Avery’s et al. ’s 1944 paper provides the first direct evidence of DNA having gene-like properties and marks the beginning of a new phase in early molecular genetics (with a strong focus on chemistry and DNA). The study of its reception shows that on the whole, Avery’s results were immediately appreciated and motivated new research on transformation, the chemical nature of DNA’s biological specificity and bacteria genetics. It shows, too, that initial problems of transferring transformation to other systems and prominent (...) criticism of its results nurtured skepticism. Avery’s experiment was downplayed and neglected particularly by many of those scientists who worked in the new fields of biochemical and biophysical genetics, genetic phage, and TMV research. This was not due to the fact that the implications of the paper could not be connected to generally accepted knowledge. Contrary to a widespread belief, the assumed uniformity of DNA as opposed to proteins was not used as an argument against the validity of Avery’s et al.’s finding. The indifference rather reflected, among other things, the disciplinary gap between the chemically oriented microbiologists and the old and new geneticists who remained committed to genetic and physical methods (in particular x-ray studies) and clung to the assumption that proteins were the sole carriers of biological specificity. The responses to Avery’s et al.’s paper show how different research interests in the areas between microbiology, genetics, and biochemistry interacted with the prejudices, dogmas, individual farsightedness or short-sightedness, and scientific authority during a pivotal period of early molecular biology. (shrink)

Until the 1930s Germany had been the international leader in biochemistry, chemistry, and areas of biology. After WWII, however, molecular biology as a new interdisciplinary scientific enterprise was scarcely represented in Germany for almost 20 years. Three major reasons for the low performance of molecular biology are discussed: first, the forced emigration of Jewish scientists after 1933, which not only led to the expulsion of future distinguished molecular biologists, but also to a strong decline of ''dynamic biochemistry'', a field which (...) contributed greatly to molecular biology. Second, German university structures that strongly impeded interdisciplinary research. Third, the international isolation and self-isolation of German scientists that was a major obstacle to the implementation of new fields of research developed elsewhere. Despite the fact that there was no official boycott against Germany as there had been after WWI and despite the Cold War policy of integrating Germans into the West, as a consequence of National Socialism and WWI for many years only very few German scientists gained access to the international community of molecular biologists. Max Delbruck played an important role in helping the Germans establish modern, mostly molecular, biology because he retained strong connections to Germany. Most importantly, it required a new generation of young scientists who had received part of their training in the US to establish modern molecular biology at German universities and Max Planck Institutes. (shrink)

Chemistry and biochemistry in Germany was notably affected by the dismissal and emigration of Jewish scientists. The expulsion of Jewish scientists aided to significantly reduce the international regard for German science, particularly in biochemistry, physical chemistry, and quantum chemistry, after 1945. In most cases remaining scientists adjusted quickly after 1933 to the new political circumstances, with a few exceptions. A number of them even actively supported the politics of National Socialism. This fact as well as the common stance to forget (...) the 12 years of National Socialist rule complicated the exchange of international scientific knowledge after 1945 and delayed affiliation of the weakened fields of research to the level of international research. (shrink)

The article recalls the anti-molecular transformation of biology 100 hundred years ago. The author recounts protein chemist Wolfgang Pauli’s announcement of a new era of biomedical research in 1905. Colloidal chemistry was supposed to be the center of the era described by Pauli. The author discusses the aspects that remained from the three decades in which colloidal science exerted a great influence on biological and biochemical research.

The encounter between two fundamentally different approaches in seminal research in molecular biology-the problems, aims, methods and metaphysics - is delineated and analyzed. They are exemplified by the microbiologist Oswald T. Avery who, in line with the reductionist mechanistic metaphysics of Jacques Loeb, attempted to explain basic life phenomena through chemistry; and the theoretical physicist Max Delbrück who, influenced by Bohr’s antimechanistic views, preferred to explain these phenomena without chemistry. Avery’s and Delbrück’s most important studies took place concurrently. Thus analysis (...) of their contrasting approaches lends itself to examination of the Weltanschauungen view concerning the role of fundamental (metaphysical) assumptions in scientific change, that is, the view that empirical research cannot be neutral in regard to the worldviews of the researchers. This study shows that the initial ostensible disparity (non-integratibility) of the two approaches lasted for just a short time. Ironically it was a student of Delbrück’s school, James Watson, who (with Crick) proposed a chemical model, the DNA double helix, as a solution to Delbrück’s problem. The structure of DNA has not been seriously challenged over the past half century. Moreover, Watson’s and Crick’s work did not call into question the validity of Delbrück’s research, but opened it up to entirely new approaches. The case of Avery and Delbrück demonstrates that after initial obstacles were overcome the different fundamental attitudes and the resulting research practices were capable of integration. © 2008 Stazione Zoologica Anton Dohrn. (shrink)

