Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Sartre posed a problem for himself in his discussion of bad faith: how is it possible to deceive oneself, given the unity and translucency of consciousness? Many critics of Sartre interpret translucency as transparency; some, such as M.R. Haight, conclude that Sartre's account of consciousness makes self-deception impossible.A reply to those critics takes the form of showing that translucent consciousness has a number of dimensions: (a) non-positional versus positional aspects; (b) prereflective versus reflective levels; (c) temporally synthetic flux; and (d) (...) the first-person perspective versus the third-person perspective. These dimensions enable Sartre to succeed in describing subtle and varied patterns of self-deception, based on such strategies as obscuring, evasion, distraction, misdescription and disavowal. The translucency of consciousness is not a barrier to self-deception.However, there is another problem in Sartre's claim that all purposive activity is conscious, including our practice of self-deception. The bodily subject of consciousness performs important purposive activities beyond the range of the most obscure non-positional consciousness. This calls into question Sartre's existentialist claim that we are wholly responsible for all we do. (shrink)

Sartre posed a problem for himself in his discussion of bad faith: how is it possible to deceive oneself, given the unity and translucency of consciousness? Many critics of Sartre interpret translucency as transparency; some, such as M.R. Haight, conclude that Sartre's account of consciousness makes self-deception impossible.A reply to those critics takes the form of showing that translucent consciousness has a number of dimensions: (a) non-positional versus positional aspects; (b) prereflective versus reflective levels; (c) temporally synthetic flux; and (d) (...) the first-person perspective versus the third-person perspective. These dimensions enable Sartre to succeed in describing subtle and varied patterns of self-deception, based on such strategies as obscuring, evasion, distraction, misdescription and disavowal. The translucency of consciousness is not a barrier to self-deception.However, there is another problem in Sartre's claim that all purposive activity is conscious, including our practice of self-deception. The bodily subject of consciousness performs important purposive activities beyond the range of the most obscure non-positional consciousness. This calls into question Sartre's existentialist claim that we are wholly responsible for all we do. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:God’s Knowledge of the World: Medieval Theories of Divine Ideas from Bonaventure to Ockham by Carl A. VaterBenjamin R. DeSpainVATER, Carl A. God’s Knowledge of the World: Medieval Theories of Divine Ideas from Bonaventure to Ockham. Washington, D.C.: The Catholic University of America Press, 2022. xi + 294 pp. Cloth, $75.00Carl Vater skillfully blends historical and constructive concerns in his study of medieval theories of the divine ideas. (...) The book, first, makes a significant contribution to the body of scholarly resources on medieval philosophy by systematically mapping out the complex intellectual history of the divine ideas between the years 1250 and 1325. Throughout the work Vater displays a staggering command of the relevant literature, figures, and ideas from this period of philosophical development. Second, he provides a robust defense and promotion of John Duns Scotus’s theory of the divine ideas, which he regularly insists is the best theory. Through careful analysis of the often subtle differences in medieval articulations of the divine ideas to answer the questions of how God knows and produces creatures, Vater makes the case that Scotus avoided certain pitfalls in earlier theories that rely on a flawed understanding of relations influenced, principally, by Avicenna’s notion of essence.The book itself is divided into five parts with each systematically detailing a particular theory, beginning with the “imitability theory” represented by Thomas Aquinas, Henry of Ghent, and Bonaventure—the one figure, in Vater’s narrative, capable of escaping Scotus’s subsequent critiques. According to Vater, the imitability theory is defined by several notable characteristics, including that the divine ideas are “secondary objects of the divine intellect when it knows the divine essence,” that they perform both cognitive and causal roles, that they are relations, and that there are many of them. The “infinite intellect theory” critiques the imitability theory for depending on a notion of relations that is mistaken for supposing that relations can be known before the terms of the relation are themselves known. In this section, Vater examines the works of Peter John Olivi and his student Petrus de Trabibus. The third part considers what Vater calls the “objectum cognitum theory” developed by James of Viterbo. Here, according to Vater, we encounter the first signs, following Olivi and de Trabibus’s critique of the imitability theory, of the shift away from identifying the divine ideas with relations to defining them as creatures themselves. This shift culminates in the “creatura intellecta theory” introduced by Richard of Mediavilla, but it is not properly developed until Scotus, who concludes that “God knows relations because he knows possible creatures.” The section ends with an analysis of Scotus’s influence on the theories of early Thomists and Scotists, including John of Paris, Thomas of Sutton, and Henry of Harclary. In the fifth part, Vater turns to the “nominalist theory” of Peter Auriol and [End Page 373] William of Ockham. Although both Auriol and Ockham offer accounts of the divine ideas, these are, as Vater says, little more than nods to the Augustinian tradition that ultimately amount to a rejection of the divine ideas.Vater’s approach to these medieval theories has many strengths. By not only classifying the prominent theories during this period but also systematically organizing his interpretation of each respective author, he is able to create a comparative framework for assessing the central issues at play in the divine ideas, such as their status, definition, cognitive and causal roles, plurality and unity, exemplarity, and the question of nonexistent possibles, and he traces variations in each area to identify where change, development, and critique are actually occurring within this seventy-five years of intellectual history. He also is attentive to figures often overlooked in larger narrations of medieval philosophy, and he locates their contributions to the varied development of the divine ideas. More importantly, however, Vater is able to maintain coherence in his evaluation of these complex, intertwining layers of medieval philosophical reflection by constantly returning to the overarching theme of relations in the movement from identifying the divine ideas with relations to approaching them as creatures themselves. Vater is correct when he notes that the divine ideas form a... (shrink)

