Resumo: O artigo parte do problema apontado por Michel Foucault na primeira aula do curso A Hermenêutica do sujeito, datada de 6/01/1982, a saber: o que se passa com o ser do sujeito em sua relação com a verdade? Para desenvolver tal indagação, o filósofo analisa, entre outros aspectos, saberes e práticas característicos da espiritualidade no período de ouro do cuidado de si (séculos I e II). Além de acompanhá-lo em parte desse percurso, pretendemos, com nosso texto, pôr em cena (...) as inflexões que ele implica tanto para o campo da psicologia como para o da formação de professores. Em ambos, é comum que emerjam polêmicas quanto às teorias a adotar como base para uma intervenção mais eficaz ou, preferencialmente, mais crítica. A diferenciação clássica entre ciências naturais e ciências humanas jamais se ausenta desse debate. O presente artigo adota caminho distinto, pois buscamos um modo de arrancar de nossas entranhas o momento cartesiano, arriscando-nos a adotar posturas antipsicologistas e eventualmente antiepistemológicas. Melhor dizendo, indagamos: como, na psicologia e na educação, a constituição de si por si mesmo pode se transformar em uma ética metodológica (ou metodologia ética) de trabalho? Palavras-chave: cuidado de si; espiritualidade; momento cartesiano; psicologia; educação Refusing the Cartesian model: How to equip oneself in psychology and education? Abstract: The present article starts from the problem pointed out by Michel Foucault in the first class of the course The Hermeneutics of the subjetict, dated 6/01/1982, namely: what happens to the being of the subject in its relation to truth? In order to develop this question, the philosopher analyzes, among other aspects, knowledge and practices characteristic of spirituality in the golden period of the care of the self (1st and 2nd centuries). Besides accompanying him in part, we intend, with our text, to put into scene the inflections that implies both for the field of psychology and for the field of teacher’s training. In both fields, it is common for polemics to emerge regarding the theories to be adopted as a basis for a more effective or, preferably, more critical intervention. The differentiation classic between natural sciences and human sciences is never absent from this debate. The present article adopts a different path, for seek a way to pull the Cartesian moment out of our guts, risking to adopt anti-psychological and eventually anti-epistemological postures. Better saying, we inquire how, in psychology and education, the constitution of the self for its own sake can become a methodological ethics (or ethical methodology) of work? Key-words: self-care; spirituality; Cartesian moment; psychology; education Rechazar el modelo cartesiano: ¿Cómo equiparse en psicología y educación? Resúmen: El artículo parte del problema señalado por Michel Foucault en la primera clase do curso La Hermenéutica del sujeto, realizada el 6/01/1982, a saber: ¿qué sucede con el ser del sujeto en su relación con la verdad? Para desarrollar esta cuestión, el filósofo analiza, entre otros aspectos, los conocimientos y las prácticas propias de la espiritualidad en el período de oro del cuidado del yo (siglos I y II). Además de acompañarlo en parte em el camino, nuestro texto pretende destacar las inflexiones que él implica tanto para el campo de la psicología como para el de la formación de maestros. En ambos, es común que surjan controversias en cuanto a las teorías que deben adoptarse como base para una intervención más eficaz o, preferiblemente, más crítica. La diferenciación clásica entre ciencias naturales y ciencias humanas nunca está ausente de este debate. El presente artículo adopta un camino diferente, ya que buscamos una forma de arrancar de dentro, el momento cartesiano, arriesgándonos a adoptar posturas antipsicológicas y, eventualmente antiepistemológicas. Mejor dicho, indagamos ¿cómo, en psicología y educación, la constitución del yo por sí mismo puede convertirse en una ética metodológica (o metodología ética) del trabajo? Palabras clave: cuidado de si; espiritualidad; momento cartesiano; psicología; educación Data de registro: 11/07/2022 Data de aceite: 26/10/2022. (shrink)

A DIGNIDADE DA PESSOA HUMANA E SEUS SUBPRINCÍPIOS.

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 − the “plunger” − pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex − the “barrel” − into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the “barrel” is an ATP-independent process, whereas extraction (...) of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model. The peroxin PEX5 is the peroxisomal matrix protein receptor. It shuttles between the cytosol and the organelle membrane, where it gets inserted into the docking/translocation module, thus pushing the cargo-protein into the peroxisome lumen. Resetting the system involves PEX5 monoubiquitination and its extraction from the membrane by the AAA-ATPases, PEX1/PEX6. (shrink)

