The first promising results from “streamlined,” minimal genomes tend to support the notion that these are a useful tool in biological systems engineering. However, compared with the speed with which genomic microbial sequencing has provided us with a wealth of data to study biological functions, it is a slow process. So far only a few projects have emerged whose synthetic ambition even remotely matches our analytic capabilities. Here, we survey current technologies converging into a future ability to engineer large‐scale biological (...) systems. We argue that the underlying synthetic technology, de novo DNA synthesis, is already rather mature – in particular relative to the scope of our current synthetic ambitions. Furthermore, technologies towards rationalizing the design of the newly synthesized DNA fragment are emerging. These include techniques to implement complex regulatory circuits, suites of parts on a DNA and RNA level to fine tune gene expression, and supporting computational tools. As such DNA fragments will, in most cases, be destined for operating in a cellular context, attention has to be paid to the potential interactions of the host with the functions encoded on the engineered DNA fragment. Here, the need of biological systems engineering to deal with a robust and predictable bacterial host coincides with current scientific efforts to theoretically and experimentally explore minimal bacterial genomes. (shrink)

According to Stalnaker’s Hypothesis, the probability of an indicative conditional, $\Pr(\varphi \rightarrow \psi),$ equals the probability of the consequent conditional on its antecedent, $\Pr(\psi | \varphi)$ . While the hypothesis is generally taken to have been conclusively refuted by Lewis’ and others’ triviality arguments, its descriptive adequacy has been confirmed in many experimental studies. In this paper, we consider some possible ways of resolving the apparent tension between the analytical and the empirical results relating to Stalnaker’s Hypothesis and we argue (...) that none offer a satisfactory resolution. (shrink)

abstract Even though much research has been devoted to studies of safety, the concept of safety is in itself under‐theorised, especially concerning its relation to epistemic uncertainty. In this paper we propose a conceptual analysis of safety. The paper explores the distinc‐tion between absolute and relative safety, as well as that between objective and subjective safety. Four potential dimensions of safety are discussed, viz. harm, probability, epistemic uncertainty, and control. The first three of these are used in the proposed definition (...) of safety, whereas it is argued that control should not be included in a reasonable definition of safety. It is shown that strictly speaking, an objective safety concept is not attainable. Instead, an intersubjective concept is proposed that brings us as close as possible to an objective concept. (shrink)

Mainstream moral theories deal with situations in which the outcome of each possible action is well-determined and knowable. In order to make ethics relevant for problems of risk and uncertainty, moral theories have to be extended so that they cover actions whose outcomes are not determinable beforehand. One approach to this extension problem is to develop methods for appraising probabilistic combinations of outcomes. This approach is investigated and shown not to solve the problem. An alternative approach is then developed. Its (...) starting-point is that everyone has a prima facie moral right not to be exposed to risk. However, this right can be overridden if the risk-exposure is part of an equitable system for risk-taking that works to the advantage of the individual risk-exposed person. (shrink)

Cost–benefit analysis (CBA) is much more philosophically interesting than has in general been recognized. Since it is the only well-developed form of applied consequentialism, it is a testing-ground for consequentialism and for the counterfactual analysis that it requires. Ten classes of philosophical problems that affect the practical performance of cost–benefit analysis are investigated: topic selection, dependence on the decision perspective, dangers of super synopticism and undue centralization, prediction problems, the indeterminateness of our control over future decisions, the need to exclude (...) certain consequences for moral reasons, bias in the delimitation of consequences, incommensurability of consequences, difficulties in defending the essential requirement of transferability across contexts, and the normatively questionable but equally essential assumption of interpersonal compensability. (Published Online July 31 2007). (shrink)

The AGM (Alchourrón-Gärdenfors-Makinson) model of belief change is extended to cover changes on sets of beliefs that are not closed under logical consequence (belief bases). Three major types of change operations, namely contraction, internal revision, and external revision are axiomatically characterized, and their interrelations are studied. In external revision, the Levi identity is reversed in the sense that one first adds the new belief to the belief base, and afterwards contracts its negation. It is argued that external revision represents an (...) intuitively plausible way of revising one's beliefs. Since it typically involves the temporary acceptance of an inconsistent set of beliefs, it can only be used in belief representations that distinguish between different inconsistent sets of belief. (shrink)

