The technology of undersea communications, from stranded-wire telegraph cables in the 1850s to fiber-optic cables at the end of the twentieth century, and its social, political, and economic impact. By the end of the twentieth century, fiber-optic technology had made possible a worldwide communications system of breathtaking speed and capacity. This amazing network is the latest evolution of communications technologies that began with undersea telegraph cables in the 1850s and continued with coaxial telephone cables a hundred years later. Communications under (...) the Seas traces the development of these technologies and assesses their social, economic, and political effects. If we cannot predict the ultimate consequences of today's wired world--its impact on economic markets, free expression, and war and peace--or the outcome of the conflict between wired and wireless technology, we can examine how similar issues have been dealt with in the past. The expert contributors to this volume do just that, discussing technical developments in undersea cables, management of the cables by private and public interests, and the impact on military and political activities. Chapters cover such topics as the daring group of nineteenth-century entrepreneurs who wove a network of copper wires around the world ; the opening of the telegraphic network to general public use; the government- and industry-forced merger of wireless and cable companies in Britain; and the impact of the cable network on diplomacy during the two world wars. (shrink)

Governing boards utilize executive compensation contracts in an attempt to align executive actions with corporate goals. The objective is to ensure that executive performance provides value to the organization in terms of successful outcomes. A key performance criteria typically specified in CEO compensation contracts is earnings targets. However, using earnings as a performance evaluation may be problematic because some firms exhibit robust and sustained earnings over time (high earnings persistence), and other firms, such as high growth oriented firms, exhibit weak (...) or sometimes negative earnings over time (low earnings persistence). Our study reveals that the effect of high earnings persistence results in firms that focus more heavily on cash compensation (salary and bonus) rather than on equity compensation (stock options, etc.) to compensate executive performance. Additionally, for firms characterized by low earnings persistence, our study indicates that cash flows from operations act as a supplementary performance measure to accounting earnings, and become increasingly important as a means to justify executive cash compensation. (shrink)

Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

China is a country that has undertaken a great transformation since the late 1970' s, and among these changes, has seen a massive growth in the advertising industry with the influx of foreign advertisers, and the development of regional and global media, such as satellite television and the Internet. This has resulted in the Chinese people of all ages having a greater opportunity of exposure to different types of advertising, including the advertising of potentially controversial products, which could clash with (...) traditional Chinese values. Using a stakeholder theory approach, this study analyzes the responses of 630 Chinese respondents to discover who is offended by controversial advertisements and determine ways potentially offensive advertising messages can be reduced, thereby assisting marketers in being more socially responsible in their advertising messages. (shrink)

Traditional model systems such as fly, mouse, and chick have formed the foundation of the EvoDevo research program. These animal systems have provided a wealth of information on the patterns and mechanisms of developmental change over large phylogenetic scales. However, the almost exclusive focus on individual embryos as model organisms has also limited the field’s ability to address the central roles that natural selection and life history adaptation play in the evolution of developmental systems. Likewise, focus on this small set (...) of “unitary” model organisms may also constrain the explanatory reach and theoretical robustness of EvoDevo if we consider that many core developmental processes like homeostatic regulation, ontogenetic differentiation, and norms of reaction are also manifest at other levels of biological organization, such as colonial organisms. The study of social insect systems can help bridge these considerable gaps in EvoDevo’s current approach. Because social insect colonies span the fine line between simple associations of “unitary” organisms and full-fledged “superorganisms,” these systems help elucidate what kinds of processes fundamentally characterize developmental systems and their evolution. What is more, the traits of social insect colonies show high degrees of population-level variability that can be linked directly to selective factors in the environment, making them ideal systems in which to more fully integrate EcoEvoDevo approaches. (shrink)

We show that there exists a properly Σ2 minimal degree b, and moreover that b can be chosen to join with 0′ to 0″ – so that b is a 0″ complement for every degree a such that 0′ ≤ a < 0″.

The influence that philosophy of science has had on scientific practice is as controversial as it is undeniable, especially in the case of biology. The dynamic between philosophy and biology as disciplines has developed along two different lines that can be characterized as 'paternal', on the one hand, and more 'fraternal', on the other. The role Popperian principles of demarcation and falsifiability have played in both the systematics community as well as the ongoing evolution-creation debates illustrate these contrasting forms of (...) interdisciplinary engagement, underscoring the influence philosophy of science in shaping our contemporary understanding of biology in the North American context. However, a strict disciplinary distinction between philosophy and science may itself be a false dichotomy that risks hampering future development of the biological sciences. By actively engaging with philosophical considerations as an integral part of their scientific practice, nineteenth-century biologists offer an interesting counterpoint to current trends of overspecialization and provide a model of scientists who avoided extremes of antagonism with, or subservience to, philosophy. (shrink)