(Spanish) RESUMEN: La libertad absoluta postulada por Viktor Emil Frankl y Jean-Paul Sartre, la Shoah y la creencia en un dios omnipotente, bueno y justo parecen contradecirse. La pregunta por el sentido del sufrimiento de las víctimas del Holocausto (la verdadera catástrofe, el mayor crimen contra la humanidad), simbolizado por Auschwitz, y como punto de inflexión en la historia, es terriblemente dolorosa y parece no tener una respuesta filosófica ni teológica. A mi juicio, es importantísimo distinguir entre las víctimas inocentes (...) de la Shoah que perecieron y las víctimas inocentes que sufrieron un verdadero infierno y perdieron a sus seres queridos, pero que lograron sobrevivir. Ambas son víctimas, por supuesto, pero así como encontrarle un posible sentido al sufrimiento de las víctimas masacradas y gaseadas podría suponer un insulto a su sufrimiento y agonía –en especial, al horror que sufrieron los niños–, el horrible sufrimiento de los supervivientes pudo dar, tal vez, de alguna manera, un sentido a sus vidas después de la liberación de los campos de concentración y exterminio, ya fuera como voz, como protesta o como simple supervivencia. Frankl apuesta por un sentido último (que abraza el sentido del sufrimiento de las víctimas), y Sartre, aunque parezca no apostar por sentido alguno, volcó su vida al compromiso político después de la Segunda Guerra Mundial, y ello parece vislumbrar una minúscula pizca de sentido después de la barbarie. La filosofía de Frankl es un sí a la vida incluso en las situaciones más extremas, un grito casi nietzscheano que exalta el valor de la vida más allá de cualquier sufrimiento. Frankl, padre de la logoterapia y superviviente del Holocausto, abre una puerta a Dios al hablar de un dios inconsciente, una dimensión suprahumana y una fe incondicional, y define la religión como espiritualidad y como la búsqueda del hombre por el sentido último. Según Frankl, la libertad no se contradice con Dios, y la religión existe no a raíz de la barbarie, sino a pesar de la barbarie. El existencialismo sartreano es una filosofía de la libertad radical y de la responsabilidad. El hombre está condenado a ser libre. El ser humano es un ser en el que la existencia precede a la esencia. Somos totalmente responsables de lo que somos. Sartre afirma que la libertad humana es incompatible con Dios. En un mundo sin Dios, la moral la construyen los hombres, con sus propias decisiones y sus acciones, y la existencia y el sufrimiento de las víctimas no tienen sentido alguno. Sartre define al hombre como libertad, responsabilidad, angustia y contingencia. Frankl define al hombre como libertad, responsabilidad, espiritualidad y búsqueda de sentido. Con esta tesis me propongo entrar en la resbaladiza dimensión del dolor, la desesperación, el sentido y sinsentido del sufrimiento de las víctimas (teniendo presente los horrores de Auschwitz, que en teología y filosofía ha simbolizado desde la liberación de los campos la muerte de Dios y la muerte de la moral). Es verdad que no solo los hombres, mujeres y niños judíos fueron víctimas de la barbarie alemana, pero, como reza el mensaje de Elie Wiesel en la exposición permanente del Block 27 del Auschwitz-Birkeanu State Museum: "Not all victims were Jewish in this place, but all Jews were victims". La Shoah no es un episodio dentro de la Segunda Guerra Mundial, sino un punto de inflexión en la historia de la humanidad, y es una catástrofe que nos concierne a todos, hombres y mujeres judíos y no judíos, religiosos e irreligiosos, creyentes e increyentes, como seres libres, responsables y morales que somos –o que deberíamos ser. Muchas de las víctimas del Holocausto, en medio de la desesperación, entraron en las cámaras de gas orando, aferrándose a la esperanza de que ese final espeluznante no era un punto final. Con esta tesis no me propongo de ninguna manera responder a la eterna pregunta de si Dios existe o no, sino que propongo interpretar ese grito hacia Dios como un desesperado anhelo de esperanza. También me propongo encontrar una coherencia en las posturas de estos dos grandes pensadores para quienes la libertad y la responsabilidad definen al hombre: Frankl (quien apuesta por una dimensión suprahumana donde existe un sentido último en el que el sufrimiento de las víctimas tiene que tener algún sentido, aunque ese sentido sea completamente incomprensible en la dimensión humana) y Sartre (el existencialista ateo por excelencia, para quien el mundo, la existencia y el sufrimiento son absolutamente contingentes). En el primer capítulo expongo la logoterapia y el existencialismo sartreano: describo las tres dimensiones del hombre y las tres búsquedas de sentido propuestas por Frankl, y expongo las cinco consecuencias de "l'existence précède l'essence", centrándome en la libertad y la responsabilidad, y hablo del suicidio. El segundo capítulo está dedicado al dios inconsciente frankleano, la dimensión suprahumana, la búsqueda por el sentido último y la fe incondicional. En el tercer capítulo ilustro la libertad sin Dios sartreana, la ontología sartreana, el ateísmo sartreano y el humanismo sartreano, y hablo sobre la responsabilidad, la mauvaise foi, la contingencia, la situation y la angustia. El cuarto capítulo es necesariamente histórico (sin dejar de ser filosófico): me pregunto por la muerte de Dios después de Auschwitz, argumento y defiendo la unicidad del Holocausto (la Shoah es un punto de inflexión en la historia de la humanidad), describo las masacres antes de los campos de exterminio (Einsatzgruppen, Ordnungspolizei y Wehrmacht), el gigantesco complejo de Auschwitz (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), reflexiono sobre Dios y el mal (centrándome en los niños de Auschwitz), describo los días de Frankl en Auschwitz, hablo de Dios como esperanza, de la inmortalidad y la escatología, de la crueldad de Dios, de la relación entre el cristianismo y el antisemitismo, del islam y el antisemitismo, critico el silencio de Dios, hablo de la muerte de Dios y del juicio contra Dios. En el quinto capítulo expongo la moral frankleana (una moral que atañe al hombre y no a Dios), basándome en su teoría del amor y en su única obra de teatro (Synchronisation in Binkerwald), y la moral sartreana (una moral que atañe a una humanidad sin Dios), recordando a Dostoyevsky, analizando la famosa cita de Garcin en Huis clos "L'enfer, c'est les Autres", criticando el marxismo de Sartre y cuestionando (con la mirada de Frankl y Sartre) el verso de Brecht "Erst kommt das Fressen, dann kommt die Moral"; al final del capítulo incluyo una reflexión propia y las críticas frankleana y sartreana sobre la impunidad de los verdugos y colaboradores después del Holocausto (con el permiso de Dios). Después de la Conclusión, añado un Apéndice sobre las vidas de Frankl y Sartre, para poder entender mejor su obra. PALABRAS CLAVE: logoterapia, existencialismo