The proliferation of mitochondrial DNA (mtDNA) with deletion mutations has been linked to aging and age related neurodegenerative conditions. In this study we model the effect of mtDNA half-life on mtDNA competition and selection. It has been proposed that mutation deletions (mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}) have a replicative advantage over wild-type (mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}) and that this is detrimental to the host cell, especially in post-mitotic (...) cells. An individual cell can be viewed as forming a closed ecosystem containing a large population of independently replicating mtDNA. Within this enclosed environment a selfishly replicating mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} would compete with the mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} for space and resources to the detriment of the host cell. In this paper, we use a computer simulation to model cell survival in an environment where mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} compete with mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} such that the cell expires upon mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} extinction. We focus on the survival time for long lived post-mitotic cells, such as neurons. We confirm previous observations that mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} do have a replicative advantage over mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}. As expected, cell survival times diminished with increased mutation probabilities, however, the relationship between survival time and mutation rate was non-linear, that is, a ten-fold increase in mutation probability only halved the survival time. The results of our model also showed that a modest increase in half-life had a profound affect on extending cell survival time, thereby, mitigating the replicative advantage of mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}. Given the relevance of mitochondrial dysfunction to various neurodegenerative conditions, we propose that therapies to increase mtDNA half-life could significantly delay their onset. (shrink)

I am grateful to Dr William L. Craig for his reply to an earlier article of mine in this journal, on the relationship between God and time. Craig and I agree on most points with respect to the relationship between God and time. What then is there for us to disagree about? The point Craig argues for is, eternity is ‘coincident’ with our history, i.e. the duration of our space–time is simultaneous with some duration of eternity. But I already agree (...) to this point. In fact, I argued that if God sustains the universe, and if the universe and God are temporal, then God's time must be related to our time. We are in God's time, and God's time is our time, when by time we mean ‘ontological time’ or what I call duration, rather than Measured Time. If this is so, where is our disagreement? Our disagreement turns on this question: does history measure eternity? Does the ‘cosmic time’ of our universe give a proper measure to the same duration of God's time in eternity? I say it does not, while Craig says that it does. (shrink)

The sublime evokes our awe, our terror, and our wonder. Applied first in ancient Greece to the heights of literary expression, in the 18th-century the sublime was extended to nature and to the sciences, enterprises that viewed the natural world as a manifestation of God's goodness, power, and wisdom. In The Scientific Sublime, Alan Gross reveals the modern-day sublime in popular science. He shows how the great popular scientists of our time--Richard Feynman, Stephen Hawking, Steven Weinberg, Brian Greene, Lisa (...) Randall, Rachel Carson, Stephen Jay Gould, Steven Pinker, Richard Dawkins, and E. O. Wilson--evoke the sublime in response to fundamental questions: How did the universe begin? How did life? How did language? These authors maintain a tradition initiated by Joseph Addison, Edmund Burke, Immanuel Kant, and Adam Smith, towering 18th-century figures who adapted the literary sublime first to nature, then to science--though with one crucial difference: religion has been replaced wholly by science. In a final chapter, Gross explores science's attack on religion, an assault that attempts to sweep permanently under the rug two questions science cannot answer: What is the meaning of life? What is the meaning of the good life? (shrink)

In this essay I wish to defend the intuition that God transcends time, of which he is the Creator. To do this, I will develop a new understanding of the term ‘timeless eternity’ as it applies to God. This assumes the inadequacy of the traditional notion of divine eternity, as it is found in Boethius, Anselm and Aquinas. Very briefly, the reasons for this inadequacy are as follows. God sustains the universe, which means in part that he is responsible for (...) the fundamental ontological status of things. Because the universe is an everchanging reality, things do change in their fundamental ontological status at different times – a change we must ascribe to God, and cannot ascribe to the objects themselves, since this has to do with their very existence. God himself, therefore, does different things at different times. This implies change in God. Whenever a change occurs, a duration occurs. Therefore, God is in time. But I do not think it is proper to say that God is in our time. God transcends time, and he is the Creator of our space-time. It is theologically more proper to say that we are in God's time, and I will adopt this language here. (shrink)