Empathy is an integral aspect of human existence. Without at least a basic ability to access others’ affective life, social interactions would be well-nigh impossible. Yet, recent studies seem to show that the means we have acquired to access others’ emotional life no longer function well in what has become our everyday business – technologically mediated interactions in digital spaces. If this is correct, there are two important questions: (1) What makes empathy for frequent internet users so difficult? and (2) (...) What can we do to alleviate the negative consequences? Correspondingly, the aim of this paper is twofold. First, we identify structural differences between offline and technologically mediated interactions that can explain why digital empathy is harder to achieve. Second, drawing on the literature on ‘situated affectivity,’ we consider the idea of modifying digital spaces in ways specifically designed to ‘scaffold’ empathy where our evolved mechanisms fail. Section 2 argues that empathy is requires interpreting the behavior of embodied subjects. Section 3 identifies three factors that are crucial for this interpretative endeavor: the empathizer’s affective repertoire, their perceptual input, and their background knowledge. Section 4 argues that technologically mediated interactions differ from face-to-face interactions with regard to these factors in ways which render our evolved empathy mechanisms less effective in the digital world. Section 5 introduces the idea that situational factors can serve as ‘empathic scaffolds,’ i.e., as ‘tools’ that can ‘shape’ people’s empathic reactions. Section 6 wraps up the main line of reasoning, responds to objections and invites further scholarship. (shrink)

In non-technical contexts, the word “risk” refers, often rather vaguely, to situations in which it is possible but not certain that some undesirable event will occur. In technical contexts, the word has many uses and specialized meanings. The most common ones are the following.

In order to explore the quantifiability and formalizability of uncertainty a wide range of uncertainties are investigated. They are summarized under eight main categories: factual, possibilistic, metadoxastic, agential, interactive, value, structural, and linguistic uncertainty. This includes both classical uncertainty and the uncertainties commonly called great, deep, or radical. For five of the eight types of uncertainty, both quantitative and non-quantitative formalizations are meaningful and available. For one of them (interactive uncertainty), only non-quantitative formalizations seem to be meaningful, and for two (...) (agential and structural uncertainty) neither quantitative nor non-quantitative formalization seems to be a useful approach. (shrink)

ABSTRACT Semi-revision is a mode of belief change that differs from revision in that the input sentence is not always accepted. A constructive approach to semi-revision is proposed. It requires an efficient treatment of local inconsistencies, which is more easily obtainable in belief base models than in belief set models. Axiomatic characterizations of two semi-revision operators are reported.

A definition of pseudoscience is proposed, according to which a statement is pseudoscientific if and only if it (1) pertains to an issue within the domains of science, (2) is not epistemically warranted, and (3) is part of a doctrine whose major proponents try to create the impression that it is epistemically warranted. This approach has the advantage of separating the definition of pseudoscience from the justification of the claim that science represents the most epistemically warranted statements. The definition is (...) used to explain why proponents of widely divergent criteria for the demarcation between science and pseudoscience tend to be in almost complete agreement on the particular demarcations that should presumably be based on these general criteria. (shrink)

It has been much debated whether epistemic relativism in academia, for instance in the form of social constructivism, the strong programme, deconstructionism, and postmodernism, has paved the way for the recent upsurge in science denial, in particular climate science denial. In order to provide an empirical basis for this discussion, an extensive search of the social science literature was performed. It showed that in the 1990s, climate science was a popular target among academic epistemic relativists. In particular, many STS scholars (...) used it as an allegedly clear example of claims by natural scientists that should be treated as mere social constructions, rather than as reports on the actual state of the natural world. A few connections between social constructivists and corporate science denialism were also uncovered, but the extent of such connections could not be determined. With few exceptions, the stream of criticism of climate science from academic relativists has dwindled since the 1990s. One reason for this seems to be that the contrarian position lost its attraction when it became associated with corporate and right-wing propagandists. (shrink)

This book provides a critical examination of how the choice of what to believe is represented in the standard model of belief change. In particular the use of possible worlds and infinite remainders as objects of choice is critically examined. Descriptors are introduced as a versatile tool for expressing the success conditions of belief change, addressing both local and global descriptor revision. The book presents dynamic descriptors such as Ramsey descriptors that convey how an agent’s beliefs tend to be changed (...) in response to different inputs. It also explores sentential revision and demonstrates how local and global operations of revision by a sentence can be derived as a special case of descriptor revision. Lastly, the book examines revocation, a generalization of contraction in which a specified sentence is removed in a process that may possibly also involve the addition of some new information to the belief set. (shrink)

