BackgroundThe SARS-CoV-2 pandemic has highlighted once more the great need for comprehensive access to, and uncomplicated use of, pre-existing patient data for medical research. Enabling secondary research-use of patient-data is a prerequisite for the efficient and sustainable promotion of translation and personalisation in medicine, and for the advancement of public-health. However, balancing the legitimate interests of scientists in broad and unrestricted data-access and the demand for individual autonomy, privacy and social justice is a great challenge for patient-based medical research.MethodsWe therefore (...) conducted two questionnaire-based surveys among North-German outpatients (n = 650) to determine their attitude towards data-donation for medical research, implemented as an opt-out-process.ResultsWe observed a high level of acceptance (75.0%), the most powerful predictor of a positive attitude towards data-donation was the conviction that every citizen has a duty to contribute to the improvement of medical research (> 80% of participants approving data-donation). Interestingly, patients distinguished sharply between research inside and outside the EU, despite a general awareness that universities and public research institutions cooperate with commercial companies, willingness to allow use of donated data by the latter was very low (7.1% to 29.1%, depending upon location of company). The most popular measures among interviewees to counteract reservations against commercial data-use were regulation by law (61.4%), stipulating in the process that data are not sold or resold (84.6%). A majority requested control of both the use (46.8%) and the protection (41.5%) of the data by independent bodies.ConclusionsIn conclusion, data-donation for medical research, implemented as a combination of legal entitlement and easy-to-exercise-right to opt-out, was found to be widely supported by German patients and therefore warrants further consideration for a transposition into national law. (shrink)

The engineering-based approach of synthetic biology is characterized by an assumption that ‘engineering by design’ enables the construction of ‘living machines’. These ‘machines’, as biological machines, are expected to display certain properties of life, such as adapting to changing environments and acting in a situated way. This paper proposes that a tension exists between the expectations placed on biological artefacts and the notion of producing such systems by means of engineering; this tension makes it seem implausible that biological systems, especially (...) those with properties characteristic of living beings, can in fact be produced using the specific methods of engineering. We do not claim that engineering techniques have nothing to contribute to the biotechnological construction of biological artefacts. However, drawing on Descartes’s and Kant’s thinking on the relationship between the organism and the machine, we show that it is considerably more plausible to assume that distinctively biological artefacts emerge within a paradigm different from the paradigm of the Cartesian machine that underlies the engineering approach. We close by calling for increased attention to be paid to approaches within molecular biology and chemistry that rest on conceptions different from those of synthetic biology’s engineering paradigm. (shrink)

Multiple arousal theory suggests that there is more than one arousal system and that the activity of the multiple arousal systems can be observed using electrodermal measures at various body sites. The ideas expressed by multiple arousal theory are interesting but they do not constitute a theory. The absence of a specific definition of arousal and the lack of testable predictions prevent multiple arousal theory from constituting a useful theoretical framework for focussed empirical research.

This paper studies a decision maker who tackles a choice problem by selecting a subset of (at most) two alternatives which he will consider further in the second stage of his deliberation. We focus on the first stage where he chooses the delebration set. We axiomatize three types of procedures: (i) The top two: the decision maker has in mind an ordering and chooses the two maximal alternatives. (ii) The two extremes: the decision maker has in mind an ordering and (...) chooses the maximal and the minimal alternatives. (iii) The top and the top: the decision maker has in mind two orderings and he chooses the maximal elements. (shrink)

Foreword by Julian Assange............................................................................................. .. 4 Introduction........................................................................................ ................................. 5 Correspondence with Academic Journals........................................................................... 6..