sartreano, búsqueda de sentido, libertad, responsabilidad, moral, angustia, sufrimiento, supervivientes, víctimas, contingencia, espiritualidad, religión, Dios, esperanza, antisemitismo, culpa, Auschwitz, Holocausto, Shoah. /// (English) ABSTRACT: The absolute freedom defended by Viktor Emil Frankl and Jean-Paul Sartre, the Shoah and the belief in an omnipotent, benevolent and just God seem to contradict each other. The question of the meaning of the victims' suffering of the Holocaust (the true catastrophe, the biggest crime against humanity), simbolised by Auschwitz and as a turning point in History, is terribly painful and doesn't seem to have an answer. In my opinion, it's crucial to distinguish between the innocent victims of the Shoah who perished and the innocent victims who sufferend a real hell and lost their loved ones, but managed to survive. Both are victims, of course, but just as finding a possible meaning to the suffering of the massacred and gassed victims could result in an insult to their suffering and agony –especially to the horror that the children suffered– the gigantic suffering of the survivors could, maybe, somehow, give a meaning to their lives after the liberation of the concentration and extermination camps, either as a voice, as a protest, or as a simple survival. Frankl believes in an ultimate meaning (that embraces the meaning of the victims' suffering), and Sartre, even if it appears not to embrace any meaning, turned his life to political engagement after War World II, and that attitude seems to give a tiny glimpse of meaning after the barbarity. Frankl's philosophy says yes to life even in the most extreme situations, and it's a Nietzschean-like scream that exalts the value of life beyond any monstrous suffering. Frankl, the father of logotherapy and a Holocaust survivor, opens a door to God when he talks about an unconscious God, a supra-human dimension and an unconditional faith; he defines religion as spirituality and as man's search for ultimate meaning. According to Frankl, freedom is not contradictory with God, and religion exists not because of the barbarity but in spite of the barbarity. Sartrean existentialism is a philosophy of radical freedom and responsibility. Men are condemned to be free. We are beings where the existence precedes the essence. We are completely responsible of what we are. Sartre argues that human freedom is incompatible with God. In a godless world, morality is constructed by people, with their own choices and actions, and human existence and the suffering of the victims don't have any meaning. Sartre defines man as freedom, responsibility, Angst and contingency. Frankl defines man as freedom, responsibility, spirituality and search for meaning. With this dissertation I attempt to enter in the slippery dimension of the pain, despair, meaning and meaninglessness of the victims' suffering (having in mind the horrors of Auschwitz, that in theology and in philosophy have simbolised, since the liberation of the camps, the death of God and the death of morality). It's true that not only Jewish men, women and children were victims of the German barbarity, but, as Elie Wiesel's message from the permanent exhibition from Block 27 of the Auschwitz-Birkeanu State Museum reads: "Not all victims were Jewish in this place, but all Jews were victims". The Shoah is not an episode inside War World II, but a turning point in the history of humankind, and a catastrophe that embraces us all, Jewish and not not Jewish men and women, religious and not religious, believers and not believers, as the free, responsible and moral beings that we all are –or that we should be. A lot of the victims, in the midst of their desperation, entered into the gas chambers praying, holding to the hope that their horrifying end was not the ultimate end. With this dissertation I do not attempt to answer the eternal question of the existence of God, rather, I will try to interpret that scream to God as a longing for hope. I also intend to find a coherence between the thought of these two great thinkers for whom freedom and responsibilty define man: Frankl (who argues that there is a suprahuman dimension where an ultimate meaning exists and where the victims' suffering has to have a meaning, even if this meaning is completely incomprehensible in the human dimension) and Sartre (the atheist existentialist par excellence, for whom the world, human existence and suffering are absolutely contingent). In the first chapter I expose logotherapy and Sartrean existentialism: I describe the three dimensions of man, the three searches for meaning, the five consequences of "l'existence précède l'essence" and I speak about suicide. The second chapter delves into the unconscious God, the supra-human dimension, the ultimate meaning and the unconditional faith. In the third chapter I expose the freedom without God defended by Sartre, Sartre's ontology, Sartre's atheism, Sartre's humanism, and his ideas about responsibility, mauvaise foi, contingency, situation, and Angst. The fourth chapter is necessarily historical (while being philosophical too): I wonder about the death of God after Auschwitz, I argue and defend the uniqueness of the Holocaust (the Shoah is a turning point in the history of humankind), I describe the massacres before the extermination camps (Einsatzgruppen, Ordnungspolizei y Wehrmacht), the gigantic Auschwitz camp complex (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), I reflect on God and evil (focusing on the children of Auschwitz), I describe Frankl's days in Auschwitz, I talk about God as hope, about immortality and escathology, I discuss God's cruelty, the relationship between Christianity and antisemitism and Islam and antisemitism, I question the silence of God, and I talk about the death of God and about the trial against God. In the fifth chapter I talk about the Franklean morality (a morality that concerns man and not God), on the basis of his love theory and his only work of theater (Synchronisation in Binkerwald), and the Sartrean morality (a morality that concerns a humanity without God), remembering Dostoyevsky, analysing Garcin's famous quote in Huis clos "L'enfer, c'est les Autres", crticizing Sartre's marxism and questioning (with Frankl's and Sartre's eyes) Brecht's verse "Erst kommt das Fressen, dann kommt die Moral"; at the end of the chapter I include my own reflection (and Frankl and Sartre's critique) about the impunity of the executioners and collaborators after the Holocaust (with God's permission). After the Conclusion, I add an Appendix about the lives of Frankl and Sartre, which helps understanding better their work. KEYWORDS: logotherapy, existentialism, search for meaning, freedom, responsibility, morality, Angst, suffering, survivors, victims, contingency, spirituality, religion, God, hope, antisemitism, guilt, Auschwitz, Holocaust, Shoah. (shrink)

