During the course of evolution, variations of a protein sequence is an ongoing phenomenon however limited by the need to maintain its structural and functional integrity. Deciphering the evolutionary path of a protein is thus of fundamental interest. With the development of new methods to visualize high dimension spaces and the improvement of phylogenetic analysis tools, it is possible to study the evolutionary trajectories of proteins in the sequence space. Using the data-driven high-dimensional scaling method, we show (...) that it is possible to predict and represent potential evolutionary trajectories by representing phylogenetic trees into a 3D projection of the sequence space. With the case of the aminodeoxychorismate synthase, an enzyme involved in folate synthesis, we show that this representation raises interesting questions about the complexity of the evolution of a given biological function, in particular concerning its capacity to explore the sequence space. (shrink)

I consider recent uses of the notion of neutrality in evolutionary biology and ecology, questioning their relevance to the kind of explanation recently labeled ‘topological explanation’. Focusing on fitness landscapes and genotype-phenotype maps, I explore the explanatory uses of neutral subspaces, as modeled in two perspectives: hyperdimensional fitness landscapes and RNA sequence-structure maps. I argue that topological properties of such spaces account for features of evolutionary systems: respectively, capacity for adaptive evolution toward global optima and mutational robustness of genotypes. (...) Thus many models appealing to “neutral” manifolds provide topological alternatives to hypothetical mechanisms. (shrink)

Human behavior unfolds primarily in built environments, where the arrangement of objects is a result of ongoing human decisions and actions, yet these organizational decisions have received limited experimental study. In two experiments, we introduce a novel paradigm designed to explore how individuals organize task-relevant objects in space. Participants completed goals by locating and accessing sequences of objects in a computer-based task, and they were free to rearrange the positions of objects at any time. We measure a variety of (...) organization changes and evaluate how these measures relate to individual differences in performance. In Experiment 1, we show that with weak structure in task demands, changes in object positions that arise through performance of the task lead to improved order, characterized predominantly by a centralization of frequently used items and a peripheralization of infrequently used objects. In Experiment 2, with increased task structure, we observe more refined organizational tendencies, with selective contraction and clustering of interrelated task-relevant objects. We further demonstrate that these more selective organization behaviors are reliably associated with individual differences in task performance. Collectively, these two studies reveal properties of space and of task demands that support and facilitate effective organization of the environment in support of ongoing behavior. (shrink)

This paper studies the metric structure of the space Hr of absolutely summable sequences of real numbers with at most r nonzero terms. Hr is complete, and is located and nowhere dense in the space of all absolutely summable sequences. Totally bounded and compact subspaces of Hr are characterized, and large classes of located, totally bounded, compact, and locally compact subspaces are constructed. The methods used are constructive in the strict sense. MSC: 03F65, 54E50.

We must understand that with the possibility of commercial space travel on our horizon, it comes with a number of significant practical and moral challenges. This volume provides the first comprehensive and unifying analysis concerning the rise of private space exploration, with a view toward developing policy that may influence real-world decision making. The plethora of questions demanding serious attention - privatisation and commercialisation, the impact on the environment, health futures, risk assessment, responsibility and governance - are (...) directly addressed in this scholarly work. (shrink)

New discoveries about materials and solar energy raise the possibility of a long-tenn shift of mining, refining, and manufacturing from Earth’s surface to locations outside Earth’s ecosphere, allowing Earth to begin to relax back toward its natural state. A little-discussed ambivalence toward the potential of space exploration exists among environmentalists. One camp sees it as a human adventure that may allow a bold initiative to improve Earth; another camp shies away from “heavy technology” and thus distrusts efforts as (...) massive as space exploration or utilization. Due to impending resource depletion on Earth, we may have only until the mid-twenty-first century to pursue the promising potential of space exploration to alleviate environmental problems of Earth. Subsequently, there may be too litde industlial base to support vigorous exploration and exploitation of resources in space. (shrink)

A multidisciplinary collection which brings together cutting edge research about the cultural politics of space.