Achieving the global benefits of artificial intelligence (AI) will require international cooperation on many areas of governance and ethical standards, while allowing for diverse cultural perspectives and priorities. There are many barriers to achieving this at present, including mistrust between cultures, and more practical challenges of coordinating across different locations. This paper focuses particularly on barriers to cooperation between Europe and North America on the one hand and East Asia on the other, as regions which currently have an outsized impact (...) on the development of AI ethics and governance. We suggest that there is reason to be optimistic about achieving greater cross-cultural cooperation on AI ethics and governance. We argue that misunderstandings between cultures and regions play a more important role in undermining cross-cultural trust, relative to fundamental disagreements, than is often supposed. Even where fundamental differences exist, these may not necessarily prevent productive cross-cultural cooperation, for two reasons: (1) cooperation does not require achieving agreement on principles and standards for all areas of AI; and (2) it is sometimes possible to reach agreement on practical issues despite disagreement on more abstract values or principles. We believe that academia has a key role to play in promoting cross-cultural cooperation on AI ethics and governance, by building greater mutual understanding, and clarifying where different forms of agreement will be both necessary and possible. We make a number of recommendations for practical steps and initiatives, including translation and multilingual publication of key documents, researcher exchange programmes, and development of research agendas on cross-cultural topics. (shrink)

We show that every nonzero $\Delta _{2}^{0}$ e-degree bounds a minimal pair. On the other hand, there exist $\Sigma _{2}^{0}$ e-degrees which bound no minimal pair.

We show that every nonzero Δ20, e-degree bounds a minimal pair. On the other hand, there exist Σ20, e-degrees which bound no minimal pair.

The ability to recover from official match-play across a single and multiple matches is often considered a key factor in subsequent performance for modern professional basketball. The aims of this study were to: explore the differences in match performances between different match congestion cycles ; and identify the key performance indicators discriminating between winning and losing during different match congestion cycles. The current study indicated that scoring close to or very far away was significantly greater for winning matches separated by (...) 1- and 2-days of rest compared to consecutive matches. Additionally, shooting efficiency, and attaining Defensive Rebounds and Steals, were significant offensive and defensive KPIs that differentiated winning and losing teams. Similarly, opponent quality and match pace were important situational variables that affected match outcome during different match congestion cycles. While match location had an impact on winning following 1- and 2-days of rest, it had no impact for back-to-back matches. The current results will support coaches' offensive, defensive and recovery strategies during various match congestion cycles for a greater probability of winning NBA matches. (shrink)

As it has become more and more urgent to solve the problems of environmental protection, we consider it necessary to conduct multilevel studies to examine the impact of business strategy on both employees’ and firms’ performances in environmental protection. Synthesizing the perspectives of strategic orientation, corporate strategy, and firm performance, we propose a comprehensive theoretical model linking market orientation and environmental performance. Based on a survey of 134 matched chief executive officers, senior marketing managers and frontline workers from Chinese firms, (...) we found that market orientation positively affects environmental strategy which, in turn, influences both environmental product quality and employees’ environmental involvement. These latter two variables consequently have a positive influence on environmental performance. At the same time, environmental commitment moderates the link between market orientation and environmental strategy. (shrink)

Introduction of human plasma protein genes into the mouse genome to produce transgenic mice furnishes an in vivo model for correlating chromosomal DNA sequences with developmental and tissue‐specific expression. The liver produces an array of plasma proteins that circulate throughout the body contributing to homeostasis. Non‐hepatic tissue sites of synthesis have been identified where a local provision of plasma proteins in needed. Analysis of expression of human plasma protein genes in ageing transgenic mice appears especialy promising in identifying DNA sequences (...) that respond to environmental adversities such as inflammatory factors, hormonal changes and metal toxicity. The results indicate that human genes encoding and controlling liver plasma proteins serve as useful models for studying genetic regulation in the background of development and ageing. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

In this article, we discuss a hypothesis to explain the preferential synthesis of the superoxide sensitive form of aconitase in mitochondria and the phenotype observed in manganese superoxide dismutase mutant mice, which show a gross over accumulation of stored fat in liver. The model proposes that intermediary metabolism is redox regulated by mitochondrial superoxide generated during mitochondrial respiration. This regulates the level of reducing equivalents (NADH) entering the electron transport chain (ETC) through the reversible inactivation of mitochondrial aconitase. This control (...) mechanism has a dual function; firstly, it regulates levels of superoxide generated by the ETC and, secondly, it fine‐tunes metabolism by channeling citrate either for the production of NADH for energy metabolism or diverting it for the synthesis of fats. In this setting, the mitochondrial redox state influences metabolic decisions via a superoxide–aconitase rheostat. BioEssays 26:894–900, 2004. © 2004 Wiley Periodicals, Inc. (shrink)