O silêncio e a invisibilidade são as palavras que melhor representam a história da mulher no decorrer de muitos séculos. Desde a antiguidade, as mulheres foram impedidas de falar, e até nos dias atuais, infelizmente, pouco se valoriza o discurso feminino. Em diversas sociedades, o direito a expressar-se é severamente combatido, punido com rigor. A essas mulheres, vilipendiadas em seus direitos, resta um único espaço: o da subalternidade. Nesse contexto de subalternidade, habitando o espaço prisional marginal, fazer uso da (...) palavra e apropriar-se do direito à fala é um ato de coragem e de rebeldia. O presente artigo analisa o testemunho de uma mulher em situação de prisão que, até chegar ali, teve quase todos os seus direitos humanos profanados. A narrativa destaca suas experiências e traz à luz suas memórias e a maneira como dialoga com o passado. A partir da cela da prisão, a mulher produz o seu discurso, elabora o seu balbucio, que embora abafado, ultrapassa as grades e os altos muros. É através do poder de sua voz que ela reivindica o direito à fala, o direito de recontar-se, de falar de si. Neste artigo, analisamos, sob a perspectiva dos Estudos Culturais, a história narrada por VB1, uma mulher negra que cumpre pena em regime fechado. A partir desta análise, propomos uma reflexão sobre o espaço prisional, o direito à fala e o papel da memória nesse processo. Teremos como referências teóricas as identidades culturais em tempos de pós-modernidade com Stuart Hall, as reflexões sobre memória individual e coletiva de Maurice Halbwachs, estudos acerca da subalternidade com Hugo Achugar e Gayatri Spivak, espaço fronteiriço e memórias subalternas com Edgar Nolasco, reflexões sobre o papel da mulher propostas por Michele Perrot, entre outros. Palavras-chave: Subalternidade. Memorialística. Prisão. (shrink)