In a detailed and spirited critique, Professor James M. Humber has found my defence of the ontological argument unconvincing. Humber's case rests upon his claim that my ‘error’ is due to my ‘having accepted an incorrect definition of “physically necessary being” … ’. Now I do indeed claim that God must be conceived as a factuall necessary being, i.e. as eternally independent. I take the notion of God's aseity or eternal independence to be relatively straightforward and uncontroversial; it is accepted (...) as an essential component of the concept God by many philosophers who also insist that there is no acceptable form of demonstrative theism. Thus, it is widely held that ‘God is a factually necessary being’ does not imply ‘God is a logically necessary being’; that God is eternally independent does not imply that he exists in all possible worlds. But it is precisely this view that I have argued is incorrect. While I concur that there is an intelligible concept of God as factually necessary, I deny that the existence of such a being is logically contingent, a mere matter of empirical fact. Indeed, a rigorous inspection of the concept of an eternally independent being reveals that whether that concept is instantiated, i.e. whether there exists a being exemplifying that concept, is knowable a priori . My claim is in fact stronger than this. I argue that the existence of an eternal, independent, omniscient and omnipotent being is demonstrable by conceptual analysis. It is Humber's contention that my alleged demonstration of God's existence crumbles upon the discovery of the unacceptability of my definition of ‘factually necessary being’. Let us see. (shrink)

Examines the nature of rhetorical theory and criticism, the rhetoric of science, and the impact of poststructuralism and postmodernism on contemporary accounts of rhetoric.

This paper examines Ian Hacking's arguments in favor of entity realism. It shows that his examples from science do not support his realism. Furthermore, his proposed criterion of experimental use is neither sufficient nor necessary for conferring a privileged status on his preferred unobservables. Nonetheless his insight is genuine; it may be most profitably seen as part of a more general effort to create a space for a new form of scientific and philosophical certainty, one that does not require foundations.

This accessible book examines the philosophical foundations of Chaim Perelman's rhetorical theory. In addition to offering a brief biography, it explores Perelman's deep philosophical commitments and his concern for the ways in which the details of actual texts realize those commitments. The authors show that Perelman still reigns supreme when it comes to the elucidation of actual texts. His is a microanalysis of arguments, one that is endlessly suggestive of ways of analyzing texts at the level of the word and (...) phrase, the arrangement of parts, and the structure of arguments. Book jacket. (shrink)

Alan Gross applies the principles of rhetoric to the interpretation of classical and contemporary scientific texts to show how they persuade both author and audience. This invigorating consideration of the ways in which scientists--from Copernicus to Darwin to Newton to James Watson--establish authority and convince one another and us of the truth they describe may very well lead to a remodeling of our understanding of science and its place in society.

In debate with John Caiazza, we clarify the meaning of the terms technology and secular, arguing that technology is not really secular. Only when combined with antireligious secularism do we get the modern techno‐secular worldview. Science is not secular in the strong sense, nor does its practice automatically lead to the techno‐secular. As a complete worldview, techno‐secularism is antireligious, but it also is dehumanizing and destructive of our environment. Religion may provide a transcendent source for a humanizing morality that might (...) move technology in a more ecofriendly, humane direction. The alternative is not a happy one for our posthuman technological future. (shrink)