This book aims to contribute significantly to the understanding of issues of value which repeatedly emerge in interdisciplinary discussions on space and society. Although a recurring feature of discussions about space in the humanities, the treatment of value questions has tended to be patchy, of uneven quality and even, on occasion, idiosyncratic rather than drawing upon a close familiarity with state-of-the-art ethical theory. One of the volume's aims is to promote a more robust and theoretically informed approach to (...) the ethical dimension of discussions on space and society. While the contributions are written in a manner which is accessible across disciplines, the book still withstands scrutiny by those whose work is primarily on ethics. At the same time it allows academics across a range of disciplines an insight into current approaches toward how the work of ethics gets done. The issues of value raised could be used to inform debates about regulation, space law and protocols for microbial discovery as well as longer-range policy debates about funding. (shrink)

This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.

There is copious scientific and technical literature analysing the issues of the environmental threat to orbital space. There is also now increasing legal awareness of the problems facing the space environment. These inquiries almost always focus on solutions based on processes, technology or providing sufficient alarm to jolt the international community into action. This discussion will adopt a different focus, providing an overview of the value system that is currently in place regarding human space activity and examining (...) how this value system has shaped normative ethical positions on space exploration. The inquiry will consider whether the values of space exploration have been sufficiently concerned with the environmental impact of such activity and whether it is possible to generate the consensus needed to embed an ethical approach to space exploration. It is contended that only through embedding a concern for the environment at the core of human space activity will there be an enduring solution to the crisis posed by debris in Earth orbit. By promoting conservative consumption of outer space resources, such an embedded concern would become a natural process in space activity rather than a chastisement or limit progress. More crucially, such an overarching ethical position would ensure that the problems which have affected Earth orbit will not be exported when human space exploration leads to settlement on other celestial bodies. The inquiry will start by examining the evolving nature of space activity, looking at the predominantly military backdrop to the early years of exploration. During these early years, the challenge of simply getting into space overrode any environmental consideration. More significantly, there was not the diversity of entities looking to go into orbit meaning that the amount of debris was limited, thereby softening concern. Space activity during this time was largely limited to two superpowers, Russia and America. Inevitably, this geopolitical situation shaped the law that was to govern space activity, and this is the law which has shaped normative behaviour in space. Indeed, had space remained the purview of States, environmental damage may have been significantly reduced, making it easier to regulate. This development is crucial to understanding the way in which shared human values have evolved, but is only part of the picture. Following this, the different generations of space travellers will be studied allowing for an evaluation of how their competing interests and backgrounds have shaped the value systems underpinning the exploration of space. The discussion will then go on to review the emerging body of literature discussing ethical approaches to space and establish the extent to which ethical values have shifted to match the diversity of actors in the space environment. There will then be a critique of how the change in the global space environment has necessitated a change in environmental governance, and whether this has actually occurred. Finally, the discussion will conclude with suggestions as to the way in which legal devices can be used to shape behaviours and begin the process of embedding a much-needed environmental ethic into space activity. (shrink)

This volume provides a rigorous philosophical investigation of the rationales, challenges, and promises of the coming Space Age. Over the past decade, space exploration has made significant and accelerating progress, and its potential has attracted growing attention from science, states, businesses, innovators, as well as the media and society more generally. However, philosophical theorizing concerning the premises, values, meanings, and impacts of space exploration is still in its infancy, and this potentially immense field of study (...) is far from mainstream yet. This book advances outer space philosophy by integrating key scientific and societal debates sparked by recent developments in space research and activities with conceptual, existential, ethical, aesthetic, and political themes and concerns. It maps various regions of philosophical exploration, reflection, and speculation regarding humanity's present and future irradiation into outer space, to promote a broad, rich, and nuanced societal debate regarding this transformative enterprise, which is as stimulating as it can be disorienting. This book will be a fascinating philosophical and ethical exploration for academics, researchers and students interested in philosophy, space studies, science and technology studies, future studies, and sustainability. (shrink)

Enzyme engineering allows to explore sequence diversity in search for new properties. The scientific literature is populated with methods to create enzyme libraries for engineering purposes, however, choosing a suitable method for the creation of mutant libraries can be daunting, in particular for the novices. Here, we address both novices and experts: how can one enter the arena of enzyme library design and what guidelines can advanced users apply to select strategies best suited to their purpose? Section I is (...) dedicated to the novices and presents an overview of established and standard methods for library creation, as well as available commercial solutions. The expert will discover an up‐to‐date tool to freshen up their repertoire (Section I) and learn of the newest methods that are likely to become a mainstay (Section II). We focus primarily on in vitro methods, presenting the advantages of each method. Our ultimate aim is to offer a selection of methods/strategies that we believe to be most useful to the enzyme engineer, whether a first‐timer or a seasoned user. (shrink)

This paper offers an analysis of the ethical values that have accompanied human exploration of space so far, and emphasizes the need to infuse human space activity with new ethical values by means of new and well-constructed legislation. One of the values that we deem particularly important in the creation of a new approach towards space exploration is care for the natural environment, including the space environment.

