Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

'You shouldn't drink too much. The Earth is round. Milk is good for your bones.' Are any of these claims true? How can you tell? Can you ever be certain you are right? For anyone tackling philosophical logic and critical thinking for the first time, Critical Thinking: An Introduction to Reasoning Well provides a practical guide to the skills required to think critically. From the basics of good reasoning to the difference between claims, evidence and arguments, Robert Arp and (...) Jamie Carlin Watson cover the topics found in an introductory course. Now revised and fully updated, this Second Edition features a glossary, chapter summaries, more student-friendly exercises, study questions, diagrams, and suggestions for further reading. Topics include: the structure, formation, analysis and recognition of arguments deductive validity and soundness inductive strength and cogency inference to the best explanation truth tables tools for argument assessment informal and formal fallacies With real life examples, advice on graduate school entrance exams and an expanded companion website packed with additional exercises, an answer key and help with real life examples, this easy-to-follow introduction is a complete beginner's tool set to good reasoning, analyzing and arguing. Ideal for students in basic reasoning courses and students preparing for graduate school. (shrink)

J. Willard Gibbs derived the following equation to quantify the maximum work possible for a chemical reaction$${\text{Maximum work }} = \, - \Delta {\text{G}}_{{{\text{rxn}}}} = \, - \left( {\Delta {\text{H}}_{{{\text{rxn}}}} {-}{\text{ T}}\Delta {\text{S}}_{{{\text{rxn}}}} } \right) {\text{ constant T}},{\text{P}}$$ Maximum work = - Δ G rxn = - Δ H rxn - T Δ S rxn constant T, P ∆Hrxn is the enthalpy change of reaction as measured in a reaction calorimeter and ∆Grxn the change in Gibbs energy as measured, if (...) feasible, in an electrochemical cell by the voltage across the two half-cells. To Gibbs, reaction spontaneity corresponds to negative values of ∆Grxn. But what is T∆Srxn, absolute temperature times the change in entropy? Gibbs stated that this term quantifies the heating/cooling required to maintain constant temperature in an electrochemical cell. Seeking a deeper explanation than this, one involving the behaviors of atoms and molecules that cause these thermodynamic phenomena, I employed an “atoms first” approach to decipher the physical underpinning of T∆Srxn and, in so doing, developed the hypothesis that this term quantifies the change in “structural energy” of the system during a chemical reaction. This hypothesis now challenges me to similarly explain the physical underpinning of the Gibbs–Helmholtz equation$${\text{d}}\left( {\Delta {\text{G}}_{{{\text{rxn}}}} } \right)/{\text{dT}} = - \Delta {\text{S}}_{{{\text{rxn}}}} \left( {\text{constant P}} \right)$$ d Δ G rxn / dT = - Δ S rxn constant P While this equation illustrates a relationship between ∆Grxn and ∆Srxn, I don’t understand how this is so, especially since orbital electron energies that I hypothesize are responsible for ∆Grxn are not directly involved in the entropy determination of atoms and molecules that are responsible for ∆Srxn. I write this paper to both share my progress and also to seek help from any who can clarify this for me. (shrink)

Robert Bass argues that the evidential problem of evil can be strengthened by the application of a Bayesian conditionalization argument. I argue that, whatever the merits of Bayesian conditionalization arguments, they are unsuccessful in substantiating the evidential problem of evil because the problem of evil doesn’t meet the necessary conditions for applying the formula informatively. I offer two examples to show that a successful application of the Bayesian formula must pass two tests, the competency test and the connection test. (...) I then show that the problem of evil passes neither, and is therefore not strengthened by the Bayesian analysis. I conclude that Bass’s reformulated argument poses no substantive threat to theism. (shrink)