The relationship between religiosity and ethical behavior at work has remained elusive. In fact, inconsistent results in observed magnitudes and direction led Hood et al. (The psychology of religion: An empirical approach, 1996 ) to describe the relationship between religiosity and ethics as “something of a roller coaster ride.” Weaver and Agle (Acad Manage Rev 27(1):77–97, 2002 ) utilizing social structural versions of symbolic interactionism theory reasoned that we should not expect religion to affect ethical outcomes for all religious individuals; (...) rather, such a relationship likely depends on specific religious attitudes including religious motivation orientation (intrinsic RMO vs. extrinsic RMO), perceived sacred qualities of work (job sanctification), and views of God (VOG, loving vs. punishing). We examined the effects of these three religious attitudes on participants’ judgments of 29 ethically questionable vignettes. Consistent with symbolic interactionism theory, intrinsic RMO and having a loving view of God were both negatively related to endorsing ethically questionable vignettes, whereas extrinsic RMO was positively related to endorsing the vignettes. Unexpectedly, job sanctification was positively related to endorsing the vignettes. However, both intrinsic and extrinsic RMO moderated this relationship such that sanctifying one’s job was related to ethical judgments only for those who were: (a) low in intrinsic RMO or (b) high in extrinsic RMO. We reasoned based on symbolic interactionism theory that intrinsically motivated participants, in contrast to extrinsically motivated participants, may have utilized their religious beliefs as a guiding framework in making ethical judgments. (shrink)

A reading of a sample of taxonomical papers leads to the conclusion that new species identification is both taxonomically plausible and philosophically incoherent. As a result, taxonomy becomes a science that apparently violates a necessary condition of its rationality. It is this apparent violation that is the focus of the philosophical debate, a debate whose goal for taxonomy is theoretical coherence at a global level. In this paper, I assess the appropriateness of this goal.

The advent of new forestry in the United States represents a traumatic shift in the philosophy of national forestry praxis, a broadening of values to include aesthetics and sustainability of natural ecological process. The ethics of traditional forestry are shown to be 'Stoic utilitarian' and positivist, while the ethics of new forestry adhere closely to the 'land ethic' of Aldo Leopold. Aesthetics in traditional forestry are shown to be modernist, and to have developed from, and in opposition to a Romantic (...) aesthetic of the late nineteenth century. This transition is traced from the first U.S. landscape architect, Frederick Law Olmsted Sr., to the first U.S.-born forester, Gifford Pinchot. The language and precepts of new forestry are shown to parallel those of postmodernism, and the possibility of a broadened aesthetics of forestry, developed through postmodernist criticism, is outlined. The language of gardening is used as a model of forestry praxis, with traditional forestry adhering to the principles of vegetable gardening, while new forestry offers an opportunity to flesh out an entire spectrum of gardening genres. (shrink)

A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand‐dependent neuronal growth and differentiation or axon guidance. Acting as “dependence receptors”, they may also regulate neuronal cell survival by inducing apoptosis in the absence of cognate ligand. Receptor‐initiated apoptosis requires proteolytic (caspase) cleavage and exposure of a pro‐apoptotic region in the cytoplasmic domains of the receptors. In contrast, classical apoptosis induced by growth factor or cytokine deprivation involves loss of survival signaling without receptor (...) cleavage. DCC, UNC5, RET and Ptc1 are downregulated or mutated in diverse cancers, and show properties characteristic of tumor suppressors, consistent with their ability to promote neuronal cell death. Dysfunctional dependence receptors have been linked to the loss of specific neurons in certain inherited and neurodegenerative diseases. Dependence receptor‐initiated apoptosis represents a novel paradigm for the controlled removal of specific cells during neural development and elimination of malignant cells that have strayed beyond regions of ligand availability. BioEssays 26:656–664, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Richard Swinburne is one of the most distinguished philosophers of religion of our day. In this volume, many notable philosophers in Britain and america unite to honour him and to discuss various topics to which he has contributed significantly. These include general topics in the philosophy of religion such as revelation, and faith and reason, and the specifically Christian doctrines of the Trinity, the Incarnation, and atonement. In the spirit of the movement which Richard Swinburned has spearheaded, the essays in (...) this collection use analytic philosophical methods to examine doctrines in particular religious traditions, expanding upon traditional discussions of theism. As such, this volume represents a field-report on the interaction of philosophy and Christian thought in the English-speaking world: a fitting tribute to the Nolloth Professor of the Philosophy of Christian Religion at the University of Oxford. Richard Swinburne has himself contributed and individual and personal Intellectural Autobiography.Contributors: William P. Alston, David Brown, Richard M. Gale, Rom Harré, Brian Hebblethwaite, John Hick, Peter van Inwagen, J. R. Lucas, David McNaughton, Philip L. Quinn, Eleonore Stump, William J. Wainwright, C. J. F. Williams. (shrink)