In his article, “Should Space Travel be Human or Robotic? Reasons for and against full automation for space missions,” Maurizio Balistreri explores the ongoing debate regarding whether space travel, exploration, and extra-terrestrial colonization should be the domain of humans or robots. Balistreri explores both technical and normative arguments for why extraterrestrial ventures ought to be wholly robotic or human, ultimately taking no explicit side in the debate. However, in this article we argue that by even posing (...) the question in this binary fashion, Balistreri and others are making a mistake at the outset. We show that there are certain missions and aims which require humans and others that plausibly may be undertaken solely by robots, but for all missions and aims there is likely to be some degree of human-robot pairing. More than this, we show that the question should not be whether space travel, exploration, or extra-terrestrial colonization ought to be generally human-centric or robot-centric, but rather that each and every mission should be examined on its own, as the values and disadvantages of humans versus robots are apt to be highly specific to the realities of particular discrete missions. (shrink)

The work and ideas of Rudolf Laban, dancer, choreographer and seminal theoretician of movement and dance, have had a profound impact across a range of disciplines. This book explores this impact.

The moral obligation to support space exploration follows from our obligations to protect the environment and to survive as a species. It can be justified through three related arguments: one supporting space exploration as necessary for acquiring resources, and two illustrating the need for space technology in order to combat extraterrestrial threats such as meteorite impacts. Three sorts of objections have been raised against this obligation. The first are objections alleging that supporting space (...) class='Hi'>exploration is impractical. The second is the widely held notion that space exploration and environmentalism are at odds with one another. Finally, there are two objections to using space resources that Robert Sparrow has raised on the topic of terraforming. The obligation to support space exploration can be defended in at least three ways: (1) the "argument from resources," that space exploration is useful for amplifying our available resources; (2) the "argument from asteroids," that space exploration is necessary for protecting the environment and its inhabitants from extraterrestrial threats such as meteorite impacts; and (3) the "argument from solar burnout," that we are obligated to pursue interstellar colonization in order to ensure long-term human survival. (shrink)

Mounting ambitions and capabilities for public and private, non-government sector crewed space exploration bring with them an increasingly diverse set of space travelers, raising new and nontrivial ethical, legal, and medical policy and practice concerns which are still relatively underexplored. In this piece, we lay out several pressing issues related to ethical considerations for selecting space travelers and conducting human subject research on them, especially in the context of non-governmental and commercial/private space operations.

Human space exploration requires massive budgets every fiscal year. Especially under severe financial constraint conditions, governments are forced to justify to society why spending so much tax revenue for human space exploration is worth the cost. The value of human space exploration might be estimated in many ways, but its social significance and cost-effectiveness are two key ways to gauge that worth. Since these measures should be applied country by country because sociopolitical conditions differ (...) in each country and must be taken into consideration, the study on the social significance of human space exploration must take the coloration of a case-study. This paper, focusing on the case of Japan with surveying Japanese literary and national documents as well as taking its sociopolitical conditions into account, examines the social significance of human space exploration. -/- First, we give an overview of the circumstances surrounding Japan's human space exploration program. Derived from the statements of such relevant parties as scholars, journalists, policy makers, and astronauts, this overview indicates that the main concerns about human space exploration in Japan are its social significance and cost-effectiveness (Section 1). Next, an overview of behavioral science—an essential field for human space exploration (referred to in this paper as space behavioral science) that provides support for astronauts—is presented from the perspective of stress research in isolated and confined environments (Section 2). We then give two examples of where such knowledge from space behavioral science research has been applied to terrestrial isolated and confined environments. One is JAXA’s support in 2009 for people who were vulnerable to infection by a new strain of flu and accordingly placed in an isolated and confined facility under the Infectious Disease Law and the Quarantine Law. The other is NASA's support in 2010 for Chilean mine workers who were trapped 700 m underground after a mining accident (Section 3). Based on these case studies, we illustrate the further social utility of such knowledge through a discussion of potential applications in other situations in Japan. Focusing on Japan for its geographical and social features in being an earthquake-prone archipelago and having the world's preeminent aging society, we show that refugees living in evacuation centers and people in an elderly-elderly homecare situation pose socially problematic situations specific to Japan. We then argue that space behavioral scientific knowledge can be applied to support people under these and other isolated and confined environments in various ways (Section 4). Finally, we demonstrate that such an application can be understood as an ethical contribution to Japanese society and that this contribution can be embedded in Japan's space policy (Section 5). We conclude that human space exploration can be a socially significant and cost-effective endeavor that is worthy of tax revenue expenditures because space behavioral science is highly likely to provide unique and useful knowledge to help address various social problems concerning terrestrial isolated and confined environments and support people in sufferings there. (shrink)