Creationists have acquired a more sophisticated intellectual arsenal. This book reveals the insubstantiality of their arguments. Creationism is no longer the simple notion it once was taken to be. Its new advocates have become more sophisticated in how they present their views, speaking of "intelligent design" rather than "creation science" and aiming their arguments against the naturalistic philosophical method that underlies science, proposing to replace it with a "theistic science." The creationism controversy is not just about the status of Darwinian (...) evolution—it is a clash of religious and philosophical worldviews, for a common underlying fear among Creationists is that evolution undermines both the basis of morality as they understand it and the possibility of purpose in life. In Tower of Babel, philosopher Robert T. Pennock compares the views of the new creationists with those of the old and reveals the insubstantiality of their arguments. One of Pennock's major innovations is to turn from biological evolution to the less charged subject of linguistic evolution, which has strong theoretical parallels with biological evolution, both in content and in the sort of evidence scientists use to draw conclusions about origins. Of course, an evolutionary view of language does conflict with the Bible, which says that God created the variety of languages at one time as punishment for the Tower of Babel. Several chapters deal with the work of Phillip Johnson, a highly influential leader of the new Creationists. Against his and other views, Pennock explains how science uses naturalism and discusses the relationship between factual and moral issues in the creationism-evolution controversy. The book also includes a discussion of Darwin's own shift from creationist to evolutionist and an extended argument for keeping private religious beliefs separate from public scientific knowledge. (shrink)

_The Concept of Analytic Contact_ presents practitioners with new ways to assist the often severely disturbed patients that come to see them in both private and institutional settings. In this book Robert Waska outlines the use of psychoanalysis as a method of engagement that can be utilised with or without the addition of multiple weekly visits and the analytic couch. The chapters in this book follow a wide spectrum of cases and clinical situations where hard to reach patients are (...) provided with the best opportunity for health and healing through the establishment of analytic contact. Divided into four parts, this book covers: the concept of analytic contact caution and reluctance concerning psychological engagement drugs, mutilation, and psychic fragmentation clinical reality, psychoanalysis and the utility of analytic contact. Analytic contact is demonstrated to be a valuable clinical approach to working analytically with a complicated group of patients in a successful manner. It will be of great interest to all practitioners in the field of psychoanalysis and psychotherapy. (shrink)

Confusing clinical standoffs, loyalty to self-destruction and abrupt terminations are challenging and under-examined problems for the modern psychoanalytic practitioner. _The Danger of Change_ is a timely book that addresses the so-called resistant patient so many clinicians are familiar with. Robert Waska blends theory based on Melanie Klein’s classical stance with the more contemporary Freudian/Kleinian school, to demonstrate how to understand patients that are resistant to progress. Divided into four sections, this book covers: reluctant patients and the fight against change: (...) caught between the paranoid and depressive world greed and the dangers of change interruptions to the process of change: loss, envy, and the death instinct working toward change in the face of overwhelming odds Extensive and detailed clinical material is used to bring clarity to subjects including symbolism, conflict resolution, projective identification, the depressive and paranoid positions, change and trust. _The Danger of Change_ brings hope and clarity to cases involving patients who experience progress as a threat to their emotional wellbeing. It will be of great interest to all practising psychoanalysts, as well as those studying psychoanalytic theory and practice. (shrink)