This essay is a case study of the self-destruction that occurs in the work of a social-constructionist historian of science who embraces a radical philosophy of science. It focuses on Thomas Laqueur's Making Sex: Body and Gender from the Greeks to Freud in arguing that a history of science committed to the social construction of science and to the central theses of Kuhnian, Duhemian, and Quinean philosophy of science is incoherent through self-reference. Laqueur's text is examined in detail in order (...) to make the main point; a similar phenomenon in the work of the feminist historian of science Evelyn Fox Keller is then briefly discussed. (shrink)

Intended for logicians and mathematicians, this text is based on Dr. Hamilton's lectures to third and fourth year undergraduates in mathematics at the ...

Gallup surveys consistently show that nine in 10 Americans express a belief in God (Nash, Business, religion, and spirituality: A new synthesis, 2003 ), while more than 45 % claim to have some awareness of God on the job (Nash and McLellan, Church on Sunday, Work on Monday: The Challenges of Fusing Christian Values with Business Life, 2001 ). Recently, Lynn et al. (Journal of Business Ethics 85:227–243, 2009 ) argued that the ability to integrate the specific beliefs and practices (...) of one’s faith with the work one does represent an important although neglected area of research. As such, they developed and demonstrated convergent validity for the faith at work scale, designed to measure the extent to which individuals believe they are able to integrate their Judaeo-Christian beliefs and practices and their work. In a subsequent study, Lynn et al. (Human Relations 64:675–701, 2010 ) demonstrated that the faith at work scale was related to faith maturity, church attendance, age, and denominational strictness, and negatively associated with organizational size. No research, however, has examined the possible positive benefits of integrating faith and work. I therefore developed and tested hypotheses concerning the relationship between the faith at work scale and seven important life and work outcomes (satisfaction with life, intent to leave one’s job, self-rated job performance, job satisfaction, and three forms of organizational commitment). In all, four of seven hypotheses were confirmed. (shrink)

A cutting-edge survey of contemporary thought at the intersection of science and Christianity. Provides a cutting-edge survey of the central ideas at play at the intersection of science and Christianity through 54 original articles by world-leading scholars and rising stars in the discipline Focuses on Christianity's interaction with Science to offer a fine-grained analysis of issues such as multiverse theories in cosmology, convergence in evolution, Intelligent Design, natural theology, human consciousness, artificial intelligence, free will, miracles, and the Trinity, amongst many (...) others Addresses major historical developments in the relationship between science and Christianity, including Christian patristics, the scientific revolution, the reception of Darwin, and twentieth century fundamentalism Divided into 9 Parts: Historical Episodes; Methodology; Natural Theology; Cosmology & Physics; Evolution; The Human Sciences; Christian Bioethics; Metaphysical Implications; The Mind; Theology; and Significant Figures of the 20th Century Includes diverse perspectives and broadens the conversation from the Anglocentric tradition. (shrink)

In this collection edited by Alan G. Gross and Arthur E. Walzer, scholars in communication, rhetoric and composition, and philosophy seek to “reread” Aristotle’s Rhetoric from a purely rhetorical perspective.

This chapter contains sections titled: * Miracles: A Theological Definition * Violation and Intervention: A Critique of Metaphors * Physically Impossible and SEE: Definition * Miracles, Science, and the Order of Nature * Conclusions * Notes * References * Further Reading.