In diesem Buch werden Aspekte der Aussagenlogik und der Prädikaten­ logik der ersten Stufe behandelt. Eine Mathematisierung und Kalkü­ lisierung der Logik kann natürlich ganz verschieden ausfallen, je nach dem, von welchen Motiven man sich primär leiten läßt. Wir stellen drei Gesichtspunkte, die uns auch als die wesentlichsten erscheinen, in den Vordergrund: Die Formalisierung des Wahrheits­ begriffes, die Formalisierung des Beweisbarkeitsbegriffes und das Problem des Suchens nach Beweisen. Diese drei Aspekte führen zu drei verschiedenen Arten von Kalkülen. Die Betonung des (...) Wahrheitsbegriffes führte auf die untersuchung der Hilberttypkalküle von einem Standpunkt, wie er etwa auch im Buch von Rasiowa-Sikorski [Ra-Si] eingenommen wird. Hierbei wurde besonderen Wert auf die algebraischen Techniken gelegt, denn die Natur der Vollständigkeitsbeweise in diesen Kalkülen läßt sich u. E. eigentlich nur algebraisch verstehen. Etwas überspitzt könnte man formulieren, daß die Vollständigkeitsbeweise in Hilberttypkal­ külen Korollare zu Betrachtungen über Kongruenzrelationen in ge­ wissen Boole'schen Algebren sind. Bei den modelltheoretischen Be­ trachtungen haben wir uns kurz ge faßt und nur einige grundlegende Begriffe vorgestellt. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

This workshop on stochastic theory and adaptive control assembled many of the leading researchers on stochastic control and stochastic adaptive control to increase scientific exchange and cooperative research between these two subfields of stochastic analysis. The papers included in the proceedings include survey and research. They describe both theoretical results and applications of adaptive control. There are theoretical results in identification, filtering, control, adaptive control and various other related topics. Some applications to manufacturing systems, queues, networks, medicine and other topics (...) are gien. (shrink)

This volume presents the proceedings of the workshop CSL '91 (Computer Science Logic) held at the University of Berne, Switzerland, October 7-11, 1991. This was the fifth in a series of annual workshops on computer sciencelogic (the first four are recorded in LNCS volumes 329, 385, 440, and 533). The volume contains 33 invited and selected papers on a variety of logical topics in computer science, including abstract datatypes, bounded theories, complexity results, cut elimination, denotational semantics, infinitary queries, Kleene algebra (...) with recursion, minimal proofs, normal forms in infinite-valued logic, ordinal processes, persistent Petri nets, plausibility logic, program synthesis systems, quantifier hierarchies, semantics of modularization, stable logic, term rewriting systems, termination of logic programs, transitive closure logic, variants of resolution, and many others. (shrink)

For decades, aesthetics has been subjected to a variety of critiques, often concerning its treatment of beauty or the autonomy of art. Collectively, these complaints have generated an anti-aesthetic stance prevalent in the contemporary art world. Yet if we examine the motivations for these critiques, Michael Kelly argues, we find theorists and artists hungering for a new kind of aesthetics, one better calibrated to contemporary art and its moral and political demands. Following an analysis of the work of Stanley (...) Cavell, Arthur Danto, Umberto Eco, Susan Sontag, and other philosophers of the 1960s who made aesthetics more responsive to contemporary art, Kelly considers Sontag's aesthetics in greater detail. In _On Photography_ (1977), she argues that a photograph of a person who is suffering only aestheticizes the suffering for the viewer's pleasure, yet she insists in _Regarding the Pain of Others_ (2003) that such a photograph can have a sustainable moral-political effect precisely because of its aesthetics. Kelly considers this dramatic change to be symptomatic of a cultural shift in our understanding of aesthetics, ethics, and politics. He discusses these issues in connection with Gerhard Richter's and Doris Salcedo's art, chosen because it is often identified with the anti-aesthetic, even though it is clearly aesthetic. Focusing first on Richter's Baader-Meinhof series, Kelly concludes with Salcedo's enactments of suffering caused by social injustice. Throughout _A Hunger for Aesthetics_, he reveals the place of critique in contemporary art, which, if we understand aesthetics as critique, confirms that it is integral to art. Meeting the demand for aesthetics voiced by many who participate in art, Kelly advocates for a critical aesthetics that confirms the limitless power of art. (shrink)