Review of James S. J. Schwartz and Tony Milligan, eds.: The Ethics of Space Exploration.

Drawing from the varieties of capitalism theoretical framework, the study explores the home country influences of multinational corporations on their corporate social responsibility practices when they operate outside their national/regional institutional contexts. The study focusses on a particular CSR practice of seven MNCs from three varieties of capitalism – coordinated, mixed and liberal market economies – operating in the oil and gas sector of the Nigerian economy. The study concludes that the corporate codes of conduct of these MNCs operating in (...) Nigeria, to a large extent, reflect the characteristics of their home countries' model of capitalism, respectively, albeit with certain degree of modifications. The home countries' model of capitalism is also found to have implications for the degree of adaptability of these MNCs' CSR practices to the Nigerian institutional context – with the mixed market economy model of capitalism adapting more flexibly than the liberal and coordinated market economies, respectively. The findings of this study will contribute to the emerging literature on the institutional embeddedness of CSR practices in transnational social spaces, understanding of varieties of capitalism, and CSR in developing economies. (shrink)

The field of Astroethics addresses moral and societal issues arising out of speculation regarding terrestrial contact with extraterrestrial life in both its intelligent and non-intelligent forms. This chapter tackles 15 ethical quandaries, 12 of which are associated with space exploration within the solar system plus 3 with exoplanet communication. Within our solar ghetto, scientists expect at best to find only microbial life, leaving intelligent life to exoplanets elsewhere in our galaxy. The intra-solar system quandaries are these: What does (...) planetary protection mean? Does microbial life have intrinsic value? Should space explorers invoke the Precautionary Principle? Should we clean up our space junk? What should we do about satellite surveillance? Should we weaponize space? Should scientific research take priority over commercial space ventures? Should we terraform Mars? Should we colonize Mars? Should we prepare for bombardment of Earth by asteroids? Should we rely upon a single planetary community of moral deliberation? Should we pursue the good of the galactic commons? The extra-solar quandaries deal with three degrees of extraterrestrial intelligent creatures: those with less intelligence than us Homo sapiens, our Extraterrestrial Intelligent creatures peers in intelligence, and ETI who are superior to us in intelligence. To each quandary we ask: What is our terrestrial moral responsibility toward extraterrestrial life? Our answer is grounded in an appeal to a galactic common good. (shrink)

Although environmental philosophy and the human exploration of space share common beginnings, scholars from either field have not given adequate attention to the possible connections between them. In this essay, we seek to spur the rapprochement and cross-fertilization of philosophy and space policy by highlighting the philosophic dimensions of space exploration, pulling together issues and authors that have had insufficient contact with one another. We do so by offering an account of three topics: planetary (...) class='Hi'>exploration, planetary protection and the search for extraterrestrial life, and terraforming. The resulting synthesis seeks to change our thinking about earthbound environmental ethics as it considers the philosophical dimensions of space exploration, and introduces the possible benefits of a humanities-oriented approach to space policy. (shrink)

Although environmental philosophy and the human exploration of space share common beginnings, scholars from either field have not given adequate attention to the possible connections between them. In this essay, we seek to spur the rapprochement and cross-fertilization of philosophy and space policy by highlighting the philosophic dimensions of space exploration, pulling together issues and authors that have had insufficient contact with one another. We do so by offering an account of three topics: planetary (...) class='Hi'>exploration, planetary protection and the search for extraterrestrial life, and terraforming. The resulting synthesis seeks to change our thinking about earthbound environmental ethics as it considers the philosophical dimensions of space exploration, and introduces the possible benefits of a humanities-oriented approach to space policy. (shrink)

