Research in infection biology aims to understand the complex nature of host–pathogen interactions. While this knowledge facilitates strategies for preventing and treating diseases, it can also be intentionally misused to cause harm. Such dual-use risk is potentially high for highly pathogenic microbes such as Risk Group-3 (RG3) bacteria and RG4 viruses, which could be used in bioterrorism attacks. However, other pathogens such as influenza virus (IV) and enterohemorrhagic Escherichia coli (EHEC), usually classified as RG2 pathogens, also demonstrate high dual-use risk. (...) As the currently approved therapeutics against these pathogens are not satisfactorily effective, previous outbreaks of these pathogens caused enormous public fear, media attention and economic burden. In this interdisciplinary review, we summarize the current perspectives of dual-use research on IV and EHEC, and further highlight the dual-use risk associated with evolutionary experiments with these infectious pathogens. We support the need to carry out experiments pertaining to pathogen evolution, including to gain predictive insights on their evolutionary trajectories, which cannot be otherwise achieved with stand-alone theoretical models and epidemiological data. However, we also advocate for increased awareness and assessment strategies to better quantify the risks-versus-benefits associated with such evolutionary experiments. In addition to building public trust in dual-use research, we propose that these approaches can be extended to other pathogens currently classified as low risk, but bearing high dual-use potential, given the particular pressing nature of their rapid evolutionary potential. (shrink)

This article is a slightly modified version of a paper presented to the International Conference on ‘Malthus Yesterday and Today’, Société de démographie historique Paris, 27–29 May 1980.

In this paper, my main aim is to analyse Mao’s conception of Marxist theory and his Marxist subjectivity in theory construction in his three articles. While doing so, I will use two main approaches, first is the idea that Karl Marx’s method in understanding social relations and his theory of knowledge is in many aspects compatible and in continuation with an epistemological reading of Hegel’s subjectivity, and the second is the general structure about the relationship between the object and subject’s (...) process of knowing is similar in all three thinkers. While doing so, I will advocate the position that Mao’s epistemology is compatible with the Marxist understanding of Hegelian epistemology, and that from such an epistemological understanding it is possible to investigate Mao’s three texts in a way that yields, not an orthodox or “end result” Marxism, but instead a more general, meta epistemological understanding of Marx, that is understood better structurally. Eventually, I will claim that while using “scientific” or “orthodox” Marxism as a method to understand society, Mao further uses the subjective element in the same way as Hegel and Marx used it, although eventually he diverts the Marxist subjective manoeuvre to another direction. (shrink)

In this paper, I will briefly summarize the history and current accounts of Evolutionary Medicine (EM). I will show that EM, in its current forms, is using an evolutionary understanding that carries the explanatory framework, as well as explanatory limits, of the Modern Synthesis (MS). I will then point out some essential elements that need to be seen as limiting factors within EM and analyze the limitations that are brought about by the MS understanding of it. On this basis, I (...) will argue that if the latest developments in evolutionary theory are considered – in particular, those pertaining to the inheritance mechanisms highlighted by the Extended Evolutionary Synthesis (EES), and the newly introduced evolutionary entities – EM will have a much broader explanatory scope and increased explanatory power in addition to greater relevance, which will enable its application in medical explanations. (shrink)

Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo-assembled genomes were used to understand genomic plasticity and to perform coalescent analyses. (...) The ST45 population contained two distinct sublineages, which correlated with the isolates’ geographical origins. One sublineage primarily consisted of European/North American isolates, while the second sublineage primarily consisted of African and Australian isolates. Bayesian analysis predicted ST45 originated in northwestern Europe about 500 years ago. Isolation time, host, and clinical symptoms did not correlate with phylogenetic groups. Our phylogenetic analyses suggest multiple acquisitions of the SCCmec element and key virulence factors throughout the evolution of the ST45 lineage. (shrink)

Collected works of Dngul-chu Dbyangs-can-grub-paʼi-rdo-rje, 1809-1887 on Tibetan Buddhist doctrines, philosophy, and rituals of Dge-lugs-pa.

In this volume, Bilsel argues that the museum has produced a modern decor, an iconic image, which has replaced the lost antique originals, rather than creating an explicitly hypothetical representation of Antiquity.

Paraconsistent logics are the formal systems in which absurdities do not trivialise the logic. In this paper, we give Hintikka-style game theoretical semantics for a variety of paraconsistent and non-classical logics. For this purpose, we consider Priest’s Logic of Paradox, Dunn’s First-Degree Entailment, Routleys’ Relevant Logics, McCall’s Connexive Logic and Belnap’s four-valued logic. We also present a game theoretical characterisation of a translation between Logic of Paradox/Kleene’s K3 and S5. We underline how non-classical logics require different verification games and prove (...) the correctness theorems of their respective game theoretical semantics. This allows us to observe that paraconsistent logics break the classical bidirectional connection between winning strategies and truth values. (shrink)

Ethical violations can cause wasteful use of resources, unfair advantage for some scientists over others, and setting a bad example to the scientific community and young scientists_._ Awareness of these violations helps to prevent moral contamination of the academic community. A web-based survey with 30 items was sent to all residents and academic staff worked at different faculties in our university to evaluate the participants' thoughts and knowledge about academic publication ethics. There were 48 female and 53 male respondents. 44.6% (...) of the participants had never taken ethics courses. 57.4% of the participants think that the ethics course should be given throughout life. The responses to “when ethical course should be given?” was significantly different between males and females, but not according to academic titles and age ranges. Except residents, all participants had complete information about the predatory journals, books and congresses. 29% of the participants were not aware of ghost authorship and 20% were misinformed. The participants did not have sufficient knowledge and awareness about plagiarism, except for some sub-titles. Although lack of awareness is mostly evident among non-academicians, both academicians and non-academicians need to be educated and trained about plagiarism. (shrink)

A. Raghuramaraju has curated and edited this volume, which proposes a major breakthrough in the field of philosophical studies. The volume reproduces not only Desire and Liberation and Kalidas Bhattacharyya's introduction to it, but also the letters that Bhattacharyya wrote to Chandidas, and Chandidas's own commentary on his text. In Desire and Liberation Vaddera Chandidas creates a new metaphysical system. The author rejects major convergences inphilosophy from both India and the West, especially on the ontological primacy of non-being that results (...) in permanence. He is especially opposed to the idea of permanence, which renders unreliable anything that is not permanent but changing. Chandidas points out that contradictoriness is the structural 'tinge' ofreality. (shrink)

This article provides a brief overview of several formal frameworks concerning the relation between knowledge on the one hand, and obligation on the other. We discuss the paradox of the knower, knowledge based obligation, knowingly doing, deontic dynamic epistemology, descriptive obligations, and responsibilities as dynamic epistemology.