Este artigo busca elaborar em sua parte inicial uma visão panorâmica sobre a História Cultural, esclarecendo e discutindo alguns aspectos relacionados a esta modalidade da História. Na sua segunda parte, a História das Idéias é apresentada em suas relações dialógicas com a História Cultural e outras modalidades historiográficas. No decorrer do texto, são discutidos diversos dos conceitos envolvidos na perspectiva da História Cultural e da História das Idéias, a partir de uma produção historiográfica diversificada que se desenvolveu ao longo do (...) século XX. O artigo remete a obra recentemente publicada pelo autor deste texto, cujo principal objetivo é o de elaborar uma visão panorâmica das diversas modalidades da História nos dias de hoje. (shrink)

Este trabajo estudió la defensa del niño concebido aún no nato y el reconocimiento del no nacido en los casos que se trate de su bien en el ordenamiento jurídico venezolano. El objetivo general estuvo dirigido al examen del ordenamiento jurídico patrio en cuanto a las normas que salvaguardan la vida desde la concepción en el seno materno. Se trata pues de una investigación documental, en donde se analizó la doctrina nacional y foránea sobre la protección del no nacido, su (...) reconocimiento, además se tomó en cuenta lo establecido en el Catecismo de la Iglesia Católica y en el Compendio de la Doctrina Social de la Iglesia sobre el aborto y la defensa de la vida, también se analizaron las leyes nacionales que tratan sobre la materia objeto de estudio. Se concluyó que aunque el ordenamiento jurídico venezolano no expresa claramente la defensa de la vida desde el momento de su concepción, reconoce los derechos del no nacido cuando se trate de su bien; tomando esto en cuenta se hace un análisis extenso haciendo uso de la hermenéutica jurídica para determinar que la norma protege la vida del concebido puesto que el bien más preciado que tiene el hombre es el derecho a la vida. . (shrink)

En este escrito se presentan algunos desarrollos de la teoría política de John Rawls ahondando en aquellas categorías que permitan contrastar aspectos de los planteamientos rawlsianos con spectos del pensamiento utilitarista clásico. El propósito es discernir qué tan grande es la deuda que tienen pensadores contemporáneos como Rawls con autores clásicos del siglo XIX tales como Bentham y Mill.

In this paper we examine some proposals to disprove the hypothesis that the interaction between mind and matter causes the collapse of the wave function, showing that such proposals are fundamentally flawed. We then describe a general experimental setup retaining the key features of the ones examined, and show that even a more general case is inadequate to disprove the mind-matter collapse hypothesis. Finally, we use our setup provided to argue that, under some reasonable assumptions about consciousness, such hypothesis is (...) unfalsifiable. (shrink)

RESUMEN: La muerte del hombre anunciada por Foucault está en estrecha relación con la muerte de Dios anunciada por Nietzsche. El retorno del lenguaje conlleva la desaparición del hombre como figura cardinal del saber moderno. La historia es discontinua. Foucault dudó de las verdades de cada época y de las verdades intemporales. En este artículo trazo el recorrido del hombre en Les mots et les choses, mostrando la tensión entre el lenguaje y la desaparición del hombre, hablo de la discontinuidad (...) de la historia y los “jeux de vérité”, y muestro que Foucault se consideraba, por encima de todo, un pensador escéptico. / ABSTRACT: The death of man proclaimed by Foucault is in close relationship with the death of God proclaimed by Nietzsche. The return of language is linked with the disappearance of man. History is discontinuos. Foucault doubted the truths of each era as well as the timeless truths. In this article I present man’s journey in Foucault’s Les mots et les choses, showing the tension between language and the disappearance of man, I talk about historical discontinuity and the “jeux de vérité”, and I argue that Foucault considered himself, above all, a skeptical thinker. (shrink)

Constellations, Volume 28, Issue 4, Page 511-521, December 2021.

In this article, we apply deductive content analysis to the 100 most influential publications in the field of social entrepreneurship to identify the normative assumptions in SE scholarship. Using eight contemporary schools of thought in political philosophy as a template for analysis, we identify the philosophies underlying SE literature and the important consequences of their normative stances, such as: ambiguous concepts, justifications and critiques, and normative contradictions. Our study contributes to the SE literature by proposing that political philosophy can help (...) to identify what counts as the ‘social’ in SE. We are showing some of the field’s inherent normative tensions that could dampen its impact, and propose ways in which a normative awareness would help to establish a basis upon which to evaluate and demonstrate the social, economic, and cultural impact of SE. (shrink)

Como é possível extrair filosofia de um texto de quatro ou cinco páginas, arbitrariamente montado ao longo de mil anos de citações na Antiguidade, cujo tamanho original se desconhece, e suas partes, precariamente conectadas, juntam-se a partir de critérios e suposições tardias? Normalmente, nem se quer refletimos sobre questões desse tipo quando tratamos de estudar o pensamento de um autor, pois é comum que o estudo de um filósofo não passe pela história da obra em questão, quando e de que (...) forma ocorreu a transmissão do texto ao longo da história. No presente artigo, teceremos algumas considerações importantes que leitor não familiarizado com o Poema de Parmênides tem de ter para que evite cair em armadilhas e reproduza dogmaticamente interpretações convencionalmente estabelecidas. (shrink)