Three early 20th-century attempts at unifying separate areas of biology, in particular development, genetics, physiology, and evolution, are compared in regard to their success and fruitfulness for further research: Jacques Loeb’s reductionist project of unifying approaches by physico-chemical explanations; Richard Goldschmidt’s anti-reductionist attempts to unify by integration; and Sewall Wright’s combination of reductionist research and vision of hierarchical genetic systems. Loeb’s program, demanding that all aspects of biology, including evolution, be studied by the methods of the experimental sciences, proved highly (...) successful and indispensible for higher level investigations, even though evolutionary change and properties of biological systems up to now cannot be fully explained on the molecular level alone. Goldschmidt has been appraised as pioneer of physiological and developmental genetics and of a new evolutionary synthesis which transcended neo-Darwinism. However, this study concludes that his anti-reductionist attempts to integrate genetics, development and evolution have to be regarded as failures or dead ends. His grand speculations were based on the one hand on concepts and experimental systems that were too vague in order to stimulate further research, and on the other on experiments which in their core parts turned out not to be reproducible. In contrast, Sewall Wright, apart from being one of the architects of the neo-Darwinian synthesis of the 1930s, opened up new paths of testable quantitative developmental genetic investigations. He placed his research within a framework of logical reasoning, which resulted in the farsighted speculation that examinations of biological systems should be related to the regulation of hierarchical genetic subsystems, possibly providing a mechanism for development and evolution. I argue that his suggestion of basing the study of systems on clearly defined properties of the components has proved superior to Goldschmidt’s approach of studying systems as a whole, and that attempts to integrate different fields at a too early stage may prove futile or worse. © 2011 Elsevier Inc. (shrink)

Strong Turing Determinacy, or ${\mathrm {sTD}}$, is the statement that for every set A of reals, if $\forall x\exists y\geq _T x (y\in A)$, then there is a pointed set $P\subseteq A$. We prove the following consequences of Turing Determinacy ( ${\mathrm {TD}}$ ) and ${\mathrm {sTD}}$ over ${\mathrm {ZF}}$ —the Zermelo–Fraenkel axiomatic set theory without the Axiom of Choice: (1) ${\mathrm {ZF}}+{\mathrm {TD}}$ implies $\mathrm {wDC}_{\mathbb {R}}$ —a weaker version of $\mathrm {DC}_{\mathbb {R}}$.(2) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that every (...) set of reals is measurable and has Baire property.(3) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that every uncountable set of reals has a perfect subset.(4) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that for every set of reals A and every $\epsilon>0$ :(a)There is a closed set $F\subseteq A$ such that $\mathrm {Dim_H}(F)\geq \mathrm {Dim_H}(A)-\epsilon $, where $\mathrm {Dim_H}$ is the Hausdorff dimension.(b)There is a closed set $F\subseteq A$ such that $\mathrm {Dim_P}(F)\geq \mathrm {Dim_P}(A)-\epsilon $, where $\mathrm {Dim_P}$ is the packing dimension. (shrink)

