emotional appraisal are linked to atypicalities in sensory processing that may impact embodiment. A latent profile analysis revealed five classes of individuals distinguished by the relative strength of different alexithymic traits and by differences in IA and sensory processing styles. The classes identified included two lexithymic, one modal, and two alexithymic groups, showing different susceptibilities to SPS. Overall, our findings lend support to the view that alexithymia is associated with atypicalities in both bottom–up and top–down processes that impact emotion processing and regulation. They also raise the possibility that individuals with different alexithymia subtypes may differ with regard to a range of factors, including not only SPS but also early life experiences, mental health outcomes, and susceptibility to various personality disorders. (shrink)

Principlism is an ethical framework that has dominated bioethical discourse for the past 50 years. There are differing perspectives on its proper scope and limits. In this article, we consider to what extent principlism provides guidance for the abortion and euthanasia debates. We argue that whilst principlism may be considered a useful framework for structuring bioethical discourse, it does not in itself allow for the resolution of these neuralgic policy discussions. Scholars have attempted to use principlism to analyse the ethics (...) and legality of abortion and euthanasia; but such efforts are methodologically problematic. We close with a consideration of the proper scope of principlism in bioethics–a vision that is more modest than the manner in which principlism is often deployed in contemporary academic bioethics and medical education. (shrink)

Rigby (Center for the Study of Forgiveness and Reconciliation, Coventry U., England) investigates different approaches to "policing" the past, from mass purges ...

인간의 이성적 의식과 법의 관계를 밝히고 법의 해석 과 판단에 인간의 의식이 어떻게 작용하는가를 고찰 한 저술. 제1부에서는 법의 형이상학적인 측면에서 법의 실체, 그리스의 법, 데카르트의 법, 로크와 법, 칸트와 법, 헤겔과 법, 아담스미스의 법의 경제, 중국의 도덕과 법사상을 다루었다. 제2부에서는 심리학적 분석으로 헌법의 심리학적 해석, 법의 판결절차, 증거법, 형법과 죄, 청소년과 가족법, 조세법, 플라톤의 법, 칸트의 도덕론의 경험적 확인, 헤겔의 자아와 노동법, 법의 4차원에 대해 다뤘다.

This study of the Confessions engages with contemporary philosophers and psychologists antagonistic to religion and demonstrates the enduring value of Augustine's journey for those struggling with theistic incredulity and religious narcissism. Paul Rigby draws on current Augustinian scholarship and the works of Paul Ricœur to cross-examine Augustine's testimony. This analysis reveals the sophistication of Augustine's confessional text, which anticipates the analytical mindset of his critics. Augustine presents a coherent, defensible response to three age-old problems: free will and grace; goodness, (...) innocent suffering, and radical evil; and freedom and predestination. The Theology of Augustine's Confessions moves beyond commentary and allows present-day readers to understand the Confessions as its original readers experienced it, bridging the divide introduced by Kant, Hegel, Freud, Nietzsche, Heidegger, and their descendants. (shrink)

George Berkeley is one of the greatest and most influential modern philosophers. In defending the immaterialism for which he is most famous, he redirected modern thinking about the nature of objectivity and the mind's capacity to come to terms with it. Along the way, he made striking and influential proposals concerning the psychology of the senses, the workings of language, the aims of science, and the scope of mathematics. In this Companion volume a team of distinguished authors not only examines (...) Berkeley's achievements but also his neglected contributions to moral and political philosophy, his writings on economics and development, and his defense of religious commitment and religious life. The volume places Berkeley's achievements in the context of the many social and intellectual traditions - philosophical, scientific, ethical, and religious - to which he fashioned a distinctive response. (shrink)

This controversial book is an impassioned African response to the racial stereotyping of African people and people of African descent by prominent white scholars. It highlights how the media contributes to the growth of racist ideas, particularly in reporting current events in Africa, and demonstrates how some of America’s most revered intellectuals cloak racist ideologies in ostensibly egalitarian discourses. The author seeks to rewrite the image of 'race' in order to show the damage racism can cause serious scholarship.