Phosphatidylinositol‐3‐kinases (PI3Ks) are lipid kinases that produce 3‐phosphorylated derivatives of phosphatidylinositol upon activation by various cues. These 3‐phosphorylated lipids bind to various protein effectors to control many cellular functions. Lipid phosphatases such as phosphatase and tensin homolog (PTEN) terminate PI3K‐derived signals and are critical to ensure appropriate signaling outcomes. Many lines of evidence indicate that PI3Ks and PTEN, as well as some specific lipid effectors are highly compartmentalized, either in plasma membrane nanodomains or in endosomal compartments. We examine the evidence (...) for specific recruitment of PI3Ks, PTEN, and other related enzymes to membrane nanodomains and endocytic compartments. We then examine the hypothesis that scaffolding of the sources (PI3Ks), terminators (PTEN), and effectors of these lipid signals with a common plasma membrane nanodomain may achieve highly localized lipid signaling and ensure selective activation of specific effectors. This highlights the importance of spatial regulation of PI3K signaling in various physiological and disease contexts. (shrink)

This paper is the result of reflections inspired by observing and participating in dancing sessions with children. Our experience of the latter led to the production of images that provoked a variety of questions, and invited us to think about the relationships between bodies, dance, and various forms of education. Among these questions were: what clues about the experience of human embodiment are given through observing children’s dance? What can children teach us through participating with them in this performative medium, (...) and what are its implications for education, most especially in light of our observations of children's inventiveness in this regard? Our impressions resonate and find expression in the oeuvre of Gilles Deleuze, Félix Guattari, Michel Foucault, Jan Masschelein and Manoel de Barros. Placing ourselves under their influence, we mobilized our thinking and opened ourselves to the emergent character of their ideas, resulting in what might be called a form of “dancing-writing” in which those two forms of expression interact. This dancing-writing is informed by and imbued with children’s lived experience: step by step, we walked the paths that they opened, recording as best we could their multisensorial approach to the world—gaze, taste, smell, sound, touch, movement. Ours was an experience of research on movement, with movement, in movement. As such, we harbor no intention to present final answers, but rather offer the reader an invitation to think philosophically and childishly. Ours is an invitation to dance with and among the questions which that very dance inspired. (shrink)

The connection between quantum physics and the mind has been debated for almost a hundred years. There are several proposals as to how quantum effects might be relevant to understanding consciousness, including von Neumann’s Consciousness Causes Collapse interpretation (CCC), Penrose’s Orchestrated objective reduction (Orch OR), Atmanspacher quantum emergence theory, or Vitiello’s field theory. In this paper, we examine the CCC, in particular Stapp’s theory of interaction of mind and matter, and discuss how this imposes constraints to possible brain structures. We (...) then argue that those constraints may allow us to identify a possible locus of the interaction between mind and matter, if CCC is true. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2017 Heft: 214 Seiten: 373-391.

Skipper and Millstein (2005) argued that existing conceptions of mechanisms failed to "get at" natural selection, but left open the possibility that a refined conception of mechanisms could resolve the problems that they identified. I respond to Skipper and Millstein, and argue that while many of their points have merit, their objections can be overcome and that natural selection can be characterized as a mechanism. In making this argument, I discuss the role of regularity in mechanisms, and develop an account (...) of stochastic (i.e., probabilistic) mechanisms. Explaining the phenomenon of adaptation through the mechanism of natural selection illustrates the power and flexibility of using mechanistic strategies to explain natural phenomena. (shrink)

Para Kant, os jogos desempenham um papel extremamente importante na vida humana, já que são responsáveis por colocarem o espírito em atividade e, ao fazê-lo, avivá-lo na direção da sociabilidade, da moderação e do refinamento. De acordo com suas Lições de pedagogia e de antropologia, os jogos não são uma mera distração, eles são uma ótima ferramenta para se aprender a viver. O objetivo deste artigo é o de, em um primeiro momento, recuperar alguns dados biográficos de Kant para aclarar, (...) à luz dos jogos, a dinamicidade subjacente à austeridade do cumprimento da famosa rotina do filósofo alemão e, em seguida, explorar conceitualmente o destaque que Kant dá aos jogos no processo de moralização da criança e do adulto. (shrink)

Quantum indistinguishability directly relates to the philosophical debate on the notions of identity and individuality. They are crucial for our understanding of multipartite quantum systems. Furthermore, the correct interpretation of this feature of quantum theory has implications that transcend fundamental science and philosophy, given that quantum indistinguishability is a resource in quantum information theory. Most of the conceptual analysis of quantum indistinguishability is restricted to studying the permutational invariance of quantum states, the concomitant quantum statistics and their entanglement. Here, we (...) analyse the role of indistinguishability and non-individuality in other areas of quantum theory. We start by analysing how a very peculiar use of indistinguishability underlies Feynman’s rules for summing amplitudes in interference phenomena. Next, we study how quantum indistinguishability is underestimated in several topics of debate in the quantum physics literature, such as the Einstein–Podolsky–Rosen argument, Bell’s inequalities and the Bell–Kochen–Specker theorem. Finally, we argue that an ontology of truly indistinguishable entities can serve as a basis for a quantum ontology that can give interesting answers to the interpretational problems of quantum mechanics. We claim that, in addition to superposition, contextuality and entanglement, indistinguishability (understood in a robust ontological sense) is one of the central features of quantum physics. -/- . (shrink)

Tentativa de estabelecer um monismo pulsional a partir do conceito nietzschiano de vontade de poder e o conceito freudiano de princípio de prazer. Nossa intenção é unificá-los na ideia de uma pulsão existencial originária, presente e efetivamente atuante em todos os processos existenciais – a pulsão de poder absoluto.