Michael Philips’ ‘Racist Acts and Racist Humor’ attempts to analyze the ethics of racism. At the heart of his discussion is the view that… “racist” is used in its logically primary sense when it is attributed to actions. All other uses of “racist” … must be understood directly or indirectly in relation to this one. Accordingly, racist beliefs are beliefs about an ethnic group used to “justify” racist acts, racist feelings are feelings about an ethnic group that typically give (...) rise to such acts, and racist epithets are the stings and arrows by means of which certain such acts are carried out. Books and films are said to be racist … if they perpetuate and stimulate racist beliefs or feelings. (shrink)

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 67 Heft: 2 Seiten: 211-231.

Richter begins with a set of counter examples to a position that he acknowledges is not important to me. He goes on to produce counter examples to a position I do not hold. And he concludes by imputing a project to me that I nowhere endorse and by ridiculing that project. Part of his confusion is my fault since what I have done is not entirely consistent with what I claimed to have done. So let me try to clarify (...) and to develop what I take to be valuable in my paper.To begin with, it was not my main intent to offer an account of the ordinary use of the term ‘racist’. Indeed, for reasons that will be dear presently, I now think that the attempt to provide such an account is misguided. Whether I have offered an account of what Richter calls a ‘central use’ depends on what he means by ‘central use.’ Judging from his proposed counter examples, he seems to hold that whatever satisfies the definition of a central use of some expression ‘e’ will be acknowledged by all competent speakers as a case of e.In this sense of ‘central use’ I have not offered an account of a central use of ‘racist’ either. What, then, have I done? (shrink)

Entscheidungen verweisen in einem begrifflichen Sinne auf Gründe. Entscheidungssysteme bieten eine probabilistische Verlässlichkeit als Rechtfertigung von Empfehlungen an. Doch nicht für alle Situationen mögen Verlässlichkeitsgründe auch angemessene Gründe sein. Damit eröffnet sich die Idee, die Güte von Gründen von ihrer Angemessenheit zu unterscheiden. Der Aufsatz betrachtet an einem Beispiel, einem KI-Lügendetektor, die Frage, ob eine (zumindest aktuell nicht gegebene) hohe Verlässlichkeit den Einsatz rechtfertigen kann. Gleicht er nicht einem Richter, der anhand einer Statistik Urteile fällen würde?

We explore the idea that eye-movement strategies in reading are precisely adapted to the joint constraints of task structure, task payoff, and processing architecture. We present a model of saccadic control that separates a parametric control policy space from a parametric machine architecture, the latter based on a small set of assumptions derived from research on eye movements in reading (Engbert, Nuthmann, Richter, & Kliegl, 2005; Reichle, Warren, & McConnell, 2009). The eye-control model is embedded in a decision architecture (...) (a machine and policy space) that is capable of performing a simple linguistic task integrating information across saccades. Model predictions are derived by jointly optimizing the control of eye movements and task decisions under payoffs that quantitatively express different desired speed-accuracy trade-offs. The model yields distinct eye-movement predictions for the same task under different payoffs, including single-fixation durations, frequency effects, accuracy effects, and list position effects, and their modulation by task payoff. The predictions are compared to—and found to accord with—eye-movement data obtained from human participants performing the same task under the same payoffs, but they are found not to accord as well when the assumptions concerning payoff optimization and processing architecture are varied. These results extend work on rational analysis of oculomotor control and adaptation of reading strategy (Bicknell & Levy, ; McConkie, Rayner, & Wilson, 1973; Norris, 2009; Wotschack, 2009) by providing evidence for adaptation at low levels of saccadic control that is shaped by quantitatively varying task demands and the dynamics of processing architecture. (shrink)