This paper introduces a possible alternative model of gravity based on the theory of fractional-dimension spaces and its applications to Newtonian gravity. In particular, Gauss’s law for gravity as well as other fundamental classical laws are extended to a D-dimensional metric space, where D can be a non-integer dimension. We show a possible connection between this Newtonian Fractional-Dimension Gravity (NFDG) and Modified Newtonian Dynamics (MOND), a leading alternative gravity model which accounts for the observed properties of galaxies and other astrophysical (...) structures without requiring the dark matter hypothesis. The MOND acceleration constant $${a_{0}} \simeq 1.2 \times 10^{-10} \text {m}\, \text{s}^{-2}$$ can be related to a natural scale length $$l_{0}$$ in NFDG, i.e., $$a_{0} \approx GM/l_{0}^{2}$$, for astrophysical structures of mass M, and the deep-MOND regime is present in regions of space where the dimension is reduced to $$D \approx 2$$. For several fundamental spherically-symmetric structures, we compare MOND results, such as the empirical Radial Acceleration Relation (RAR), circular speed plots, and logarithmic plots of the observed radial acceleration $$g_{obs}$$ vs. the baryonic radial acceleration $$g_{bar}$$, with NFDG results. We show that our model is capable of reproducing these results using a variable local dimension $$D\left( w\right)$$, where $$w =r/l_{0}$$ is a dimensionless radial coordinate. At the moment, we are unable to derive explicitly this dimension function $$D\left( w\right)$$ from first principles, but it can be obtained empirically in each case from the general RAR. Additional work on the subject, including studies of axially-symmetric structures, detailed galactic rotation curves fitting, and a possible relativistic extension, will be needed to establish NFDG as a viable alternative model of gravity. (shrink)

Kn. 1. Filosofsko-teoreticheskie istochniki -- kn. 2. Ėtika biznesa kak sistemoobrazui︠u︡shchiĭ print︠s︡ip formirovanii︠a︡ sovremennoĭ ėkonomicheskoĭ kulʹtury.

This paper offers a comprehensive discussion on the concept of Africa and freedom, freedoms in indigenous Africa, literacy and freedom from external forces, freedom under colonial rule, the role of World War II, decolonization and the Independence Movement in Africa, independent African and new challenges for freedom and finally a way forward.

Dying is part of life. Dying and Human Dignity offers the reader a complete overview and a profound evaluation of the knowledge we have about dying. Experts from a wide range of disciplines cast light on this subject from their specific perspectives. This handbook is an essential reference work for everyone who wants to inform himself about dying for either professional or personal reasons.

Caring for the stranger -- Why compassion in politics? -- Historical perspectives on social welfare and global development -- Historical perspectives on human rights -- Compassion in religious and secular thought -- Justice and moral responsibility -- Altruism, empathy, and the making of "Us" and "Them" -- The moral politics of Liberals and Conservatives -- Politics against compassion in the United States -- Compassion in public policy and law -- Creating a more compassionate and just society.

What do we do when we say ‘We’? This paper pursues a response from analytic pragmatism. The guiding idea of analytic pragmatism is to look to what one must implicitly know how do to be able to use expressions to say something, including how to make that implicit know-how explicit. Accordingly, the question we are tasked to answer is what one must know how to do to say ‘We’ – that is, what practical know-how saying ‘We’ requires and can be (...) employed to make explicit. The concept normative ascent is introduced in developing an answer. On this approach, the know-how in question turns out to be a distinctively normative capacity. Both being and saying ‘We’ turns out to involve being able to do and say something normative. (shrink)

This book studies the history of intercultural human rights. It examines the foundational elements of human rights in the East and the West and provides a comparative analysis of the independent streams of thought originating from the two different geographic spaces. It traces the genesis of the idea of human rights back to ancient Indian and Greco-Roman texts, especially concepts such as the Rigvedic universal moral law, the Upanishadic narratives, the Romans' model of governance, the rule of law, and administration (...) of justice. It also looks at Cicero's concept of rights and duties which focuses on quality of compassion and fair play, and Seneca's expositions on mercy, empathy, justice and checks on the arbitrary exercise of power. An important contribution, this book fills a significant gap in the study of human rights. It will be useful for students and researchers of political science, ancient history, religion and civilizations, philosophy, history, human rights, governance, law, sociology, and South Asian studies. The book also caters to general readers interested in the history of human rights. (shrink)

Монография посвящена творчеству Б. Н. Чичерина - ключевой фигуре русской философии права XIX века. Его идеи были итоговыми для естественно-правовой традиции, в отношении которой мыслитель был не только преемником, но и критиком.