With the ratification of Multilateral Environmental Agreements the countries of the international community or of intentional communities—be they political, economic, financial, securitarian or strategic—endow these instruments of international cooperation with significant autonomy. From the 3550 dates of ratification of these MEAs recorded from 1979 to mid-September 2014, we produce a graph whose vertices are the 48 MEAs and whose links are induced by the succession of ratifications in time. On this basis we propose a diagnosis on the international acceptance of (...) this type of legal instruments and their vulnerability in a global context that builds on the change in the balance of powers as a result of globalization, the break of the bipolar and then unipolar system, and the rise of new powers. Thus, it appears that a global environmental order has been promoted and implemented with some success in the 90s mainly by liberal Western countries who were then able to lead other countries less likely to bind to the fulfillment of environmental obligations. However, the expansion of this global environmental order now seems frozen, due to the current crisis of multilateralism. The rise of many countries, particularly in the South, whose environmental, political and economic weight grew, confronted with the “stable community” formed in the past 35 years suggests that there is a real power shift in the international arena and consequently, multilateralism needs to reflect this new reality. In other terms, the global environmental order is being slowly reformed. As a consequence, the treaties formed clusters in the past but they did not follow the same pattern since the twenty-first century began. (shrink)

O filósofo alemão Hans Jonas dedica-se a questões que estão na agenda da discussão ética contemporânea. Sua teoria ético-metafísica, explicitada no livro O princípio responsabilidade: ensaio de uma ética para a civilização contemporânea retoma e amplia as indagações a respeito da relação existente entre homem e técnica na modernidade. O ponto de partida da sua tese é a afirmação de que as novas dimensões do agir humano - ocasionadas pela tecnologia - tornaram possível a realização de ações de grande impacto (...) tanto no globo terrestre quanto ao próprio homem. Questões como clonagem, manipulação genética, controle de comportamento, entre outras, mostram como a humanidade pode recriar um novo modelo humano. A partir destes pressupostos , este artigo concentra-se nas questões bioéticas mais especificamente no campo da medicina. Nossa pretensão é mostrar como Jonas propõe a aplicação de sua teoria moral na prática médica. (shrink)

O presente artigo tem por objetivo apresentar a relação entre biopolítica e nazismo à luz da obra de Michel Foucault e Giorgio Agamben. Para Foucault, o nazismo utilizou-se do racismo de Estado para proteger uma raça e legitimar a morte daqueles que representavam uma espécie de perigo biológico. Seguindo a mesma via, Agamben nos convida a refletir sobre os campos de concentração não como um fato histórico superado, mas como uma estrutura de poder que vem sendo cada vez mais utilizada (...) nas democracias contemporâneas, marcada pela vigência do estado de exceção e produção da vida nua.Palavras-chave: Foucault.Agamben.Biopolítica. Campo. AbstractThis article aims to present the relationship between biopolitics and Nazism in the light of the work of Michel Foucault and Giorgio Agamben. According to Foucault, Nazism used state racism to protect a race and legitimize the death of those who represented a kind of biological danger. Following the same path, Agamben invites us to reflect on the concentration camps not as an outdated historical fact, but as a power structure which has been increasingly used in contemporary democracies, marked by the validity of the state of exception and production of bare life.Keywords: Foucault. Agamben. Biopolitics. Field. ORCID https://orcid.org/0000-0003-1386-955X. (shrink)

A chegada e o estabelecimento da reflexão filosófica europeia no Brasil são indissociáveis do aristotelismo português trazido pelos jesuítas desde sua chegada ao então território colonial em 1549. A compreensão de determinados aspectos relacionados a este acontecimento não deve implicar na proposição de um fator determinista para a interpretação do modo como a filosofia é multiplamente tratada e pesquisada no país, mas certamente consiste em um fator imprescindível para a sua consideração. A argumentação a seguir visa indicar alguns aspectos ainda (...) presentes na forma segundo a qual a filosofia ainda é pensada entre nós. (shrink)

Le président Brésilien Luiz Ignacio Lula da Silva a assis son pouvoir sur sa personnalité et des origines populaires qui rompent toute idée de compromission avec les élites. Mais si sa personnalité lui permet de ne pas être une émmanation de son parti , il n'en est pas moins dépendant, pour l'entretien de son image, de celui-ci et des luttes opaques qui s'y déroulent .Brazilian President Luiz Inacio Lula da Silva has based its power on his personality and popular origins (...) that break any idea of ​​compromise with elites. But if his personality can not be a émmanation his party , it is no less dependent for the maintenance of its image, one opaque and struggles taking place. (shrink)

Philip Pettit sustenta que o neorrepublicanismo pode contribuir para o movimento feminista, visto que o seu princípio normativo central, o ideal de liberdade como ausência de dominação, pode ser amplamente utilizado na luta pela igualdade política, jurídica, social e cultural entre homens e mulheres. Com base em escritos de algumas autoras feministas, o artigo pretende discutir os limites da concepção neorrepublicana de liberdade, ao não considerar a dimensão social, cultural e estrutural da dominação masculina, para a causa feminista.