Published posthumously in 1908, Ecce Homo was written in 1888 and completed just a few weeks before Nietzsche’s complete mental collapse. Its outrageously egotistical review of the philosopher’s life and works—featuring chapters called Why I Am So Wise and Why I Write Such Good Books—are redeemed from mere arrogance by masterful language and ever-relevant ideas. In addition to settling scores with his many personal and philosophical enemies, Nietzsche emphasizes the importance of questioning traditional morality, establishing autonomy, and making a commitment (...) to creativity. Essential reading for students of philosophy, this unique memoir is crucial to an understanding of Nietzsche’s other works. (shrink)

Although Walter Benjamin's writings are considered to be among the most powerful theoretical enterprises of the twentieth century, his ideas are resistant to cooptation by the doctrines of various critical programs. These essays engage this resistance by examining the ghostly in Benjamin's work. The contributors show that the haunting truths Benjamin offers point towards new forms of responsibility. These truths reside in a figurative elsewhere, a ghostly space that his texts delimit but never fully inhabit, and these essays seek to (...) do justice to the ghosts of Benjamin. Issues explored include: the status of the image in Benjamin's literary reflections and in his meditations on cinema and visual culture; abiding Benjaminian notions of messianism, aura, reproducibility, semblance, and melancholy; Benjamin's relation to Freud; his innovative rethinking of history, virtuality, and translation; and his reflections on tragedy and prophecy, the geometrical dimensions of writing, and the relation between eros and language. (shrink)

Die gängigen Prognosen, nach denen die Religionen im Kontext der Moderne oder im Zuge der Globalisierung an Bedeutung verlieren würden, haben sich nicht bestätigt. Das Gegenteil ist der Fall: Jenseits von nihilistischen Entwürfen und virtuellen Konstruktionen öffneten sich auch und gerade in der Literatur Räume für die Belebung religiöser Weltsicht. Ausgehend von Heinrich Böll und seiner Anfang der 1960er Jahre eingeleiteten Distanzierung von der Institution Kirche, wird am Beispiel von Botho Strauß und Peter Handke, die seit den 1970er und 1980er (...) Jahren eine ins Metaphysische zielende Subjektivität repräsentieren, eine Renaissance des Religiösen konstatiert, die sich in den Werken des jüngeren Autors Ralf Rothmann seit den 1990er Jahren mit selbstbewusster Deutlichkeit fortschreibt. Anhand der geistesgeschichtlichen Trias Gnostizismus, Philosophie und Mystik nimmt die Verfasserin eine Fokussierung vor, die die ästhetischen Konzeptionen der Autoren deutlich werden lässt und sie zueinander in Beziehung setzt. (shrink)

Gerhard Richter's groundbreaking study argues that the concept of "afterness" is a key figure in the thought and aesthetics of modernity. It pursues questions such as: What does it mean for something to "follow" something else? Does that which follows mark a clear break with what came before it, or does it in fact tacitly perpetuate its predecessor as a consequence of its inevitable indebtedness to the terms and conditions of that from which it claims to have departed? Indeed, (...) is not the very act of breaking with, and then following upon, a way of retroactively constructing and fortifying that from which the break that set the movement of following into motion had occurred? The book explores the concept and movement of afterness as a privileged yet uncanny category through close readings of writers such as Kant, Kafka, Heidegger, Bloch, Benjamin, Brecht, Adorno, Arendt, Lyotard, and Derrida. It shows how the vexed concepts of afterness, following, and coming after shed new light on a constellation of modern preoccupations, including personal and cultural memory, translation, photography, hope, and the historical and conceptual specificity of what has been termed "after Auschwitz." The study's various analyses—across a heterogeneous collection of modern writers and thinkers, diverse historical moments of articulation, and a range of media—conspire to illuminate Lyotard's apodictic statement that "after philosophy comes philosophy. But it has been altered by the 'after.'" As Richter's intricate study demonstrates, much hinges on our interpretation of the "after." After all, our most fundamental assumptions concerning modern aesthetic representation, conceptual discourse, community, subjectivity, and politics are at stake. (shrink)