Specified meet contraction is the operation defined by the identity where ∼ is full meet contraction and f is a sentential selector, a function from sentences to sentences. With suitable conditions on the sentential selector, specified meet contraction coincides with the partial meet contractions that yield a finite-based contraction outcome if the original belief set is finite-based. In terms of cognitive realism, specified meet contraction has an advantage over partial meet contraction in that the selection mechanism operates on sentences rather (...) than on temporary infinite structures (remainders) that are cognitively inaccessible. Specified meet contraction provides a versatile framework in which other types of contraction, such as severe withdrawal and base-generated contraction, can be expressed with suitably chosen properties of the sentential selector. (shrink)

A descriptor is a set of sentences that are truth-functional combinations of expressions of the form \ , where \ is a metalinguistic belief predicate and p a sentence in the object language in which beliefs are expressed. Descriptor revision ) is an operation of belief change that takes us from a belief set K to a new belief set \ where \ is a descriptor representing the success condition. Previously studied operations of belief change are special cases of descriptor (...) revision, hence sentential revision can be represented as \ , contraction as \ , multiple contraction as \ , replacement as \ , etc. General models of descriptor revision are constructed and axiomatically characterized. The common selection mechanisms of AGM style belief change cannot be used, but they can be replaced by choice functions operating directly on the set of potential outcomes . The restrictions of this construction to sentential revision ) and sentential contraction give rise to operations with plausible properties that are also studied in some some detail. (shrink)

A new formal model of belief dynamics is proposed, in which the epistemic agent has both probabilistic beliefs and full beliefs. The agent has full belief in a proposition if and only if she considers the probability that it is false to be so close to zero that she chooses to disregard that probability. She treats such a proposition as having the probability 1, but, importantly, she is still willing and able to revise that probability assignment if she receives information (...) that gives her sufficient reasons to do so. Such a proposition is undoubted, but not undoubtable. In the formal model it is assigned a probability 1 − δ, where δ is an infinitesimal number. The proposed model employs probabilistic belief states that contain several underlying probability functions representing alternative probabilistic states of the world. Furthermore, a distinction is made between update and revision, in the same way as in the literature on belief change. The formal properties of the model are investigated, including properties relevant for learning from experience. The set of propositions whose probabilities are infinitesimally close to 1 forms a belief set. Operations that change the probabilistic belief state give rise to changes in this belief set, which have much in common with traditional operations of belief change. (shrink)

An operator of contraction for a belief set (a theory) can be obtained by assigning to it a belief base and an operator of partial meet contraction for that base. It is argued that closure of the base under disjunction is an intuitively reasonable condition. Axiomatic characterizations are given of the contractions of belief sets that can be generated by (various types of) partial meet contraction on disjunctively closed bases. The corresponding revision operators are also characterized. Finally, some results are (...) reported on operations on bases that are closed under material implication. (shrink)

This is a reply to a comment by Kåre Letrud [Letrud, Kåre. 2019. “The Gordian Knot of Demarcation: Tying Up Some Loose Ends.” International Studies in the Philosophy of Science 32 : 3–11. doi:10...

Nietzsche’sEinverleibungas learning theory: Towards an integrated corporality in pedagogy and philosophy educationThe traditional distinction of Western philosophy between body and mind still permeates many contemporary pedagogical frameworks. In this article, I will reconstruct in Nietzsche’s philosophy the basis for a constructive pedagogical model that understands learners in an integrated way. The first part of this article will argue that this model ofembodiment(‘Einverleibung’) forms a learning theoretical foundation. In the second part, I will build on this Nietzschean learning theory in order (...) to re-evaluate specific contemporary pedagogical trends, a.o. Bloom’s taxonomy and competency-based education within the context of expertise development. Finally, I elaborate on the meaning of Nietzsche’s model of Einverleibung for a 21st century philosophy education thatembodiesan emancipatory and inclusive didactic. (shrink)

Different similarity relations on sets are introduced, and their logical properties are investigated. Close relationships are shown to hold between similarity relations that are based on symmetrical difference and operators of belief contraction that are based on relational selection functions. Two new rationality criteria for minimal belief contraction, the maximizing property and the reducing property, are proposed.