The development and deployment of artificial intelligence (AI) is and will profoundly reshape human society, the culture and the composition of civilisations which make up human kind. All technological triggers tend to drive a hype curve which over time is realised by an output which is often unexpected, taking both pessimistic and optimistic perspectives and actions of drivers, contributors and enablers on a journey where the ultimate destination may be unclear. In this paper we hypothesise that this journey is not (...) dissimilar to the personal journey described by the Kubler-Ross change curve and illustrate this by commentary on the potential of AI for drug discovery, development and healthcare and as an enabler for deep space exploration and colonisation. Recent advances in the call for regulation to ensure development of safety measures associated with machine-based learning are presented which, together with regulation of the rapidly emerging digital after-life industry, should provide a platform for realising the full potential benefit of AI for the human species. (shrink)

In sequence-space synaesthesia, members of linguistic sequences such as numbers, days of the week and letters of the alphabet are perceived to occupy spatial positions, either in the mind's eye or as locations in space around the body. In this chapter, we begin by considering the possible sequences that can induce this type of synaesthesia, with the focus on numbers, time-units and letters. We evaluate the various methods used to test the genuineness of self-reports of this type (...) of synaesthesia, and we make suggestions for novel techniques that could address the shortcomings of the current methods. Lastly, we briefly outline the current theories on the neural basis of this type of synaesthesia, including the recent reification hypothesis. We conclude by discussing how scientific findings with sequence-space synaesthetes can be beneficial for the study of cognitive psychology more generally. (shrink)

This paper discusses DNA-based stochastic optimizations under the constraint that the search starts from a given point in a search space. Generally speaking, a stochastic optimization method explores a search space and finds out the optimum or a sub-optimum after many cycles of trials and errors. This search process could be implemented efficiently by ``molecular computing'', which processes DNA molecules by the techniques of molecular biology to generate and evaluate a vast number of solution candidates at a time. (...) We assume the exploration starting from a single point, and propose a method to embody DNA-based optimization under this constraint, because this method has a promising application in the research field of protein engineering. In this application, a string of nucleotide bases encodes a protein possessing a specific activity, which could be given as a value of an objective function. Thus, a problem of obtaining a protein with the optimum or a sub-optimum about the desired activity corresponds to a combinatorial problem of obtaining a base sequence giving the optimum or a sub-optimum in the sequence space. Biologists usually modify a base sequence corresponding to a naturally occurring protein into another sequence giving a desired activity. In other words, they explore the space in the proximity of a natural protein as a start point. We first examined if the optimization methods that involve a single start point, such as simulated annealing, Gibbs sampler, and MH algorithms, can be implemented by DNA-based operations. Then, we proposed an application of genetic algorithm, and examined the performance of this application on a model fitness landscape by computer experiments. These experiments gave helpful guidelines in the embodiments of DNA-based stochastic optimization, including a better design of crossover operator. (shrink)

Genetic variability is considered a key to the evolvability of species. The conversion of an adenosine (A) to inosine (I) in primary RNA transcripts can result in an amino acid change in the encoded protein, a change in secondary structure of the RNA, creation or destruction of a splice consensus site, or otherwise alter RNA fate. Substantial transcriptome and proteome variability is generated by A‐to‐I RNA editing through site‐selective post‐transcriptional recoding of single nucleotides. We posit that this epigenetic source of (...) phenotypic variation is an unrecognized mechanism of adaptive evolution. The genetic variation introduced through editing occurs at low evolutionary cost since predominant production of the wild‐type protein is retained. This property even allows exploration of sequence space that is inaccessible through mutation, leading to increased phenotypic plasticity and provides an evolutionary advantage for acclimatization as well as long‐term adaptation. Furthermore, continuous probing for novel RNA editing sites throughout the transcriptome is an intrinsic property of the editing machinery and represents the molecular basis for increased adaptability. We propose that higher organisms have therefore evolved to systems with increasing RNA editing activity and, as a result, to more complex systems. (shrink)

This chapter contains sections titled: McDowell on the Space of Reasons Brandom's Inferentialism Ilyenkov on the Ideal Conclusion.

In this work we report a simple way to assign a single numeric value in a three-dimensional space to a given nucleotide sequence. The method reported allows for theoretical comparisons of naturally occurring nucleotide sequences.