The advent of new forestry in the United States represents a traumatic shift in the philosophy of national forestry praxis, a broadening of values to include aesthetics and sustainability of natural ecological process. The ethics of traditional forestry are shown to be 'Stoic utilitarian' and positivist, while the ethics of new forestry adhere closely to the 'land ethic' of Aldo Leopold. Aesthetics in traditional forestry are shown to be modernist, and to have developed from, and in opposition to a Romantic (...) aesthetic of the late nineteenth century. This transition is traced from the first U.S. landscape architect, Frederick Law Olmsted Sr., to the first U.S.-born forester, Gifford Pinchot. The language and precepts of new forestry are shown to parallel those of postmodernism, and the possibility of a broadened aesthetics of forestry, developed through postmodernist criticism, is outlined. The language of gardening is used as a model of forestry praxis, with traditional forestry adhering to the principles of vegetable gardening, while new forestry offers an opportunity to flesh out an entire spectrum of gardening genres. (shrink)

Interleukin 1β‐converting enzyme (ICE)‐like proteases (caspases) play an important role in programmed cell death (apoptosis), and elucidating the consequences of their proteolytic activity is central to our understanding of the molecular mechanisms of cell death. Diverse structural and regulatory proteins and enzymes, including protein kinase Cδ, the retinoblastoma protein (a protein involved in cell survival), the DNA repair enzyme DNA‐dependent protein kinase and the nuclear lamins, undergo specific and limited endoproteolytic cleavage by various caspases during apoptosis. Since individual caspases can (...) cleave multiple substrates, the consequences of cleavage of only a single substrate are still poorly understood. Nevertheless, proteolytic activation of protein kinase Cδ may be an important early step in the cell death pathway, and cleavage of the retinoblastoma protein could suppress its cell survival function, whereas proteolytic inactivation of DNA repair enzymes might compromise the ability of the cell to reverse DNA fragmentation. On the other hand, cleavages of nuclear and cytoplasmic structural proteins (e.g. the lamins and Gas2) appear to be required for or contribute to the dramatic rearrangements in cellular architecture that are necessary for the completion of the cell death process. An emerging theme is that parallel and sequential proteolytic activation and inactivation of key protein substrates occurs during the multiple steps of apoptosis. (shrink)

The ArgumentConflicts between scientists over credit for their discoveries are conflicts, not merely in, but of science because discovery is not a historical event, but a retrospective social judgment. There is no objective moment of discovery; rather, discovery is established by means of a hermeneutics, a way of reading scientific articles. The priority conflict between Roger Guillemin and Andrew Schally over the discovery of the brain hormone, TRF, serves as an example. The work of Robert Merton, Thomas Kuhn, Augustine Brannigan, (...) and Grygory Markus shows that scientists read scientific articles by means of the application of a set of pragmatic rules that subtend the normative requirements of what counts as a scientific discovery. In other words, there is a hermeneutics of science, but it is internal to that form of life. Recategorization of priority conflicts has an impact on our view of scientific controversy generally. The impact is the revision of the boundary lines of scientific controversy and the further specification of its fine-structure. (shrink)

Philosophers from anselm and scotus to hartshorne and malcolm have argued that the true claim that God is a necessary being implies that theism is a-Priori demonstrable. Philosophers such as hick, Penelhum, And geach have denied this, Contending 1) that god's necessity is factual, Indicating his eternal independence, Rather than logical, Indicating his existence in all possible worlds, And 2) that from the former nothing follows a-Priori about the truth or falsity of theism. I argue that factual and logical necessity (...) are conceptually inseparable, That God can be demonstrated to exist in all possible worlds. I take statements about the modalities of existence of things to be equivalent to statements about the modalities of instantiation of concepts, And argue that the concept God is necessarily instantiated, I.E., That God necessarily exists. The argument is compared and contrasted to a similar argument of hartshorne's. (shrink)

An overview of several philosophical issues that arise from the recent growth of interest in the relationships between science and theology. The interactions between theology and science are complex, and often highly contextual in nature. This makes simple typologies of their interaction rather dubious. There are some similarities between religion and science, including the difficulty of defining them. Concerns about the use and meaning of language, and issues of realism and anti-realism, are found in both areas of thought. Epistemology is (...) important to both areas, and there is increasing acceptance of differing epistemologies not only in religion and science, but also within the various scientific disciplines. One central issue is the question of legitimate influence between science and theology given their aims and methods. Another issue surrounds the question of naturalism in natural science. Also important to note is the variety of god-concepts at work in the current dialogue between science and theology. (shrink)