Preface 9 PART I: RELIGIOUS, SCIENTIFIC, AND PHILOSOPHICAL BACKGROUND Introduction to Part I 19 1. The Bible 27 2. Natural Theology 33 William Paley 3. On the Origin of Species 38 Charles Darwin 4. Objections to Mr. Darwin’s Theory of the Origin of Species 65 Adam Sedgwick 5. The Origin of Species 73 Thomas H. Huxley 6. What Is Darwinism? 82 Charles Hodge 7. Darwinism as a Metaphysical Research Program 105 Karl Popper 8. Karl Popper’s Philosophy of Biology 116 Michael (...) Ruse 9. Human Nature: One Evolutionist’s View 136 Francisco Ayala 10. Universal Darwinism 158 Richard Dawkins PART II: CREATION SCIENCE AND THE McLEAN CASE Introduction to Part II 187 11. The Creationists 192 Ronald L. Numbers 12. Creation, Evolution, and the Historical Evidence 231 Duane T. Gish 13. Witness Testimony Sheet: McLean v. Arkansas Board of Education 253 Michael Ruse 14. United States District Court Opinion: McLean v. Arkansas Board of Education 279 Judge William R. Overton 15. The Demise of the Demarcation Problem 312 Larry Laudan 16. Science at the BarùCauses for Concern 331 Larry Laudan 17. Pro Judice 337 Michael Ruse 18. More on Creationism 345 Larry Laudan 19. Commentary: Philosophers at the BarùSome Reasons for Restraint 350 Barry R. Gross PART III: INTELLIGENT DESIGN CREATIONISM AND THE KITZMILLER CASE Introduction to Part III 369 20. But Isn’t It Creationism? The Beginnings of "Intelligent Design" in the Midst of the Arkansas and Louisiana Litigation 377 Nick Matzke 21. What Is Darwinism? 414 Phillip E. Johnson 22. Is It Science Yet? Intelligent Design, Creationism, and the Constitution 426 Matthew Brauer, Barbara Forrest, and Steven G. Gey 23. Kitzmiller v. Dover Area School District Expert Witness Testimony 434 Michael Behe 24. Kitzmiller v. Dover Area School District Expert Report 456 Robert T. Pennock 25. A Step toward the Legalization of Science Studies 485 Steve Fuller 26. What Is Wrong with Intelligent Design? 495 Elliott Sober 27. United States District Court Memorandum Opinion: Kitzmiller, et al. v. Dover Area School District, et al. 506 Judge John E. Jones II 28. Can’t Philosophers Tell the Difference between Science and Religion? Demarcation Revisited 536 Robert T. Pennock. (shrink)

An anthology of writings by proponents and critics of intelligent design creationism.

Responsible conduct of research training typically includes only a subset of the issues that ought to be included in science ethics and sometimes makes ethics appear to be a set of externally imposed rules rather than something intrinsic to scientific practice. A new approach to science ethics training based upon Pennock’s notion of the scientific virtues may help avoid such problems. This paper motivates and describes three implementations—theory-centered, exemplar-centered, and concept-centered—that we have developed in courses and workshops to introduce students (...) to this scientific virtue-based approach. (shrink)

An exploration of the scientific mindset—such character virtues as curiosity, veracity, attentiveness, and humility to evidence—and its importance for science, democracy, and human flourishing. Exemplary scientists have a characteristic way of viewing the world and their work: their mindset and methods all aim at discovering truths about nature. In An Instinct for Truth, Robert Pennock explores this scientific mindset and argues that what Charles Darwin called “an instinct for truth, knowledge, and discovery” has a tacit moral structure—that it is (...) important not only for scientific excellence and integrity but also for democracy and human flourishing. In an era of “post-truth,” the scientific drive to discover empirical truths has a special value. Taking a virtue-theoretic perspective, Pennock explores curiosity, veracity, skepticism, humility to evidence, and other scientific virtues and vices. He explains that curiosity is the most distinctive element of the scientific character, by which other norms are shaped; discusses the passionate nature of scientific attentiveness; and calls for science education not only to teach scientific findings and methods but also to nurture the scientific mindset and its core values. Drawing on historical sources as well as a sociological study of more than a thousand scientists, Pennock's philosophical account is grounded in values that scientists themselves recognize they should aspire to. Pennock argues that epistemic and ethical values are normatively interconnected, and that for science and society to flourish, we need not just a philosophy of science, but a philosophy of the scientist. (shrink)

Offering readings from 50 of the most eminent contributors to psychology, this text-reader represents the historical development of psychology from the Renaissance to the present. Contributors range from Descartes, Locke, Hume, Kant, and Darwin through Adler, Tolman, Guthrie, Hull, and Skinner. "Far and away the most concise and pedagogically useful book of its kind ever to appear." --Psychological Record.