The article examines one quodlibet of thomas of sutton (c. 1287 a. d.) and compares it with a quodlibet of william of ockham (d. 1349 a. d.). both attack the position of henry of ghent on the distinction between essence and existence. and both reach opposite conclusions. thomas of sutton argued that the distinction is a real one, while ockham saw it only as nominal and connotative. the opposing views stem from different epistemologies and different metaphysics.

Neuroscientists are searching for the engram within the conceptual framework established by John Locke's theory of mind. This framework was elaborated before the development of information theory, before the development of information processing machines and the science of computation, before the discovery that molecules carry hereditary information, before the discovery of the codon code and the molecular machinery for editing the messages written in this code and translating it into transcription factors that mark abstract features of organic structure such as (...) anterior and distal. The search for the engram needs to abandon Locke's conceptual framework and work within a framework informed by these developments. The engram is the medium by which information extracted from past experience is transmitted to the computations that inform future behavior. The information-conveying symbols in the engram are rapidly generated in the course of computations, which implies that they are molecules. (shrink)

The case for God -- Possibilities -- The illusion of Descartes -- Self-creation, part 1 -- Self-creation, part 2 -- Self-existence -- Necessary being -- The God of the Bible vs. the God of philosophy -- Kant's moral argument -- Vanity of vanities -- The psychology of atheism.

Who are you, God? -- Who made you, God? -- I want to find you, God -- I can't see you, God -- How much do you know, God? -- Where is truth, God? -- The shadow doesn't turn -- The just judge -- The invincible power -- Can I trust you, God? -- The love that will not let us go -- The name above all names.

Knowledge of God -- In essence -- In person -- Incommunicable attributes -- Communicable attributes -- The will of God -- Providence.

There are an infinite variety of attitudes to euthanasia, each individual response to the concept being influenced by many factors. Consequently there is a literature on the subject ranging from the popular article to papers in specialized journals. This study, however, has taken a well defined sample of people, inviting them to answer a questionnaire which was designed to elicit their attitudes to euthanasia in a way which could be analysed statistically. Nor surprisingly attitudes appeared to 'harden' as those answering (...) the questionnaire grew more experienced in dealing with patients and also more professionally established. Thus it was found that of the seven groups questioned practising physicians showed more positive attitudes to euthanasia and their responses did not differ significantly from those of senior medical students. It is these groups which actually or potentially have to resolve the clinical dilemma posed by the dying patient. (shrink)

Recent reports published by the United Nations and the World Health Organization suggest that the brain drain of healthcare professionals from the developing to the developed world is decimating the provision of healthcare in poor countries. The migration of these key workers is driven by a combination of economic inequalities and the recruitment policies of governments in the rich world. This article assesses the impact of the healthcare brain drain and argues that wealthy countries have a moral obligation to reduce (...) the flow of healthcare workers from the developing to the developed world. (shrink)