Available methods such as technology assessment and risk analysis have failed to predict the effects of technological choices. We need to give up the futile predictive ambitions of previous approaches and instead base decisions on systematic studies of alternative future developments. It will then be necessary to cope with mere possibility arguments, i.e., arguments in which a conclusion is drawn from a mere possibility that a course of action may have certain consequences. A five-step procedure is proposed for the assessment (...) of such arguments. It includes a search for mere possibility arguments pointing in different directions, a scientific evaluation that may lead to the specification or refutation of some of these arguments, two symmetry tests, evaluation of the seriousness of the arguments in terms of novelty, spatio-temporal unlimitedness and interference with complex systems, and hypothetical retrospection that aims at finding a course of action that will be defensible in retrospect. (shrink)

In 1974, a wonderful little book came out entitled Formal Philosophy: Selected Papers of Richard Montague, edited by Richmond H. Thomason. The book was a beautiful testimony to the fact that formal methods may indeed clarify, sharpen and solve philosophical problems, defusing airy philosophical intuitions in clear, crisp and concise ways while at the same time turning philosophical wonder into scientific inquiry.

Farmers all over the world perform experiments, and have done so since long before modern experimental science and its recognized forerunners. There is a rich anthropological literature on these experiments, but the philosophical issues that they give rise to have not received much attention. Based on the anthropological literature, this study investigates methodological and philosophical issues pertaining to farmers’ experiments, including the choice of interventions to be tested, the planning of experiments, and the use of control fields and other means (...) to deal with confounding factors. Farmers’ experiments have some advantages over the field trials of agricultural scientists, but also some comparative disadvantages. The two experimental traditions are complementary, and neither of them can replace the other. Several aspects of farmers’ experiments are shown to have a direct bearing on central topics in the philosophy of science. (shrink)

Farmers all over the world perform experiments, and have done so since long before modern experimental science and its recognized forerunners. There is a rich anthropological literature on these experiments, but the philosophical issues that they give rise to have not received much attention. Based on the anthropological literature, this study investigates methodological and philosophical issues pertaining to farmers’ experiments, including the choice of interventions to be tested, the planning of experiments, and the use of control fields and other means (...) to deal with confounding factors. Farmers’ experiments have some advantages over the field trials of agricultural scientists, but also some comparative disadvantages. The two experimental traditions are complementary, and neither of them can replace the other. Several aspects of farmers’ experiments are shown to have a direct bearing on central topics in the philosophy of science. (shrink)

Although it has often been claimed that all the information contained in second-order probabilities can be contained in first-order probabilities, no practical recipe for the elimination of second-order probabilities without loss of information seems to have been presented. Here, such an elimination method is introduced for repeatable events. However, its application comes at the price of losses in cognitive realism. In spite of their technical eliminability, second-order probabilities are useful because they can provide models of important features of the world (...) that are cognitively more plausible than those that can be obtained with single-level probabilities. (shrink)

A general theory of coherence is proposed, in which systemic and relational coherence are shown to be interdefinable. When this theory is applied to sets of sentences, it turns out that logical closure obscures the distinctions that are needed for a meaningful analysis of coherence. It is concluded that references to “all beliefs” in coherentist phrases such as “all beliefs support each other” have to be modified so that merely derived beliefs are excluded. Therefore, in order to avoid absurd conclusions, (...) coherentists have to accept a weak version of epistemic priority, that sorts out merely derived beliefs. Furthermore, it is shown that in belief revision theory, coherence cannot be adequately represented by logical closure, but has to be represented separately. (shrink)

Clinical Ethics, Ahead of Print. It could hardly be denied that healthcare should be patient-centred. However, some of the practices commonly described as patient-centred care may have ethically problematic consequences. This article identifies and discusses twelve ethical conflicts that may arise in the application of person-centred care. The conflicts concern e.g. privacy, autonomous decision-making, safeguarding medical quality, and maintaining professional egalitarianism as well as equality in care. Awareness of these potential conflicts can be helpful in finding the best way to (...) ensure that healthcare has its focus on the needs and interests of the patients. Patient-centred care may have to take different forms, depending of the nature of the disease, the patient’s life situation, and the economic, organizational and technological resources available to the healthcare unit. (shrink)

Research is subject to more stringent ethical requirements than most other human activities, and a procedure that is otherwise allowed may be forbidden in research. Hence, risk-taking is more restricted in scientific research than in most non-research contexts, and privacy is better protected in scientific questionnaires than in marketing surveys. Potential arguments for this difference are scrutinized. The case in its favour appears to be weak. A stronger case can be made in favour of a difference in the opposite direction: (...) If perilous or otherwise problematic activities have to be performed it is usually better to perform them in a research context where they are properly evaluated so that guidance is obtained for the future. However, retreating from current ethical demands on research is not a desirable direction to go. Instead, research ethics can serve to inspire the introduction of more stringent ethical principles in other social sectors. (shrink)