In the 2005 Kitzmiller v Dover Area School Board case, a federal district court ruled that Intelligent Design creationism was not science, but a disguised religious view and that teaching it in public schools is unconstitutional. But creationists contend that it is illegitimate to distinguish science and religion, citing philosophers Quinn and especially Laudan, who had criticized a similar ruling in the 1981 McLean v. Arkansas creation-science case on the grounds that no necessary and sufficient demarcation criterion was possible and (...) that demarcation was a dead pseudo-problem. This article discusses problems with those conclusions and their application to the quite different reasoning between these two cases. Laudan focused too narrowly on the problem of demarcation as Popper defined it. Distinguishing science from religion was and remains an important conceptual issue with significant practical import, and philosophers who say there is no difference have lost touch with reality in a profound and perverse way. The Kitzmiller case did not rely on a strict demarcation criterion, but appealed only to a “ballpark” demarcation that identifies methodological naturalism (MN) as a “ground rule” of science. MN is shown to be a distinguishing feature of science both in explicit statements from scientific organizations and in actual practice. There is good reason to think that MN is shared as a tacit assumption among philosophers who emphasize other demarcation criteria and even by Laudan himself. (shrink)

According to J. L. Schellenberg’s argument from the reasonableness of nonbelief, the fact that many people inculpably fail to find sufficient evidence for the existence of God constitutes evidence for atheism. Schellenberg argues that since a loving God would not withhold the benefits of belief, the lack of evidence for God’s existence is incompatible with divine love. I argue that Schellenberg has not successfully defended his argument’s two controversial premises, that God’s love is incompatible with his allowing some to remain (...) in doubt that he exists, and that the nonbelief of some agnostics is inculpable. From the standpoint of what Christians believe about God, there are plausible reasons, which Schellenberg has not succeeded in refuting, for thinking that all nonbelief is culpable. I argue also that a loving God could have reasons remaining hidden to some persons, which are consistent with his desire to draw all people to faith. (shrink)

In the 2005 Kitzmiller v Dover Area School Board case, a federal district court ruled that Intelligent Design creationism was not science, but a disguised religious view and that teaching it in public schools is unconstitutional. But creationists contend that it is illegitimate to distinguish science and religion, citing philosophers Quinn and especially Laudan, who had criticized a similar ruling in the 1981 McLean v. Arkansas creation-science case on the grounds that no necessary and sufficient demarcation criterion was possible and (...) that demarcation was a dead pseudo-problem. This article discusses problems with those conclusions and their application to the quite different reasoning between these two cases. Laudan focused too narrowly on the problem of demarcation as Popper defined it. Distinguishing science from religion was and remains an important conceptual issue with significant practical import, and philosophers who say there is no difference have lost touch with reality in a profound and perverse way. The Kitzmiller case did not rely on a strict demarcation criterion, but appealed only to a “ballpark” demarcation that identifies methodological naturalism as a “ground rule” of science. MN is shown to be a distinguishing feature of science both in explicit statements from scientific organizations and in actual practice. There is good reason to think that MN is shared as a tacit assumption among philosophers who emphasize other demarcation criteria and even by Laudan himself. (shrink)

I consider what it might mean to teach creationism and offer a variety of educational, legal, religious, and philosophical arguments for why it is improper to teach it in public school science classes and possibly elsewhere as well. I rebut the standard creationist arguments for inclusion. I also rebut Rawlsian arguments offered by philosopher of religion Alvin Plantinga.

In his keynote address at a recent Intelligent Design (ID) conference at Biola University, ID leader William Dembski began by quoting "a well-known ID sympathizer" whom he had asked to assess the current state of the ID movement. Dembski explained that he had asked because, "after some initial enthusiasm on his part three years ago, his interest seemed to have flagged" (Dembski 2002). The sympathizer replied that..