A intenção do artigo é examinar a reflexão de Algernon Sidney no que se refere ao direito de resistência do povo contra governos tirânicos. Amplamente discutido por autores das mais diversas vertentes políticas, o direito de resistência ocupou um lugar de destaque no debate jurídico, teológico e político no decorrer dos séculos XVI e XVII. Além dos tradicionais argumentos apresentados por huguenotes franceses, monarcômacos escoceses e defensores da causa parlamentar durante as guerras civis inglesas, a defesa de Sidney do direito (...) do povo de julgar, combater e depor tiranos é feita também com base em princípios republicanos, como o império da lei, o bem comum e, principalmente, a liberdade. (shrink)

Instances of negative causation—preventions, omissions, and the like—have long created philosophical worries. In this paper, I argue that concerns about negative causation can be addressed in the context of causal explanation generally, and mechanistic explanation specifically. The gravest concern about negative causation is that it exacerbates the problem of causal promiscuity—that is, the problem that arises when a particular account of causation identifies too many causes for a particular effect. In the explanatory context, the problem of promiscuity can be solved (...) by characterizing the phenomenon to be explained as a contrast between two or more events or non-events. This contrastive strategy also can solve other problems that negative causation presents for the leading accounts of mechanistic explanation. Along the way, I argue that to be effective, accounts of causal explanation must incorporate negative causation. I also develop a taxonomy of negative causation and incorporate each variety of negative causation into the leading accounts of mechanistic explanation. (shrink)

It is about analyzing the connection between just memory, narration and art, using an approach that mixes philosophy and visual arts. We will start from the perspective of the French philosopher Paul Ricoeur on fair memory, presented in his work Memory, History, Oblivion (2000), according to which there is an institutionalized ideologization of memory in which narrations are silenced or distorted by the so-called official history. In the process of recovering fair memory, these narratives need to be heard, recognized and (...) valued, deconstructing abusive mechanisms that silence them with the aim of producing oblivion or that manipulate them involve distorting the facts to benefit hegemonic discourses. Next, we will discuss how the myth of Brazilian racial democracy is an example of institutionalized ideologization of memory, considering mainly the reflections of Brazilian philosophy Sueli Carneiro in Device of raciality (2023). Finally, we will show how Elian Almeida's pictorial counter-narratives, especially the Vogue series (2020), work to strengthen and disseminate unofficial narratives about Brazil that have been suffocated by official history. (shrink)

Quelle est la tâche – plutôt que la contribution – de la philosophie à l’égard du langage? Dans cet article, il s’agit de revisiter la réponse de Paul Ricœur à cette question, à partir de son texte “Philosophie et langage.” Ricœur assigne à la philosophie la tâche de se réapproprier la triple médiation langagière: “chemin” du langage vers monde, “chemin” du langage vers le sujet et “chemin” du langage vers la communauté humaine. Partant de l’expérience concrète des sujets parlants, Ricœur (...) s’oppose à la clôture systémique présupposée par la conception structuraliste du langage, qui suspend la fonction de la référence dans la relation de signification. À partir d’une conception élargie de la référence – qui inclut la fonction poétique du langage –, le philosophe dégage de la notion de “monde du texte” la dimension ontologique constitutive du langage: dans sa fonction poétique, en effet, le langage révèle, selon lui, les possibilités multiples de notre mode d’existence. Nous montrons enfin que c’est à travers la notion d’attestation que Ricœur établit une connexion entre la réouverture de la triple médiation du langage et l’élaboration de cette nouvelle ontologie. (shrink)

O presente artigo visa problematizar a concepção de música proposta pelo filósofo Friedrich Schelling em sua obra ‘Filosofia da Arte’, na qual essa forma artística é concebida enquanto uma potência real do Absoluto. Desse modo, pretende-se apontar para o caráter inovador e peculiar da concepção schelliniana em contraste com a noção romântica de música absoluta, assim como situá-la dentro do panorama geral do sistema de identidades desenvolvido pelo autor. -/- This article aims to discuss the musical conception proposed by German (...) philosopher Friedrich Schelling in his work ‘Philosophy of Art’, which conceives music as a real potency (Potenz) of Absolute. Therefore, we intent to underlie the peculiar and original aspects of Schelling’s ideas as they are demonstrated by his philosophical system of identities, in contrast with the romantic notion of absolute music. (shrink)