Mainstream risk analysis deviates in at least two important respects from the rationality ideal of mainstream economics. First, expected utility maximization is not applied in a consistent way. It is applied to endodoxastic uncertainty, i.e. the uncertainty (or risk) expressed in a risk assessment, but in many cases not to metadoxastic uncertainty, i.e. uncertainty about which of several competing assessments is correct. Instead, a common approach to metadoxastic uncertainty is to only take the most plausible assessment into account. This will (...) typically lead to risk-prone deviations from risk-neutrality. Secondly, risks and benefits for different persons are added to form a total value of risk. Such calculations are used to support the view that one should accept being exposed to a risk if it brings greater benefits for others. This is in stark contrast to modern Paretian welfare economics, that refrains from interindividual comparisons and does not require people to accept a disadvantage because it brings a larger advantage for others. (Published Online July 11 2006). (shrink)

An experiment, in the standard scientific sense of the term, is a procedure in which some object of study is subjected to interventions that aim at obtaining a predictable outcome or at least predictable aspects of the outcome. The distinction between an experiment and a non-experimental observation is important since they are tailored to different epistemic needs. Experimentation has its origin in pre-scientific technological experiments that were undertaken in order to find the best technological means to achieve chosen ends. Important (...) parts of the methodological arsenal of modern experimental science can be traced back to this pre-scientific, technological tradition. It is claimed that experimentation involves a unique combination of acting and observing, a combination whose unique epistemological properties have not yet been fully clarified. (shrink)

Two recent defences of the recovery postulate for contraction of belief sets are analyzed. It is concluded that recovery is defensible as a by-product of a formalization that is idealized in the sense of being simplified for the sake of clarity. However, recovery does not seem to be a required feature of the doxastic behaviour of ideal (perfectly rational) agents. It is reasonable to expect that there should be epistemic residues (remnants of rejected beliefs), but not that these should always (...) suffice to recover all the original beliefs if the discarded belief is reinstated. (shrink)

By replacement is meant an operation that replaces one sentence by another in a belief set. Replacement can be used as a kind of Sheffer stroke for belief change, since contraction, revision, and expansion can all be defined in terms of it. Replacement can also be defined either in terms of contraction or in terms of revision. Close connections are shown to hold between axioms for replacement and axioms for contraction and revision. Partial meet replacement is axiomatically characterized. It is (...) shown that this operation can have outcomes that are not obtainable through either partial meet contraction or partial meet revision. (shrink)

Our uncertainty about matters of fact can often be adequately represented by probabilities, but there are also cases in which we, intuitively speaking, know too little even to assign meaningful probabilities. In many of these cases, other formal representations can be used to capture some of the prominent features of our uncertainty. This is a non-technical overview of some of these representations, including probability intervals, belief functions, fuzzy sets, credal sets, weighted credal sets, and second order probabilities.

A value statement such as “she is a good teacher” is categoryspecified, i.e., the criteria of evaluation are specified as those that are applicable to a given category, in this case the category of teachers. In this study of categoryspecified value statements, certain categories are identified that cannot be used to specify value aspects. Special attention is paid to categories that are constituted by functional characteristics. The logical properties of value statements that refer to such categories are shown to differ (...) significantly from the corresponding properties in social choice theory. (shrink)

Science is praxis relevant to the extent that it guides goal-directed action by telling us how to act in order to achieve the goals. Investigations aiming at high praxis relevance are performed in various disciplines under names such as clinical trials, evaluation research, intervention research and social experiments. In this contribution, the notion of (direct) praxis relevance is delineated, and it is distinguished from related properties of science such as those of being applied and being practically useful in a wider (...) sense. Recommendations for the achievement of praxis relevance are offered in the form of five principles: the prerogative of direct experiments, minimized theory-induced uncertainty, multiple approximations, causal chain decomposition and successive improvements. (shrink)

Safety is an essential ethical requirement in engineering design. Strategies for safe design are used not only to reduce estimated probabilities of injuries but also to cope with hazards and eventualities that cannot be assigned meaningful probabilities. The notion of safe design has important ethical dimensions, such as that of determining the responsibility that a designer has for future uses (and misuses) of the designed object.