The ATM protein kinase is centrally involved in the cellular response to ionizing radiation (IR) and other DNA double‐strand‐break‐inducing insults. Although it has been well established that IR exposure activates the ATM kinase domain, the actual mechanism by which ATM responds to damaged DNA has remained enigmatic. Now, a landmark paper provides strong evidence that DNA‐strand breaks trigger widespread activation of ATM through changes in chromatin structure.1 This review discusses a checkpoint activation model in which chromatin perturbations lead to the (...) conversion of inactive ATM domains to phosphorylated, active ATM monomers. The new findings underscore the critical importance of epigenetic events in genome function and surveillance in mammalian cells. BioEssays 25:627–630, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Key Words creation science, evolution education s Abstract Creationism, the rejection of evolution in favor of supernatural design, comes in many varieties besides the common young-earth Genesis version. Creationist attacks on science education have been evolving in the last few years through the alliance of different varieties. Instead of calls to teach “creation science,” one now finds lobbying for “intelligent design” (ID). Guided by the Discovery Institute’s “Wedge strategy,” the ID movement aims to overturn evolution and what it sees as (...) a pernicious materialist worldview and to renew a theistic foundation to Western culture, in which human beings are recognized as being created in the image of God. Common ID arguments involving scientific naturalism, “irreducible complexity,” “complex specified information,” and “icons of evolution,” have been thoroughly examined and refuted. Nevertheless, from Kansas to Ohio to the U.S. Congress, ID continues lobbying to teach the controversy, and scientists need to be ready to defend good evolution education. (shrink)

This book presents Cicero's natural law theory, including valuable definitions of the state, the ideal state, the ideal ruler, and the laws for the ideal state. Explanations are offered of the Greek sources of Cicero's republican philosophy, his influence on the Principate of Augustus, and his role in the development of modern political philosophy. As all the ages of the world have not produced a greater statesman and philosopher united than Cicero, his authority should have great weight (John Adams, 1787).

The philosophers of the Vienna circle once made quite a stir by proposing to show not merely that certain metaphysical propositions were false, but that metaphysical propositions as such were meaningless, except for a possible emotive or poetic significance. The manifesto of the group, the Wissenschaftliche Weltauffassung der Wiener Kreis, published in 1929, had it that the task of the adherent of the scientific world–outlook was “to clear out of the way the metaphysical and theological debris of the centuries.” A (...) non–metaphysical view of the nature of philosophy was subsequently propounded by the members of the circle in such essays as Schlick’s “Die Wende der Philosophie,” published in the first number of Erkenntnis in 1930, Carnap’s “Die alte und die neue Logik,” also published in the first issue of Erkenntnis, and his “Überwindung der Metaphysik durch logische Analyse der Sprach,” published in Erkenntnis in 1931. Ayer picked up the theme in his “Demonstration of the Impossibility of Metaphysics,” published in Mind in 1934, and in his Language, Truth, and Logic, published in 1935. Such radical interpretations of the nature of traditional metaphysics were highly provocative in philosophical circles for a decade. (shrink)

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1955.

That Intelligent Design Creationism rejects the methodological naturalism of modern science in favor of a premodern supernaturalist worldview is well documented and by now well known. An irony that has not been sufficiently appreciated, however, is the way that ID Creationists try to advance their premodern view by adopting (if only tactically) a radical postmodern perspective. This paper will reveal the deep threads of postmodernism that run through the ID Creationist movement’s arguments, as evidenced in the writings and interviews of (...) its key leaders. Seeing their arguments and activities from this perspective highlights the danger to science posed by both ID Creationism and radical postmodernism. (shrink)

_A resolute defense of philosophy and hermeneutics against the threats of dogmatism and relativism._.

The article examines the philosophical works of Ugo Perone. It explores the different aspects of temporality and spatiality inherent in Perone's understanding of time in the figure of threshold, and analyzes the notion of the so-called political present. Also investigated are the claims of Perone about the significance of politics and the public space on the human life.

The political does not exist. What exists is individual and collective life; there is nature, with its inexhaustible cycles; there is the world, the (blind and astute) interlacement of the actions, conflicts and visions that will become history. The political exists only as an invention: the invention of a specific space of the relation that intercepts life, modifies nature, and is a curvature of the world. I would like to dwell on this invention, not without warning that the political of (...) which one speaks precedes and constitutes specific kinds of politics, since it is the condition of their possibility. (shrink)